WO2007137389A1

WO2007137389A1 - Use of compounds obtained from the neem tree (azadirachta indica) for the treatment of hiv/aids

Info

Publication number: WO2007137389A1
Application number: PCT/CA2006/001970
Authority: WO
Inventors: Rajesh Radhakrishnan
Original assignee: 2033261 Ontario Inc
Priority date: 2006-05-26
Filing date: 2006-12-04
Publication date: 2007-12-06
Also published as: GB0712015D0; WO2007137386A1; CN101389344A

Abstract

A pharmaceutical compound for treating patients suffering with the human immunodeficiency virus is disclosed. This compound comprises an effective quantity of the following elements: compounds obtained from the neem tree (Azadirachta Indica); and a protein supplement. This compound can be produced as follows: by immersing the powder of the neem tree in water, in such a way that the components of the same can be extracted in order to produce an aqueous extract; and by mixing the aqueous extract with a protein supplement to make a drink. A method of treatment for a patient suffering from the human immunodeficiency virus is also disclosed. This method can comprise a step of administering this drink orally to the same patient.

Description

Use of components obtained from neem (Azaώrachta indica) for the treatment of HIV / AIDS

FIELD OF THE INVENTION

The present invention relates to the treatment of people with human immunodeficiency virus (HIV).

GENERAL INFORMATION ON THE INVENTION

Neem (Azadirachta Indica) is a plant that grows naturally in several parts of the world where the climate is hot, especially in India and Africa. Throughout India and Africa, various parts of the neem tree, including the leaves, bark, flowers and seeds, are used as remedies for various ailments in humans

The state of the art suggests the use of neem-derived compounds for the treatment of people with the human immunodeficiency virus (HIV), which is said to be a difficult-to-treat infection, in part due to the capacity of the virus. to position themselves deeply in the muscle tissue of infected people.

For example, in US 5,370,873 (Udeinya) issued on December 6, 1994, we teach how to produce a pharmaceutical preparation based on neem leaves. Udeinya shows how to pick green leaves from mature trees. The leaves are dried in the oven, ground into a coarse powder and reduced to an extract using a mixture of acetone and distilled water. The solvent is collected using a vortex-type evaporation process. The precipitates forming on the wall of the rotor are removed using acetone. Evaporation of the acetone solution at room temperature allows the deposition of a substance designated under the name of IRAB. IRAB is said to be useful in inhibiting the development of the HIV virus when mixed with a physiologically acceptable carrier. However, Udeinya does not disclose diets or dosage levels in addition to not disclosing a useful carrier. SUMMARY OF THE INVENTION

An pharmaceutical composition for the treatment of patients with the human immunodeficiency virus constitutes an aspect of the invention. This composition includes an effective quantity of the following elements: components obtained from neem (Azadirachta Index); and a protein supplement.

Another aspect of the invention is a pharmaceutical composition for the treatment of patients with the human immunodeficiency virus. This composition is produced by immersing neem powder (Azadirachta Indica) in water so that it can extract components of this same neem powder in order to produce an aqueous extract; and mixing the aqueous extract with a protein supplement.

Another aspect of the invention is a method of treatment for a patient with the human immunodeficiency virus. This method includes the step of orally administering to the same patient an effective amount of neem components combined with a protein supplement.

Other advantages and features of the present invention will become more apparent upon review of the following detailed description and of the appended claims relating to the photo, the latter being briefly described below.

BRIEF DESCRIPTION OF THE PHOTO

FIGURE 1 represents a photo demonstrating the effects of the treatment. DETAILED DESCRIPTION

A preferred method for the treatment of HIV infection is described below.

In this method, 1.25 liters of drinking water are mixed with 20 grams of powdered neem tree available on the market, namely of the type derived from the bark, leaves, flowers and seeds, to form a slurry.

The volume of the slurry is reduced by boiling to 750 ml to extract the components of the neem powder.

The reduced slurry is filtered through a cloth to produce an aqueous extract containing components extracted from neem powder as well as to produce a depleted residue of neem powder.

The aqueous extract is mixed with 112.5 g of protein drink powder available on the market to produce a pharmaceutical composition in the form of a drink. A portion of this drink is ingested by the patient 5 times a day, 5 to 6 days a week, so that the total amount of protein ingested by the patient is approximately 1 gram / kg of body weight / day. In this first choice method, the protein drink powder is of the type comprising approximately 89% equivalent by weight of whey protein isolate (whey protein isolate) microfiltered by tangential flow and 11% equivalent by weight of corosolic acid, protease I, protease II and piperine extract. For example, in the case of a 100 kg patient, each serving is prepared by mixing 150 ml of aqueous extract with 22.5 grams of protein shake powder (containing approximately 20 grams of protein). In the case of extreme fatigue, the treatment is interrupted for 2 to 3 days before continuing.

Treatment continues in this way for at least a year.

Thereafter, once the HIV hemograms have dropped below 50 / ml, treatment continues, but the amount of neem in each serving is cut in half.

Thus, in the case of the first choice method described above, 10 grams of neem powder, rather than 20 grams, is used to form the porridge.

Treatment continues until HIV infection is cleared, which can take 2 to 3 years.

Figure 1 is a photo of the skin of a male patient being treated. The visible discoloration of the tissue inside the encircled area 20 is indicative of the action of the composition which is suppressing HIV deep in the patient's muscle tissue.

Without wishing to be limited to theoretical notions, it is believed that the components extracted from neem trees are adapted to facilitate the production of antibodies against HIV. As the main constituent of antibodies is a protein, this production is supported by the protein supplement, which makes the protein easily and quickly usable in the body for the production of antibodies. Although only one example of the present invention has been shown and described herein, it will be understood that various changes are likely to occur. For example, while the commercially available protein supplement drink mix is recommended, other sources of protein may be used. The simple whey isolate (whey protein isolate), for example, can serve as a substitute for the protein supplement drink mix. Furthermore, while the water used to extract the components of neem powder is described as being used to form the base of a drink, the water could just as easily be evaporated from the aqueous extract, thereby producing a residue of neem, which could be mixed with protein and reduced to a tablet, capsule or similar form for daily ingestion, or made into a powder to mix with water to make a drink. This drink could itself be dehydrated and powdered, and then rehydrated and used at a later date. The protein supplement and neem components could also be ingested separately. While whey protein (whey protein isolate) is recommended for use as a protein supplement, other sources of protein may be used. Compounds used by the body in the formation of proteins, ie amino acids, could also be used and are intended to meet the definition of the term "protein supplements" as used herein. Therefore, the invention should be considered to be limited only by the claims appended hereto, intentionally interpreted.

Claims

1. A pharmaceutical composition for the treatment of patients suffering from an infection with the human immunodeficiency virus, which composition comprises an effective amount of the following elements: components obtained or neem (A∑adirachta Indica); and a protein supplement.

2. A pharmaceutical composition according to claim 1, in which the components are obtained by extracting powdered neem tree using water.

3. A pharmaceutical composition according to claim 1, wherein the protein supplement comprises a whey isolate (whey protein isolate).

4. A pharmaceutical composition according to claim 1, wherein the components are obtained from the bark, seeds, flowers and leaves of the neem tree.

5. A pharmaceutical composition according to claim 1 in the form of a drink.

6. A pharmaceutical composition for the treatment of patients suffering from the human immunodeficiency virus, this composition being produced as follows: by immersing neem powder (Azadirachta Indicated) in water so that that it can extract components of this same neem powder in order to produce an aqueous extract; and mixing the aqueous extract with a protein supplement.

7. A composition according to claim 6, in which the powdered neem tree is a powder obtained from the bark, seeds, flowers and leaves of the neem tree.

8. A composition according to claim 6, wherein the immersion step comprises boiling water.

9. A composition according to claim 8, in which approximately 40% of the volume of water evaporates during the immersion step.

10. A composition according to claim 6, in which the water comes into contact with the powdered neem tree and then is filtered to produce an aqueous extract and a depleted residue of neem powder.

11. A composition according to claim 6, in which the powdered neem tree and the water are supplied in a weight ratio of approximately 20: 1250 for the immersion step.

12. A composition according to claim 6, in which the aqueous extract and the protein supplement are mixed in a weight ratio of approximately 1500: 225 at the mixing stage.

13. A method of treatment for a patient with human immunodeficiency virus comprising the step of orally administering to the same patient an effective amount of neem components combined with a protein supplement.

14. A method according to claim 13 in which the effective quantity of neem components and protein supplement are supplied in the form of a drink produced in the following manner:

by immersing neem powder (Azadirachta Indica) in water so that it can extract components of this same neem powder to produce an aqueous extract; and

by mixing the aqueous extract with a protein supplement.

15. A method according to claim 14, in which the powdered neem tree is a powder composed of bark, seeds, flowers and neem leaves.

16. A method according to claim 14, wherein the immersion step comprises boiling the water.

17. A method according to claim 14, in which the water comes into contact with the powdered neem tree and then is filtered in order to produce an aqueous extract and a depleted residue of neem powder.

18. A method according to claim 14, wherein the aqueous extract and the protein supplement are mixed in a weight ratio of about 1500: 225 at the mixing stage.

19. A method according to claim 14, in which, as an initial stage of treatment, in the drink, the weight ratio of:

grams of neem powder from which the components of the neem tree are derived;

protein

is approximately 1: 5 and

the drink is administered orally to the patient

several times a day, so that the total amount of protein administered to the patient each day is 1 gram per kilogram of body weight; and

for at least a year, and until the blood count of the virus drops below 50 / ml.

20. A method according to claim 19, in which, as an initial stage of treatment, in the drink, the weight ratio of:

the grams of neem powder from which the components of the neem tree are derived; protein

is approximately 1:10 and

the drink is administered orally to the patient several times a day, so that the total amount of protein administered to the patient each day is 1 gram per kilogram of body weight.