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WO2009022280A2 - Module de transport d'un dispositif de diagnostic à cartouche unique - Google Patents

Module de transport d'un dispositif de diagnostic à cartouche unique Download PDF

Info

Publication number
WO2009022280A2
WO2009022280A2 PCT/IB2008/053205 IB2008053205W WO2009022280A2 WO 2009022280 A2 WO2009022280 A2 WO 2009022280A2 IB 2008053205 W IB2008053205 W IB 2008053205W WO 2009022280 A2 WO2009022280 A2 WO 2009022280A2
Authority
WO
WIPO (PCT)
Prior art keywords
cartridge
plane
transport module
diagnostic device
diagnosing
Prior art date
Application number
PCT/IB2008/053205
Other languages
English (en)
Other versions
WO2009022280A3 (fr
Inventor
Jozef Christiaan Mathieu Versleegers
Arnold Aalders
Original Assignee
Koninklijke Philips Electronics N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips Electronics N.V. filed Critical Koninklijke Philips Electronics N.V.
Publication of WO2009022280A2 publication Critical patent/WO2009022280A2/fr
Publication of WO2009022280A3 publication Critical patent/WO2009022280A3/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00039—Transport arrangements specific to flat sample substrates, e.g. pusher blade

Definitions

  • the invention relates to a diagnostic device, more particularly a diagnostic device including a single cartridge, and still more particularly a transport module of the single-cartridge diagnostic device.
  • a detection method is known based on a DNA/RNA amplification process.
  • the detection is done by performing a number of process steps using different instruments , for example a Biorobot for lysis, washing, mixing and elusion, a PCR Cycler for DNA/RNA amplification, and an appropriate optical or electro-magnetic system for detection and identification of the specific amplified DNA/RNA.
  • the samples are handled manually from machine to machine and the detection results are obtained after about 6 hours.
  • An integrated diagnostic device is one in which at least some and preferably all of the above process steps are performed inside a single cartridge without manual interference. This device gives the results sooner and is user- friendly. This device avoids the risk of cross-contamination because all processes are done in a closed disposable cartridge.
  • the execution of the analyses is performed fully automatically , leading to a drastic reduction of processing time to about 2 hours, eliminating all intermediate manual steps and also avoiding operator handling errors.
  • US-20060002820-A1 describes a new apparatus which is useful for high throughput of samples without the necessity of interrupting any analysis carried out with said apparatus for reloading of disposables.
  • the apparatus comprises a transfer module, a first plane to store the disposables and a second plane to process samples within said disposables.
  • the transfer module is an elevator for transporting said disposables from said plane for storage to said plane for processing.
  • This apparatus uses one actuator for moving the disposables from the output position of the first plane to the input position of the second plane and at least three actuators for positioning the disposables from the input position of the first plane to the output position of the first plane. This makes the apparatus bulky and complex. It would therefore be advantageous to have a diagnostic device which does not have the disadvantages described above and more in particular to have a compact diagnostic device that minimizes handling errors.
  • a single-cartridge diagnostic device comprises a transport module for receiving a cartridge on a first plane, wherein the cartridge is configured to hold a sample to be diagnosed; a diagnosing platform disposed on a second plane, wherein the diagnosing platform is configured for receiving the cartridge from the first plane, and wherein the cartridge is transported along a single axis from the first plane to the second plane.
  • the single axis transportation makes the diagnostic device compact as it needs a less complex mechanism. Compact devices occupy less space in a laboratory.
  • the axis is a vertical axis.
  • the cartridge is tansported vertically from the first plane to the second plane.
  • the second plane is parallel to the first plane.
  • the alignment of the cartridge with the diagnosing platform is crucial to ensure a correct diagnosis.
  • accurate alignment can be achieved
  • the cartridge is preloaded with the sample.
  • the current invention involves the miniaturization and full integration of various and different process steps so as to form a single disposable cartridge.
  • Containers with various processing fluids are an integral part of the cartridge.
  • the execution of the analyses is performed fully automatically , leading to a drastic reduction of processing times, elimination of intermediate manual steps and avoidance of operator handling errors.
  • the cartridge is designed so as to be disposable. This avoids the risk of cross- contamination.
  • the fully closed cartridge preferably contains all elements for executing the process steps on the fluids: e.g channels to transport the fluids, specific chambers for mixing, lysing, washing, temperature cycling.
  • the preferably pre-loaded cartridge is inserted into the diagnostic device on the first plane.
  • the transport module comprises a single actuator for actuating the transport module; and a receiver for receiving the cartridge on the first plane.
  • the single actuator makes the diagnostic device compact. Space in laboratories is expensive and there is always a drive to keep the diagnostic device as compact as possible.
  • the forces required to interface the cartridge with the diagnosing platform during the diagnosing process are relatively high ( ⁇ 400N). The transport module ensures that this interfacing force is provided.
  • the transport module further comprises a positioning device for accurately positioning the cartridge onto the transport module.
  • the positioning device preferably comprises pins for accurately positioning the cartridge onto the transport module.
  • the positioning device preferably comprises pins for accurately positioning the cartridge onto the transport module.
  • the cartridge is accurately and automatically positioned when the transport module trans ports the cartridge from the first plane to the second plane, and requires no additional steps and actuators.
  • the diagnosing platform is provided with an optical detector for diagnosing the sample.
  • the cartridge is provided with radiation transport ports for allowing access of an excitation beam from the optical detector and emision of fluorescence light from the detection spots.
  • a method of diagnosing a sample comprises providing a cartridge onto a first plane; transporting the cartridge from the first plane to a second plane along a single axis; and diagnosing the sample upon receiving the cartridge on the second plane. The method involves very few steps and thus simplifies the diagnosing process.
  • the cartridge is preloaded with the sample.
  • transporting the cartridge to the second plane is performed by a transport module.
  • the axis is a vertical axis.
  • the transporting of the cartridge comprises positioning the cartridge onto the transport module using positioning pins provided on the transport module; and transporting the cartridge to interface with a diagnostic platform on the second plane.
  • transporting the cartridge to the second plane is performed by a single actuator.
  • a diagnostic system comprises the diagnostic device as described above.
  • the diagnostic system may be able to diagnose multiple samples.
  • Fig. 1 shows an overall view of a diagnostic device
  • Fig. 2 shows a positioning pin
  • Fig. 3 shows an internal view of a transport module
  • Fig. 4 shows an embodiment wherein the transport module is in its lower state
  • Fig. 5 shows an embodiment wherein a cartridge is positioned by positioning pins provided on the transport module
  • Fig. 6 shows an embodiment wherein the cartridge is aligned with Z-references on a diagnosing platform
  • Fig. 7 shows an embodiment of the invention wherein the cartridge is finally positioned.
  • the diagnostic device 100 comprises a single actuator 1, gear wheels 2, side plates 3, crank bars 4, central guiding shafts 5, guiding wheels 6, guiding cranks 7, a diagnosing platform 8, a transport module 9, a receiver 10 to receive a cartridge 11, X-Y positioning pin 12 and R z positioning pin 13.
  • the diagnosing platform 8 includes Z -references 14 and aligns with a surface 15 provided in the cartridge 11.
  • the surface 15 is a hole , when viewed from the bottom, and a surface when viewed from the top.
  • the first plane is denoted by 200 whereas the second plane is denoted by 300.
  • the cartridge 11 is received by the receiver 10 on the first plane 200 as shown in Figure 1.
  • the transport module 9 is positioned by two central shafts 5, and four crank bars 4 as illustrated in Figure 2
  • the crank bars are actuated using the gear wheels 2 and the actuator 1.
  • the receiver 10 is positioned by the same two central shafts 5, four guiding wheels 6 and guiding cranks 7 and the shape of the side plates 3.
  • the bottom position in Z direction of the receiver 10 is derived from the shape of the side plates 3.
  • the diagnostic device 100 after receiving the cartridge is shown in Figure 3 and is ready to interface the cartridge 11 with the diagnosing platform 8 with the help of the transport module 9.
  • the diagnosing platform 8 may have a PCR head and a heater for lysis of the sample besides the optics module .
  • the interfacing sequence is done in three steps. All three steps are performed by the actuator 1.
  • the actuator 1 operates continuously. As soon as the actuator 1 starts turning the gear wheels 4, the transport module starts to move vertically up.
  • the transport module 9 reaches the receiver 10, two positioning pins 12 and 13 on the transport module position the cartrdige in the X, Y and R z direction.
  • the cartridge 11 is loaded onto the receiver 10 on the first plane 200, it has some play in all directions. This play can result in large positioning errors (in the X, Y andR z direction). These errors need to be smaller for the diagnostic device 100 to work efficiently.
  • two positioning pins 12 and 13 on the transport module 9 enter two holes 15 that are in the cartridge 11.
  • These holes 15 are holes, when viewed from the bottom, so that the positioning pins can align with them.
  • the holes 15 are surfaces, when viewed from the top, so they can align smoothly with the diagnosing platform 8.
  • the positioning pins 12 and 13 and the holes 15 in the cartridge 11 have very little play. In this way the cartridge 11 positions itself with regard to the transport module 9 in X, Y and R z directions. No force other then the positioning force is applied on the cartridge . This ends step one and is shown in Figure 5.
  • the diagnostic platform 8 consists of the z-references 14. As soon as the transport module 9 along with the cartridge 11 reach the diagnostic platform 8, the cartridge 11 is fully constrained and positioned. This is shown in Figure 6.
  • the transport module 9 is moved to its final psition. Since the cartridge 11 is already positioned, the (minimal) forces applied by the last interfacing features on the cartridge 11 do not influence the positioning of the cartridge 11. All three steps are carried out during gradual motion of the transport module 9.

Landscapes

  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

L'invention concerne un dispositif de diagnostic à cartouche unique qui comprend un module de transport pour recevoir une cartouche sur un premier plan. La cartouche est configurée de façon à contenir un échantillon devant être diagnostiqué. Le dispositif comprend également une plate-forme de diagnostic disposée sur un deuxième plan, qui est configurée pour recevoir la cartouche à partir du premier plan. La cartouche est transportée le long d'un axe unique du premier plan au deuxième plan. Le mouvement d'axe unique du module de transport permet de rendre le dispositif de diagnostic compact.
PCT/IB2008/053205 2007-08-14 2008-08-11 Module de transport d'un dispositif de diagnostic à cartouche unique WO2009022280A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07114316.8 2007-08-14
EP07114316 2007-08-14

Publications (2)

Publication Number Publication Date
WO2009022280A2 true WO2009022280A2 (fr) 2009-02-19
WO2009022280A3 WO2009022280A3 (fr) 2009-04-09

Family

ID=40202939

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/053205 WO2009022280A2 (fr) 2007-08-14 2008-08-11 Module de transport d'un dispositif de diagnostic à cartouche unique

Country Status (1)

Country Link
WO (1) WO2009022280A2 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105199951A (zh) * 2015-10-27 2015-12-30 北京中科紫鑫科技有限责任公司 一种dna测序仪的供液系统
CN105259165A (zh) * 2015-10-27 2016-01-20 北京中科紫鑫科技有限责任公司 一种dna测序仪的试剂供应装置
CN105385590A (zh) * 2015-11-02 2016-03-09 北京中科紫鑫科技有限责任公司 一种试液自动供应的箱式dna测序仪
WO2020070012A1 (fr) * 2018-10-01 2020-04-09 Boehringer Ingelheim Vetmedica Gmbh Analyseur pour tester un échantillon
US10744502B2 (en) 2016-10-07 2020-08-18 Boehringer Ingelheim Vetmedica Gmbh Analysis device and method for testing a sample

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5061446A (en) * 1988-07-28 1991-10-29 Jean Guigan Device for performing biological analyses by immunoenzymatic detection of antibodies or antigens in a serum
US20040101951A1 (en) * 2002-11-27 2004-05-27 Albert Vent Mounting platform for biological growth plate scanner
US20060002820A1 (en) * 2004-07-01 2006-01-05 Roche Molecular Systems, Inc. Multi-level diagnostic apparatus with a lift system
US20060073073A1 (en) * 2004-09-29 2006-04-06 Fichera Stephen L Platform apparatus with horizontal slide translation and method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5061446A (en) * 1988-07-28 1991-10-29 Jean Guigan Device for performing biological analyses by immunoenzymatic detection of antibodies or antigens in a serum
US20040101951A1 (en) * 2002-11-27 2004-05-27 Albert Vent Mounting platform for biological growth plate scanner
US20060002820A1 (en) * 2004-07-01 2006-01-05 Roche Molecular Systems, Inc. Multi-level diagnostic apparatus with a lift system
US20060073073A1 (en) * 2004-09-29 2006-04-06 Fichera Stephen L Platform apparatus with horizontal slide translation and method

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105199951A (zh) * 2015-10-27 2015-12-30 北京中科紫鑫科技有限责任公司 一种dna测序仪的供液系统
CN105259165A (zh) * 2015-10-27 2016-01-20 北京中科紫鑫科技有限责任公司 一种dna测序仪的试剂供应装置
CN105385590A (zh) * 2015-11-02 2016-03-09 北京中科紫鑫科技有限责任公司 一种试液自动供应的箱式dna测序仪
US10744502B2 (en) 2016-10-07 2020-08-18 Boehringer Ingelheim Vetmedica Gmbh Analysis device and method for testing a sample
WO2020070012A1 (fr) * 2018-10-01 2020-04-09 Boehringer Ingelheim Vetmedica Gmbh Analyseur pour tester un échantillon
CN112805568A (zh) * 2018-10-01 2021-05-14 勃林格殷格翰维特梅迪卡有限公司 用于测试样品的分析仪
JP2022501611A (ja) * 2018-10-01 2022-01-06 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハーBoehringer Ingelheim Vetmedica GmbH サンプルを検査するための分析器

Also Published As

Publication number Publication date
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