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WO2007021353A3 - Improving antibody expression using vectors containing insulator elements - Google Patents

Improving antibody expression using vectors containing insulator elements Download PDF

Info

Publication number
WO2007021353A3
WO2007021353A3 PCT/US2006/022131 US2006022131W WO2007021353A3 WO 2007021353 A3 WO2007021353 A3 WO 2007021353A3 US 2006022131 W US2006022131 W US 2006022131W WO 2007021353 A3 WO2007021353 A3 WO 2007021353A3
Authority
WO
WIPO (PCT)
Prior art keywords
insulator elements
vectors containing
antibody expression
containing insulator
improving antibody
Prior art date
Application number
PCT/US2006/022131
Other languages
French (fr)
Other versions
WO2007021353A2 (en
Inventor
Sanjaya Singh
Original Assignee
Tanox Inc
Sanjaya Singh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanox Inc, Sanjaya Singh filed Critical Tanox Inc
Priority to AU2006280428A priority Critical patent/AU2006280428A1/en
Priority to JP2008515874A priority patent/JP2008543283A/en
Priority to MX2007015540A priority patent/MX2007015540A/en
Priority to CA002611465A priority patent/CA2611465A1/en
Priority to EP06813200A priority patent/EP1899478A2/en
Publication of WO2007021353A2 publication Critical patent/WO2007021353A2/en
Publication of WO2007021353A3 publication Critical patent/WO2007021353A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention relates to the improved production of a therapeutic antibody comprising the use of insulator elements flanking the immunoglobulin sequence(s). Cell survival is also improved with the increase in the number of insulator elements.
PCT/US2006/022131 2005-06-10 2006-06-07 Improving antibody expression using vectors containing insulator elements WO2007021353A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2006280428A AU2006280428A1 (en) 2005-06-10 2006-06-07 Improving antibody expression using vectors containing insulator elements
JP2008515874A JP2008543283A (en) 2005-06-10 2006-06-07 Improving antibody expression using vectors containing insulator elements
MX2007015540A MX2007015540A (en) 2005-06-10 2006-06-07 Improving antibody expression using vectors containing insulator elements.
CA002611465A CA2611465A1 (en) 2005-06-10 2006-06-07 Improving antibody expression using vectors containing insulator elements
EP06813200A EP1899478A2 (en) 2005-06-10 2006-06-07 Improving antibody expression using vectors containing insulator elements

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68962305P 2005-06-10 2005-06-10
US60/689,623 2005-06-10

Publications (2)

Publication Number Publication Date
WO2007021353A2 WO2007021353A2 (en) 2007-02-22
WO2007021353A3 true WO2007021353A3 (en) 2007-08-30

Family

ID=37758005

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/022131 WO2007021353A2 (en) 2005-06-10 2006-06-07 Improving antibody expression using vectors containing insulator elements

Country Status (6)

Country Link
EP (1) EP1899478A2 (en)
JP (1) JP2008543283A (en)
AU (1) AU2006280428A1 (en)
CA (1) CA2611465A1 (en)
MX (1) MX2007015540A (en)
WO (1) WO2007021353A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2711505C9 (en) * 2013-02-01 2020-08-12 Селексис С.А. Improved expression and processing of transgene
EP3368664A4 (en) * 2015-10-28 2019-08-28 Sangamo Therapeutics, Inc. Liver-specific constructs, factor viii expression cassettes and methods of use thereof
JP6823791B2 (en) * 2018-09-25 2021-02-03 国立研究開発法人産業技術総合研究所 Artificial chromosome vector and transformed mammalian cell
JP2022509451A (en) * 2018-10-24 2022-01-20 セレキシス エスエー Expression system, recombinant cells and their use

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030087342A1 (en) * 2001-01-26 2003-05-08 Nicolas Mermod Matrix attachment regions and methods for use thereof
US20040072352A1 (en) * 2000-12-15 2004-04-15 Kim Jeong Do Expression vector for animal cell containing nuclear matrix attachment region of interferon beta
WO2005047512A2 (en) * 2003-11-12 2005-05-26 Shering Corporation Plasmid system for multigene expression

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040072352A1 (en) * 2000-12-15 2004-04-15 Kim Jeong Do Expression vector for animal cell containing nuclear matrix attachment region of interferon beta
US20030087342A1 (en) * 2001-01-26 2003-05-08 Nicolas Mermod Matrix attachment regions and methods for use thereof
WO2005047512A2 (en) * 2003-11-12 2005-05-26 Shering Corporation Plasmid system for multigene expression

Also Published As

Publication number Publication date
EP1899478A2 (en) 2008-03-19
MX2007015540A (en) 2008-03-07
CA2611465A1 (en) 2007-02-22
JP2008543283A (en) 2008-12-04
AU2006280428A1 (en) 2007-02-22
WO2007021353A2 (en) 2007-02-22

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