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WO2009019673A2 - Ampoule de mélange multichambre - Google Patents

Ampoule de mélange multichambre Download PDF

Info

Publication number
WO2009019673A2
WO2009019673A2 PCT/IL2007/000987 IL2007000987W WO2009019673A2 WO 2009019673 A2 WO2009019673 A2 WO 2009019673A2 IL 2007000987 W IL2007000987 W IL 2007000987W WO 2009019673 A2 WO2009019673 A2 WO 2009019673A2
Authority
WO
WIPO (PCT)
Prior art keywords
ampoule
mixture
axially displaceable
housing
plunger element
Prior art date
Application number
PCT/IL2007/000987
Other languages
English (en)
Other versions
WO2009019673A3 (fr
Inventor
Shlomo Haimi
Yehezkel Menashe
Original Assignee
Shlomo Haimi
Yehezkel Menashe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shlomo Haimi, Yehezkel Menashe filed Critical Shlomo Haimi
Priority to PCT/IL2007/000987 priority Critical patent/WO2009019673A2/fr
Publication of WO2009019673A2 publication Critical patent/WO2009019673A2/fr
Publication of WO2009019673A3 publication Critical patent/WO2009019673A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3125—Details specific display means, e.g. to indicate dose setting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3125—Details specific display means, e.g. to indicate dose setting
    • A61M2005/3126—Specific display means related to dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31501—Means for blocking or restricting the movement of the rod or piston
    • A61M2005/31508—Means for blocking or restricting the movement of the rod or piston provided on the piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/288—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened by piercing without internal pressure increase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31591—Single dose, i.e. individually set dose administered only once from the same medicament reservoir, e.g. including single stroke limiting means

Definitions

  • the present invention relates to medical ampoules and, in particular, it concerns a multi-chambered ampoule configured to allow mixing of two or more substances just prior to use.
  • U.S. Patent No. 6,981,963 to Barker et al. discloses a device for mixing and injecting medication from a two-chambered cartridge.
  • a two-chambered cartridge is attached to a barrel and contains components of a medication stored separately in the chambers.
  • a plunger in the rearward end of the cartridge can be advanced into the cartridge thereby forcing a piercing member to puncture a sealing membrane allowing the separate components to combine.
  • the cartridge is advanced forwardly into the barrel, the medication is injected through a needle and into a patient.
  • the Barked device suffers from complexity of design and manufacture and does not allow for dispensing of the combined components into a standard syringe or with another dispensing device.
  • U.S. Patent No. 6,113,257 to Sharon et al. discloses a container holding two separate components which are mixed prior to use.
  • the container includes a housing with a dispensing opening and neck portion between the opening and the bottom end of the housing.
  • the container further includes a displaceable member disposed within the housing and having a partition wall with an edge adapted for a sealing engagement with internal walls of the neck portion, thereby defining two compartments separated by the partition wall.
  • the displaceable member is axially displaceable between two positions along an axis extending through the neck portion.
  • the present invention is a multi-chambered ampoule configured to allow mixing of two or more substances just prior to use that has a simple design and flexible dispensing modes.
  • a multicompartment ampoule for the storage and mixing of multiple components of a mixture
  • the ampoule comprising: a) an ampoule housing defining an interior volume, said ampoule housing having a initially sealed proximal end; b) an end plug configured to seal a distal end of said ampoule housing, said end plug having an axial through bore; c) an axially displaceable plunger element configured such that a portion of said plunger element passes thorough said axial through bore into said interior volume and is fixedly attached to at least a first axially displaceable piston element slideablely deployed within said ampoule housing so as to sealingly divide said interior volume into at least first and second storage regions; and d) at least a first one-way flow configuration configured such that axial displacement of said plunger element in a first direction discharges a first component of the mixture from said first storage region through said one-way flow configuration into said second storage region so as to mix with at least a second component of the mixture
  • said ampoule housing and said axially displaceable piston element have corresponding substantially circular cross-sectional contours.
  • At least a portion of said one-way flow configuration is configured in said plunger element.
  • At least said second component of the mixture is in a solid state. According to a further teaching of the present invention, at least said second component of the mixture is in a powdered state.
  • said plunger element is configured with at least one indicator of volume dispensation corresponding to axial displacement of said axially displaceable piston element. According to a further teaching of the present invention, dispensing of the mixture effects axial displacement of said plunger element in a second direction.
  • an adjustable displacement limitation element configured to limit said axial displacement of said plunger element in said second direction, thereby limiting an amount of the mixture dispensed.
  • axial displacement of said plunger element in a second direction effects dispensing of the mixture.
  • a needle cannula configured for attachment to said proximal dispensing end of said ampoule housing.
  • an adjustable displacement limitation element configured to limit said axial displacement of said plunger element in said second direction, thereby limiting an amount of the mixture dispensed.
  • said one-way flow configuration includes a one-way valve.
  • a method for storing multiple components of a mixture in separate compartments of an ampoule, then combining and mixing the components prior to use comprising: a) providing a multi-compartmental ampoule having: i) an ampoule housing having an interior volume, said interior volume being divided into at least first and second storage regions by at least a first axially displaceable piston element slideablely deployed within said ampoule housing; and ii) at least a first one-way flow configuration configured such that axial displacement of said axially displaceable piston element in a first direction discharges a first component of the mixture from said first storage region through said one-way flow configuration into said second storage region so as to mix with at least a second component of the mixture being stored therein; and b) axially displacing said axially displaceable piston element in a first direction
  • an axially displaceable plunger element configured such that a portion of said plunger element extends into said interior volume and is fixedly attached to said axially displaceable piston element such that axial displacement of said plunger element affects axial displacement of said piston element.
  • a method for storing, mixing and dispensing multiple components of a mixture from an ampoule having separate storage compartments comprising: a) providing a multi-compartmental ampoule having: i) an ampoule housing defining an interior volume, said ampoule housing having a proximal dispensing end; ii) an axially displaceable plunger element configured such that a portion of said plunger element extends into said interior volume and is fixedly attached to at least a first axially displaceable piston element slideablely deployed within said ampoule housing so as to sealingly divide said interior volume into at least first and second storage regions; and iii) at least a first one-way flow configuration configured such that axial displacement of said plunger element in a first direction discharges a first component of the mixture from said first storage region through said one-way flow passage into said second storage region so as to mix with at least a second component of the mixture being stored therein; b) axial
  • said plunger element is implemented with at least one indicator of volume dispensation corresponding to axial displacement of said axially displaceable piston element.
  • an adjustable displacement limitation element configured to limit said axial displacement of said plunger element in said second direction, thereby limiting an amount of the mixture dispensed.
  • FIG. 1 is longitudinal cross-sectional view of a preferred embodiment of a syringe constructed and operative according to the teachings of the present invention, showing the beginning of the combining process;
  • FIG. 2 is longitudinal cross-sectional view of the embodiment of FIG. 1 as the combining process continues:
  • FIG. 3 is longitudinal cross-sectional view of the embodiment of FIG. 1 at the completion of the combining process
  • FIG. 4 is a detail of the embodiment of FIG. 1 showing a preferred embodiment of a piston and one-way flow passage constructed and operative according to the teachings of the present invention
  • FIG. 5 is longitudinal cross-sectional view of a preferred embodiment of an ampoule constructed and operative according to the teachings of the present invention, shown with the components of the mixture in a storage state;
  • FIG. 6 is longitudinal cross-sectional view of the embodiment of FIG. 5 shown with the components of the mixture in a mixed state.
  • the present invention is a multi-chambered ampoule configured to allow mixing of two or more substances just prior to use that has a simple design and flexible dispensing modes.
  • the present invention provides a multi-compartment ampoule for the storage of the separated components of a multiple component mixture and then mixing them together in a single ampoule.
  • This provides a method of storing the separate components in a manner that will provide the longest shelf life for the components. It also provides a sterile mixing environment.
  • a further advantage is that the mixing process may be performed by personnel with lower technical skills than are currently required for such a task. This is of particular benefit for use in situation where a sterile environment is not available such as in the field for example.
  • the embodiments described herein are configured with two separate compartments, this is not intended as a limitation, and it should be understood that embodiment having more than two compartments are within the scope of the present invention.
  • the ampoule housing defines an interior volume, and is initially sealed at its proximal end by substantially any known arrangement such as, but not limited to, a cap and any ampoule sealing membrane known in the art.
  • the distal end of the ampoule housing is sealed by an end plug configured with an axial through bore.
  • a portion of an axially displaceable plunger element passes thorough the axial through bore and extends into the interior volume and is fixedly attached to an axially displaceable piston element slideablely deployed within the ampoule housing so as to sealingly divide the interior volume into at least first and second storage regions that are pre-filled with the separate components that will be mixed together just prior to use. It will be appreciated that at least one of the components may be stored in a solid state, such as a powder.
  • all of the components may be liquids.
  • Axial displacement of the plunger element, and thereby the piston element, in a first direction discharges a first component of the mixture from the distal storage region through a one-way flow passage into the proximal storage region. Therefore, the volume of the storage regions varies as the piston is displaced within the interior volume of the ampoule housing. Once the two components are in a single storage region, they may be thoroughly mixed together.
  • the one-way flow passage may be configured using substantially any one of the numerous methods known in the art such as, but not limited to, one-way ball valves, and flap valves, for example.
  • the one-way flow passage is configured to be normally closed having an opening threshold pressure differential great enough to maintain the seal between the two storage regions during shipping and storage. It will be appreciated that any of the storage regions may be sealed in a state of vacuum. In such an embodiment, the opening threshold pressure differential of the one-way flow passage is great enough to withstand the associated vacuum pressure. It should be noted that although the preferred embodiments described herein relate to ampoules having a substantially cylindrical body, this is not intended as a limitation and substantially any suitable cross-sectional contour is within the scope of the present invention; therefore, the term "axial" is used herein with regard to a direction of motion and is not intended to suggest or imply any geometrical shape to any of the structural elements of the present invention.
  • dispensing of the mixture may be by any number of methods.
  • the mixture may be dispensed as if from a standard ampoule, wherein the needle of a syringe is inserted through the sealing membrane and the prescribed amount of the mixture is drawn out.
  • the ampoule may be inserted into an injection device, such as an injection pen for example, in a manner similar to a standard ampoule.
  • FIG. 1 Further features of the present invention are to provide a needle cannula configured for attachment directly to the proximal dispensing end of the ampoule housing and to provide graduated markings on the shaft of the plunger that are indicative of volumetric dispensation corresponding to the axial displacement of the piston element.
  • the combination of these features with the basic ampoule of the present invention provides an embodiment that can store the separated components of the mixture before use, provide a way of mixing the components together in the same ampoule and that can be used as the syringe to dispense the mixture directly into the patient. It should be noted that this syringe embodiment is of particular benefit in the areas of emergency and combat field medicine.
  • FIGS 1-4 illustrate a first preferred embodiment 2 that may be used primarily as a syringe.
  • the syringe housing 4 is configured with a proximal dispensing end 6 and a substantially cylindrical body 8.
  • the proximal dispensing end 6 may be sealed by a removable cap or, as illustrated here, an ampoule sealing membrane 50 as is known in the art.
  • the syringe housing 4 is sealed at its distal end by an end plug 14, which is configured with an axial through bore 16.
  • the interior volume of the body 8 is divided into first 10 and second 12 storage regions by the axially displaceable piston element 20.
  • Each of the storage regions 10 and 12 contain different components 10a and 12a respectively that are to later be combined and mixed together into the mixture referred to as 1012a.
  • Component 12a is preferably a liquid.
  • either of the first 10 and second 12 storage regions may be sealed in a vacuum state. This may be of particular benefit regarding components of a mixture that deteriorate with prolonged exposure to the atmosphere, even in a closed container.
  • the plunger element 22 extends through the through bore 16 into the interior volume of the body 8 and is fixedly attached to the axially displaceable piston element 20. Therefore, axial displacement of the plunger element 22 affects axial displacement of the axially displaceable piston element 20.
  • the one-way flow passage 30 is configured in the proximal end of the plunger element 22. It will be understood that one or more oneway flow passages may alternatively be configured elsewhere such as in the axially displaceable piston element 20, for example.
  • the piston is configured as an element that allows through flow of the contents of the second storage region 12 when displaced in the first direction, and is sealed and applies pressure to the mixed contents of the first storage region 10 when displaced in the second direction.
  • component 12a is discharged from storage region 12 through the one-way flow passage 30 and into storage region 10, there to be combined and mixed with component 10a.
  • the distal end 32 of the one-way flow passage 30 may optionally be configured as a nozzle that generates turbulence as component 12a is discharged into storage region 10.
  • Figure 4 illustrates the syringe as the discharge process continues throughout the full distal stroke of the plunger element 22, thereby combining and mixing the components 10a and 12a to produce the desired mixture 1012a.
  • the syringe is ready to dispense the now prepared mixture 1012a as prescribed. Since, the one-way flow passage 30 is configured to allow only the contents of storage region 12 to flow in to storage region 10 as the plunger element 22, and thereby the piston element 20, is axially displaced in a proximal direction, the mixture 1012a is dispended through the needle cannula 40.
  • the graduated markings 24 on the shaft of the plunger element 22 that are indicative of volumetric dispensation of the mixture 1012a corresponding to the axial displacement of the piston element 20.
  • the adjustable displacement limitation element 26 which is configured to limit the axial displacement of the plunger element 22 in the proximal direction, may be moved along the shaft of the plunger element 22 to the appropriate marking and thereby limit the amount of the mixture 1012a dispensed.
  • Figures 5 and 6 illustrate a second preferred embodiment 200 of the present invention that may be used as a syringe or as a standard ampoule, as discussed above.
  • the elements of this embodiment are number similarly to the corresponding elements of embodiment 2 such that all reference numbers are increased by 200; therefore, the syringe housing 4 of embodiment 2 becomes the ampoule housing 204 of embodiment 200 and so on.
  • embodiment 200 is substantially the same as that of embodiment 2, the main difference being the shape of the proximal end 206 of the ampoule housing 204.
  • the proximal end 206 is shaped substantially the same as a standard medical ampoule. Therefore, this embodiment of the present invention may be used in substantially the same manner as a standard medical ampoule. That is, embodiment 200 may be used to fill a standard medical syringe. In such a case, the vacuum created by drawing the mixture 21012a out of storage region 210 draws the piston element 220, and therefore the plunger element 222, is a proximal direction.
  • the adjustable displacement limitation element 226 may be slidingly adjusted to the appropriate graduated markings 224 on the shaft of the plunger element 222 and thereby limit the amount of the mixture 21012a dispensed.
  • the ampoule of embodiment 200 may be used with an appropriately configured injection device.
  • This embodiment may also have a needle cannula 240 attached to the distal end 206 of the ampoule housing 204 and the mixture may be delivered directly to the patient.
  • a needle cannula 240 attached to the distal end 206 of the ampoule housing 204 and the mixture may be delivered directly to the patient.

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  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

La présente invention concerne une ampoule multicompartiment pour le stockage des composants séparés d'un mélange de composants multiples puis leur mélange dans une même ampoule. Le logement d'ampoule comporte une extrémité d'injection proximale. L'extrémité distale du logement d'ampoule est fermée par une douille terminale comportant un trou traversant axial. Une partie d'un élément plongeur mobile dans le sens axial traverse le trou traversant axial, s'étend dans le volume intérieur et est fixée de manière stationnaire à un élément piston mobile dans le sens axial, qui se déploie de manière coulissante dans le logement d'ampoule afin de diviser hermétiquement le volume intérieur en au moins une première et une seconde région de stockage qui sont préremplies avec les composants séparés qui seront mélangés ensemble juste avant leur utilisation. Le déplacement axial de l'élément plongeur, et ainsi de l'élément piston, dans une première direction, déverse un premier composant du mélange de la région de stockage distale à la région de stockage proximale, à travers une configuration d'écoulement à sens unique. Une fois les deux composants réunis dans une même région de stockage, ils peuvent être efficacement mélangés ensemble. Une fois les composants mélangés, l'injection du mélange peut être effectuée selon divers procédés. Le mélange peut être injecté comme s'il provenait d'une ampoule standard, en insérant l'aiguille d'une seringue à travers la membrane hermétique, et en extrayant la quantité prescrite de mélange. En variante, l'ampoule peut être insérée dans un dispositif d'injection, tel un stylet d'injection par exemple, comme pour une ampoule standard. Les caractéristiques supplémentaires d'une canule d'aiguille configurée pour être fixée directement à l'extrémité d'injection proximale du logement d'ampoule, et les graduations sur la tige du plongeur indiquant le volume injecté, combinées avec l'ampoule de base, constituent un mode de réalisation permettant de stocker les composants séparés du mélange avant utilisation, permettent de mélanger les composants ensemble dans la même ampoule, et peuvent être utilisés sous forme de seringue pour injecter le mélange directement dans le patient.
PCT/IL2007/000987 2007-08-07 2007-08-07 Ampoule de mélange multichambre WO2009019673A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/IL2007/000987 WO2009019673A2 (fr) 2007-08-07 2007-08-07 Ampoule de mélange multichambre

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IL2007/000987 WO2009019673A2 (fr) 2007-08-07 2007-08-07 Ampoule de mélange multichambre

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Publication Number Publication Date
WO2009019673A2 true WO2009019673A2 (fr) 2009-02-12
WO2009019673A3 WO2009019673A3 (fr) 2016-06-09

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2405961A2 (fr) * 2009-03-09 2012-01-18 Purdue Research Foundation Dispositif compact pour mélanger et distribuer rapidement des substances à un patient
WO2017005914A1 (fr) * 2015-07-08 2017-01-12 Guerbet Seringue et son procédé d'assemblage

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5785683A (en) * 1995-07-17 1998-07-28 Szapiro; Jaime Luis Disposable syringe with two variable volume chambers
DE19912322A1 (de) * 1999-03-19 2000-09-28 Vetter & Co Apotheker Spritze für medizinische Zwecke

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2405961A2 (fr) * 2009-03-09 2012-01-18 Purdue Research Foundation Dispositif compact pour mélanger et distribuer rapidement des substances à un patient
EP2405961A4 (fr) * 2009-03-09 2012-08-08 Purdue Research Foundation Dispositif compact pour mélanger et distribuer rapidement des substances à un patient
WO2017005914A1 (fr) * 2015-07-08 2017-01-12 Guerbet Seringue et son procédé d'assemblage
FR3038518A1 (fr) * 2015-07-08 2017-01-13 Guerbet Sa Seringue et son procede d'assemblage
US10744266B2 (en) 2015-07-08 2020-08-18 Guerbet Syringe and method for assembling it
USRE49516E1 (en) 2015-07-08 2023-05-02 Guerbet Syringe and method for assembling it

Also Published As

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