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WO2007133802A3 - Pharmaceutical formulations of pimavanserin - Google Patents

Pharmaceutical formulations of pimavanserin Download PDF

Info

Publication number
WO2007133802A3
WO2007133802A3 PCT/US2007/011720 US2007011720W WO2007133802A3 WO 2007133802 A3 WO2007133802 A3 WO 2007133802A3 US 2007011720 W US2007011720 W US 2007011720W WO 2007133802 A3 WO2007133802 A3 WO 2007133802A3
Authority
WO
WIPO (PCT)
Prior art keywords
pimavanserin
pharmaceutical formulations
useful
disclosed
conditions associated
Prior art date
Application number
PCT/US2007/011720
Other languages
French (fr)
Other versions
WO2007133802A2 (en
Inventor
Bo-Ragnar Tolf
Nathalie Schlienger
Mikkel Boas Thygesen
Original Assignee
Acadia Pharm Inc
Bo-Ragnar Tolf
Nathalie Schlienger
Mikkel Boas Thygesen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acadia Pharm Inc, Bo-Ragnar Tolf, Nathalie Schlienger, Mikkel Boas Thygesen filed Critical Acadia Pharm Inc
Priority to EP07794929A priority Critical patent/EP2037918A2/en
Priority to CA002652300A priority patent/CA2652300A1/en
Priority to JP2009511049A priority patent/JP2009537538A/en
Publication of WO2007133802A2 publication Critical patent/WO2007133802A2/en
Publication of WO2007133802A3 publication Critical patent/WO2007133802A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Disclosed herein are stable pharmaceutical formulations of pimavanserin, which is useful for treating conditions associated with serotonin receptors.
PCT/US2007/011720 2006-05-15 2007-05-15 Pharmaceutical formulations of pimavanserin WO2007133802A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP07794929A EP2037918A2 (en) 2006-05-15 2007-05-15 Pharmaceutical formulations of pimavanserin
CA002652300A CA2652300A1 (en) 2006-05-15 2007-05-15 Pharmaceutical formulations of pimavanserin
JP2009511049A JP2009537538A (en) 2006-05-15 2007-05-15 Pimavanserin pharmaceutical formulation

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80086406P 2006-05-15 2006-05-15
US60/800,864 2006-05-15
US85466506P 2006-10-26 2006-10-26
US60/854,665 2006-10-26

Publications (2)

Publication Number Publication Date
WO2007133802A2 WO2007133802A2 (en) 2007-11-22
WO2007133802A3 true WO2007133802A3 (en) 2008-01-24

Family

ID=38669082

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/011720 WO2007133802A2 (en) 2006-05-15 2007-05-15 Pharmaceutical formulations of pimavanserin

Country Status (5)

Country Link
US (1) US20070264330A1 (en)
EP (1) EP2037918A2 (en)
JP (1) JP2009537538A (en)
CA (1) CA2652300A1 (en)
WO (1) WO2007133802A2 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7790899B2 (en) * 2004-09-27 2010-09-07 Acadia Pharmaceuticals, Inc. Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
CN101677971A (en) * 2007-03-19 2010-03-24 阿卡蒂亚药品公司 The combination of 5-HT2A inverse agonist and antagonist and antipsychotic drug
EP2173343A1 (en) * 2007-05-18 2010-04-14 Acadia Pharmaceuticals Inc. Use of pimavanserin in the treatment of parkinson and symptoms thereof
CA2816957A1 (en) * 2010-11-07 2012-05-10 Targegen, Inc. Compositions and methods for treating myelofibrosis
CN102600146B (en) * 2012-04-11 2014-10-08 兆科药业（合肥）有限公司 Lercanidipine hydrochloride and losartan potassium compound preparation and preparation method thereof
WO2014075692A1 (en) * 2012-11-19 2014-05-22 Azanta A/S Dispersible tablet
WO2014085362A1 (en) * 2012-11-27 2014-06-05 Acadia Pharmaceuticals Inc. Methods for the treatment of parkinson's disease psychosis using pimavanserin
PL3325444T3 (en) 2015-07-20 2021-12-06 Acadia Pharmaceuticals Inc. Methods for preparing n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and polymorphic form c
CN105929030B (en) * 2015-12-18 2018-08-21 重庆两江药物研发中心有限公司 The detection method of organic impurities in a kind of piperazine Ma Selin
US10953000B2 (en) 2016-03-25 2021-03-23 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome P450 modulators
WO2017165635A1 (en) 2016-03-25 2017-09-28 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome p450 modulators
WO2017172757A1 (en) * 2016-03-29 2017-10-05 Acadia Pharmaceuticals Inc. 5-ht2a serotonin receptor inverse agonists or antagonists for use in reducing amyloid-beta peptides and accumulation of amyloid plaques
EP3558311A1 (en) 2016-12-20 2019-10-30 Acadia Pharmaceuticals Inc. Pimavanserin alone or in combination for use in the treatment of alzheimer's disease psychosis
EP3615028A1 (en) 2017-04-28 2020-03-04 Acadia Pharmaceuticals Inc. Pimavanserin for treating impulse control disorder
US20210077479A1 (en) * 2017-08-30 2021-03-18 Acadia Pharmaceuticals Inc. Formulations of pimavanserin
KR20200110648A (en) 2017-12-05 2020-09-24 선오비온 파마슈티컬스 인코포레이티드 Non-racemic mixtures and uses thereof
AU2018378348B2 (en) 2017-12-05 2024-09-19 Sunovion Pharmaceuticals Inc. Crystal forms and production methods thereof
CN109908097A (en) * 2017-12-13 2019-06-21 北京万全德众医药生物技术有限公司 Linkou County Mo Fanse collapses sustained release tablets
IT201800003736A1 (en) 2018-03-19 2019-09-19 Lundbeck Pharmaceuticals Italy S P A Process for the production of Pimavanserin
IT201800009690A1 (en) 2018-10-23 2020-04-23 Lundbeck Pharmaceuticals Italy Spa PROCESS FOR THE PRODUCTION OF PIMAVANSERINA
WO2020092618A1 (en) 2018-10-30 2020-05-07 Acadia Pharmaceuticals Inc. Methods of treating depression, anxiety and sexual dysfunction using the compound primavanserin
CN109613164B (en) * 2019-01-08 2021-02-09 丽珠集团新北江制药股份有限公司 Detection method of pimavanserin tartrate
CN109613163B (en) * 2019-01-08 2021-01-26 丽珠集团新北江制药股份有限公司 Detection method for pimavanserin tartrate and impurities thereof
BR112021024380A2 (en) 2019-06-04 2022-04-19 Sunovion Pharmaceuticals Inc Modified release formulations and uses thereof
US20220288048A1 (en) 2019-07-22 2022-09-15 Acadia Pharmaceuticals Inc. Pimavanserin for treating schizophrenia or for treating psychosis secondary to neurodegenerative disorders or depressive disorder
WO2021030607A1 (en) 2019-08-15 2021-02-18 Acadia Pharmaceuticals Inc. Pimavanserin for treating neurodegenerative diseases
US11648242B2 (en) * 2019-12-12 2023-05-16 Aurobindo Pharma Ltd Pharmaceutical composition comprising pimavanserin, process of preparation and use thereof
WO2022094230A1 (en) 2020-11-02 2022-05-05 Acadia Pharmaceuticals Inc. Compounds for treating psychosis or depression
WO2023128900A1 (en) * 2021-12-30 2023-07-06 Pharmactive Ilac Sanayi Ve Ticaret A.S. Pharmaceutical compositions comprising pimavanserin as active ingredient and relevant excipients
CN117074579B (en) * 2023-10-16 2023-12-22 江苏东科康德药业有限公司 Analysis method of related substances of amisulpride oral solution

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005063254A2 (en) * 2003-12-22 2005-07-14 Acadia Pharmaceuticals Inc. Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders
WO2005102342A1 (en) * 2004-04-22 2005-11-03 Boehringer Ingelheim International Gmbh New pharmaceutical compositions for the treatment of sexual disorders ii
WO2006036874A1 (en) * 2004-09-27 2006-04-06 Acadia Pharmaceuticals Inc. Salts of n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and their preparation

Family Cites Families (8)

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GB8628475D0 (en) * 1986-11-28 1987-01-07 Glaxo Group Ltd Medicaments
US6419956B1 (en) * 1999-12-30 2002-07-16 Ancile Pharmaceuticals Odor-masking coating for a pharmaceutical preparation
ATE512136T1 (en) * 2003-01-16 2011-06-15 Acadia Pharm Inc SELECTIVE SEROTONIN 2A/2C RECEPTOR INVERSAGONISTS AS THERAPEUTICS FOR NEUROGENERATIVE DISEASES
US20050065183A1 (en) * 2003-07-31 2005-03-24 Indranil Nandi Fexofenadine composition and process for preparing
PL1729739T3 (en) * 2004-03-29 2017-04-28 Les Laboratoires Servier Process for preparing a solid pharmaceutical composition
US20050261278A1 (en) * 2004-05-21 2005-11-24 Weiner David M Selective serotonin receptor inverse agonists as therapeutics for disease
US7820695B2 (en) * 2004-05-21 2010-10-26 Acadia Pharmaceuticals, Inc. Selective serotonin receptor inverse agonists as therapeutics for disease
DE602005011326D1 (en) * 2004-10-19 2009-01-08 Krka Tovarna Zdravil D D SOLID PHARMACEUTICAL COMPOSITION WITH DONEPEZILHYDROCHLORIDE

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005063254A2 (en) * 2003-12-22 2005-07-14 Acadia Pharmaceuticals Inc. Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders
WO2005102342A1 (en) * 2004-04-22 2005-11-03 Boehringer Ingelheim International Gmbh New pharmaceutical compositions for the treatment of sexual disorders ii
WO2006036874A1 (en) * 2004-09-27 2006-04-06 Acadia Pharmaceuticals Inc. Salts of n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and their preparation

Also Published As

Publication number Publication date
CA2652300A1 (en) 2007-11-22
US20070264330A1 (en) 2007-11-15
JP2009537538A (en) 2009-10-29
WO2007133802A2 (en) 2007-11-22
EP2037918A2 (en) 2009-03-25

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