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WO2009027540A1 - Raccord à baïonnette pour dispositif d'injection médical et cartouche - Google Patents

Raccord à baïonnette pour dispositif d'injection médical et cartouche Download PDF

Info

Publication number
WO2009027540A1
WO2009027540A1 PCT/EP2008/061506 EP2008061506W WO2009027540A1 WO 2009027540 A1 WO2009027540 A1 WO 2009027540A1 EP 2008061506 W EP2008061506 W EP 2008061506W WO 2009027540 A1 WO2009027540 A1 WO 2009027540A1
Authority
WO
WIPO (PCT)
Prior art keywords
container
medical delivery
lugs
delivery system
joint
Prior art date
Application number
PCT/EP2008/061506
Other languages
English (en)
Inventor
Torben Strøm HANSEN
Henrik Siiger
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Publication of WO2009027540A1 publication Critical patent/WO2009027540A1/fr

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
    • F16L37/00—Couplings of the quick-acting type
    • F16L37/24—Couplings of the quick-acting type in which the connection is made by inserting one member axially into the other and rotating it to a limited extent, e.g. with bayonet action
    • F16L37/244—Couplings of the quick-acting type in which the connection is made by inserting one member axially into the other and rotating it to a limited extent, e.g. with bayonet action the coupling being co-axial with the pipe
    • F16L37/252—Couplings of the quick-acting type in which the connection is made by inserting one member axially into the other and rotating it to a limited extent, e.g. with bayonet action the coupling being co-axial with the pipe the male part having lugs on its periphery penetrating in the corresponding slots provided in the female part
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3129—Syringe barrels
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
    • F16B21/00—Means for preventing relative axial movement of a pin, spigot, shaft or the like and a member surrounding it; Stud-and-socket releasable fastenings
    • F16B21/02—Releasable fastening devices locking by rotation
    • F16B21/04—Releasable fastening devices locking by rotation with bayonet catch
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic

Definitions

  • the invention relates to a medical delivery device adapted for delivering of one or more doses of a drug to a subject, and concerns particularly the interface between an exchange- able drug container, such as a cartridge or other, and the medical delivery device
  • Subcutaneous, intravenous and intramuscular delivery of liquid drugs by injection or infusion is common in the medical arts. As some medications such as insulin must be administered frequently to a patient, easy performance of the devices to perform the injections or infusions is desirable.
  • a drug containing reservoir In a range of common medical delivery devices, whether pen-like injection devices with needles - manual or intelligent and optionally motor driven, jet-injection needles devices, pumps etc. it is necessary to connect a drug containing reservoir to the medical de- vice.
  • the drug container can be a cartridge, a flexible reservoir or other known containers, and it can be suited for single time use or for multiple drug deliveries. In any case it is preferable to have an easy operational, yet secure connection between the medical delivery device and the drug container. Also the cost associated to produce the connection is critical, which is especially the case for single time use containers.
  • WO 03015853 discloses a medical device connected to a medium-filled vial via a thread connection (19).
  • the thread connection requires the user to first rotationally position the two connecting parts to let them engage and secondly rotate the two parts relatively until the thread connection reaches a stop.
  • GB 1132065 discloses a medical needleless injection device where a bayonet coupling attaches a liquid containing ampoule to the device.
  • the bayonet coupling has two lugs, therefore to connect the parts, the user first have to rotationally position the two connecting parts by up to 180° and the push and turn to lock the bayonet coupling.
  • US 6053890 discloses a jet injector with a bayonet coupling having a limited number of studs to cooperate with mating bayonet structures.
  • the WO 03015853, GB 1132065 and US 6053890 suffers from a range of drawbacks when regarding the above mentioned important features of a liquid drug delivery device.
  • Care per- sonnel need fast and effective equipment to ensure that valuable time is spent with aid of patients in mind. Therefore fumbling for correct orientation of the parts to be connected is undesirable especially for the care personnel, but indeed also to the patient him or her-self. Important is off course especially the safety.
  • a drawback to the WO 03015853 solution is that the connection is potentially not well defined; as the thread can be tightened to various extent, with possible waste or damage as a result of under- or over-tightening.
  • EP 1536854 has a "more than two lugs bayonet connection" which addresses the problem of simple handling. However, as EP 1536854 solely concerns the connection of a needle hub to a medical cartridge, it does not solve the problem of the large forces to be withstood by the connection in a jet-injection device.
  • one of the objectives of the present invention is to provide a connection between a medical delivery device and a drug container which is strong, easy to operate, safe and well defined, suiting both multiple use as well as single use containers. Accordingly the connection should further be cheap and quick to manufacture.
  • connection between a medical device and a drug container such as a cartridge or any other known drug container according to the invention is obtained by a multiple-lugs bayonet coupling.
  • the three or more supporting lugs for the bayonet coupling solves the before mentioned drawbacks of the known technique as more supporting lugs distributes the force among all the lugs and at the same time, the more lugs are used, the less angle the two parts have to be rotationally positioned before a connection is possible.
  • the strength of the bayonet coupling is especially increased when the lugs of the bayonet coupling are constructed in a slim, elongate shape in the axial direction of the device / container, whereby a large number of lugs can be achieved yet having a relatively large fastening area of each of the lugs.
  • the container is elongate in shape, there is room for elongate lugs without compromising the total length of the device or container.
  • connection force among more than two lugs reduces the risk of breakage due to material or moulding faults and in the case of moulded parts, more than two lugs reduces the moulding cycle time and therefore the production price, as the local material thickness and therefore the curing time is reduced as compared to the traditional two-lugs bayonet coupling.
  • connection parts are further reduced or even avoided by curving the opposing surfaces of the lugs and the associated indentation, whereby only axial movement of the two connection parts, that is the medical delivery device and the drug container, is required:
  • the parts will by further axial relative movement closer together be forced to rotate relatively to each other, because of the tangential force component derived from the curved surfaces, until the correct angular position is obtained and further axial movement of the parts will let the lugs engage the associated bayonet indents.
  • the advantage of guiding curved surfaces can also be used in the bottom of the indentations.
  • a flexible element such as a spring can provide a rejecting force from the device relative to the container, such that the container will always be ejected from the device once the assembling force from the user is removed, unless the lugs have entered the well-defined connecting position of the associated indentations.
  • a medical delivery device comprising a drug container suitable to be fixed to said device by a quick fix and release joint characterized in that, said joint comprises at least three joint couples, each couple comprising an axial elongated lug and an associated support member, whereby the joining force is distributed among more than two joint couples and whereby rotational orientation of the drug container to said device is done in less than a 120 degree rotation of the drug container relative to the device.
  • a medical delivery device characterized in that, said joint is a bayonet joint with three or more bayonet joint couples.
  • a medical delivery device characterized in that, said joint is a snap joint with three or more snap joint couples.
  • joint couples are formed by bended plate or punched plate on at least the device part of the joint couple.
  • a medical delivery device according to any of the features 1 - 3 characterized in that, at least part of said joint couples are formed by moulded plastic material.
  • a medical delivery device characterized in that, the axial alignment of said container relative to said device is guided by an interface part of said device, said container or both said device and said container.
  • a medical delivery device according to any of the above features characterized in that, the rotational alignment of said container relative to said device to enable assembly of said joint couples is guided by an interface part of said device, said container or both said device and said container.
  • a medical delivery device according to feature 6 or feature 7 characterized in that, said interface parts on either the container, the device or both comprise one or more angled surfaces.
  • a medical delivery device characterized in that, said joint comprise a counter rotational safety catch, such that unintentional counter rotation leading to release of the joint is avoided.
  • a method for joining a medical delivery device and a drug container comprising the steps of: • roughly axially aligning said device and said container
  • Fig. 1 shows a well known principle of connecting a medical jet unit to a drug cartridge via a bayonet lock connection.
  • Fig. 2 shows the connection of a medical jet injector to a drug containing cartridge via a multiple elongate lug bayonet lock according to the invention.
  • Fig. 3 a cross sectional view of the multiple elongate bayonet lock according to the invention.
  • distal distal
  • proximal proximal
  • radial radial
  • Figure 1 shows a well known principle of the connection of a medical jet injection unit 12 to a drug containing cartridge 1 1 by means of a bayonet lock comprising two lugs 14 and two associated supports 16 placed as protrusions on the inside of the hollow, cylindrical female connecting part 13 of the injection unit 12.
  • the drug containing cartridge 11 can be an injection moulded plastic part. This being the case, the curing time is relatively increased due to the material thickness and concentration related to the large and compact lugs 14.
  • the male cartridge part When connecting the cartridge 11 to the medical device 13, the male cartridge part is co- axially mated to the female medical device part, thereafter the two parts are axially moved towards each other until a stop is reached, or until the lugs 14 collides with the proximal side of the protruding supports 16 - as is most likely the case since an exact angular positioning of the cartridge relative to the medical device is a precondition to connection of the two parts.
  • the two parts are rotated relatively to each other until the lugs are angularly oriented to the passage between the supports, which allows for the cartridge and the medical device to be moved further towards one another, until finally the lugs pass the distal side of the supports and the cartridge is rotated relatively to the device part to lock the bayonet connection.
  • the necessary relative turn of the cartridge relative to the device part can in worst case be up to 180°.
  • FIG 2 a supreme alternative to the known technique according to the invention is shown.
  • the two bayonet connection lugs are here exchanged with a plurality of lugs 24, in this case 10 lugs, each of the lugs having an connecting-cross-section to the cartridge 21 much smaller than the lugs 14 of the known device, and having therefore a much smaller material thickness and material concentration than the lugs 14 of the known bayonet connection.
  • This has the consequence that the curing time of an injection moulded cartridge with connection lugs 24 according to the present invention is reduced as compared to the cartridge of the known art, hence production time and price per unit can be reduced accordingly.
  • the car- tridge typically has an elongate shape to provide room for the drug and to provide space for the displacement of an internal piston moving towards the outlet when the drug has to be expelled. Because of this elongate space, there is sufficient room for elongate lugs without needing to redesign the typical cartridge.
  • the elongate lugs provides an advantageous com- promise of small local material concentration, yet a large force absorbing area, and the elongated force absorbing area is even orientated in the most advantageous direction relative to the direction of the force to be absorbed.
  • the lugs are integrated parts of a moulded cartridge of plastic material which makes it easy to acquire the desired shape of the lugs.
  • the distal end of the lugs which is the first part of the lugs to come into contact with the female bayonet connection part 23, when the cartridge is moved axially towards the medical device, can have a guide, 25, in this case a stepped down part which guide the cartridge into correct coaxial alignment with the medical device even if the user moves the two parts together with a slight dis-alignment. Further guides to secure the correct angular alignment can also be made on the cartridge bayonet lugs.
  • the rotational alignment is acquired by the female counterpart to the bayonet lugs, the protruding supports, 26, by having an angled face on the proximal part of the support, which is the face turning towards the approaching corresponding lug, when assembling the bayonet lug.
  • the parts are relatively rotated to one of the correct angular positions as the lugs slips along the angled surface of the guiding face of the protrusions without the user needing to actively rotating the parts.
  • the medical device part of the bayonet coupling can be made of a thin sheet material, for instance of a suitable metal, which makes it possible to produce the protrusions by a stamping process, possibly followed by a rolling of the sheet to form a cylindrical part.
  • a stamping process possibly followed by a rolling of the sheet to form a cylindrical part.
  • other well known materials and processes can be used, such as moulded plastics analogue to the cartridge part.
  • FIG 3 a cross sectional view shows of the assembled cartridge, 31 , and medical device, 32 is shown. It is clear from the hatched area that large forces can be withstood by the elongated lugs 34.
  • the associated protrusions, 36 can in this embodiment have a smaller area, since the material chosen is metal plate.
  • the guiding recess, 35 can be seen, which helps to coaxially position the cartridge relative to the medical device when assembling the two.
  • the illustrated embodiment in figure 3 further includes a spring 37 for securing the cartridge in the locked bayonet position once the two have been assembled. To ensure an even supporting face, a disc is positioned between the spring and the cartridge.
  • the bayonet coupling When the bayonet coupling is equipped with a sufficient amount of angled guiding faces for coaxial and rotational guidance of the cartridge relative to the medical device, it is possible for the user only to position the two parts roughly coaxial and only apply an axial force on the cartridge towards the medical device, then the positioning and locking of the bayonet coupling will happen automatically. Further, if the device is equipped with a spring 37, the cartridge will be pushed away from the medical device, it not securely jointed to the medical device, hence, the user will have assurance that he or she has properly jointed the two.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Mechanical Engineering (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention se rapporte à un système médical d'administration (22) tel qu'un système d'injection par jet. Ledit système comprend un dispositif médical d'administration et un réservoir à médicament (21) adaptés pour être couplés ensemble le long d'un axe principal par un accouplement à baïonnette. Ledit accouplement à baïonnette comprend au moins cinq couples de joints, chaque couple comprenant une saillie (24), disposée sur le récipient ou le dispositif, et un élément de support associé (26), disposé sur l'autre parmi le récipient et le dispositif, de telle sorte qu'au moins deux saillies desdits cinq couples de joints ou plus se présentent sous forme de saillies axiales allongées, chacune ayant une longueur axiale plus grande que sa largeur circonférentielle. L'accouplement spécifique proposé assure une manipulation améliorée, une résistance mécanique améliorée et un temps d'établissement réduit au cours de la fabrication.
PCT/EP2008/061506 2007-08-30 2008-09-01 Raccord à baïonnette pour dispositif d'injection médical et cartouche WO2009027540A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07115300.1 2007-08-30
EP07115300 2007-08-30

Publications (1)

Publication Number Publication Date
WO2009027540A1 true WO2009027540A1 (fr) 2009-03-05

Family

ID=38786857

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/061506 WO2009027540A1 (fr) 2007-08-30 2008-09-01 Raccord à baïonnette pour dispositif d'injection médical et cartouche

Country Status (1)

Country Link
WO (1) WO2009027540A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011007316A1 (fr) * 2009-07-17 2011-01-20 Koninklijke Philips Electronics N.V. Dispositif d'administration de fluide à microjet monté sur le poignet
WO2011073528A1 (fr) * 2009-12-18 2011-06-23 Uponor Innovation Ab Raccord entre deux pièces de tuyauterie
CN103547303A (zh) * 2011-03-25 2014-01-29 赛诺菲-安万特德国有限公司 给药装置
GB2505162A (en) * 2012-07-11 2014-02-26 Max Doughty Injector with hook locking system for casing
WO2015047808A1 (fr) * 2013-09-27 2015-04-02 Gkn Sinter Metals, Llc Ensemble de support à engrenage planétaire et procédé de fabrication associé
CN109854592A (zh) * 2019-04-08 2019-06-07 东莞市勇迈五金制品有限公司 一种五金套管连接配件

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4449539A (en) * 1980-12-30 1984-05-22 Walter Sarstedt Kunstoff-Spritzgusswerk Blood extraction device
US6053890A (en) * 1995-10-09 2000-04-25 Moreau Defarges; Alain Needleless jet injection device comprising a moulded-on cartridge
US20020188249A1 (en) * 2001-06-08 2002-12-12 Sergio Landau Durable needle-less jet injector apparatus and method
EP1440703A2 (fr) * 2003-01-23 2004-07-28 Becton Dickinson and Company Dispositif de branchement d'un fluide pour ensemble de prelevement sanguin
EP1536854B1 (fr) * 2002-07-03 2006-11-02 Novo Nordisk A/S Systeme de montage d'aiguille pour le montage d'un ensemble aiguille

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4449539A (en) * 1980-12-30 1984-05-22 Walter Sarstedt Kunstoff-Spritzgusswerk Blood extraction device
US6053890A (en) * 1995-10-09 2000-04-25 Moreau Defarges; Alain Needleless jet injection device comprising a moulded-on cartridge
US20020188249A1 (en) * 2001-06-08 2002-12-12 Sergio Landau Durable needle-less jet injector apparatus and method
EP1536854B1 (fr) * 2002-07-03 2006-11-02 Novo Nordisk A/S Systeme de montage d'aiguille pour le montage d'un ensemble aiguille
EP1440703A2 (fr) * 2003-01-23 2004-07-28 Becton Dickinson and Company Dispositif de branchement d'un fluide pour ensemble de prelevement sanguin

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011007316A1 (fr) * 2009-07-17 2011-01-20 Koninklijke Philips Electronics N.V. Dispositif d'administration de fluide à microjet monté sur le poignet
WO2011073528A1 (fr) * 2009-12-18 2011-06-23 Uponor Innovation Ab Raccord entre deux pièces de tuyauterie
RU2551912C2 (ru) * 2009-12-18 2015-06-10 Юпонор Инновейшн Аб Соединение между двумя элементами трубопровода
CN103547303A (zh) * 2011-03-25 2014-01-29 赛诺菲-安万特德国有限公司 给药装置
CN103547303B (zh) * 2011-03-25 2015-11-25 赛诺菲-安万特德国有限公司 给药装置
GB2505162A (en) * 2012-07-11 2014-02-26 Max Doughty Injector with hook locking system for casing
WO2015047808A1 (fr) * 2013-09-27 2015-04-02 Gkn Sinter Metals, Llc Ensemble de support à engrenage planétaire et procédé de fabrication associé
CN105579169A (zh) * 2013-09-27 2016-05-11 Gkn烧结金属有限公司 行星齿轮架组件及有关制造方法
US10151382B2 (en) 2013-09-27 2018-12-11 Gkn Sinter Metals, Llc Planetary gear carrier assembly and related method of making
CN109854592A (zh) * 2019-04-08 2019-06-07 东莞市勇迈五金制品有限公司 一种五金套管连接配件

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