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WO2007018671A3 - Compositions et methodes de traitement d'etats associes a la signalisation de l'ephrine au moyen de cupredoxines - Google Patents

Compositions et methodes de traitement d'etats associes a la signalisation de l'ephrine au moyen de cupredoxines Download PDF

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Publication number
WO2007018671A3
WO2007018671A3 PCT/US2006/019684 US2006019684W WO2007018671A3 WO 2007018671 A3 WO2007018671 A3 WO 2007018671A3 US 2006019684 W US2006019684 W US 2006019684W WO 2007018671 A3 WO2007018671 A3 WO 2007018671A3
Authority
WO
WIPO (PCT)
Prior art keywords
cupredoxins
compositions
methods
conditions related
treating conditions
Prior art date
Application number
PCT/US2006/019684
Other languages
English (en)
Other versions
WO2007018671A2 (fr
Inventor
Ananda Chakrabarty
Gupta Tapas Das
Tohru Yamada
Anita Chaudhari
Arsenio Fialho
Yonghua Zhu
Original Assignee
Univ Illinois
Ananda Chakrabarty
Gupta Tapas Das
Tohru Yamada
Anita Chaudhari
Arsenio Fialho
Yonghua Zhu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/244,105 external-priority patent/US7691383B2/en
Application filed by Univ Illinois, Ananda Chakrabarty, Gupta Tapas Das, Tohru Yamada, Anita Chaudhari, Arsenio Fialho, Yonghua Zhu filed Critical Univ Illinois
Priority to EP06813192A priority Critical patent/EP1888106A4/fr
Priority to JP2008512587A priority patent/JP2008539795A/ja
Priority to CA002608512A priority patent/CA2608512A1/fr
Priority to MX2007014598A priority patent/MX2007014598A/es
Priority to AU2006277009A priority patent/AU2006277009A1/en
Priority to BRPI0612424-0A priority patent/BRPI0612424A2/pt
Publication of WO2007018671A2 publication Critical patent/WO2007018671A2/fr
Priority to IL187138A priority patent/IL187138A0/en
Publication of WO2007018671A3 publication Critical patent/WO2007018671A3/fr
Priority to NO20076391A priority patent/NO20076391L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des compositions et des méthodes d'utilisation de cuprédoxines, et de variants, de dérivés et d'équivalents structuraux de cuprédoxines qui interfèrent avec le système de signalisation de l'éphrine dans des cellules mammifères. De manière spécifique, l'invention concerne des compositions et des méthodes faisant intervenir des cuprédoxines, de type azurine, rusticyanine et plastocyanine, et des variants, dérivés et équivalents structuraux associés, pour le traitement du cancer chez des mammifères.
PCT/US2006/019684 2005-05-20 2006-05-19 Compositions et methodes de traitement d'etats associes a la signalisation de l'ephrine au moyen de cupredoxines WO2007018671A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP06813192A EP1888106A4 (fr) 2005-05-20 2006-05-19 Compositions et méthodes de traitement d'états associés à la signalisation de l'éphrine au moyen de cuprédoxines
JP2008512587A JP2008539795A (ja) 2005-05-20 2006-05-19 キュプレドキシンを用いたエフリン信号伝達に関する症状を治療するための組成物および方法
CA002608512A CA2608512A1 (fr) 2005-05-20 2006-05-19 Compositions et methodes de traitement d'etats associes a la signalisation de l'ephrine au moyen de cupredoxines
MX2007014598A MX2007014598A (es) 2005-05-20 2006-05-19 Composiciones y metodos para tratar condiciones relacionadas con senalizacion de efrina con cupredoxinas.
AU2006277009A AU2006277009A1 (en) 2005-05-20 2006-05-19 Compositions and methods for treating conditions related to ephrin signaling with cupredoxins
BRPI0612424-0A BRPI0612424A2 (pt) 2005-05-20 2006-05-19 composiÇÕes e mÉtodos para tratar condiÇÕes relacionadas com a sinalizaÇço da efrina com cupredoxinas
IL187138A IL187138A0 (en) 2005-05-20 2007-11-04 Compositions and methods for treating conditions related to ephrin signaling with cupredoxins
NO20076391A NO20076391L (no) 2005-05-20 2007-12-11 Sammensetninger og metoder for behandling av tilstander relatert til efrinsignaler med cupredoxin

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US68281205P 2005-05-20 2005-05-20
US60/682,812 2005-05-20
US11/244,105 US7691383B2 (en) 2004-10-07 2005-10-06 Cupredoxin derived transport agents and methods of use thereof
US11/244,105 2005-10-06
US76474906P 2006-02-03 2006-02-03
US60/764,749 2006-02-03

Publications (2)

Publication Number Publication Date
WO2007018671A2 WO2007018671A2 (fr) 2007-02-15
WO2007018671A3 true WO2007018671A3 (fr) 2007-11-22

Family

ID=37727776

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/019684 WO2007018671A2 (fr) 2005-05-20 2006-05-19 Compositions et methodes de traitement d'etats associes a la signalisation de l'ephrine au moyen de cupredoxines

Country Status (10)

Country Link
EP (1) EP1888106A4 (fr)
JP (1) JP2008539795A (fr)
KR (1) KR20080040631A (fr)
AU (1) AU2006277009A1 (fr)
BR (1) BRPI0612424A2 (fr)
CA (1) CA2608512A1 (fr)
IL (1) IL187138A0 (fr)
MX (1) MX2007014598A (fr)
NO (1) NO20076391L (fr)
WO (1) WO2007018671A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7381701B2 (en) 2001-02-15 2008-06-03 The Borad Of Trustees Of The University Of Illinois Compositions and methods for treating conditions related to ephrin signaling with cupredoxins
US7556810B2 (en) 2005-07-19 2009-07-07 The Board Of Trustees Of The University Of Ilinois Compositions and methods to control angiogenesis with cupredoxins
US9096663B2 (en) 2001-02-15 2015-08-04 The Board Of Trustees Of The University Of Illinois Compositions and methods for treating conditions related to ephrin signaling with cupredoxins and mutants thereof
KR20070108128A (ko) 2004-10-07 2007-11-08 아난다 차크라바르티 쿠프레독신 유래된 수송제 및 이들의 이용 방법
MX2008000993A (es) * 2005-07-19 2008-03-19 Univ Illinois Composiciones y metodos para controlar la angiogenesis con cupredoxinas.
BRPI0615562A2 (pt) 2005-07-19 2010-01-26 Univ Illinois agentes de transporte para atravessamento da barreira sangue-cérebro e entrada nas células cancerìgenas do cérebro e métodos para o seu uso
CN101595124A (zh) * 2006-09-14 2009-12-02 伊利诺斯大学理事会 使用铜氧还蛋白预防癌症的组合物及方法
WO2008086523A2 (fr) * 2007-01-11 2008-07-17 The Board Of Trustees Of The University Of Illinois Compositions et méthodes permettant de traiter des affections associées à la signalisation de l'éphrine avec des cuprexodines et des mutants de celles-ci
TWI443109B (zh) 2007-08-30 2014-07-01 Daiichi Sankyo Co Ltd 抗ｅｐｈａ２抗體
KR101102829B1 (ko) * 2008-09-12 2012-01-05 재단법인 제주테크노파크 구멍갈파래 추출물과 그것의 항염증제로서의 용도
CN110090295B (zh) * 2018-01-29 2022-12-23 武汉康理通科技有限公司 Ephrin-B1在制备治疗炎症性肠病的药物中的用途
WO2023205752A2 (fr) * 2022-04-22 2023-10-26 University Of Miami Peptides mimétiques de ligand d'éphrine pour le traitement de maladies neurodégénératives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20030081445A (ko) * 2001-02-15 2003-10-17 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 세포 사멸을 조절하는 세포독성인자
US7491394B2 (en) * 2001-02-15 2009-02-17 The Board Of Trustees Of The University Of Illinois Cytotoxic factors for modulating cell death

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PUNJ V. ET AL.: "Bacterial cupredoxin azurin as an inducer of apoptosis and regression in human breast cancer", ONCOGENE, vol. 23, 2004, pages 2367 - 2378, XP003018759 *

Also Published As

Publication number Publication date
IL187138A0 (en) 2008-02-09
BRPI0612424A2 (pt) 2009-01-27
AU2006277009A1 (en) 2007-02-15
JP2008539795A (ja) 2008-11-20
MX2007014598A (es) 2008-02-07
NO20076391L (no) 2008-02-15
CA2608512A1 (fr) 2007-02-15
EP1888106A4 (fr) 2009-01-14
WO2007018671A2 (fr) 2007-02-15
EP1888106A2 (fr) 2008-02-20
KR20080040631A (ko) 2008-05-08

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