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WO2009047634A3 - Aqueous formulations of acetaminophen for injection - Google Patents

Aqueous formulations of acetaminophen for injection Download PDF

Info

Publication number
WO2009047634A3
WO2009047634A3 PCT/IB2008/003217 IB2008003217W WO2009047634A3 WO 2009047634 A3 WO2009047634 A3 WO 2009047634A3 IB 2008003217 W IB2008003217 W IB 2008003217W WO 2009047634 A3 WO2009047634 A3 WO 2009047634A3
Authority
WO
WIPO (PCT)
Prior art keywords
acetaminophen
injection
aqueous formulations
formulations
preparing
Prior art date
Application number
PCT/IB2008/003217
Other languages
French (fr)
Other versions
WO2009047634A2 (en
Inventor
Perez Sergio Lloret
Pena Agnes Fernandez
Original Assignee
Combino Pharm Sl
Perez Sergio Lloret
Pena Agnes Fernandez
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Combino Pharm Sl, Perez Sergio Lloret, Pena Agnes Fernandez filed Critical Combino Pharm Sl
Priority to EP08837144A priority Critical patent/EP2170313A2/en
Publication of WO2009047634A2 publication Critical patent/WO2009047634A2/en
Publication of WO2009047634A3 publication Critical patent/WO2009047634A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to novel stable aqueous formulations of acetaminophen for injection as well as processes for preparing and using the same.
PCT/IB2008/003217 2007-06-18 2008-06-18 Aqueous formulations of acetaminophen for injection WO2009047634A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08837144A EP2170313A2 (en) 2007-06-18 2008-06-18 Aqueous formulations of acetaminophen for injection

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92919207P 2007-06-18 2007-06-18
US60/929,192 2007-06-18

Publications (2)

Publication Number Publication Date
WO2009047634A2 WO2009047634A2 (en) 2009-04-16
WO2009047634A3 true WO2009047634A3 (en) 2009-06-04

Family

ID=40429866

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/003217 WO2009047634A2 (en) 2007-06-18 2008-06-18 Aqueous formulations of acetaminophen for injection

Country Status (3)

Country Link
EP (1) EP2170313A2 (en)
AR (1) AR067048A1 (en)
WO (1) WO2009047634A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2243477A1 (en) * 2009-04-22 2010-10-27 Fresenius Kabi Deutschland GmbH Paracetamol for parenteral application
CN102711726A (en) * 2009-12-10 2012-10-03 特克尼梅德医疗技术股份公司 Method and composition for preparing stable liquid formulations of paracetamol
PT2377516E (en) 2010-04-14 2012-07-02 Braun Melsungen Ag Acetaminophen composition
MX2012014800A (en) 2010-06-30 2013-01-29 Troikaa Pharmaceuticals Ltd Pharmaceutical compositions comprising paracetamol and process for preparing the same.
ZA201300398B (en) * 2012-11-27 2013-09-25 Genfarma Laboratories S L Injectable liquid formulation of the combination of tramadol and paracetamol
US20180000940A1 (en) 2014-12-20 2018-01-04 Troikaa Pharmaceuticals Limited Injectable formulations of paracetamol

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6028222A (en) * 1996-08-05 2000-02-22 Scr Pharmatop Stable liquid paracetamol compositions, and method for preparing same
US6992218B2 (en) * 2000-06-06 2006-01-31 Pharmatop Scr Method for obtaining aqueous formulations of oxidation-sensitive active principles
US20060084703A1 (en) * 2003-02-14 2006-04-20 Tho Nguyen-Xuan Injectable liquid formulation of paracetamol
WO2008007150A1 (en) * 2006-07-13 2008-01-17 Unilever Plc Preparation of pharmaceutical compositions

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1992334A1 (en) * 2007-05-08 2008-11-19 Docpharma NV/SA Storage-stable formulation of oxidation-sensitive phenolic drug, especially paracetamol, comprises aqueous drug solution deoxygenated by a temperature-controlled manufacturing process of the formulation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6028222A (en) * 1996-08-05 2000-02-22 Scr Pharmatop Stable liquid paracetamol compositions, and method for preparing same
US6992218B2 (en) * 2000-06-06 2006-01-31 Pharmatop Scr Method for obtaining aqueous formulations of oxidation-sensitive active principles
US20060084703A1 (en) * 2003-02-14 2006-04-20 Tho Nguyen-Xuan Injectable liquid formulation of paracetamol
WO2008007150A1 (en) * 2006-07-13 2008-01-17 Unilever Plc Preparation of pharmaceutical compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"PERFALGAN RTM CONSUMER MEDICINE INFORMATION", MEDICINE LEAFLET, 2004, XP002522560, Retrieved from the Internet <URL:http://www.bmsa.com.au/documents/Perfalgan_cmi.pdf> *

Also Published As

Publication number Publication date
EP2170313A2 (en) 2010-04-07
WO2009047634A2 (en) 2009-04-16
AR067048A1 (en) 2009-09-30

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