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WO2007094316A1 - Composition rafraîchissant la bouche - Google Patents

Composition rafraîchissant la bouche Download PDF

Info

Publication number
WO2007094316A1
WO2007094316A1 PCT/JP2007/052513 JP2007052513W WO2007094316A1 WO 2007094316 A1 WO2007094316 A1 WO 2007094316A1 JP 2007052513 W JP2007052513 W JP 2007052513W WO 2007094316 A1 WO2007094316 A1 WO 2007094316A1
Authority
WO
WIPO (PCT)
Prior art keywords
refreshing
composition
mouth
weight
agent
Prior art date
Application number
PCT/JP2007/052513
Other languages
English (en)
Japanese (ja)
Inventor
Bingqiao Zhu
Original Assignee
Kobayashi Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kobayashi Pharmaceutical Co., Ltd. filed Critical Kobayashi Pharmaceutical Co., Ltd.
Publication of WO2007094316A1 publication Critical patent/WO2007094316A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to a refreshing composition in the mouth which effectively removes unpleasant bad breath and gives a refreshing feeling to the oral cavity as well as a refreshing feeling to breath.
  • Patent Document 1 in order to solve the problem that aspartame is easily decomposed by heat and enzymes, aspartame is mixed with lipid to obtain an aspartame monolipid gel.
  • Patent Document 1 Japanese Patent Application Laid-Open No. 60-241872
  • the present inventor has found that in a composition comprising lipid, a refreshing agent having affinity for lipid and a sweetener, fatty acid tridallycera as lipid.
  • a refreshing agent having affinity for lipid and a sweetener
  • fatty acid tridallycera as lipid.
  • dipeptide sweeteners as id and sweeteners, and by defining the ratio of the refreshing agent and dipeptide sweetener to be blended into them, the refreshing feeling can be maintained only by the texture and stability, and the sweetness and refreshing feeling
  • the present inventors have found that a mouth-cooling composition having an excellent balance can be obtained and completed the present invention.
  • the mouth refreshing composition according to the present invention is selected from (A) medium chain fatty acid tridalylide, (B) dipeptide sweetener, and (C) menthol and its derivatives, mint essential oil and eucalyptus essential oil. At least one refreshing agent, and the proportion of the dipeptide sweetener (B) in the composition is 0.5 to 5% by weight, and the amount of the refreshing agent (C) in the composition is ratio is one that is 10 to 35 weight 0/0.
  • the proportion of the dipeptide sweetener (B) in the composition is preferably 0.5 to 2% by weight.
  • the proportion of the cooling agent (C) in the composition is preferably 12 to 20% by weight.
  • the ratio of the refreshing agent (C) to 1 part by weight of the dipeptide sweetener (B) is not limited, but is preferably 8 to 30 parts by weight, more preferably 10 to 16 parts by weight from the viewpoint of taste.
  • the mouth refreshing composition according to the present invention is not particularly limited, but is a dipeptide sweetener (B) based on 100 parts by weight of medium-chain fatty acid tridalylide (A) from the standpoint of stability and refreshment.
  • the ratio is preferably 0.5 to 40 parts by weight, more preferably 1 to 25 parts by weight, and even more preferably 1 to 15 parts by weight.
  • the medium-chain fatty acid triglyceride used in the mouth refreshing composition according to the present invention may be a glycerin ester having a saturated fatty acid strength of 8 to C: LO, for example, C8 acid such as triglyceride strength prillate.
  • C8 acid such as triglyceride strength prillate.
  • Mixtures such as triglycerides, triglycerides of C10 acid such as triglyceride purinate, and C8 acid ZC10 acid triglyceride, C8 acid ZC10 acid ZC12 acid tridalylide can be used.
  • C8 acid, ZC10 acid triglyceride can be suitably used.
  • the dipeptide sweetener (B) used in the mouth refreshing composition according to the present invention is any sweetener that is hydrophilic and has an action of reducing the bitter taste exhibited by the refreshing agent and the fragrance. But it can be used. As a typical example of a sweetener that exhibits such an action, Although it is a part-time, it is not limited to this.
  • the refreshing agent (C) used in the mouth refreshing composition according to the present invention is selected from the group consisting of menthol and its derivatives, mint essential oil and eucalyptus essential oil. Of these, menthol and z or derivatives thereof can be preferably used.
  • Menthol may be a natural product or a synthetic product.
  • the menthol derivatives include 3- (1-menthoxy) propane 1,2 diol, p-menthane 3,8 diol, 6 isopropyl — 9-methyl 1,4 dioxaspiro (4,5) -decane-2-methanol, Menthyl succinate and its alkaline earth salts, trimethylcyclohexanol, N-ethyl-2-isopropyl-1-5-methylcyclohexanecarboxamide, 3- (1-menthoxy) 2-methyl-propane 1,2-diol, menthone Glycerin ketal, menthyl lactate, [1 / R, 2 'S, 5' R] — 2— (5 ′ —methyl-2 ′ — (methylethyl) cyclohexyloxy) ethane-1-ol, [1 / R, 2 ′ S, 5 'R] — 3— (5 ′ —
  • the mint essential oil used as the refreshing agent (C) in the present invention is not particularly limited as long as it is an essential oil of the genus plant, but is preferably peppermint (Mentha piperita L.) or spare mint (Mentha). spicata L.) and Japanese peanut power (Mentha arvensis L.) are used, particularly preferably an essential oil of peppermint, most preferably US peppermint oil.
  • the method for collecting the essential oil is not particularly limited, and examples thereof include a steam distillation method, a solvent extraction method, a supercritical fluid extraction method, and the like, but the steam distillation method is preferably used.
  • Eucalyptus essential oil has an excellent deodorizing action in addition to a bactericidal action.
  • the essential oil from which the leaf strength of Eucalyptus groprus is extracted is preferred.
  • the refreshing composition in the mouth according to the present invention may further contain a fragrance.
  • a fragrance natural fragrances and artificial fragrances can be used as long as they are edible! / Can be used even when there is a discrepancy.
  • blended fragrances particularly blended fragrances that impart fruit flavor and Z or a cool feeling can be preferably used.
  • Such blended fragrances include peach flavor, apple flavor, Strawberry Frano 1, Nonana Flano 1, Nonap No Le Freno, Grape Frano 1, Mango Freno, Tropicano Lef Frereno 1, Spanish Freno, Minoretta Flavor, Funolex Mix Flavor , Lemon flavor, lime flavor, orange flavor, grapefruit flavor and the like can be used in the present invention.
  • the proportion of perfume is usually in the range of about 0.1 to about 20% by weight, preferably about 1 to about 15% by weight.
  • the refreshing composition in the mouth according to the present invention may further contain a refreshing agent other than the refreshing agent (C).
  • This additional refreshing agent is a natural or artificial refreshing agent that releases refreshing ingredients commonly used in oral products such as dentifrices, mouth washes, mouth fresheners, gums, and wrinkles. It's okay.
  • naturally derived refreshing agents include mastic oil, parsley oil, varnish oil, winter green oil, cassia oil, lemon oil, orange oil, cardamom oil, coriander oil, mandarin oil, lime oil, lavender oil.
  • Natural essential oils such as laurel oil, camomile oil, caraway oil, bay oil, lemongrass oil, pine-dollar oil, neroli oil, rose oil and jasmine oil can be used in the present invention.
  • the mouth refreshing composition according to the present invention may also contain an emulsifier in order to dissolve the hydrophilic component in the lipophilic component as long as the effects of the present invention are not impaired.
  • Any emulsifier can be used as long as it is edible.
  • the milk powder satisfying such conditions propylene glycol fatty acid ester, glycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, lecithin, silicone and combinations thereof can be used in the present invention. is there.
  • the mouth refreshing composition according to the present invention includes a dipeptide sweetener, acesulfame potassium, stevia, saccharin, thaumatin, and combinations thereof.
  • the method for producing the mouth refreshing composition according to the present invention is not particularly limited.
  • Any additional cooling agents, flavors, sweeteners, and the like that are added depending on the conditions may be added and mixed in an appropriate order.
  • a liquid mixture is prepared by mixing medium-chain fatty acid tridalylide and a sweetener.
  • the resulting liquid mixture is then stirred under warming, preferably at a temperature of about 75 ° C. to about 80 ° C., preferably for about 1 hour.
  • a cooling agent and a fragrance are added to the liquid mixture cooled to room temperature, and then the mixture is stirred for about 30 minutes, and the additive is dissolved.
  • the mouth freshening composition of the present invention is prepared.
  • the mouth cooling composition according to the present invention is, for example, in a product form encapsulated with a soft film agent. Next, this product form will be described.
  • soft film agent is a component for forming a film for encapsulating the mouth refreshing composition according to the present invention, and includes a water-degradable polymer capsule base. And may contain plasticizers, water, sweeteners and colorants.
  • Any water-degradable polymer capsule base can be used as long as it is generally used as an edible capsule base.
  • Such capsule bases include, for example, gelatin, agar, xanthan gum, caraca gum, locust bean gum, gum arabic, pullulan, methinoresenorelose, hydroxyetinoresenorelose, hydroxypropinoremethinoresole mouth. , Sodium alginate, and combinations thereof.
  • the plasticizer may be any plasticizer that promotes plasticization of the capsule base described above and is applicable to food / pharmaceutical applications.
  • examples of the plasticizer that satisfies such conditions include glycerin, sorbitol, propylene glycol, and combinations thereof.
  • the water may be any potable water.
  • distilled water, deionized water, alkaline ionized water and the like are exemplified in addition to tap water.
  • the dipeptide sweetener and other acesulfame potassium, stevia, saccharin, thaumatin, sucralose, etc. are used alone or in combination of two or more. be able to.
  • a natural or synthetic food colorant having a desired color system can be appropriately selected according to the color to be imparted to the final product. For example, when giving a blue color For example, Blue No. 1, Red No. 106 for red colors, Yellow No. 4 for yellow colors, and Green No. 3 for green colors can be suitably used. Of course, these two or more colorants can be used in combination.
  • a seasoning, an anti-oxidation agent and the like can be optionally added.
  • benzoic acid (salt), sorbic acid (salt), etc. as preservatives; organic acids, such as succinic acid, malic acid, tartaric acid, fumaric acid, darconic acid, succinic acid; bitterness
  • organic acids such as succinic acid, malic acid, tartaric acid, fumaric acid, darconic acid, succinic acid
  • bitterness examples of the agent include caffeine
  • Seasonings such as glutamic acid, glycine, alanine, and arginine
  • the antioxidant include vitamin C, vitamin E, and sorbic acid (salt).
  • the soft film agent that encapsulates the mouth-cooling composition is manufactured according to a known capsule film manufacturing method. Specifically, first, a liquid mixture obtained by mixing a plasticizer and water with a water-degradable polymer capsule base is preferably heated at a temperature of about 65 ° C to about 75 ° C. Stir for about 1 hour to obtain the original coating. Colorants and sweeteners are further added to the original coating material and stirred. A soft film agent is manufactured by these series of procedures.
  • the mouth cooling composition is encapsulated with a soft film agent. Cooling in the mouth with a soft film agent
  • the composition can be encapsulated by a well-known method for producing soft capsules in the art, for example, rotary soft encapsulation or seamless encapsulation. Is possible. From the viewpoint of giving a beautiful transparency to the final product, a seamless encapsulation method is preferred in which no seams appear on the surface of the mouth cooling composition, that is, the product surface is finished smoothly.
  • the size (outer diameter) of the product form in which the mouth-cooling composition is encapsulated with a soft film is generally about 0.3 mm to about 20 mm, preferably about 3 mm to about 10 mm. It is.
  • medium chain fatty acid tridalylide a mixture of triglycerides (C8ZC10 acid triglyceride) that has saturated fatty acid power of 8 and 10 carbon atoms, dipeptide sweetener (B) aspartame, and refreshing sweetener (C Menthol as a fragrance and soda flavor as a fragrance, and the proportions shown in Table 1 (dipeptide sweetener (B): 0.5-5 wt%, refreshing agent (C): 10-35 wt%)
  • a mouth-cooling composition was obtained. Specifically, C8ZC10 acid triglyceride and aspartame were mixed to prepare a liquid mixture and stirred at 75 ° C for 1 hour. Thereafter, menthol and soda flavor were added to the liquid mixture cooled to room temperature and stirred for 30 minutes to obtain a refreshing composition in the mouth.
  • the refreshing agent (C) is blended in a proportion other than the range of 10 to 35% by weight, and in Comparative Examples 5 to 7, the dipeptide sweetener (B) is 0.5.
  • the dipeptide sweetener (B) is 0.5.
  • Ten panelists ate capsules filled with 120 mg of the mouth refreshing composition and evaluated the refreshing feeling according to the following criteria.
  • Ten panelists ate capsules filled with 120 mg of the mouth refreshing composition and evaluated sweetness according to the following criteria.
  • Ten panelists ate capsules filled with 120 mg of the mouth refreshing composition and evaluated the texture according to the following criteria.
  • Ten panelists ate capsules filled with 120 mg of the mouth refreshing composition and evaluated the sustainability of the refreshing feeling according to the following criteria.
  • dipeptide sweetener and the refreshing agent are within a predetermined range (dipeptide sweetener (B): 0.5 to 5% by weight, refreshing agent (C): 10 to Example 1-8 (medium chain fatty acid tridalylide (A)) formulated at 35% by weight) and Comparative Example 8 (castor oil) were compared to those containing medium chain fatty acid tridalylide, a dipeptide sweetener and a cooling agent.
  • the in-mouth refreshing compositions of Examples 1-8 are excellent in stability, texture and persistence of refreshing feeling.
  • dipeptide sweetener (B) 0.
  • Examples 1 to 8 formulated with 5 to 5% by weight, refreshing agent (C): 10 to 35% by weight) and Comparative Examples 1 to 4 (cooling agent (C): other than 10 to 35% by weight) ) And Comparative Examples 5 to 7 (dipeptide sweetener (B): other than the range of 0.5 to 5% by weight), the blending ratio of the dipeptide sweetener and the refreshing agent is defined within a predetermined range.
  • Examples 1, 2 and 8 in which the ratio of the refreshing agent (C) to 10 parts by weight of the dipeptide sweetener (B) is 10 to 16 parts by weight In addition to the sustainability of feeling and refreshing feeling, it can be seen that a refreshing composition in the mouth with excellent taste can be obtained.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne une composition rafraîchissant la bouche comprenant à la fois un agent rafraîchissant ayant une affinité pour les lipides et un édulcorant, composition qui a d'excellentes texture et stabilité (c'est-à-dire sans précipité et avec un bon aspect) et est excellente en termes de persistance du caractère rafraîchissant et en termes d'équilibre entre la sucrosité et le caractère rafraîchissant (c'est-à-dire en termes de goût). L'invention concerne une composition rafraîchissant la bouche qui comprend (A) un triglycéride d'acide gras à chaîne moyenne, (B) un édulcorant de type dipeptide et (C) au moins un agent rafraîchissant sélectionné dans le groupe constitué du menthol et de dérivés de celui-ci, de l'huile essentielle de menthe poivrée et de l'huile essentielle d'eucalyptus, la teneur de l'édulcorant (B) dans la composition étant de 0,5 à 5 % en poids et celle de l'agent rafraîchissant (C) étant de 10 à 35 % en poids.
PCT/JP2007/052513 2006-02-14 2007-02-13 Composition rafraîchissant la bouche WO2007094316A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006037214A JP5345273B2 (ja) 2006-02-14 2006-02-14 口中清涼化組成物
JP2006-037214 2006-02-14

Publications (1)

Publication Number Publication Date
WO2007094316A1 true WO2007094316A1 (fr) 2007-08-23

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PCT/JP2007/052513 WO2007094316A1 (fr) 2006-02-14 2007-02-13 Composition rafraîchissant la bouche

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JP (1) JP5345273B2 (fr)
WO (1) WO2007094316A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6360339B2 (ja) * 2014-03-31 2018-07-18 小林製薬株式会社 ゼラチンカプセル剤およびその製造方法
JP6602578B2 (ja) * 2015-07-10 2019-11-06 小林製薬株式会社 経口組成物

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999012516A1 (fr) * 1997-09-10 1999-03-18 Morishita Jintan Co., Ltd. Capsule molle multicouche servant a eliminer l'haleine desagreable et procede de production de ladite capsule
WO1999016470A1 (fr) * 1997-09-30 1999-04-08 Daiichi Pharmaceutical Co., Ltd. Preparation orale
JP2000026257A (ja) * 1998-07-08 2000-01-25 Kao Corp 口腔用組成物
JP2000273050A (ja) * 1999-03-19 2000-10-03 Kobayashi Pharmaceut Co Ltd 苦みがマスキングされた液状製剤
JP2000273051A (ja) * 1999-03-19 2000-10-03 Kobayashi Pharmaceut Co Ltd 苦みがマスキングされた液状製剤
JP2003125706A (ja) * 2001-10-23 2003-05-07 Lion Corp 口中清涼製剤
US20040013722A1 (en) * 2002-07-18 2004-01-22 Yang Joo Hwan Gelatin soft capsule having the properties of removal of oral smell and cleaning of oral cavity
WO2005002536A1 (fr) * 2003-07-07 2005-01-13 Kobayashi Pharmaceutical Co., Ltd. Rafraichisseur d'haleine et processus de production de celui

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2961587B2 (ja) * 1992-06-27 1999-10-12 花王株式会社 界面活性剤含有継ぎ目無しカプセル粒子
JP2003095953A (ja) * 2001-09-25 2003-04-03 Nof Corp ホスファチジルセリン含有組成物、製造方法および用途
EP1757275A1 (fr) * 2004-04-21 2007-02-28 Kyowa Hakko Kogyo Co., Ltd. Capsule sans couture contenant un ingrédient actif soluble dans l'eau

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999012516A1 (fr) * 1997-09-10 1999-03-18 Morishita Jintan Co., Ltd. Capsule molle multicouche servant a eliminer l'haleine desagreable et procede de production de ladite capsule
WO1999016470A1 (fr) * 1997-09-30 1999-04-08 Daiichi Pharmaceutical Co., Ltd. Preparation orale
JP2000026257A (ja) * 1998-07-08 2000-01-25 Kao Corp 口腔用組成物
JP2000273050A (ja) * 1999-03-19 2000-10-03 Kobayashi Pharmaceut Co Ltd 苦みがマスキングされた液状製剤
JP2000273051A (ja) * 1999-03-19 2000-10-03 Kobayashi Pharmaceut Co Ltd 苦みがマスキングされた液状製剤
JP2003125706A (ja) * 2001-10-23 2003-05-07 Lion Corp 口中清涼製剤
US20040013722A1 (en) * 2002-07-18 2004-01-22 Yang Joo Hwan Gelatin soft capsule having the properties of removal of oral smell and cleaning of oral cavity
WO2005002536A1 (fr) * 2003-07-07 2005-01-13 Kobayashi Pharmaceutical Co., Ltd. Rafraichisseur d'haleine et processus de production de celui

Also Published As

Publication number Publication date
JP5345273B2 (ja) 2013-11-20
JP2007217310A (ja) 2007-08-30

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