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WO2007077203A3 - Triterpenequinone and triterpenephenol derivatives and their application for the treatment of tumors and parasitic diseases - Google Patents

Triterpenequinone and triterpenephenol derivatives and their application for the treatment of tumors and parasitic diseases Download PDF

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Publication number
WO2007077203A3
WO2007077203A3 PCT/EP2006/070276 EP2006070276W WO2007077203A3 WO 2007077203 A3 WO2007077203 A3 WO 2007077203A3 EP 2006070276 W EP2006070276 W EP 2006070276W WO 2007077203 A3 WO2007077203 A3 WO 2007077203A3
Authority
WO
WIPO (PCT)
Prior art keywords
triterpenequinone
triterpenephenol
tumors
derivatives
treatment
Prior art date
Application number
PCT/EP2006/070276
Other languages
French (fr)
Other versions
WO2007077203A2 (en
Inventor
Sanjuan Juan Carlos Lacal
De Molina Ana Ramirez
Coronel Monica Banez
Ravelo Angel Gutierrez
Braun Ana Estevez
Mesa Siverio Dulce Yazmin
Sacau Elisa Perez
Original Assignee
Consejo Superior Investigacion
Univ La Laguna
Sanjuan Juan Carlos Lacal
De Molina Ana Ramirez
Coronel Monica Banez
Ravelo Angel Gutierrez
Braun Ana Estevez
Mesa Siverio Dulce Yazmin
Sacau Elisa Perez
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Superior Investigacion, Univ La Laguna, Sanjuan Juan Carlos Lacal, De Molina Ana Ramirez, Coronel Monica Banez, Ravelo Angel Gutierrez, Braun Ana Estevez, Mesa Siverio Dulce Yazmin, Sacau Elisa Perez filed Critical Consejo Superior Investigacion
Priority to JP2008547980A priority Critical patent/JP2009522239A/en
Priority to BRPI0620845-2A priority patent/BRPI0620845A2/en
Priority to AU2006334359A priority patent/AU2006334359A1/en
Priority to CA002635318A priority patent/CA2635318A1/en
Priority to EP06830856A priority patent/EP1976533A2/en
Priority to MX2008008556A priority patent/MX2008008556A/en
Publication of WO2007077203A2 publication Critical patent/WO2007077203A2/en
Publication of WO2007077203A3 publication Critical patent/WO2007077203A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
    • C07C49/727—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/753—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention relates to triterpenequinone and triterpenephenol derivatives, their pharmaceutically acceptable 5 salts, prodrugs, solvates or stereoisomers as selective blocking agents of the choline kinase enzyme, pharmaceutical compositions containing them and their use in the treatment of tumors and parasitic diseases or diseases caused by viruses, bacteria or fungi.
PCT/EP2006/070276 2005-12-30 2006-12-29 Triterpenequinone and triterpenephenol derivatives and their application for the treatment of tumors and parasitic diseases WO2007077203A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2008547980A JP2009522239A (en) 2005-12-30 2006-12-29 Triterpene quinones and triterpene phenol derivatives and their application for the treatment of tumors and parasitic diseases
BRPI0620845-2A BRPI0620845A2 (en) 2005-12-30 2006-12-29 triterpenoquinone and triterpenophenol derivatives and their application for the treatment of tumors and parasitic diseases
AU2006334359A AU2006334359A1 (en) 2005-12-30 2006-12-29 Triterpenequinone and triterpenephenol derivatives and their application for the treatment of tumors and parasitic diseases
CA002635318A CA2635318A1 (en) 2005-12-30 2006-12-29 Triterpenequinone and triterpenephenol derivatives and their application for the treatment of tumors and parasitic diseases
EP06830856A EP1976533A2 (en) 2005-12-30 2006-12-29 Triterpenequinone and triterpenephenol derivatives and their application for the treatment of tumors and parasitic diseases
MX2008008556A MX2008008556A (en) 2005-12-30 2006-12-29 Triterpenequinone and triterpenephenol derivatives and their application for the treatment of tumors and parasitic diseases.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ESP200503263 2005-12-30
ES200503263A ES2277568B1 (en) 2005-12-30 2005-12-30 DERIVATIVES OF TRITERPENOQUINONA AND TRITERPENOFENOLES AND ITS APPLICATION FOR THE TREATMENT OF TUMORS AND PARASITARY DISEASES.

Publications (2)

Publication Number Publication Date
WO2007077203A2 WO2007077203A2 (en) 2007-07-12
WO2007077203A3 true WO2007077203A3 (en) 2007-08-30

Family

ID=37946257

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/070276 WO2007077203A2 (en) 2005-12-30 2006-12-29 Triterpenequinone and triterpenephenol derivatives and their application for the treatment of tumors and parasitic diseases

Country Status (11)

Country Link
EP (1) EP1976533A2 (en)
JP (1) JP2009522239A (en)
KR (1) KR20080083044A (en)
CN (1) CN101351211A (en)
AU (1) AU2006334359A1 (en)
BR (1) BRPI0620845A2 (en)
CA (1) CA2635318A1 (en)
ES (1) ES2277568B1 (en)
MX (1) MX2008008556A (en)
RU (1) RU2008131311A (en)
WO (1) WO2007077203A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2341729T3 (en) 2005-04-13 2010-06-25 Consejo Superior De Investigaciones Cientificas IN VITRO METHOD TO IDENTIFY COMPOUNDS FOR CANCER THERAPY.
WO2009026163A1 (en) * 2007-08-17 2009-02-26 Burnham Institute For Medical Research Compositions and methods for inhibiting growth and metastasis of melanoma
CN101434635B (en) * 2007-11-16 2012-05-16 上海华拓医药科技发展股份有限公司 Water-soluble phenolic triterpenoid with anti-tumor activity and preparation method thereof
US20100068302A1 (en) * 2008-09-17 2010-03-18 Traslational Cancer Drugs Pharma, S.L. Methods and compositions for the treatment of cancer
WO2010049173A1 (en) * 2008-10-31 2010-05-06 Cenix Bioscience Gmbh Use of inhibitors of host kinases for the treatment of infectious diseases
WO2012024893A1 (en) * 2010-08-23 2012-03-01 Suzhou Neupharma Co., Ltd. Certain chemical entities, compositions, and methods
AU2016342375B2 (en) 2015-10-23 2022-03-17 Erx Pharmaceuticals Inc Analogs of celastrol
CN108026142B (en) * 2016-07-04 2022-07-08 艾凯奇（厦门）生物科技有限公司 Ligands for orphan nuclear receptor Nur77 and uses thereof
ES2899114T3 (en) 2016-07-25 2022-03-10 Nerviano Medical Sciences Srl Purine and 3-deazapurine analogs as choline kinase inhibitors
CN110997678B (en) 2017-07-11 2023-02-21 内尔维亚诺医疗科学公司 Pyrazoloquinazoline derivatives as choline kinase inhibitors
US20220241214A1 (en) 2019-06-20 2022-08-04 University Of Iowa Research Foundation Nanoparticles comprising quinone w methides and compositions for use
CN113827599A (en) * 2021-09-23 2021-12-24 天津国际生物医药联合研究院 Potential application of demethylzelaronal in resisting dengue virus infection
CN116023426A (en) * 2022-12-30 2023-04-28 上海海洋大学 Norzeranal derivative and application thereof in preparation of anticancer drugs

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US5650167A (en) * 1995-11-16 1997-07-22 Dawa Incorporated Method and composition for treating hepatitis B
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US20040220267A1 (en) * 2003-02-07 2004-11-04 Devlin J. P. Derivatives of pentacyclic nortriterpene quinone methides as compounds useful in the treatment of inflammatory, neurodegenerative, and neoplastic diseases

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ES2117950B1 (en) 1996-08-02 1999-09-16 Univ Granada NEW COMPOUNDS THAT BLOCK THE BIOSYNTHESIS OF PHOSPHORYLCHOLINE AND ITS USE AS A SECOND MESSENGER IN CELL PROLIFERATION.

Patent Citations (5)

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US4328309A (en) * 1980-07-02 1982-05-04 The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services Method for producing tripdiolide, triptolide and celastrol
DE4117854A1 (en) * 1991-05-31 1992-12-03 Wiemann Wolfram Lipoxygenase inhibiting Celastroloid(s) - used for treating rheumatism, malaria, tumours or bacterial infection
US5650167A (en) * 1995-11-16 1997-07-22 Dawa Incorporated Method and composition for treating hepatitis B
CN1410434A (en) * 2002-11-05 2003-04-16 浙江大学 Pristimerin series dorivative possessing antioxidation and antitumour activity and its synthesis method
US20040220267A1 (en) * 2003-02-07 2004-11-04 Devlin J. P. Derivatives of pentacyclic nortriterpene quinone methides as compounds useful in the treatment of inflammatory, neurodegenerative, and neoplastic diseases

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PAVANAND, KATCHRINNEE ET AL: "Schizontocidal activity of Celastrus paniculatus Willd. against Plasmodium falciparum in vitro", PHYTOTHERAPY RESEARCH , 3(4), 136-9 CODEN: PHYREH; ISSN: 0951-418X, 1989, XP002439425 *
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SETZER, WILLIAM N. ET AL: "The cytotoxic activity of a Salacia liana species from Monteverde, Costa Rica, is due to a high concentration to tingenone", PLANTA MEDICA , 64(6), 583 CODEN: PLMEAA; ISSN: 0032-0943, 1998, XP008078001 *
SNEDEN, ALBERT T.: "Isoiguesterin, a new antileukemic bisnortriterpene from Salacia madagascariensis", JOURNAL OF NATURAL PRODUCTS , 44(4), 503-7 CODEN: JNPRDF; ISSN: 0163-3864, 1981, XP002430961 *
SOTANAPHUN UTHAI ET AL: "ANTIMICROBIAL ACTIVITY AND STABILITY OF TINGENONE DERIVATIVES", PLANTA MEDICA, THIEME, STUTTGART, DE, vol. 65, no. 5, 1999, pages 450 - 452, XP008080303, ISSN: 0032-0943 *
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THIEM, DEBORAH A. ET AL: "Bisnortriterpenes from Salacia madagascariensis", JOURNAL OF NATURAL PRODUCTS , 68(2), 251-254 CODEN: JNPRDF; ISSN: 0163-3864, 30 January 2005 (2005-01-30), XP002439426 *

Also Published As

Publication number Publication date
MX2008008556A (en) 2008-09-26
RU2008131311A (en) 2010-02-10
ES2277568B1 (en) 2008-04-01
AU2006334359A1 (en) 2007-07-12
JP2009522239A (en) 2009-06-11
BRPI0620845A2 (en) 2011-11-22
CN101351211A (en) 2009-01-21
KR20080083044A (en) 2008-09-12
WO2007077203A2 (en) 2007-07-12
EP1976533A2 (en) 2008-10-08
AU2006334359A2 (en) 2008-08-07
ES2277568A1 (en) 2007-07-01
CA2635318A1 (en) 2007-07-12

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