WO2008093650A1 - ピペラシリンナトリウムの新規な結晶 - Google Patents
ピペラシリンナトリウムの新規な結晶 Download PDFInfo
- Publication number
- WO2008093650A1 WO2008093650A1 PCT/JP2008/051232 JP2008051232W WO2008093650A1 WO 2008093650 A1 WO2008093650 A1 WO 2008093650A1 JP 2008051232 W JP2008051232 W JP 2008051232W WO 2008093650 A1 WO2008093650 A1 WO 2008093650A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- novel crystal
- piperacillin sodium
- crystals
- diffraction angles
- piperacillin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
- C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
- C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
- C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
- C07D499/68—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with aromatic rings as additional substituents on the carbon chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Crystallography & Structural Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/524,875 US20100063273A1 (en) | 2007-01-31 | 2008-01-29 | Novel crystal of piperacillin sodium |
CA002676803A CA2676803A1 (en) | 2007-01-31 | 2008-01-29 | Novel crystal of piperacillin sodium |
EP08704041A EP2128162A4 (en) | 2007-01-31 | 2008-01-29 | NEW SODIUM PIPERACILLIN CRYSTAL |
MX2009008124A MX2009008124A (es) | 2007-01-31 | 2008-01-29 | Cristal nuevo de piperacilina sodica. |
KR1020097016429A KR20090104855A (ko) | 2007-01-31 | 2008-01-29 | 피페라실린나트륨의 신규 결정 |
JP2008556092A JP5173842B2 (ja) | 2007-01-31 | 2008-01-29 | ピペラシリンナトリウムの新規な結晶 |
AU2008210929A AU2008210929A1 (en) | 2007-01-31 | 2008-01-29 | Novel crystal of piperacillin sodium |
BRPI0808375-4A BRPI0808375A2 (pt) | 2007-01-31 | 2008-01-29 | Composto |
IL200087A IL200087A0 (en) | 2007-01-31 | 2009-07-27 | Novel crystal of piperacillin sodium |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-020758 | 2007-01-31 | ||
JP2007020758 | 2007-01-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008093650A1 true WO2008093650A1 (ja) | 2008-08-07 |
Family
ID=39673961
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/051232 WO2008093650A1 (ja) | 2007-01-31 | 2008-01-29 | ピペラシリンナトリウムの新規な結晶 |
Country Status (12)
Country | Link |
---|---|
US (1) | US20100063273A1 (ja) |
EP (1) | EP2128162A4 (ja) |
JP (1) | JP5173842B2 (ja) |
KR (1) | KR20090104855A (ja) |
CN (1) | CN101611040A (ja) |
AU (1) | AU2008210929A1 (ja) |
BR (1) | BRPI0808375A2 (ja) |
CA (1) | CA2676803A1 (ja) |
IL (1) | IL200087A0 (ja) |
MX (1) | MX2009008124A (ja) |
RU (1) | RU2009132516A (ja) |
WO (1) | WO2008093650A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011040386A1 (ja) * | 2009-09-30 | 2011-04-07 | 富山化学工業株式会社 | ピペラシリンナトリウム・1水和物の新規な結晶 |
JP2015531778A (ja) * | 2012-09-14 | 2015-11-05 | ベイジン シンティエンユー テクノロジー ディベロップメント シーオー エルティーディー | ピペラシリンナトリウムとスルバクタムナトリウムの共晶及びその製造方法、並びに当該共晶を含む医薬組成物及びその応用 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102977119A (zh) * | 2012-12-14 | 2013-03-20 | 江西富祥药业股份有限公司 | 一种用溶媒法制备哌拉西林钠的工艺 |
CN109134497A (zh) * | 2017-07-24 | 2019-01-04 | 陈立平 | 一种1/2水哌拉西林钠化合物 |
CN109160918A (zh) * | 2017-07-27 | 2019-01-08 | 海南美兰史克制药有限公司 | 一种1/4水哌拉西林钠化合物及其药物组合物制剂 |
CN113209030B (zh) * | 2021-04-27 | 2023-04-25 | 海南通用康力制药有限公司 | 哌拉西林钠他唑巴坦钠无菌粉针剂的制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5123284A (en) | 1974-08-13 | 1976-02-24 | Toyama Chemical Co Ltd | Shinkina penishirinruino seizoho |
JPH0232082A (ja) | 1988-07-21 | 1990-02-01 | Maruko Seiyaku Kk | ペニシリン誘導体の製造方法 |
US20030028016A1 (en) | 2001-08-03 | 2003-02-06 | Alberto Brandt | Process for the preparation of the sodium salt of 6[D-(-)alpha-4-(ethyl-2,3-dioxo-1-piperazinocarbonylamino) phenylacetamido]penicillanic acid |
JP2007099763A (ja) * | 2005-09-08 | 2007-04-19 | Toyama Chem Co Ltd | ピペラシリンナトリウム・1水和物の新規な結晶及びその製造方法 |
JP2007246514A (ja) * | 2006-02-14 | 2007-09-27 | Toyama Chem Co Ltd | ピペラシリンナトリウムの新規な結晶 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL47168A (en) * | 1974-05-09 | 1979-07-25 | Toyama Chemical Co Ltd | Mono or dioxo piperazino(thio)carbonylamino derivatives ofpenicillins and cephalosporins and process for producing the same |
US4379152A (en) * | 1974-05-09 | 1983-04-05 | Toyama Chemical Co., Ltd. | Cephalosporins |
DE2732104A1 (de) * | 1977-07-15 | 1979-01-25 | Bayer Ag | Penicilline, verfahren zu ihrer herstellung und ihre verwendung |
JPS5446836A (en) * | 1977-09-22 | 1979-04-13 | Sangyo Kagaku Kenkyu Kyokai | Antibacterial composition |
US4610822A (en) * | 1981-03-30 | 1986-09-09 | American Cyanamid Company | Process for preparing 6-[D(-)-α-(4-C1 -C4)-alkyl-2,3-dioxo-1-piperazinocarbonylamino)phenylacetamido]penicillanic acids |
KR830001969B1 (ko) * | 1981-10-06 | 1983-09-29 | 김영설 | 6―{D―(―) α-(4―에틸-2. 3-디옥소-1 피페라지노카보닐아미노) 페닐(또는 하이드록시페닐)아세트아미도 페니실란산 및 그 염의 제조방법 |
JPS57118571A (en) * | 1981-11-26 | 1982-07-23 | Toyama Chem Co Ltd | 1-ethyl-2,3-dioxopiperazine |
YU43570B (en) * | 1984-05-30 | 1989-08-31 | Krka | Process for preparation of derivatives of d()alpha-amino-benzile-penicilyns |
PL145700B3 (en) * | 1984-08-29 | 1988-10-31 | Tarchominskie Zaklad Farma | Method of obtaining 6-/d/-/alpha-/4-ethyl-2,3-dioxy-1-piperazinylocarbonyloamino/-phenylacetamido/-penicillate sodium salt |
BG46664A1 (en) * | 1985-08-16 | 1990-02-15 | Druzhestven N Izsledovatelski | Method for preparing of 6- /d (-)- alpha- (4- ethyl- 2, 3- dioxo- 1- piperazine carbonylamino)- phenylacetamido/- penicillanic acid |
SI8711089A8 (en) * | 1987-06-11 | 1996-08-31 | Krka Tovarna Zdravil | Process for preparation of 6-/d(-)-alpha-(4-ethyl-2,3-dioxo-1- piperazine-carboxyamido)-phenylacetamido/-penicillanic acid |
GB8816620D0 (en) * | 1988-07-13 | 1988-08-17 | Lepetit Spa | Rifapentine hydrohalides |
DD295852A5 (de) * | 1988-07-18 | 1991-11-14 | Arzneimittelwerk Dresden Gmbh,De | Verfahren zur herstellung von acylureido-benzylpenicillinen und deren salzen |
DE68907062T2 (de) * | 1988-10-05 | 1993-10-07 | Upjohn Co | Feinverteiltes feste kristalline pulver durch niederschlag in einem anti-lösungsmittel. |
JP4953501B2 (ja) * | 1999-09-30 | 2012-06-13 | 大塚化学株式会社 | 3−セフェム誘導体結晶の製造方法 |
JP4749533B2 (ja) * | 1999-09-30 | 2011-08-17 | 大塚化学株式会社 | セファロスポリン結晶 |
IL156055A0 (en) * | 2000-11-30 | 2003-12-23 | Teva Pharma | Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms |
-
2008
- 2008-01-29 CA CA002676803A patent/CA2676803A1/en not_active Abandoned
- 2008-01-29 WO PCT/JP2008/051232 patent/WO2008093650A1/ja active Application Filing
- 2008-01-29 BR BRPI0808375-4A patent/BRPI0808375A2/pt not_active IP Right Cessation
- 2008-01-29 RU RU2009132516/04A patent/RU2009132516A/ru not_active Application Discontinuation
- 2008-01-29 CN CNA2008800037831A patent/CN101611040A/zh active Pending
- 2008-01-29 EP EP08704041A patent/EP2128162A4/en not_active Withdrawn
- 2008-01-29 MX MX2009008124A patent/MX2009008124A/es unknown
- 2008-01-29 JP JP2008556092A patent/JP5173842B2/ja active Active
- 2008-01-29 AU AU2008210929A patent/AU2008210929A1/en not_active Abandoned
- 2008-01-29 US US12/524,875 patent/US20100063273A1/en not_active Abandoned
- 2008-01-29 KR KR1020097016429A patent/KR20090104855A/ko not_active Application Discontinuation
-
2009
- 2009-07-27 IL IL200087A patent/IL200087A0/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5123284A (en) | 1974-08-13 | 1976-02-24 | Toyama Chemical Co Ltd | Shinkina penishirinruino seizoho |
JPH0232082A (ja) | 1988-07-21 | 1990-02-01 | Maruko Seiyaku Kk | ペニシリン誘導体の製造方法 |
US20030028016A1 (en) | 2001-08-03 | 2003-02-06 | Alberto Brandt | Process for the preparation of the sodium salt of 6[D-(-)alpha-4-(ethyl-2,3-dioxo-1-piperazinocarbonylamino) phenylacetamido]penicillanic acid |
JP2007099763A (ja) * | 2005-09-08 | 2007-04-19 | Toyama Chem Co Ltd | ピペラシリンナトリウム・1水和物の新規な結晶及びその製造方法 |
JP2007246514A (ja) * | 2006-02-14 | 2007-09-27 | Toyama Chem Co Ltd | ピペラシリンナトリウムの新規な結晶 |
Non-Patent Citations (1)
Title |
---|
See also references of EP2128162A4 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011040386A1 (ja) * | 2009-09-30 | 2011-04-07 | 富山化学工業株式会社 | ピペラシリンナトリウム・1水和物の新規な結晶 |
JP2015531778A (ja) * | 2012-09-14 | 2015-11-05 | ベイジン シンティエンユー テクノロジー ディベロップメント シーオー エルティーディー | ピペラシリンナトリウムとスルバクタムナトリウムの共晶及びその製造方法、並びに当該共晶を含む医薬組成物及びその応用 |
Also Published As
Publication number | Publication date |
---|---|
EP2128162A4 (en) | 2011-05-25 |
JPWO2008093650A1 (ja) | 2010-05-20 |
RU2009132516A (ru) | 2011-03-10 |
AU2008210929A1 (en) | 2008-08-07 |
JP5173842B2 (ja) | 2013-04-03 |
CN101611040A (zh) | 2009-12-23 |
KR20090104855A (ko) | 2009-10-06 |
BRPI0808375A2 (pt) | 2014-07-01 |
US20100063273A1 (en) | 2010-03-11 |
EP2128162A1 (en) | 2009-12-02 |
MX2009008124A (es) | 2009-10-08 |
IL200087A0 (en) | 2010-04-15 |
CA2676803A1 (en) | 2008-08-07 |
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