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WO2008113970A3 - Peptides - Google Patents

Peptides Download PDF

Info

Publication number
WO2008113970A3
WO2008113970A3 PCT/GB2008/000732 GB2008000732W WO2008113970A3 WO 2008113970 A3 WO2008113970 A3 WO 2008113970A3 GB 2008000732 W GB2008000732 W GB 2008000732W WO 2008113970 A3 WO2008113970 A3 WO 2008113970A3
Authority
WO
WIPO (PCT)
Prior art keywords
peptides
epitope
seq
peptide
variant
Prior art date
Application number
PCT/GB2008/000732
Other languages
French (fr)
Other versions
WO2008113970A2 (en
Inventor
Shahriar Behboudi
Original Assignee
Ucl Business Plc
Shahriar Behboudi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0705115A external-priority patent/GB0705115D0/en
Priority claimed from GB0705251A external-priority patent/GB0705251D0/en
Application filed by Ucl Business Plc, Shahriar Behboudi filed Critical Ucl Business Plc
Publication of WO2008113970A2 publication Critical patent/WO2008113970A2/en
Publication of WO2008113970A3 publication Critical patent/WO2008113970A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4715—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Reproductive Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pregnancy & Childbirth (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to peptides comprising a fragment of the human alpha- fetoprotein molecule of SEQ ID NO: 1, wherein said peptides comprise: (a) amino acids 46-55 of SEQ ID NO: 1; (b) a variant of (a) in which one, two or three amino acids are deleted; or (c) a variant of (a) comprising one, two, three or four amino acid substitutions from the sequence of (a); wherein said peptide is capable of activating T cells that produce TGF-β and/or GM-CSF, and wherein said peptide does not comprise a B cell epitope, a CTL epitope or a ThI epitope.
PCT/GB2008/000732 2007-03-16 2008-03-05 Peptides WO2008113970A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0705115.4 2007-03-16
GB0705115A GB0705115D0 (en) 2007-03-16 2007-03-16 Peptides
GB0705251.7 2007-03-19
GB0705251A GB0705251D0 (en) 2007-03-19 2007-03-19 Peptides

Publications (2)

Publication Number Publication Date
WO2008113970A2 WO2008113970A2 (en) 2008-09-25
WO2008113970A3 true WO2008113970A3 (en) 2008-12-24

Family

ID=39637614

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2008/000732 WO2008113970A2 (en) 2007-03-16 2008-03-05 Peptides

Country Status (1)

Country Link
WO (1) WO2008113970A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3019005A1 (en) 2016-05-18 2017-11-23 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
CN116970061A (en) 2016-12-22 2023-10-31 库尔生物制药有限公司 T cell modulating multimeric polypeptides and methods of use thereof
EP3565829A4 (en) 2017-01-09 2021-01-27 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
CN111010875B (en) 2017-03-15 2024-04-05 库尔生物制药有限公司 Methods for modulating immune responses
CN111886241A (en) 2018-01-09 2020-11-03 库尔生物制药有限公司 Multimeric T cell modulating polypeptides and methods of use thereof
WO2020132135A1 (en) * 2018-12-19 2020-06-25 Cue Biopharma, Inc. Multimeric t-cell modulatory polypeptides and methods of use thereof
KR20230009872A (en) 2020-05-12 2023-01-17 큐 바이오파마, 인크. Multimeric T-Cell Regulatory Polypeptides and Methods of Use Thereof
JP2023541366A (en) 2020-09-09 2023-10-02 キュー バイオファーマ， インコーポレイテッド MHC class II T cell modulating multimeric polypeptides and methods of use thereof to treat type 1 diabetes mellitus (T1D)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996022787A1 (en) * 1995-01-24 1996-08-01 Murgita Robert A Recombinant human alpha-fetoprotein and uses thereof
WO2001058922A2 (en) * 2000-02-10 2001-08-16 The Regents Of The University Of California Method and compositions for treating hepatocellular cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996022787A1 (en) * 1995-01-24 1996-08-01 Murgita Robert A Recombinant human alpha-fetoprotein and uses thereof
WO2001058922A2 (en) * 2000-02-10 2001-08-16 The Regents Of The University Of California Method and compositions for treating hepatocellular cancer

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ALISA AKEEL ET AL: "Analysis of CD4+ T-Cell responses to a novel alpha-fetoprotein-derived epitope in hepatocellular carcinoma patients", CLINICAL CANCER RESEARCH, THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, vol. 11, no. 18, 15 September 2005 (2005-09-15), pages 6686 - 6694, XP002476998, ISSN: 1078-0432 *
ALISA AKEEL ET AL: "Human CD4(+) T cells recognize an epitope within alpha-fetoprotein sequence and develop into TGF-beta-producing CD4(+) T cells.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 APR 2008, vol. 180, no. 7, 1 April 2008 (2008-04-01), pages 5109 - 5117, XP002491840, ISSN: 0022-1767 *
AYARU LAKSHMANA ET AL: "Unmasking of alpha-fetoprotein-specific CD4(+) T cell responses in hepatocellular carcinoma patients undergoing embolization", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, vol. 178, no. 3, 1 February 2007 (2007-02-01), pages 1914 - 1922, XP002476999, ISSN: 0022-1767 *
LIU YANG ET AL: "Hierarchy of alpha fetoprotein (AFP)-specific T cell responses in subjects with AFP-positive hepatocellular cancer.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 JUL 2006, vol. 177, no. 1, 1 July 2006 (2006-07-01), pages 712 - 721, XP002491839, ISSN: 0022-1767 *

Also Published As

Publication number Publication date
WO2008113970A2 (en) 2008-09-25

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