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WO2009051223A1 - 白内障処置のための医薬組成物 - Google Patents

白内障処置のための医薬組成物 Download PDF

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Publication number
WO2009051223A1
WO2009051223A1 PCT/JP2008/068853 JP2008068853W WO2009051223A1 WO 2009051223 A1 WO2009051223 A1 WO 2009051223A1 JP 2008068853 W JP2008068853 W JP 2008068853W WO 2009051223 A1 WO2009051223 A1 WO 2009051223A1
Authority
WO
WIPO (PCT)
Prior art keywords
cataract
treatment
pharmaceutical composition
active ingredient
disclosed
Prior art date
Application number
PCT/JP2008/068853
Other languages
English (en)
French (fr)
Inventor
Yukihiko Mashima
Ryo Inoue
Nakayuki Kishimoto
Original Assignee
R-Tech Ueno, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by R-Tech Ueno, Ltd. filed Critical R-Tech Ueno, Ltd.
Priority to JP2009538168A priority Critical patent/JPWO2009051223A1/ja
Priority to CA2702885A priority patent/CA2702885A1/en
Priority to CN2008801213455A priority patent/CN101903045B/zh
Priority to US12/738,588 priority patent/US20100210697A1/en
Priority to EP08839364A priority patent/EP2213303A4/en
Publication of WO2009051223A1 publication Critical patent/WO2009051223A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

　本発明は、白内障の処置に有効な医薬組成物を提供することを目的とする。 　ＶＡＰ－１阻害剤を有効成分として含む、白内障の処置のための医薬組成物、特に式（Ｉ）で示される化合物等を有効成分として含む、白内障の処置のための医薬組成物。 Ｒ１－ＮＨ－Ｘ－Ｙ－Ｚ　（Ｉ） （式中、各記号の定義は明細書中と同義である）
PCT/JP2008/068853 2007-10-19 2008-10-17 白内障処置のための医薬組成物 WO2009051223A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2009538168A JPWO2009051223A1 (ja) 2007-10-19 2008-10-17 白内障処置のための医薬組成物
CA2702885A CA2702885A1 (en) 2007-10-19 2008-10-17 Pharmaceutical composition for treatment of cataract
CN2008801213455A CN101903045B (zh) 2007-10-19 2008-10-17 用于治疗白内障的药物组合物
US12/738,588 US20100210697A1 (en) 2007-10-19 2008-10-17 Pharmaceutical composition for treatment of cataract
EP08839364A EP2213303A4 (en) 2007-10-19 2008-10-17 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CATARACT

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007272993 2007-10-19
JP2007-272993 2007-10-19

Publications (1)

Publication Number Publication Date
WO2009051223A1 true WO2009051223A1 (ja) 2009-04-23

Family

ID=40567484

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/068853 WO2009051223A1 (ja) 2007-10-19 2008-10-17 白内障処置のための医薬組成物

Country Status (8)

Country Link
US (1) US20100210697A1 (ja)
EP (1) EP2213303A4 (ja)
JP (1) JPWO2009051223A1 (ja)
KR (1) KR20100096094A (ja)
CN (2) CN101903045B (ja)
CA (1) CA2702885A1 (ja)
TW (1) TW200927100A (ja)
WO (1) WO2009051223A1 (ja)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009145360A1 (en) * 2008-05-30 2009-12-03 R-Tech Ueno, Ltd. Benzene or thiophene derivative and use thereof as vap-1 inhibitor
WO2011059474A1 (en) 2009-10-30 2011-05-19 Nestec S.A. Methods for maintaining eye health and ameliorating opthalmic maladies in canines
WO2011075430A1 (en) * 2009-12-14 2011-06-23 University Of Massachusetts Methods of inhibiting cataracts and presbyopia
US8507690B2 (en) 2008-01-31 2013-08-13 R-Tech Ueno, Ltd. Thiazole derivative and use thereof as VAP-1 inhibitor
WO2013163675A1 (en) 2012-05-02 2013-11-07 Pharmaxis Ltd. Substituted 3-haloallylamine inhibitors of ssao and uses thereof
US9675589B2 (en) 2013-03-14 2017-06-13 University Of Massachusetts Methods of inhibiting cataracts and presbyopia
US10736863B2 (en) 2015-11-13 2020-08-11 University Of Massachusetts Methods of inhibiting cataracts and presbyopia
EP3777846A1 (en) 2015-12-07 2021-02-17 BenevolentAI Cambridge Limited Vap-1 inhibitors for treating pain

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107915752B (zh) * 2017-11-14 2018-09-18 牡丹江医学院 一种治疗白内障的药物及其制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004067521A1 (en) 2003-01-27 2004-08-12 Astellas Pharma Inc. Thiazole derivatives and their use as vap-1 inhibitors
WO2004087138A1 (en) 2003-03-31 2004-10-14 Sucampo Ag Method for treating vascular hyperpermeable disease
WO2006011631A2 (en) 2004-07-27 2006-02-02 Astellas Pharma Inc. Thiazole derivatives having vap-1 inhibitory activity
WO2006028269A2 (en) 2004-09-09 2006-03-16 Astellas Pharma Inc. Thiazole derivatives having vap-1 ihibitory activity
JP2007519688A (ja) * 2004-01-30 2007-07-19 ファロン ファーマシューティカルズ オサケ ユキチュア メタボリックシンドロームの治療または予防に特に有効な組成物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4442118A (en) * 1981-07-23 1984-04-10 Ayerst, Mckenna & Harrison, Inc. Aldose reductase inhibition by 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid
FI20040136A0 (fi) * 2004-01-30 2004-01-30 Faron Pharmaceuticals Oy Erityisesti diabeetikoille soveltuvia koostumuksia
CA2558135C (en) * 2004-03-18 2012-08-14 R-Tech Ueno, Ltd. Aqueous composition comprising thiazole derivative
US20100190834A1 (en) * 2007-06-25 2010-07-29 R-Tech Ueno, Ltd. Composition for ophtalmic disease associated with hypoxia or ischemia

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004067521A1 (en) 2003-01-27 2004-08-12 Astellas Pharma Inc. Thiazole derivatives and their use as vap-1 inhibitors
WO2004087138A1 (en) 2003-03-31 2004-10-14 Sucampo Ag Method for treating vascular hyperpermeable disease
JP2007519688A (ja) * 2004-01-30 2007-07-19 ファロン ファーマシューティカルズ オサケ ユキチュア メタボリックシンドロームの治療または予防に特に有効な組成物
WO2006011631A2 (en) 2004-07-27 2006-02-02 Astellas Pharma Inc. Thiazole derivatives having vap-1 inhibitory activity
WO2006028269A2 (en) 2004-09-09 2006-03-16 Astellas Pharma Inc. Thiazole derivatives having vap-1 ihibitory activity

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
KAWAKAMI M. ET AL.: "Shinki Kaihatsu Tonyobyo Chiryoyaku no Genkyo to Kongo no Tenbo AGE Sogaiyaku Aminoguanidine Oyobi sono Hoka no AGE Sogaiyaku", JAPANESE JOURNAL OF CLINICAL MEDICINE, vol. 60, no. 9, 28 September 2002 (2002-09-28), pages 601 - 605, XP008134004 *
KUBO E. ET AL.: "Tonyobyo to Hakunaisho Shujutsu Tonyobyo Hakunaisho no Seiin to Ekigaku", IOL&RS, vol. 21, no. 2, 1 June 2007 (2007-06-01), pages 149 - 154, XP008134003 *
OIMOMI M. ET AL.: "Sanka . Toka Hensei Busshitsu to Shikkan 10 AGE to Hakunaisho", BIOMEDICINE & THERAPEUTICS, vol. 32, no. 4, 10 April 1998 (1998-04-10), pages 521 - 525, XP008134005 *
See also references of EP2213303A4
STOLEN C. M. ET AL.: "Semicarbazide sensitive amine oxidase overexpression has dual consequences: insulin mimicry and diabetes-like complications", THE FASEB JOURNAL, vol. 18, no. 6, April 2004 (2004-04-01), pages 702 - 704, XP002540618 *

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8507690B2 (en) 2008-01-31 2013-08-13 R-Tech Ueno, Ltd. Thiazole derivative and use thereof as VAP-1 inhibitor
JP2014205687A (ja) * 2008-05-30 2014-10-30 株式会社アールテック・ウエノ ベンゼンまたはチオフェン誘導体およびｖａｐ−１阻害剤としてのその使用
US9603833B2 (en) 2008-05-30 2017-03-28 R-Tech Ueno, Ltd. Benzene or thiophene derivative and use thereof as VAP-1 inhibitor
JP2011523649A (ja) * 2008-05-30 2011-08-18 株式会社アールテック・ウエノ ベンゼンまたはチオフェン誘導体およびｖａｐ−１阻害剤としてのその使用
WO2009145360A1 (en) * 2008-05-30 2009-12-03 R-Tech Ueno, Ltd. Benzene or thiophene derivative and use thereof as vap-1 inhibitor
WO2011059474A1 (en) 2009-10-30 2011-05-19 Nestec S.A. Methods for maintaining eye health and ameliorating opthalmic maladies in canines
US9283237B2 (en) 2009-12-14 2016-03-15 University Of Massachusetts Methods of inhibiting presbyopia
US8758802B2 (en) 2009-12-14 2014-06-24 University Of Massachusetts Methods of inhibiting cataracts and presbyopia
WO2011075430A1 (en) * 2009-12-14 2011-06-23 University Of Massachusetts Methods of inhibiting cataracts and presbyopia
WO2013163675A1 (en) 2012-05-02 2013-11-07 Pharmaxis Ltd. Substituted 3-haloallylamine inhibitors of ssao and uses thereof
US9302986B2 (en) 2012-05-02 2016-04-05 Boehringer Ingelheim International Gmbh Substituted 3-haloallylamine inhibitors of ASSAO and uses thereof
US9815782B2 (en) 2012-05-02 2017-11-14 Boehringer Ingelheim International Gmbh Substituted 3-haloallylamine inhibitors of SSAO and uses thereof
US10160723B2 (en) 2012-05-02 2018-12-25 Boehringer Ingelheim International Gmbh Substituted 3-haloallylamine inhibitors of SSAO and uses thereof
EP3438087A1 (en) 2012-05-02 2019-02-06 Boehringer Ingelheim International GmbH Substituted 3-haloallylamine inhibitors of ssao and uses thereof
US9675589B2 (en) 2013-03-14 2017-06-13 University Of Massachusetts Methods of inhibiting cataracts and presbyopia
US9789091B2 (en) 2013-03-14 2017-10-17 University Of Massachusetts Methods of inhibiting cataracts and presbyopia
US10413529B2 (en) 2013-03-14 2019-09-17 University Of Massachusetts Methods of inhibiting cataracts and presbyopia
US10736863B2 (en) 2015-11-13 2020-08-11 University Of Massachusetts Methods of inhibiting cataracts and presbyopia
EP3777846A1 (en) 2015-12-07 2021-02-17 BenevolentAI Cambridge Limited Vap-1 inhibitors for treating pain

Also Published As

Publication number Publication date
CN101903045B (zh) 2013-03-13
TW200927100A (en) 2009-07-01
US20100210697A1 (en) 2010-08-19
EP2213303A4 (en) 2011-12-28
KR20100096094A (ko) 2010-09-01
EP2213303A1 (en) 2010-08-04
JPWO2009051223A1 (ja) 2011-03-03
CN103120690A (zh) 2013-05-29
CN101903045A (zh) 2010-12-01
CA2702885A1 (en) 2009-04-23

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