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WO2008136199A1 - ウィタノライド類の製造方法 - Google Patents

ウィタノライド類の製造方法 Download PDF

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Publication number
WO2008136199A1
WO2008136199A1 PCT/JP2008/051481 JP2008051481W WO2008136199A1 WO 2008136199 A1 WO2008136199 A1 WO 2008136199A1 JP 2008051481 W JP2008051481 W JP 2008051481W WO 2008136199 A1 WO2008136199 A1 WO 2008136199A1
Authority
WO
WIPO (PCT)
Prior art keywords
means hydrogen
producing
hydroxy
withanolide
methyl
Prior art date
Application number
PCT/JP2008/051481
Other languages
English (en)
French (fr)
Inventor
Hideo Nemoto
Yuji Matsuya
Masashi Yamada
Hiroto Suzuki
Original Assignee
Meiji Dairies Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Dairies Corporation filed Critical Meiji Dairies Corporation
Publication of WO2008136199A1 publication Critical patent/WO2008136199A1/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)

Abstract

　下記式（１） （式中、Ｒ１は、水素原子、メチル基またはＣＨ２ＯＨを意味し；Ｒ２は、水素原子またはメチル基を意味し；Ｒ３は、水素原子または水酸基を意味し；Ｒ４は、水素原子または水酸基を意味し；Ｒ５は、水酸基、糖鎖または保護基を意味する）で表される化合物と触媒とを共存させて、閉環メタセシス反応を行う、下記式（２） （式中、Ｒ１～Ｒ５は式（１）のＲ１～Ｒ５と同意義を示す。）で表される化合物またはその塩の製造方法。
PCT/JP2008/051481 2007-04-26 2008-01-31 ウィタノライド類の製造方法 WO2008136199A1 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-117732 2007-04-26
JP2007117732A JP2010159211A (ja) 2007-04-26 2007-04-26 ウィタノライド類の製造方法

Publications (1)

Publication Number Publication Date
WO2008136199A1 true WO2008136199A1 (ja) 2008-11-13

Family

ID=39943319

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/051481 WO2008136199A1 (ja) 2007-04-26 2008-01-31 ウィタノライド類の製造方法

Country Status (2)

Country Link
JP (1) JP2010159211A (ja)
WO (1) WO2008136199A1 (ja)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010041681A1 (ja) * 2008-10-09 2010-04-15 リードケミカル株式会社 新規ソミノン誘導体
CN102180928A (zh) * 2011-03-15 2011-09-14 中山大学 3β,5α,6β-三羟基甾体化合物及其合成方法和应用
CN114409726A (zh) * 2022-01-24 2022-04-29 东华大学 桦木醇环烯烃衍生物及其用途和制备方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111001372A (zh) * 2019-11-21 2020-04-14 安徽科宝生物工程有限公司 一种熊去氧胆酸酯化用反应装置及其使用方法

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
GAMOH K. ET AL.: "Stereocontrolled synthesis of withanolide D and related compounds", J. CHEM. SOC. PERKIN TRANS. I, 1984, pages 449 - 454 *
GHOSH A. ET AL.: "Enzymatic Acylation and Ring-Closing Olefin Metathesis: A Convenient Strategy for the Lactone Moiety of Compactin and Mevinolin", J. ORG. CHEM., vol. 65, no. 15, 2000, pages 4779 - 4781 *
PEREZ-MEDRANO A. ET AL.: "Synthesis of the highly oxygenated ergostane type steroid (+)-withanolide E", J. AM. CHEM. SOC., vol. 113, 1991, pages 1057 - 1059 *
RAMACHANDRAN P.V. ET AL.: "Stereoselective Syntheses of (+)-Goniodiol), (-)-8-Epigoniodiol, and (+)-9-Deoxygoniopypyrone via Alkoxyallylboration and Ring-Closing Metathesis", J. ORG. CHEM., vol. 67, no. 24, 2002, pages 7547 - 7550 *
WILDEMANN H. ET AL.: "A Short Olefin Metathesis-Based Route to Enantiomerically Pure Arylated Dihydropyrans and, -Unsaturated-Valero Lactones", J. ORG. CHEM., vol. 68, no. 3, 2003, pages 799 - 804, XP002433691 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010041681A1 (ja) * 2008-10-09 2010-04-15 リードケミカル株式会社 新規ソミノン誘導体
CN102180928A (zh) * 2011-03-15 2011-09-14 中山大学 3β,5α,6β-三羟基甾体化合物及其合成方法和应用
CN102180928B (zh) * 2011-03-15 2013-01-16 广州市赛普特医药科技有限公司 3β,5α,6β-三羟基甾体化合物及其合成方法和应用
CN114409726A (zh) * 2022-01-24 2022-04-29 东华大学 桦木醇环烯烃衍生物及其用途和制备方法

Also Published As

Publication number Publication date
JP2010159211A (ja) 2010-07-22

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