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WO2008009963A3 - Pyrimidine derivatives as modulators of parathyroid hormone receptors - Google Patents

Pyrimidine derivatives as modulators of parathyroid hormone receptors Download PDF

Info

Publication number
WO2008009963A3
WO2008009963A3 PCT/GB2007/002767 GB2007002767W WO2008009963A3 WO 2008009963 A3 WO2008009963 A3 WO 2008009963A3 GB 2007002767 W GB2007002767 W GB 2007002767W WO 2008009963 A3 WO2008009963 A3 WO 2008009963A3
Authority
WO
WIPO (PCT)
Prior art keywords
parathyroid hormone
pyrimidine derivatives
modulators
hormone receptors
pth
Prior art date
Application number
PCT/GB2007/002767
Other languages
French (fr)
Other versions
WO2008009963A2 (en
Inventor
Caroline Minli Rachel Low
Lain Mair Mcdonald
Michael John Pether
John Spencer
Patrizia Tisselli
Paul Trevor Wright
Original Assignee
Black James Foundation
Caroline Minli Rachel Low
Lain Mair Mcdonald
Michael John Pether
John Spencer
Patrizia Tisselli
Paul Trevor Wright
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Black James Foundation, Caroline Minli Rachel Low, Lain Mair Mcdonald, Michael John Pether, John Spencer, Patrizia Tisselli, Paul Trevor Wright filed Critical Black James Foundation
Publication of WO2008009963A2 publication Critical patent/WO2008009963A2/en
Publication of WO2008009963A3 publication Critical patent/WO2008009963A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention is concerned with pyrimidine derivatives, their intermediates, uses thereof and processes for their production. In particular, the present invention relates to parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrp) receptor ligands, (PTH-I or PTH/PTHrp receptor ligands). The invention also relates to methods of preparing such ligands and to compounds which are useful as intermediates in such methods.
PCT/GB2007/002767 2006-07-21 2007-07-20 Pyrimidine derivatives as modulators of parathyroid hormone receptors WO2008009963A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0614579.1A GB0614579D0 (en) 2006-07-21 2006-07-21 Pyrimidine derivatives
GB0614579.1 2006-07-21

Publications (2)

Publication Number Publication Date
WO2008009963A2 WO2008009963A2 (en) 2008-01-24
WO2008009963A3 true WO2008009963A3 (en) 2008-05-08

Family

ID=36998543

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/002767 WO2008009963A2 (en) 2006-07-21 2007-07-20 Pyrimidine derivatives as modulators of parathyroid hormone receptors

Country Status (2)

Country Link
GB (1) GB0614579D0 (en)
WO (1) WO2008009963A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors

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CL2008000467A1 (en) 2007-02-14 2008-08-22 Janssen Pharmaceutica Nv COMPOUNDS DERIVED FROM 2-AMINOPIRIMIDINE, HISTAMINE RECEIVER MODULATORS H4; YOUR PREPARATION PROCEDURE; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO TREAT A SELECTED INFLAMMATORY DISORDER OF ALEGIA, ASMA
EP2300013B2 (en) 2008-05-21 2024-11-13 Takeda Pharmaceutical Company Limited Phosphorous derivatives as kinase inhibitors
GB0815369D0 (en) * 2008-08-22 2008-10-01 Summit Corp Plc Compounds for treatment of duchenne muscular dystrophy
US8586751B2 (en) 2009-06-12 2013-11-19 Bristol-Myers Squibb Company Nicotinamide compounds useful as kinase modulators
WO2012151561A1 (en) 2011-05-04 2012-11-08 Ariad Pharmaceuticals, Inc. Compounds for inhibiting cell proliferation in egfr-driven cancers
US9981918B2 (en) 2011-08-30 2018-05-29 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
AU2013204563B2 (en) 2012-05-05 2016-05-19 Takeda Pharmaceutical Company Limited Compounds for inhibiting cell proliferation in EGFR-driven cancers
US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers
EP3094631B1 (en) 2014-01-16 2019-01-09 FMC Corporation Pyrimidinyloxy benzene derivatives as herbicides
EP3169684B1 (en) 2014-07-17 2019-06-26 CHDI Foundation, Inc. Combination of kmo inhibitor 6-(3-chloro-4-cyclopropoxyphenyl)pyrimidine-4-carboxylic acid with antiviral agent for treating hiv related neurological disorders
WO2016043260A1 (en) * 2014-09-19 2016-03-24 塩野義製薬株式会社 Cyclic guanidine or amidine compound
ES2872553T3 (en) 2015-03-06 2021-11-02 Pharmakea Inc Lysyl oxidase type-2 inhibitors and uses thereof
JP6697809B2 (en) 2015-03-06 2020-05-27 ファーマケア，インク． Fluorinated lysyl oxidase-like 2 inhibitors and their use
CA2969816C (en) 2015-03-18 2022-03-01 E I Du Pont De Nemours And Company Substituted pyrimidinyloxy pyridine derivatives as herbicides
TWI828952B (en) 2015-06-05 2024-01-11 美商艾佛艾姆希公司 Pyrimidinyloxy benzene derivatives as herbicides
EP3939973A1 (en) 2015-07-06 2022-01-19 Alkermes, Inc. Hetero-halo inhibitors of histone deacetylase
EP3319968A1 (en) 2015-07-06 2018-05-16 Rodin Therapeutics, Inc. Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase
BR112018000687B1 (en) 2015-07-13 2021-05-04 Fmc Corporation compost, herbicide compositions, herbicide mixtures and methods for controlling the growth of unwanted vegetation
EA201990621A1 (en) 2016-09-07 2019-09-30 Фармакеа, Инк. CRYSTALLIC FORMS OF LYSYLOXIDASE-LIKE PROTEIN 2 INHIBITOR AND METHODS FOR PRODUCING
EP3509594A4 (en) 2016-09-07 2020-05-06 Pharmakea, Inc. Uses of a lysyl oxidase-like 2 inhibitor
AU2018207402B2 (en) 2017-01-11 2023-09-28 Alkermes, Inc. Bicyclic inhibitors of histone deacetylase
US11427549B2 (en) 2017-05-02 2022-08-30 Fmc Corporation Pyrimidinyloxy benzo-fused compounds as herbicides
TW201843148A (en) * 2017-05-08 2018-12-16 國立大學法人京都大學 Compound, light emitting material and organic light emitting element
WO2019032528A1 (en) 2017-08-07 2019-02-14 Rodin Therapeutics, Inc Bicyclic inhibitors of histone deacetylase
EP3713926B1 (en) 2017-11-21 2023-06-07 Bayer Aktiengesellschaft 2-hetarylpyrimidine-4-carboxamides as aryl hydrocarbon receptor anatgonists
CA3082858A1 (en) 2017-11-21 2019-05-31 Bayer Aktiengesellschaft 2-phenylpyrimidine-4-carboxamides as ahr inhibitors

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WO2005075458A1 (en) * 2004-02-10 2005-08-18 Sanofi-Aventis Pyrimidine derivatives as orexin receptors antagonists
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Non-Patent Citations (4)

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Title
GHOSH D ET AL: "2,4-bis(aryloxy)pyrimidines as antimierobial agents.", JOURNAL OF MEDICINAL CHEMISTRY NOV 1968, vol. 11, no. 6, November 1968 (1968-11-01), pages 1237 - 1238, XP002470439, ISSN: 0022-2623 *
KIM D H ET AL: "Synthesis of pyrido[1,2 a]pyrimido[4,5 d]pyrimidin 5 ones. Cyclization reaction of 4 [(3 hydroxy 2 pyridyl)amino] 2 phenyl 5 pyrimidinecarboxylic acid with acetic anhydride", JOURNAL OF HETEROCYCLIC CHEMISTRY 1975, vol. 12, no. 3, 1975, pages 477 - 480, XP002470440, ISSN: 0022-152X *
SAKAI NORIO ET AL: "New approach to the practical synthesis of tri- or tetrasubstituted pyrimidine derivatives: a four-component coupling reaction from a functionalized silane, two types of aromatic nitriles, and acetals.", ORGANIC LETTERS 13 OCT 2005, vol. 7, no. 21, 13 October 2005 (2005-10-13), pages 4705 - 4708, XP002470438, ISSN: 1523-7060 *
TRANTOLO D J ET AL: "Inhibitors of Bacillus subtilis DNA Polymerase III. Influence of Modifications in the Pyrimidine Ring of Anilino- and (Benzylamino)pyrimidines", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 29, no. 5, 1986, pages 676 - 681, XP002269094, ISSN: 0022-2623 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors

Also Published As

Publication number Publication date
GB0614579D0 (en) 2006-08-30
WO2008009963A2 (en) 2008-01-24

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