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WO2008155651A3 - Inositol for induction of ovulation - Google Patents

Inositol for induction of ovulation Download PDF

Info

Publication number
WO2008155651A3
WO2008155651A3 PCT/IB2008/001639 IB2008001639W WO2008155651A3 WO 2008155651 A3 WO2008155651 A3 WO 2008155651A3 IB 2008001639 W IB2008001639 W IB 2008001639W WO 2008155651 A3 WO2008155651 A3 WO 2008155651A3
Authority
WO
WIPO (PCT)
Prior art keywords
inositol
ovulation
induction
subject
composition
Prior art date
Application number
PCT/IB2008/001639
Other languages
French (fr)
Other versions
WO2008155651A2 (en
Inventor
Vittorio Unfer
Original Assignee
Lo Li Pharma Srl
Marelli Mariapina
Vittorio Unfer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lo Li Pharma Srl, Marelli Mariapina, Vittorio Unfer filed Critical Lo Li Pharma Srl
Publication of WO2008155651A2 publication Critical patent/WO2008155651A2/en
Publication of WO2008155651A3 publication Critical patent/WO2008155651A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A composition comprising inositol for induction of ovulation in a subject by administering to the subject the composition in such a quantity so as to provide at least 2 g/day of inositol.
PCT/IB2008/001639 2007-06-20 2008-06-18 Inositol for induction of ovulation WO2008155651A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000341A ITRM20070341A1 (en) 2007-06-20 2007-06-20 INOFOLIC SUPPLEMENTARY FORMULATION AIMED AT THE CONTROL OF OVULATION INDUCTION IN MEDICALALLY ASSISTED PROCREATION PROGRAMS
ITRM2007A000341 2007-06-20

Publications (2)

Publication Number Publication Date
WO2008155651A2 WO2008155651A2 (en) 2008-12-24
WO2008155651A3 true WO2008155651A3 (en) 2009-02-19

Family

ID=39940623

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/001639 WO2008155651A2 (en) 2007-06-20 2008-06-18 Inositol for induction of ovulation

Country Status (2)

Country Link
IT (1) ITRM20070341A1 (en)
WO (1) WO2008155651A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1394926B1 (en) * 2009-05-19 2012-07-27 Lo Li Pharma Srl COMPOSITION FOR THE CONTROL AND IMPROVEMENT OF FEMALE AND MALE GAMETOGENESIS.
ITMI20110445A1 (en) * 2011-03-22 2012-09-23 Lo Li Pharma Srl PHARMACEUTICAL FORMULATION INCLUDING INOSITOLO.
ITFI20110241A1 (en) * 2011-11-03 2013-05-04 Lo Li Pharma Srl FORMULATIONS TO IMPROVE THE PROBABILITY OF FECONDATION AND THE NUMBER OF PREGNANCIES
ITFI20110252A1 (en) * 2011-11-22 2013-05-23 Lo Li Pharma Srl PHARMACEUTICAL COMPOSITION INCLUDING MYO-INOSITOL AND D-CHIRO-INOSITOL.
IT201700104446A1 (en) 2017-09-19 2019-03-19 Lo Li Pharma Srl Compositions, uses and methods for the treatment of infertility and subfertility
CN111655245B (en) * 2017-11-23 2023-08-08 生物学研究院 Method for increasing embryo implantation rate in female subjects suffering from polycystic ovary syndrome

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5906979A (en) * 1998-01-27 1999-05-25 Insmed Pharmaceuticals, Inc. Compositions and methods for treating metabolic diseases characterized by hyperandrogenism and/or anovulation and/or infertility

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5906979A (en) * 1998-01-27 1999-05-25 Insmed Pharmaceuticals, Inc. Compositions and methods for treating metabolic diseases characterized by hyperandrogenism and/or anovulation and/or infertility

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
FRANKS STEPHEN: "Polycystic ovary syndrome", NEW ENGLAND JOURNAL OF MEDICINE, vol. 333, no. 13, 1995, pages 853 - 861, XP007906388, ISSN: 0028-4793 *
GERLI S ET AL: "Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial.", EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES 2003 NOV-DEC, vol. 7, no. 6, November 2003 (2003-11-01), pages 151 - 159, XP008098756, ISSN: 1128-3602 *
GERLI S ET AL: "Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS.", EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES 2007 SEP-OCT, vol. 11, no. 5, September 2007 (2007-09-01), pages 347 - 354, XP008098739, ISSN: 1128-3602 *
IUORNO MARIA J ET AL: "Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome.", ENDOCRINE PRACTICE : OFFICIAL JOURNAL OF THE AMERICAN COLLEGE OF ENDOCRINOLOGY AND THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS 2002 NOV-DEC, vol. 8, no. 6, November 2002 (2002-11-01), pages 417 - 423, XP008098754, ISSN: 1530-891X *
NESTLER JOHN E ET AL: "Ovulatory and metabolic effects of D-chiro-inositol in the polycystic ovary syndrome", NEW ENGLAND JOURNAL OF MEDICINE, vol. 340, no. 17, 29 April 1999 (1999-04-29), pages 1314 - 1320, XP007906382, ISSN: 0028-4793 *
PAPALEO ENRICO ET AL: "Myo-inositol in patients with polycystic ovary syndrome: a novel method for ovulation induction.", GYNECOLOGICAL ENDOCRINOLOGY : THE OFFICIAL JOURNAL OF THE INTERNATIONAL SOCIETY OF GYNECOLOGICAL ENDOCRINOLOGY DEC 2007, vol. 23, no. 12, December 2007 (2007-12-01), pages 700 - 703, XP008098721, ISSN: 0951-3590 *

Also Published As

Publication number Publication date
WO2008155651A2 (en) 2008-12-24
ITRM20070341A1 (en) 2008-12-21

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