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WO2007080427A3 - Method of making microneedles - Google Patents

Method of making microneedles Download PDF

Info

Publication number
WO2007080427A3
WO2007080427A3 PCT/GB2007/000117 GB2007000117W WO2007080427A3 WO 2007080427 A3 WO2007080427 A3 WO 2007080427A3 GB 2007000117 W GB2007000117 W GB 2007000117W WO 2007080427 A3 WO2007080427 A3 WO 2007080427A3
Authority
WO
WIPO (PCT)
Prior art keywords
array
microneedles
providing
making microneedles
cavities
Prior art date
Application number
PCT/GB2007/000117
Other languages
French (fr)
Other versions
WO2007080427A2 (en
Inventor
Andrew James Kirby
Original Assignee
Functional Microstructures Ltd
Andrew James Kirby
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Functional Microstructures Ltd, Andrew James Kirby filed Critical Functional Microstructures Ltd
Publication of WO2007080427A2 publication Critical patent/WO2007080427A2/en
Publication of WO2007080427A3 publication Critical patent/WO2007080427A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C59/00—Surface shaping of articles, e.g. embossing; Apparatus therefor
    • B29C59/02—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing
    • B29C59/026—Surface shaping of articles, e.g. embossing; Apparatus therefor by mechanical means, e.g. pressing of layered or coated substantially flat surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C99/00—Subject matter not provided for in other groups of this subclass
    • B81C99/0075—Manufacture of substrate-free structures
    • B81C99/0085—Manufacture of substrate-free structures using moulds and master templates, e.g. for hot-embossing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
    • B29C35/02—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould
    • B29C35/08—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation
    • B29C35/0805—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation using electromagnetic radiation
    • B29C2035/0827—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation using electromagnetic radiation using UV radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • B29L2031/7544—Injection needles, syringes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/756—Microarticles, nanoarticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2203/00—Basic microelectromechanical structures
    • B81B2203/03—Static structures
    • B81B2203/0361—Tips, pillars

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Manufacturing & Machinery (AREA)
  • Mechanical Engineering (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides a method of forming an array of solid microneedles, the method comprising: (i) providing a mould (1) having an array of cavities (2a, 2b, 2c) for the formation of microneedles; (ii) providing a substrate (5) on which the array of microneedles is to be formed; (iii) providing the array of cavities with a substance (4) from which an array of solid microneedles may be formed; and (iv) forming the array of solid microneedles (7a, 7b, 7c) on the substrate from the substance.
PCT/GB2007/000117 2006-01-16 2007-01-16 Method of making microneedles WO2007080427A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0600795.9 2006-01-16
GB0600795A GB0600795D0 (en) 2006-01-16 2006-01-16 Method of making microneedles

Publications (2)

Publication Number Publication Date
WO2007080427A2 WO2007080427A2 (en) 2007-07-19
WO2007080427A3 true WO2007080427A3 (en) 2007-09-07

Family

ID=35998088

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/000117 WO2007080427A2 (en) 2006-01-16 2007-01-16 Method of making microneedles

Country Status (2)

Country Link
GB (1) GB0600795D0 (en)
WO (1) WO2007080427A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
US9220678B2 (en) 2007-12-24 2015-12-29 The University Of Queensland Coating method
WO2009097660A1 (en) 2008-02-07 2009-08-13 The University Of Queensland Patch production
EP2294415A4 (en) 2008-05-23 2011-10-05 Univ Queensland Analyte detection by microneedle patch with analyte selective reagents.
KR100938631B1 (en) * 2008-06-18 2010-01-22 주식회사 누리엠웰니스 Process for Preparing Solid Microstructures
CN102325563A (en) * 2008-12-22 2012-01-18 昆士兰大学 Patch production
CN102458559B (en) 2009-04-10 2014-06-04 3M创新有限公司 Methods of making hollow microneedle arrays and articles and uses therefrom
JP5542404B2 (en) * 2009-10-08 2014-07-09 東レエンジニアリング株式会社 Manufacturing method of microneedle stamper
JP5558772B2 (en) * 2009-10-08 2014-07-23 東レエンジニアリング株式会社 STAMPER FOR MICRO NEEDLE SHEET, PROCESS FOR PRODUCING THE SAME, AND METHOD FOR MANUFACTURING MICRO NEEDLE USING THE SAME
US9943673B2 (en) 2010-07-14 2018-04-17 Vaxxas Pty Limited Patch applying apparatus
AU2012323782B2 (en) 2011-10-12 2017-04-06 Vaxxas Pty Limited Delivery device
AU2016214968B2 (en) 2015-02-02 2021-02-25 Vaxxas Pty Limited Microprojection array applicator and method
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
AU2016333148B2 (en) 2015-09-28 2021-10-14 Vaxxas Pty Limited Microprojection arrays with enhanced skin penetrating properties and methods thereof
GB201517373D0 (en) 2015-10-01 2015-11-18 Ge Healthcare Uk Ltd Micro-Needle Sampling Device And Use Thereof
KR101747099B1 (en) 2016-02-11 2017-06-14 권영덕 Method of Preparing Micro-Needle Using Biocompatible Polymer
JP2018015322A (en) * 2016-07-28 2018-02-01 富士フイルム株式会社 Method of producing transdermal absorption sheet
ES2960937T3 (en) 2017-03-31 2024-03-07 Vaxxas Pty Ltd Device and method for coating surfaces
CA3065371A1 (en) 2017-06-13 2018-12-20 Vaxxas Pty Limited Quality control of substrate coatings
US11464957B2 (en) 2017-08-04 2022-10-11 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP)
KR20230117261A (en) 2018-05-18 2023-08-07 포항공과대학교 산학협력단 Transdermal drug delivery patch and method for preparing same
GB2607115B (en) * 2021-06-25 2023-10-04 Cipherx Tech Ltd Method of producing a microneedle array

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002064193A2 (en) * 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
WO2004062899A2 (en) * 2003-01-16 2004-07-29 Seung-Seob Lee Method for manufacturing of polymer micro needle array with liga process
WO2005038862A2 (en) * 2003-07-07 2005-04-28 10X Technology Llc. Process and apparatus for fabricating precise microstructures and polymeric molds for making same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002064193A2 (en) * 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
WO2004062899A2 (en) * 2003-01-16 2004-07-29 Seung-Seob Lee Method for manufacturing of polymer micro needle array with liga process
WO2005038862A2 (en) * 2003-07-07 2005-04-28 10X Technology Llc. Process and apparatus for fabricating precise microstructures and polymeric molds for making same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MC ALLISTER D V ET AL: "Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 100, no. 24, 25 November 2003 (2003-11-25), pages 13755 - 13760, XP002329900, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2007080427A2 (en) 2007-07-19
GB0600795D0 (en) 2006-02-22

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