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WO2006134482A8 - Process for producing atorvastatin, pharmaceutically acceptable salts thereof and intermediates thereof - Google Patents

Process for producing atorvastatin, pharmaceutically acceptable salts thereof and intermediates thereof

Info

Publication number
WO2006134482A8
WO2006134482A8 PCT/IB2006/001613 IB2006001613W WO2006134482A8 WO 2006134482 A8 WO2006134482 A8 WO 2006134482A8 IB 2006001613 W IB2006001613 W IB 2006001613W WO 2006134482 A8 WO2006134482 A8 WO 2006134482A8
Authority
WO
WIPO (PCT)
Prior art keywords
intermediates
pharmaceutically acceptable
acceptable salts
producing
producing atorvastatin
Prior art date
Application number
PCT/IB2006/001613
Other languages
French (fr)
Other versions
WO2006134482A1 (en
Inventor
Shanghui Hu
Junhua Tao
Zhiyi Xie
Original Assignee
Pfizer
Shanghui Hu
Junhua Tao
Zhiyi Xie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer, Shanghui Hu, Junhua Tao, Zhiyi Xie filed Critical Pfizer
Priority to CA002612293A priority Critical patent/CA2612293A1/en
Priority to EP06765533A priority patent/EP1893767A1/en
Publication of WO2006134482A1 publication Critical patent/WO2006134482A1/en
Publication of WO2006134482A8 publication Critical patent/WO2006134482A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A novel process for producing atrovastatin, pharmaceutically acceptable salts thereof, and intermediates thereof using an aldolase is described. Compounds so prepared are useful as inhibitors of the HMG-CoA reductase and may thus be used as hypolipidemic and hypocholesterolemic agents.
PCT/IB2006/001613 2005-06-16 2006-06-06 Process for producing atorvastatin, pharmaceutically acceptable salts thereof and intermediates thereof WO2006134482A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002612293A CA2612293A1 (en) 2005-06-16 2006-06-06 Process for producing atorvastatin, pharmaceutically acceptable salts thereof and intermediates thereof
EP06765533A EP1893767A1 (en) 2005-06-16 2006-06-06 Process for producing atorvastatin, pharmaceutically acceptable salts thereof and intermediates thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69106505P 2005-06-16 2005-06-16
US60/691,065 2005-06-16

Publications (2)

Publication Number Publication Date
WO2006134482A1 WO2006134482A1 (en) 2006-12-21
WO2006134482A8 true WO2006134482A8 (en) 2008-03-06

Family

ID=36928182

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/001613 WO2006134482A1 (en) 2005-06-16 2006-06-06 Process for producing atorvastatin, pharmaceutically acceptable salts thereof and intermediates thereof

Country Status (6)

Country Link
EP (1) EP1893767A1 (en)
JP (1) JP2006345863A (en)
AR (1) AR055975A1 (en)
CA (1) CA2612293A1 (en)
TW (1) TW200724688A (en)
WO (1) WO2006134482A1 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008119810A2 (en) 2007-04-03 2008-10-09 Lek Pharmaceuticals D.D. Processes for the preparation of statins, particularly rosuvastatin, and intermediates for the preparation thereof
EP2017267A1 (en) * 2007-07-16 2009-01-21 LEK Pharmaceuticals D.D. Synthesis of statins
WO2009019561A2 (en) * 2007-08-03 2009-02-12 Pfizer Products Inc. Process for preparing chiral compounds
JP5731826B2 (en) 2008-01-23 2015-06-10 レツク・フアーマシユーテイカルズ・デー・デー Production method using ((2S, 4R) -4,6-dihydroxytetrahydro-2H-pyran-2-yl) methylcarboxylate and 2-deoxyribose-5-phosphate aldolase
EP2655650B1 (en) 2010-12-20 2017-12-20 LEK Pharmaceuticals d.d. Enzymatic synthesis of active pharmaceutical ingredient and intermediates thereof
EP2465936A1 (en) 2010-12-20 2012-06-20 LEK Pharmaceuticals d.d. Enzymatic synthesis of statins and intermediates thereof
JP5705580B2 (en) * 2011-02-21 2015-04-22 公益財団法人微生物化学研究会 Thioamide compound, method for producing thioamide compound, method for producing [(4R, 6R) -6-aminoethyl-1,3-dioxan-4-yl] acetate derivative, and method for producing atorvastatin
CN103060396B (en) * 2011-10-21 2017-09-12 武汉启瑞药业有限公司 A kind of new method for the Atorvastatin calcium for producing high chiral purity
WO2013068917A1 (en) * 2011-11-07 2013-05-16 Dr. Reddy's Laboratories Limited Processes for the production of a lactone statin intermediate by enzymatic oxidation
CN105272954B (en) * 2014-06-27 2017-10-13 上海弈柯莱生物医药科技有限公司 A kind of preparation method of the ketone of 6 substituent methyl, 4 hydroxy tetrahydro pyrans 2 and its derivative
EP3478848A4 (en) 2016-06-30 2020-01-29 Ardra Inc. Methods and microorganisms for producing flavors and fragrance chemicals

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7414119B2 (en) * 2002-09-20 2008-08-19 Verenium Corporation Aldolases, nucleic acids encoding them and methods for making and using them

Also Published As

Publication number Publication date
AR055975A1 (en) 2007-09-12
EP1893767A1 (en) 2008-03-05
CA2612293A1 (en) 2006-12-21
JP2006345863A (en) 2006-12-28
TW200724688A (en) 2007-07-01
WO2006134482A1 (en) 2006-12-21

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