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WO2007047838A3 - Process for preparing olmesartan medoxomil - Google Patents

Process for preparing olmesartan medoxomil Download PDF

Info

Publication number
WO2007047838A3
WO2007047838A3 PCT/US2006/040883 US2006040883W WO2007047838A3 WO 2007047838 A3 WO2007047838 A3 WO 2007047838A3 US 2006040883 W US2006040883 W US 2006040883W WO 2007047838 A3 WO2007047838 A3 WO 2007047838A3
Authority
WO
WIPO (PCT)
Prior art keywords
olmesartan medoxomil
methylethyl
carboxylate
propyl
hydroxy
Prior art date
Application number
PCT/US2006/040883
Other languages
French (fr)
Other versions
WO2007047838A2 (en
Inventor
Sonny Sebastian
Srinivas Reddy Gade
Srinivasa Reddy Mallepalli
Nageswara Rao Koduri
Ravindranath Tagore Amirisetty
Sri Hari Babu Karrothu
Original Assignee
Reddys Lab Ltd Dr
Reddys Lab Inc Dr
Sonny Sebastian
Srinivas Reddy Gade
Srinivasa Reddy Mallepalli
Nageswara Rao Koduri
Ravindranath Tagore Amirisetty
Sri Hari Babu Karrothu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reddys Lab Ltd Dr, Reddys Lab Inc Dr, Sonny Sebastian, Srinivas Reddy Gade, Srinivasa Reddy Mallepalli, Nageswara Rao Koduri, Ravindranath Tagore Amirisetty, Sri Hari Babu Karrothu filed Critical Reddys Lab Ltd Dr
Publication of WO2007047838A2 publication Critical patent/WO2007047838A2/en
Publication of WO2007047838A3 publication Critical patent/WO2007047838A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Olmesartan medoxomil, i.e. 2,3-dihydroxy-2-butenyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[p-(o-1H-tetrazol-5ylphenyl)benzyl] imidazole-5-carboxylate, cyclic 2,3-carbonate, is prepared. Precursors of Olmesartan medoxomil are prepared as well. In particular a process for the preparation of methyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{4-2-(trityltetrazol-5-yl) phenyl} methyl imidazole-5-carboxylate and its use in the preparation of Olmesartan medoxomil is disclosed. Olmesartan medoxomil is a selective angiotensin Il receptor antagonist, pharmaceutically used as an antihypertensive.
PCT/US2006/040883 2005-10-20 2006-10-18 Process for preparing olmesartan medoxomil WO2007047838A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN1517/CHE/2005 2005-10-20
IN1517CH2005 2005-10-20
US74567006P 2006-04-26 2006-04-26
US60/745,670 2006-04-26

Publications (2)

Publication Number Publication Date
WO2007047838A2 WO2007047838A2 (en) 2007-04-26
WO2007047838A3 true WO2007047838A3 (en) 2007-12-06

Family

ID=37963278

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/040883 WO2007047838A2 (en) 2005-10-20 2006-10-18 Process for preparing olmesartan medoxomil

Country Status (1)

Country Link
WO (1) WO2007047838A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0710905D0 (en) * 2007-06-07 2007-07-18 Generics Uk Ltd Amorphous olmesartan medoxomil
KR101630885B1 (en) 2008-06-09 2016-06-15 다이이찌 산쿄 가부시키가이샤 Method for producing 1-biphenylmethylimidazole compound
WO2010026255A1 (en) * 2008-09-05 2010-03-11 Krka, Tovarna Zdravil, D.D., Novo Mesto Process for preparing olmesartan medoxomil intermediate
SG175296A1 (en) * 2009-04-28 2011-11-28 Daiichi Sankyo Co Ltd Novel solvate crystals
KR101676512B1 (en) 2009-04-28 2016-11-15 다이이찌 산쿄 가부시키가이샤 Method for producing olmesartan medoxomil
WO2011007368A2 (en) 2009-07-14 2011-01-20 Cadila Healthcare Limited An improved process for preparation of olmesartan
WO2011021224A2 (en) * 2009-08-19 2011-02-24 Msn Laboratories Limited Process for (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl4-(1-hydroxy-1-methylethyl)-2-propyl-1-[4-[2-tetrazol-5-yl)phenyl]phenyl]methylimidazole-5-carboxylate
WO2011045760A2 (en) 2009-10-13 2011-04-21 Ranbaxy Laboratories Limited Micronized olmesartan medoxomil compositions
AR083523A1 (en) 2010-10-29 2013-03-06 Interquim Sa PROCEDURE FOR OBTAINING OLMESARTAN MEDOXOMILO
WO2014030082A1 (en) 2012-08-22 2014-02-27 Lupin Limited Novel method to obtain olmesartan medoxomil with reduced particle size
JP6382660B2 (en) * 2014-09-24 2018-08-29 株式会社トクヤマ Method for producing olmesartan medoxomil
CN106749195A (en) * 2016-12-30 2017-05-31 青岛黄海制药有限责任公司 A kind of olmesartan medoxomil intermediate impurities synthesis, the method for identification
CN112337419B (en) * 2020-10-27 2022-05-13 浙江花蝶染料化工有限公司 Preparation method of 4- (1-hydroxy-1-methylethyl) -2-propylimidazole-5-carboxylic acid ethyl ester

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5459148A (en) * 1992-12-17 1995-10-17 Sankyo Company, Limited Biphenyl derivatives and their use for the treatment of hypertension and cardiac disease
US5646171A (en) * 1991-02-21 1997-07-08 Sankyo Company, Limited Angiotensin II antagonist 1-biphenylmethylimidazole compounds and their therapeutic use
US5674879A (en) * 1993-09-24 1997-10-07 G.D. Searle & Co. Compositions including and methods of using conformationally restricted angiotensin II antagonist
US6878703B2 (en) * 2000-11-21 2005-04-12 Sankyo Company, Limited Pharmaceutical composition

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5646171A (en) * 1991-02-21 1997-07-08 Sankyo Company, Limited Angiotensin II antagonist 1-biphenylmethylimidazole compounds and their therapeutic use
US5459148A (en) * 1992-12-17 1995-10-17 Sankyo Company, Limited Biphenyl derivatives and their use for the treatment of hypertension and cardiac disease
US5674879A (en) * 1993-09-24 1997-10-07 G.D. Searle & Co. Compositions including and methods of using conformationally restricted angiotensin II antagonist
US6878703B2 (en) * 2000-11-21 2005-04-12 Sankyo Company, Limited Pharmaceutical composition

Also Published As

Publication number Publication date
WO2007047838A2 (en) 2007-04-26

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