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WO2006097472A3 - Novel inhibitors of glutathione-s-transferase - Google Patents

Novel inhibitors of glutathione-s-transferase Download PDF

Info

Publication number
WO2006097472A3
WO2006097472A3 PCT/EP2006/060707 EP2006060707W WO2006097472A3 WO 2006097472 A3 WO2006097472 A3 WO 2006097472A3 EP 2006060707 W EP2006060707 W EP 2006060707W WO 2006097472 A3 WO2006097472 A3 WO 2006097472A3
Authority
WO
WIPO (PCT)
Prior art keywords
transferase
treating
compounds
medical conditions
glutathione
Prior art date
Application number
PCT/EP2006/060707
Other languages
French (fr)
Other versions
WO2006097472A2 (en
Inventor
Katja Becker-Brandenburg
Herbert Zimmermann
Karin Fritz-Wolf
Original Assignee
Univ Giessen
Max Planck Gesellschaft
Katja Becker-Brandenburg
Herbert Zimmermann
Karin Fritz-Wolf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Giessen, Max Planck Gesellschaft, Katja Becker-Brandenburg, Herbert Zimmermann, Karin Fritz-Wolf filed Critical Univ Giessen
Priority to EP06708757A priority Critical patent/EP1865942A2/en
Publication of WO2006097472A2 publication Critical patent/WO2006097472A2/en
Publication of WO2006097472A3 publication Critical patent/WO2006097472A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/36—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having four or more rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to novel methods of preventing, treating, or ameliorating medical conditions, including cancer, drug resistance, and parasite infections such as malaria, by administering compounds that are capable of inhibiting glutathione-S-transferase, as well as to the use of said compounds for preparing pharmaceutical compositions for preventing, treating, or ameliorating said medical conditions. Furthermore, the invention relates to novel GST inhibitor compounds and pharmaceutical compositions comprising said GST inhibitors, optionally comprising further compounds known to be effective in treating said medical conditions.
PCT/EP2006/060707 2005-03-14 2006-03-14 Novel inhibitors of glutathione-s-transferase WO2006097472A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06708757A EP1865942A2 (en) 2005-03-14 2006-03-14 Novel inhibitors of glutathione-s-transferase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US66159605P 2005-03-14 2005-03-14
US60/661,596 2005-03-14

Publications (2)

Publication Number Publication Date
WO2006097472A2 WO2006097472A2 (en) 2006-09-21
WO2006097472A3 true WO2006097472A3 (en) 2007-09-07

Family

ID=36642696

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/060707 WO2006097472A2 (en) 2005-03-14 2006-03-14 Novel inhibitors of glutathione-s-transferase

Country Status (2)

Country Link
EP (1) EP1865942A2 (en)
WO (1) WO2006097472A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7566465B2 (en) 2006-12-21 2009-07-28 The United States Of America As Represented By The Secretary Of The Army Artemisinins in the clinical and veterinary management of kinetoplastid infections
WO2008079127A1 (en) * 2006-12-22 2008-07-03 Walter Reed Army Institute Of Research (Wrair) Artemisinins in the clinical and veterinary management of kinetoplastid infections
US20230167071A1 (en) * 2019-04-12 2023-06-01 University Of Puerto Rico Compounds with antimalarial activity
CN112063685B (en) * 2020-09-04 2024-02-02 湖南中医药大学 Screening method and application of glutathione S-transferase inhibitor

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6445311A (en) * 1987-08-12 1989-02-17 Toyo Pharma Kk Aldose reductase inhibitor
US5141741A (en) * 1988-12-09 1992-08-25 Lion Corporation Anti-sunburn skin-care preparation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6445311A (en) * 1987-08-12 1989-02-17 Toyo Pharma Kk Aldose reductase inhibitor
US5141741A (en) * 1988-12-09 1992-08-25 Lion Corporation Anti-sunburn skin-care preparation

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
ALANÍS ALMA DELIA ET AL: "Antiprotozoal activity of the constituents of Rubus coriifolius.", PHYTOTHERAPY RESEARCH : PTR. JUN 2003, vol. 17, no. 6, June 2003 (2003-06-01), pages 681 - 682, XP002390152, ISSN: 0951-418X *
CONRAD J ET AL: "Isoterchebulin and 4,6-O-isoterchebuloyl-D-glucose, novel hydrolyzable tannins from Terminalia macroptera.", JOURNAL OF NATURAL PRODUCTS. MAR 2001, vol. 64, no. 3, March 2001 (2001-03-01), pages 294 - 299, XP002390291, ISSN: 0163-3864 *
DAS M ET AL: "DIFFERENTIAL INHIBITION OF RAT AND HUMAN GLUTATHIONE-S-TRANSFERASE ISOENZYMES BY PLANT PHENOLS", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 141, no. 3, 1986, pages 1170 - 1176, XP009069157, ISSN: 0006-291X *
DAS M ET AL: "PLANT PHENOLS AS IN-VITRO INHIBITORS OF GLUTATHIONE S TRANSFERASES EC-2.5.1.18", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 120, no. 2, 1984, pages 427 - 433, XP000906942, ISSN: 0006-291X *
DELL'AGLI MARIO ET AL: "In vitro studies on the mechanism of action of two compounds with antiplasmodial activity: Ellagic acid and 3,4,5-trimethoxyphenyl (6'-O-galloyl)-beta-D-glucopyranoside.", PLANTA MEDICA, vol. 69, no. 2, February 2003 (2003-02-01), pages 162 - 164, XP002390150, ISSN: 0032-0943 *
FRITZ-WOLF KARIN ET AL: "X-ray structure of glutathione S-transferase from the malarial parasite Plasmodium falciparum.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 100, no. 24, 25 November 2003 (2003-11-25), pages 13821 - 13826, XP002390151, ISSN: 0027-8424 *
JOHNSON SANDRA A S ET AL: "Antioxidant enzyme response to hypericin in EMT6 mouse mammary carcinoma cells", FREE RADICAL BIOLOGY AND MEDICINE, vol. 24, no. 5, 15 March 1998 (1998-03-15), pages 817 - 826, XP002390153, ISSN: 0891-5849 *
LIEBAU EVA ET AL: "Structural and functional analysis of a glutathione S-transferase from Ascaris suum", BIOCHEMICAL JOURNAL, vol. 324, no. 2, 1997, pages 659 - 666, XP002390149, ISSN: 0264-6021 *
PATENT ABSTRACTS OF JAPAN vol. 013, no. 236 (C - 602) 30 May 1989 (1989-05-30) *

Also Published As

Publication number Publication date
WO2006097472A2 (en) 2006-09-21
EP1865942A2 (en) 2007-12-19

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