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WO2008120661A1 - 新規な縮合ピロール誘導体 - Google Patents

新規な縮合ピロール誘導体 Download PDF

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Publication number
WO2008120661A1
WO2008120661A1 PCT/JP2008/055856 JP2008055856W WO2008120661A1 WO 2008120661 A1 WO2008120661 A1 WO 2008120661A1 JP 2008055856 W JP2008055856 W JP 2008055856W WO 2008120661 A1 WO2008120661 A1 WO 2008120661A1
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WO
WIPO (PCT)
Prior art keywords
pyrrole derivative
hydrogen atom
novel fused
fused pyrrole
formula
Prior art date
Application number
PCT/JP2008/055856
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English (en)
French (fr)
Inventor
Toshihiko Sone
Norie Tsuboya
Original Assignee
Dainippon Sumitomo Pharma Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Sumitomo Pharma Co., Ltd. filed Critical Dainippon Sumitomo Pharma Co., Ltd.
Publication of WO2008120661A1 publication Critical patent/WO2008120661A1/ja

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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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Abstract

　本発明は、医薬として、式（１）： ［式中、Ｒ1は置換アルキル基等を表し、Ｒ2は水素原子等を表し、－Ｗ4＝Ｗ5－Ｗ6＝Ｗ7－は式：－ＣＲ4＝ＣＲ5－ＣＲ6＝ＣＲ7－（式中、Ｒ4、Ｒ5、Ｒ6及びＲ7は各々独立して式：－Ｅ－Ａ等を表し、式中Ｅは単結合等を表し、Ａは水素原子等を表）等を表し、Ｒ8は水素原子等を表し、Ｒ9はハロゲン原子で置換されたアルキル基等を表し、Ｒ10は水素原子等を表す）]で表される化合物もしくはプロドラッグ、又はそれらの薬学上許容される塩からなる有用な新規な縮合ピロール誘導体を提供する。
PCT/JP2008/055856 2007-03-29 2008-03-27 新規な縮合ピロール誘導体 WO2008120661A1 (ja)

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JP2007089807A JP2010138072A (ja) 2007-03-29 2007-03-29 新規な縮合ピロール誘導体
JP2007-089807 2007-03-29

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EP2567959A1 (en) 2011-09-12 2013-03-13 Sanofi 6-(4-Hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2021263278A1 (en) * 2020-06-23 2021-12-30 The Scripps Research Institute Rev-erb agonists for the treatment of th17-mediated inflammatory disorders
US11471455B2 (en) 2018-10-05 2022-10-18 Annapurna Bio, Inc. Compounds and compositions for treating conditions associated with APJ receptor activity
WO2023122093A1 (en) * 2021-12-20 2023-06-29 University Of Florida Research Foundation, Incorporated Rev-erb agonists for th17-mediated inflammatory disorders

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2567959A1 (en) 2011-09-12 2013-03-13 Sanofi 6-(4-Hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US11471455B2 (en) 2018-10-05 2022-10-18 Annapurna Bio, Inc. Compounds and compositions for treating conditions associated with APJ receptor activity
US11944622B2 (en) 2018-10-05 2024-04-02 Annapurna Bio, Inc. Compounds and compositions for treating conditions associated with APJ receptor activity
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