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WO2007120263A3 - Preparation of dutasteride - Google Patents

Preparation of dutasteride Download PDF

Info

Publication number
WO2007120263A3
WO2007120263A3 PCT/US2006/060767 US2006060767W WO2007120263A3 WO 2007120263 A3 WO2007120263 A3 WO 2007120263A3 US 2006060767 W US2006060767 W US 2006060767W WO 2007120263 A3 WO2007120263 A3 WO 2007120263A3
Authority
WO
WIPO (PCT)
Prior art keywords
dutasteride
preparation
dihydrodutasteride
desmethyldutasteride
purifying
Prior art date
Application number
PCT/US2006/060767
Other languages
French (fr)
Other versions
WO2007120263A2 (en
Inventor
Srinivas Katkam
Satyanarayana Komati
Srinivasulu Gudipati
Jayaprakash Pitta
Nageswara Rao Challa
Ravinder Bucchikondla
Srinivasa Rao Mallina
Adolf Ceaser Goldwyn
Manoj Ramesh Kharkar
Sharat Pandurang Narsapur
Srinivasula Reddy Maddula
Ramamurthy Kasula
Arvind Mallinath Lali
Sandeep Bhaskar Kale
Abijar Joyebbhai Bhori
Original Assignee
Reddys Lab Ltd Dr
Reddys Lab Inc Dr
Srinivas Katkam
Satyanarayana Komati
Srinivasulu Gudipati
Jayaprakash Pitta
Nageswara Rao Challa
Ravinder Bucchikondla
Srinivasa Rao Mallina
Adolf Ceaser Goldwyn
Manoj Ramesh Kharkar
Sharat Pandurang Narsapur
Srinivasula Reddy Maddula
Ramamurthy Kasula
Arvind Mallinath Lali
Sandeep Bhaskar Kale
Abijar Joyebbhai Bhori
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reddys Lab Ltd Dr, Reddys Lab Inc Dr, Srinivas Katkam, Satyanarayana Komati, Srinivasulu Gudipati, Jayaprakash Pitta, Nageswara Rao Challa, Ravinder Bucchikondla, Srinivasa Rao Mallina, Adolf Ceaser Goldwyn, Manoj Ramesh Kharkar, Sharat Pandurang Narsapur, Srinivasula Reddy Maddula, Ramamurthy Kasula, Arvind Mallinath Lali, Sandeep Bhaskar Kale, Abijar Joyebbhai Bhori filed Critical Reddys Lab Ltd Dr
Priority to EP06850136A priority Critical patent/EP1945615A2/en
Publication of WO2007120263A2 publication Critical patent/WO2007120263A2/en
Publication of WO2007120263A3 publication Critical patent/WO2007120263A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Dutasteride having low concentrations of impurities, such as dihydrodutasteride and desmethyldutasteride, and processes for purifying dutasteride.
PCT/US2006/060767 2005-11-10 2006-11-10 Preparation of dutasteride WO2007120263A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06850136A EP1945615A2 (en) 2005-11-10 2006-11-10 Preparation of dutasteride

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US73526605P 2005-11-10 2005-11-10
US60/735,266 2005-11-10
IN1655CH2005 2005-11-14
IN1655/CHE/2005 2005-11-14
US74586406P 2006-04-28 2006-04-28
US60/745,864 2006-04-28
US74621106P 2006-05-02 2006-05-02
US60/746,211 2006-05-02

Publications (2)

Publication Number Publication Date
WO2007120263A2 WO2007120263A2 (en) 2007-10-25
WO2007120263A3 true WO2007120263A3 (en) 2007-12-21

Family

ID=38609977

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/060767 WO2007120263A2 (en) 2005-11-10 2006-11-10 Preparation of dutasteride

Country Status (2)

Country Link
EP (1) EP1945615A2 (en)
WO (1) WO2007120263A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103044517A (en) * 2012-12-05 2013-04-17 华润赛科药业有限责任公司 Preparation method of five dutasteride impurities

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR070313A1 (en) * 2008-01-03 2010-03-31 Gador Sa A PROCEDURE FOR PREPARING A SOLID AND CRYSTAL FORM OF DUTASTERIDE, A POLYMORPHIC FORM OF THE COMPOUND (FORM III) AND A PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH FORM
EP2468262A1 (en) 2010-12-06 2012-06-27 Krka Tovarna Zdravil, D.D., Novo Mesto Pharmaceutical composition comprising dutasteride
CN102863507A (en) * 2012-09-29 2013-01-09 华润赛科药业有限责任公司 Dutasteride refining method
CN103724397B (en) * 2012-10-15 2015-10-21 齐鲁制药有限公司 The preparation method of a kind of dutasteride's crystal formation I
WO2019107859A1 (en) * 2017-11-28 2019-06-06 (주)아이엠디팜 Nano solubilized porous body with dutasteride encapsulated therein, pharmaceutical composition containing same and method of producing same
CN114113363B (en) * 2021-10-25 2024-06-11 人福普克药业（武汉）有限公司 Method for detecting impurities in dutasteride soft capsules

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565467A (en) * 1993-09-17 1996-10-15 Glaxo Wellcome Inc. Androstenone derivative
US7022854B2 (en) * 2003-07-17 2006-04-04 Dr. Reddy's Laboratories, Limited Forms of dutasteride and methods for preparation thereof
US7038050B2 (en) * 2003-07-19 2006-05-02 Hanmi Pharm. Co., Ltd. Method for the preparation of highly pure 1-androstene derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565467A (en) * 1993-09-17 1996-10-15 Glaxo Wellcome Inc. Androstenone derivative
US7022854B2 (en) * 2003-07-17 2006-04-04 Dr. Reddy's Laboratories, Limited Forms of dutasteride and methods for preparation thereof
US7038050B2 (en) * 2003-07-19 2006-05-02 Hanmi Pharm. Co., Ltd. Method for the preparation of highly pure 1-androstene derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103044517A (en) * 2012-12-05 2013-04-17 华润赛科药业有限责任公司 Preparation method of five dutasteride impurities

Also Published As

Publication number Publication date
EP1945615A2 (en) 2008-07-23
WO2007120263A2 (en) 2007-10-25

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