WO2009004205A2

WO2009004205A2 - Device for injecting a liquid into a body

Info

Publication number: WO2009004205A2
Application number: PCT/FR2008/050990
Authority: WO
Inventors: Eric Perouse
Original assignee: Laboratoires Perouse
Priority date: 2007-06-07
Filing date: 2008-06-04
Publication date: 2009-01-08
Also published as: FR2916979A1; FR2916979B1; WO2009004205A3

Abstract

According to the invention, the device (10) includes a needle holder (24) and an extraction assembly (27) comprising a needle protection armature (54) defining an inner volume. The holder (24) is movable relative to the armature (54) between an injection position and an extraction position of the needle. The device (10) includes a compressible envelope (28) for generating an overpressure in the injection passage of the needle (22). The envelope (28) is mechanically stacked between a contact surface (78) with the finger of an operator and a surface bearing against the body (14) to be compressed by the application on the contact surface of a force for maintaining the bearing surface against the body (14) when the bearing surface is in contact with the body (14) when withdrawing the needle.

Description

Device for injecting a liquid into a body

The present invention relates to a device for injecting a liquid into a body, in particular the body of a patient, of the type comprising:

- a needle holder carrying an injection needle to be stitched into the body, the injection needle defining an injection passage;

a needle extraction assembly comprising a needle protection armature delimiting an interior volume; the needle holder being displaceable with respect to the protective armature during the extraction of the needle between a use position, in which the needle projects out of the inner volume and an extraction position in which the needle is received in the inner volume; the extraction assembly having a bearing surface on the body, and a contact surface adapted to come into contact with at least one finger of an operator to exert a holding force of the bearing surface against the body the holding force being directed towards the body during the relative movement of the needle support relative to the protective armature between the use position and the extraction position; the device further comprising:

a compressible envelope for generating an overpressure in the injection passage. In certain pathologies, it is necessary to inject a liquid drug dose daily directly into a patient's organ. To do this, it is known to implant permanently, on the chest of the patient, a chamber disposed under the skin. This chamber is extended by a catheter running through the vein or artery to where the drug dose is to be distributed. The implantable chamber comprises a reservoir having a pierceable septum along its surface in contact with the skin.

For injection of the drug dose, the needle of the device is engaged through the patient's skin in the implantable chamber and the drug dose is injected into this chamber through the needle. To carry out such injections, an injection device is commonly used comprising a support integral with the needle. The support is extended by a pipe whose end is connected to the injection needle and the other end is equipped with a connector for connecting a syringe or a reservoir of a dose to be injected . To extract the needle from the implantable chamber, the practitioner grasps the support of the device and pulls the needle out of the patient's support.

The force deployed by the practitioner to extract the needle is relatively large, so that the risk of sting is high when the needle comes out of the skin. To avoid this risk, the injection device is commonly provided with an extraction assembly comprising a needle protection structure which receives the needle during its extraction to prevent the practitioner from pricking himself.

During the extraction of the needle, a temporary depression is generated in the implantable chamber, in particular when the perforable septum is pulled out of the body by the needle, during the initial phase of the extraction.

In vitro tests were performed to measure volume displacement at the tip of the catheter during needle removal.

When removing the needle, it adheres to the septum that rises, the internal volume of the chamber increases creating a strong suction. This aspiration is found at the end of the catheter. Then the needle exiting more of the septum, the adhesion effect decreases, the septum then returns to its original shape and the internal volume of the chamber decreases without reaching its initial value. There is then a residual volume at the end of the catheter that can cause obstruction of the catheter.

Tests have shown that the maximum suction can rise to 17μl. The residual volume for its part can go up to 7μl.

Generally, the catheters used have an internal diameter ranging from 1.57 mm to 0.65 mm. If we reason in terms of corresponding displacement at the distal end of the catheter, we obtain:

- For 17μl a displacement varying from 8 to 50mm - For 7μl a displacement varying from 6mm to 20mm.

This depression can also lead to deposition of fibrin (or other materials) which in the long run will lead to a decrease in the flow of implantable chambers that can go as far as obstruction. The chamber must therefore be replaced frequently.

To overcome this problem, FR-A-2 886 857 discloses a device of the aforementioned type, in which means for generating an overpressure are provided in the extraction assembly in order to generate an overpressure during extraction. .

An object of the invention is to provide an injection device that compensates for the body fluid reflux during the removal of the needle, especially during the initial phase of the extraction. For this purpose, the invention relates to an injection device of the aforementioned type, characterized in that the compressible envelope is stacked mechanically between the contact surface and the bearing surface, to be compressed by the application, on the contact surface, of said holding force when the bearing surface is in contact with the body, during the relative movement of the needle holder with respect to the protective armature.

The invention may include one or more of the following features, taken singly or in any technically possible combination:

the extraction assembly has a lower surface for activating the overpressure, intended to be directed towards the body, the compressible envelope projecting towards the body from the activation surface during the extraction of the needle, the application of the holding force being able to cause compression of the compressible envelope between the lower surface and an additional surface substantially parallel to the lower surface; the assembly comprises a support plate, integral with the compressible envelope and designed to be applied against the body, the compressible envelope being compressed between the activation surface and the support plate during the application of the sustaining force;

the compressible envelope delimits a portion of the bearing surface, the compressible envelope being compressed between the activation surface and the body during the application of the holding force;

the compressible envelope protrudes away from the body with respect to an upper surface of the extraction assembly, the contact surface being delimited at least partially by the compressible envelope to be compressed between the finger of a operator and the upper surface when applying the holding force;

the device comprises an injection catheter connected at one end to the needle support and opening into the injection passage of the needle, the compressible envelope being formed by a flexible section of the injection catheter;

- The protective armature is movable relative to the needle holder along an axis YY 'of extraction, the injection needle having a main portion which projects relative to the needle holder along the axis of extraction Y-Y ', and the compressible envelope is mounted slidably movable along the main section along the extraction axis YY' through a sliding fastener; - The extraction assembly comprises a base mounted on the needle holder and a pusher slidably mounted in the base, the pusher at least partially defining the contact surface;

the extraction assembly comprises a base intended to be placed facing the body, the armature comprising a linkage deployable away from the body from the base between a folded configuration on the base in the vicinity of the body and a deployed configuration away from the base away from the body, the linkage connecting the needle holder to the base;

- the compressible envelope is fixed under the base. The invention will be better understood on reading the description which follows, given solely by way of example, and with reference to the appended drawings, in which:

FIG. 1 is a perspective view of three-quarter faces of an injection device implanted in a human body, during the injection of liquid into an implantable chamber;

- Figure 2 is a view similar to Figure 1, at the beginning of the extraction of the needle holder;

FIG. 3 is a view taken in section along the median vertical plane III-III of FIG. 2; - Figure 4 is a partial sectional side view of the device of Figure 1 during the extraction of the needle;

- Figure 5 is a view similar to Figure 2 of a second injection device according to the invention;

- Figure 6 is a view similar to Figure 3 of a third injection device according to the invention;

- Figure 7 is a view similar to Figure 6, after extraction of the needle. FIGS. 1 to 4 show a first injection device 10 according to the invention connected to an implantable chamber 12.

As shown in the Figures, the chamber 12 is disposed under the skin noted 14 in the body of a patient. The chamber 12 has a generally cylindrical reservoir 16 delimited, on its face in contact with the inner surface of the skin, by a pierceable membrane 18 visible in FIG. 3. The reservoir 16 is connected to a pipe

Delivering a drug solution to a diseased organ.

The injection device 10 comprises, as known per se, a needle 22 solid with a needle holder 24 extended by an injection catheter 26 connected to the needle. 22. The extraction device 10 further comprises an extraction mechanism 27 of the needle 22, and means 28 for generating an excess pressure in the chamber 12 during the extraction of the needle 22.

The needle 22 has a free end curved point 29, so that it opens laterally relative to the general axis of the needle. It delimits internally a liquid injection passage.

The support 24 comprises an elongated and generally cylindrical central core 30 traversed right through by an axial lumen for conveying the liquid to the needle 22. The needle 22 is secured to one end of the core 30 which forms a head 32.

The needle 22 forms an extended elbow 34 on the side of the tip 29 by a main section 35 of vertical axis YY 'and, on the opposite side to the tip 29, by a perpendicular connecting section 36 engaged in the axial lumen passing through the 30, from the head 32. At its other end, the light is extended in a pin 38 ensuring the connection of the catheter 26.

On the side of the support facing the needle 22, the support 24 comprises a support plate 42 extending along the length of the support, with the exception of the end end region 32 which protrudes with respect to this support plate 42.

The mechanism 27 for extracting the needle 22 is permanently connected to the needle support 24 by being movable relative thereto between an inactive position of the extraction mechanism as illustrated by FIG. 1 and a position active extraction mechanism as shown in Figure 2 to 4.

The extraction mechanism 27 comprises a base 52 and a pusher 54 slidably mounted relative to the base 52. The base 52 is displaceable with respect to the support 24 and is articulated in particular with respect thereto. an axis XX 'extending perpendicular to the plane of the curved needle 22, horizontally in the Figures.

The base 52 is formed of a sleeve 56 defining a passage 58 of the pusher 54. The sleeve 56 is open laterally along a generatrix over a width corresponding to the width of the central core 30 of the support. On either side of this opening, the sleeve is extended by two flanks 60 adapted to engage around the central core 30.

Projection profiles are complementary recesses 61 A, 61 B of elastic engagement are provided on the sidewalls 60 and the support 24 to ensure a temporary immobilization of the extraction mechanism 27, both in its active position and in its position inactive. At its end opposite to the head 32, the sleeve 54 externally has two radial protrusions forming finger support 64.

The pusher 54 is formed of a rod 70 generally hollowed out and open at a so-called front end 71A facing the needle 22. The rod 70 defines a cylindrical internal volume 73 for receiving the needle 22, closed at the rear end 71 B of the rod 70 by a fingerrest 72. The rod 70 is open, from its front end 71 A, by a slot 74 extending along the length of the pusher over most of the length thereof. The width of the slot 74 is sufficient to receive the central core 30. The slot opens into the volume 73. At its front end 71A, the pusher 54 defines a substantially planar annular surface 76 for activating the generating means 28. an overpressure. This activation surface 76 defines, towards the axis YY 'of the rod, an opening opening into the internal volume 73 of the rod 70, for the passage of the needle 22. The surface 76 is delimited away from the axis YY 'by the sleeve 56. The activation surface 76 extends facing the skin 14 towards it, when the extraction mechanism 27 occupies its active position, substantially perpendicular to the axis Y- Y '.

The finger support 72 defines an upper surface 78 which has a concavity directed away from the skin 14. The upper surface 78 is intended to come into contact with the practitioner's fingers, particularly with his thumb, to exert a force applying and maintaining the extraction mechanism 27 against the skin 14, as will be seen below.

The pusher 54 is slidably received inside the passage 58 delimited by the base 52, between a position of use of the needle, as illustrated in FIGS. 2 to 4, and an extraction position of the needle. needle, along an extraction axis which is parallel to or coincident with the axis YY 'of the main section 35.

In the position of use of the needle, the open end 71A of the pusher is situated in the vicinity of the base 24, whereas in the extraction position, the end 71 B closed by the pusher 54 is located at near the base 52, the open end 71A extending beyond the tip 29 of the needle. The base 52 and the pusher 54 further include complementary resilient latching elements 80 capable of ensuring temporary retention of the pusher in its two extreme positions of use and extraction.

The catheter 26 comprises a flexible tube 84 which connects, upstream, a reservoir (not shown) of liquid to be injected, and downstream, the nipple 38. The tube 84 is provided, between the reservoir and the core 30, a clamp (not shown) able to selectively close the catheter 26 upstream of the device 10.

The means 28 for generating an overpressure comprise a compressible envelope containing fluid, and a support rider 88 for supporting the envelope, applied to the skin 14 and slidably engaged around the needle 22.

The compressible envelope is formed by a flexible section 86 of the injection catheter 26 engaged under the pusher 54.

The rider 88 comprises a support plate 90 applied to the skin 14, and two stirrups 92 for holding the flexible section 86. The plate 90 delimits, directed towards the skin 14, a surface 94 of support on the skin, and opposite the bearing surface 94, an upper surface 96 for supporting the flexible section 86. The plate 90 further defines a notch 98 for receiving the needle 22 opening into a rear edge 100 of the plate 90 located opposite of the support plate 42. The notch 98 comprises a central orifice 102 of substantially circular section and a slot 104 of smaller transverse dimension than that of the central orifice 102. the slot 104 opens into the edge 100, substantially in the the axis of the central core 30 when the needle 22 is received in the central orifice 102.

The stirrups 92 are placed on either side of the plate 90. They protrude away from the skin 14 from the upper surface 96. The stirrups 92 are arranged opposite one another and are spaced along an axis perpendicular to the axis of the core 30.

The flexible section 86 is engaged through the stirrups 92 which maintain it bearing on the upper surface 96. When the extraction mechanism 27 occupies its active position, and when the main section 35 of the needle 22 is received in the notch 98, the flexible portion 86 is interposed between the activation surface 76 at the open end 71A of the pusher 54 and the upper surface 96 of the rider 88, as shown in FIG.

The jumper 88 is movable relative to the needle 22 between a configuration of use of the needle 22, in which the needle 22 is placed away from the notch 98 and an extraction configuration, in which the main section 35 of the needle 22 has been inserted through the slot 104 into the orifice 102. In the extraction configuration, the rider 88 is free to slide around the needle 22 in the orifice 102, the along the Y-Y 'axis. The operation of the first injection device 10 according to the invention will now be described.

Initially, the extraction mechanism 27 is placed in its inactive position with the pusher 54 extending generally perpendicular to the main section 35 of the needle 22, being pressed along the length of the central core 30. In this position, the flanks 60 of the base 52 apply to the plate 42.

The pusher 54 is then in its position of use of the needle so that the head 30 is visible.

The jumper 88 is maintained in its configuration of use of the needle, away from the needle 22.

In this position, the needle 22 of the injection device 10 is inserted into an implantable chamber 12 and is depressed until the plate 42 bears on the skin of the patient. The presence of the extraction mechanism 27 folded along the length of the central core of the needle holder is not a problem for handling. In addition, the pusher 54 being folded along the central core, it does not protrude along its entire length relative to the skin 14 of the patient, so that the injection device 10, after placement, can be easily held by tape.

For the withdrawal of the injection device 10, the jumper 88 is moved from its configuration of use to its extraction configuration. For this purpose, the practitioner winds the catheter 26 around the needle support 24 to bring the flexible section 86 and the rider 88 to the front of the core 30 opposite the head 32.

Then, the main section 35 of the needle 22 is introduced into the notch 98 through the slot 104 by moving the rider 88 towards the support plate 42 of the needle holder 24. The lower bearing surface 96 of the jumper 88 is then placed in contact with the skin 14, as illustrated in FIG.

Then, the extraction mechanism 27 is straightened by being brought into its active position. To do this, the base 52 and the pusher 54 are tilted about the axis XX 'to be brought into the position shown in Figures 2 and 3. The pusher 54 is then placed in the axis YY' of the main section 35 of the needle, and the two extensions 64 extend generally perpendicular to the Y-Y 'axis. The head 32 of the support is received in the recessed pusher 54.

Moreover, the extraction mechanism 27 extends over the jumper 88 and the flexible section 86, which it partially covers. Thus, the sleeve 56 is placed between the stirrups 92 and rests partially in abutment on the flexible section 86. The activation surface 76 of the pusher 54 is placed in abutment on the flexible section 86, without compressing it, or by compressing it slightly. The flexible section 86 is thus interposed between two surfaces 76, 96 of the extraction mechanism, substantially perpendicular to the axis YY 'of application of the holding force, in contact with these surfaces 76, 96.

A continuous mechanical stack is thus produced along the Y-Y 'axis, between the bearing surface 94 on the skin 14, located under the rider 88 and the contact surface 78 with the practitioner's fingers, located on the support 72, via successively the plate 90, the flexible section 86 and the rod 70. This stack forms a force transmission chain from the contact surface 78 to the bearing surface 94.

In this configuration, and before any movement of the needle 22 away from the chamber 12, the generating means 28 are inactive, and fluid is able to flow freely through the flexible section which has a substantially maximum inner section .

Then, the practitioner closes the catheter 26 by activating the clamp located upstream of the flexible section 86. It then applies two fingers on either side of the base 52 under the finger-rest 64 and applies another finger, for example its thumb, on the contact surface 78. Then, it exerts on the surface 78 a holding force axis YY 'directed towards the skin 14 to cause the displacement of the pusher 54 towards the skin 14 relative to the base 52 .

The displacement of the pusher 54 downward under the effect of the holding force applied to the contact surface 78 causes the compression of the flexible section 86 by the activation surface 76 until the section 86 is crushed between the activation surface 76 and the upper surface 96. The inner section of the flexible section 86 is then minimal.

The holding force exerted by the practitioner on the contact surface 78 is transmitted to the bearing surface 94 by mechanical stacking, which maintains the bearing surface 94 applied against the skin 14 during the extraction of the 'needle.

In addition, the crushing of the flexible section 86 between two surfaces 76, 96 substantially perpendicular to the axis YY 'extraction generates an overpressure in the injection passage of the needle 22, which is transmitted to the chamber 16 and in the conduit 20, to compensate the reflux of biological fluid in the pipe 20. The volume of liquid displaced to the chamber during compression of the flexible section is thus greater than the volume normally aspirated during the withdrawal, for example greater than 7 .mu.l and preferably greater than 17 .mu.l.

The flexible section 86 is compressed exclusively under the effect of the application of the holding force, when the contact surface 96 is placed in contact with the body 14. In the absence of contact between the contact surface 96 and the body 14, and in the absence of application of the holding force, the flexible section 86 is not compressed.

Simultaneously, the operator pulls the base 52 away from the skin 14 along the pusher 54. The displacement of the sleeve 56 of the base causes that of the needle holder 24 from its position of use of the needle, in which the needle 22 projects out of the tube 70 and the inner volume 73 beyond the front end 71A, towards the extraction position of the needle. The needle 22 is gradually swallowed in the internal volume 73, as illustrated by the intermediate position shown in FIG. 4.

During this movement, the practitioner permanently exerts against the skin 14, a holding force axis YY 'directed towards the skin 14 via the pusher 54 and the rider 88. This force prevents the chamber 12 to go up upwards and thus limits the pain felt by the patient during extraction.

In the extraction position, the needle 22 has been totally swallowed inside the pusher 54. The main section 35 of the needle thus extends completely into the internal volume 73 of the pusher 54 and is protected, particularly at level of its tip 29, which avoids any risk of accidental prick of the practitioner.

The second device 1 10 according to the invention shown in Figure 5 differs from the first device 10 in that the flexible section 86 is fixed in abutment on the finger rest 72. The flexible section 86 and the finger rest 72 form therefore each a part of the contact surface 78 with the finger of the operator. In addition, the bearing surface on the skin 14 is formed by the lower annular surface 76 of the pusher 54.

In the second device 110 according to the invention, as in the first device 10, a mechanical stack is produced between the contact surface 78 and the bearing surface 76 on the skin 14 via the flexible section 86, of the finger support 72, and the pusher 54.

The overpressure in the injection passage is generated when the operator's finger exerts the holding force, by crushing the flexible section 86 between his finger and the upper surface 78. In a variant, a wheel or a piston is arranged on the finger rest 72 in order to cover the flexible section facing the upper surface 78. The flexible section 86 is thus interposed between the wheel or the piston and the upper surface 78, to be compressed by displacement of the wheel or the piston towards the upper surface 78 during the application of the holding force along the axis YY '.

A third device 140 according to the invention is shown in FIGS. 6 and 7. This third device 140 differs from the first device 10 by the nature of the extraction mechanism 27.

Thus, the extraction mechanism 27 comprises a lower base 142 and a deployable linkage 144 of protection connecting the base 142 to the support 24.

The base 142 delimits a substantially flat lower surface 146, an upper surface 148, and a slot 150 connecting the lower surface 146 to the upper surface 148 for the passage of the main section 35 of the needle 22. The upper surface 148 is extends across the support 24. The protection linkage 144 comprises, on either side of the support 24, two pairs of panels 150A, 150B. The panels 150A, 150B of each pair are hinged together by a horizontal hinge 152. The panels 150A, 150B are also articulated by horizontal hinges respectively on the support 24 and on the base 142. The panels 150A, 150B form with the support 24 and the base 142 a section of vertical section diamond-shaped 154, deployable between an elongate position substantially parallel to the skin 14, for the use of the needle (Figure 6), and an elongated position perpendicular to the skin 14, for the extraction of the needle (Figure 7).

In the position of use of the needle, the distance between the hinges 152 on either side of the support 24 and the base 142 is maximum, while in the extraction position, this distance is minimal.

The rhombic section section 154 defines an interior needle protection volume 156. In the position of use, the main section 35 of the needle 22 projects through the opening 149 out of the internal volume 156. In the extraction position, the main section 35 and the tip 29 are completely received in the internal volume 156 between the support 24 and the base 142.

The hinges 152 also define contact surfaces with the fingers of the operator.

The means 28 for generating an overpressure comprise a flexible section 86 of the catheter 26 fixed under the lower surface 146, to be interposed between this surface 146 and the skin 14. The flexible section 86 is placed in contact with the skin 14. It thus partially defines, with the lower surface 146, the bearing surface on the skin 14.

To inject liquid into the patient, the needle 22 is planted through the skin 14, keeping the mechanism 27 in its position of use of the needle. In this position, the flexible section 86 is maintained, with a maximum inner section, between the lower surface 146 and the skin 14.

Then, during extraction, the operator grasps contact surfaces on the hinges 152. He then applies a holding force directed towards the skin 14 to exert a bearing on the skin 14. This holding force causes the compression of the flexible portion 86 between the skin 14 and the surface 146, and the generation of an overpressure in the needle 22 and in the chamber 16.

Then, the operator brings the hinges 152 closer together, which progressively moves the support 24 away from the base 142 away from the skin 14. During this displacement, the needle 22 is swallowed progressively at through the opening 149 in the interior volume 156 to the extraction position shown in FIG. 7, in which it is totally received in the interior volume 156.

Claims

1 .- Injection device (10; 1 10; 140) of a liquid in a body (14), in particular the body of a patient, of the type comprising: - a needle support (24) carrying a needle injection needle (22) to be stitched into the body (14), the injection needle (22) defining an injection passage;

- an assembly (27) for extracting the needle (22) comprising a needle protection armature (54; 144) defining an interior volume (73; 156); the needle holder (24) being displaceable relative to the protective armature (54; 144) during the extraction of the needle (22) between a position of use, wherein the needle (22) protrudes out of the inner volume (73; 156) and an extraction position, in which the needle (22) is received in the inner volume (73; 156); the extraction assembly (27) having a bearing surface (94) on the body (14), and a contact surface (72; 152) adapted to contact at least one finger of an operator for exerting a force for holding the bearing surface (94) against the body (14), the holding force being directed towards the body (14) during the relative movement of the needle holder (24) relative to the protective armature (54; 144) between the use position and the extraction position; the device (10; 110; 140) further comprising: - a compressible envelope (28) for generating an overpressure in the injection passage; characterized in that the compressible envelope (28) is mechanically stacked between the contact surface (72; 152) and the bearing surface (94) to be compressed by the application on the contact surface (72; 152), of said holding force when the bearing surface (94) is in contact with the body (14), during the relative movement of the needle holder (24) with respect to the protective armature (54; 144).

2.- Device (10; 140) according to claim 1, characterized in that the extraction assembly (27) has a lower surface (76; 146) of activation of the pressure, intended to be directed towards the body (14), the compressible envelope (28) protruding towards the body (14) from the activation surface (76; 146) during the extraction of the needle (22), the application of the holding force being able to compress the compressible envelope (28) between the lower surface (76) and an additional surface (96; 14) substantially parallel to the lower surface (76).

3.- Device (10) according to claim 2, characterized in that the assembly comprises a support plate (90) integral with the compressible envelope (28) and it is pressed against the body (14), the compressible envelope (28) being compressed between the activation surface (76) and the support plate (90) during the application of the holding force.

4.- Device (140) according to claim 2, characterized in that the compressible envelope (28) defines a portion of the bearing surface, the compressible envelope (28) being compressed between the activation surface (146). ) and the body (14) during the application of the holding force.

5.- Device (120) according to claim 1, characterized in that the compressible envelope (28) protrudes away from the body (14) relative to an upper surface (78) of the extraction assembly , the contact surface being at least partially delimited by the compressible envelope (28) to be compressed between the finger of an operator and the upper surface (78) during the application of the holding force.

6. Device (10; 120; 140) according to any one of the preceding claims, characterized in that it comprises an injection catheter (26) connected at one end to the needle support (24) and opening into the injection passage of the needle (22), the compressible envelope (28) being formed by a flexible section (86) of the injection catheter (26).

7.- Device (10) according to any one of the preceding claims, characterized in that the protective armature (54) is movable relative to the needle holder (24) along an axis (Y-Y ') d extraction, the injection needle (22) having a main section (35) projecting from the needle support (24) along the extraction axis (Y-Y '), and in that the compressible envelope (28) is slidably movable along the main section (22) along the extraction axis (Y-Y ') via a sliding fastener (88).

8.- Device (10; 120) according to any one of the preceding claims, characterized in that the extraction assembly (27) comprises a base (52) mounted on the needle support (24) and a pusher (54) slidably mounted in the base (52), the pusher (54) at least partially defining the contact surface (72) and defining the interior volume.

9.- Device (140) according to any one of claims 1 to 5, characterized in that the extraction assembly (27) comprises a base (142) intended to be placed opposite the body (14), l frame comprising a linkage (144) deployable away from the body from the base (142) between a folded configuration on the base (142) in the vicinity of the body (14) and a deployed configuration away from the base (142) away from the body (14), the linkage (144) connecting the needle holder (24) to the base (142).

10.- Device (140) according to claim 7, characterized in that the compressible envelope (28) is fixed under the base (142).

1 1.- Device according to any one of the preceding claims, characterized in that the compressible envelope is adapted to be compressed exclusively under the effect of the application of the holding force when the contact surface is placed in contact of the body, the compressible envelope being uncompressed in the absence of contact between the contact surface and the body and in the absence of application of the holding force.