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WO2008096372A3 - Process for preparing highly pure ezetimibe using novel intermediates - Google Patents

Process for preparing highly pure ezetimibe using novel intermediates Download PDF

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Publication number
WO2008096372A3
WO2008096372A3 PCT/IN2008/000072 IN2008000072W WO2008096372A3 WO 2008096372 A3 WO2008096372 A3 WO 2008096372A3 IN 2008000072 W IN2008000072 W IN 2008000072W WO 2008096372 A3 WO2008096372 A3 WO 2008096372A3
Authority
WO
WIPO (PCT)
Prior art keywords
highly pure
ezetimibe
novel intermediates
preparing highly
pure ezetimibe
Prior art date
Application number
PCT/IN2008/000072
Other languages
French (fr)
Other versions
WO2008096372A2 (en
Inventor
Chidambaram Venkateswaran Srinivasan
Rahul Saxena
Pranav Gupta
Lalit Wadhwa
Original Assignee
Ind-Swift Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ind-Swift Laboratories Limited filed Critical Ind-Swift Laboratories Limited
Publication of WO2008096372A2 publication Critical patent/WO2008096372A2/en
Publication of WO2008096372A3 publication Critical patent/WO2008096372A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

The present invention relates to an industrially advantageous process for the preparation of ezetimibe of formula (I) in high yields by using novel benzyl ester intermediates. The present invention further provides a process for the purification of ezetimibe of formula (I).
PCT/IN2008/000072 2007-02-06 2008-02-06 Process for preparing highly pure ezetimibe using novel intermediates WO2008096372A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN234DE2007 2007-02-06
IN234/DEL/2007 2007-02-06
IN216DE2008 2008-01-25
IN216/DEL/2008 2008-01-25

Publications (2)

Publication Number Publication Date
WO2008096372A2 WO2008096372A2 (en) 2008-08-14
WO2008096372A3 true WO2008096372A3 (en) 2010-06-24

Family

ID=39682193

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000072 WO2008096372A2 (en) 2007-02-06 2008-02-06 Process for preparing highly pure ezetimibe using novel intermediates

Country Status (1)

Country Link
WO (1) WO2008096372A2 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006137080A1 (en) * 2005-06-22 2006-12-28 Manne Satyanarayana Reddy Improved process for the preparation of ezetimibe
EP2128133A1 (en) * 2008-05-26 2009-12-02 Lek Pharmaceuticals D.D. Ezetimibe process and composition
WO2009157019A2 (en) * 2008-06-23 2009-12-30 Ind-Swift Laboratories Limited Process for preparing ezetimibe using novel allyl intermediates
WO2010113175A2 (en) 2009-04-01 2010-10-07 Matrix Laboratories Ltd Enzymatic process for the preparation of (s)-5-(4-fluoro-phenyl)-5-hydroxy- 1morpholin-4-yl-pentan-1-one, an intermediate of ezetimibe and further conversion to ezetimibe
CN102531985B (en) * 2011-04-25 2013-12-18 开原亨泰制药股份有限公司 Method for preparing ezetimibe key intermediate
WO2012155932A1 (en) * 2011-05-17 2012-11-22 Pharmathen S.A. Improved process for the preparation of ezetimibe
CN103373970A (en) * 2012-04-16 2013-10-30 重庆圣华曦药业股份有限公司 Synthetic method for Ezetimibe intermediate
CN102854274B (en) * 2012-09-13 2017-08-22 北京万全德众医药生物技术有限公司 A kind of method of use liquid chromatography for separating and determining Ezetimibe raw material and its preparation
CN104356041A (en) * 2014-11-06 2015-02-18 成都森科制药有限公司 Preparation method for Ezetimibe
CN104447473B (en) * 2014-11-06 2016-11-16 成都森科制药有限公司 The preparation method of Ezetimibe intermediate
CN106706818B (en) * 2015-11-13 2018-08-03 广州骏思知识产权管理咨询有限公司韶关分公司 A kind of Ezetimibe intermediate optical purity assay method
CN105541690B (en) * 2015-12-16 2018-08-21 江苏恒盛药业有限公司 A kind of preparation method of aza cyclo-butanone derivatives
CN107176920B (en) * 2017-04-19 2019-09-20 江苏恒盛药业有限公司 A kind of new technique for synthesizing of ezetimibe
CN110845384B (en) * 2019-12-04 2021-07-20 广东省生物医药技术研究所 Dissociation method of titanium complex drug and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0720599A1 (en) * 1993-09-21 1996-07-10 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
WO2006137080A1 (en) * 2005-06-22 2006-12-28 Manne Satyanarayana Reddy Improved process for the preparation of ezetimibe
US20070049748A1 (en) * 2005-08-26 2007-03-01 Uppala Venkata Bhaskara R Preparation of ezetimibe

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0720599A1 (en) * 1993-09-21 1996-07-10 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
WO2006137080A1 (en) * 2005-06-22 2006-12-28 Manne Satyanarayana Reddy Improved process for the preparation of ezetimibe
US20070049748A1 (en) * 2005-08-26 2007-03-01 Uppala Venkata Bhaskara R Preparation of ezetimibe

Also Published As

Publication number Publication date
WO2008096372A2 (en) 2008-08-14

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