[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

WO2006094210A3 - Tetrahydroquinoxalinone sirtuin modulators - Google Patents

Tetrahydroquinoxalinone sirtuin modulators Download PDF

Info

Publication number
WO2006094210A3
WO2006094210A3 PCT/US2006/007656 US2006007656W WO2006094210A3 WO 2006094210 A3 WO2006094210 A3 WO 2006094210A3 US 2006007656 W US2006007656 W US 2006007656W WO 2006094210 A3 WO2006094210 A3 WO 2006094210A3
Authority
WO
WIPO (PCT)
Prior art keywords
diseases
sirtuin
disorders
tetrahydroquinoxalinone
modulating compounds
Prior art date
Application number
PCT/US2006/007656
Other languages
French (fr)
Other versions
WO2006094210A2 (en
Inventor
Jill Milne
Karl D Normington
Michael Milburn
Original Assignee
Sirtris Pharmaceuticals Inc
Jill Milne
Karl D Normington
Michael Milburn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sirtris Pharmaceuticals Inc, Jill Milne, Karl D Normington, Michael Milburn filed Critical Sirtris Pharmaceuticals Inc
Publication of WO2006094210A2 publication Critical patent/WO2006094210A2/en
Publication of WO2006094210A3 publication Critical patent/WO2006094210A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
PCT/US2006/007656 2005-03-03 2006-03-03 Tetrahydroquinoxalinone sirtuin modulators WO2006094210A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US65895005P 2005-03-03 2005-03-03
US60/658,950 2005-03-03
US71031305P 2005-08-22 2005-08-22
US60/710,313 2005-08-22

Publications (2)

Publication Number Publication Date
WO2006094210A2 WO2006094210A2 (en) 2006-09-08
WO2006094210A3 true WO2006094210A3 (en) 2007-03-29

Family

ID=36941869

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/007656 WO2006094210A2 (en) 2005-03-03 2006-03-03 Tetrahydroquinoxalinone sirtuin modulators

Country Status (1)

Country Link
WO (1) WO2006094210A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101616919B (en) * 2006-12-28 2012-10-10 雅培制药有限公司 Inhibitors of poly(adp-ribose)polymerase
US8685970B2 (en) 2008-05-01 2014-04-01 GlaxoSmithKline, LLC Quinolines and related analogs as sirtuin modulators
CA2729128C (en) 2008-07-03 2016-05-31 Sirtris Pharmaceuticals, Inc. Benzimidazoles and related analogs as sirtuin modulators
AU2009295948B2 (en) 2008-09-29 2013-12-05 GlaxoSmithKline, LLC Quinazolinone, quinolone and related analogs as sirtuin modulators
AU2009333588A1 (en) 2008-12-08 2011-07-21 Northwestern University Method of modulating HSF-1
AR077958A1 (en) 2009-08-27 2011-10-05 Vifor Int Ag ANTOGONIST QUINOXALINONES OF HEPCIDINE
JP2013509442A (en) * 2009-10-29 2013-03-14 サートリス ファーマシューティカルズ， インコーポレイテッド Bicyclic pyridines and analogs as sirtuin regulators
US8916528B2 (en) 2011-11-16 2014-12-23 Resveratrol Partners, Llc Compositions containing resveratrol and nucleotides
KR20160006215A (en) * 2013-05-13 2016-01-18 글락소스미스클라인 엘엘씨 Substituted bridged urea analogs as sirtuin modulators
BR112016011024B1 (en) 2013-11-18 2020-09-01 Forma Therapeutics, Inc COMPOUND, PHARMACEUTICAL COMPOSITION AND USES OF THE SAME
RU2720237C2 (en) 2013-11-18 2020-04-28 Форма Терапеутикс, Инк. Compositions containing benzopiperazine as bromodomain bet inhibitors
JP2017534663A (en) * 2014-11-19 2017-11-24 グラクソスミスクライン、インテレクチュアル、プロパティー、（ナンバー２）、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ （Ｎｏ．２） Ｌｉｍｉｔｅｄ Substituted bridged urea analogs as sirtuin regulators
CN106146416B (en) * 2016-08-01 2019-02-19 河南大学 Nitrogen replaces 3- oxo -6- substituted-tetrahydro quinoxaline structural compounds, preparation method and its medical usage
GB201713009D0 (en) 2017-08-14 2017-09-27 Bp Oil Int Ltd Methods for reducing oxidation
GB201713023D0 (en) * 2017-08-14 2017-09-27 Bp Oil Int Ltd Methods for blending fuels
GB201713019D0 (en) 2017-08-14 2017-09-27 Bp Oil Int Ltd Methods for controlling deposits
GB2574862A (en) * 2018-06-21 2019-12-25 Curadev Pharma Ltd Azaheterocyclic small molecule modulators of human STING
KR20230034222A (en) 2020-06-11 2023-03-09 씨에이치디아이 파운데이션, 인코포레이티드 Heterocyclic compounds and imaging agents for imaging huntingtin protein

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005002555A2 (en) * 2003-07-01 2005-01-13 President And Fellows Of Harvard College Sirt1 modulators for manipulating cell/organism lifespan/stress response

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005002555A2 (en) * 2003-07-01 2005-01-13 President And Fellows Of Harvard College Sirt1 modulators for manipulating cell/organism lifespan/stress response
US20050096256A1 (en) * 2003-07-01 2005-05-05 President And Fellows Of Harvard College Compositions for manipulating the lifespan and stress response of cells and organisms

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PORCU M ET AL: "The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER, HAYWARTH, GB, vol. 26, no. 2, February 2005 (2005-02-01), pages 94 - 103, XP004727629, ISSN: 0165-6147 *

Also Published As

Publication number Publication date
WO2006094210A2 (en) 2006-09-08

Similar Documents

Publication Publication Date Title
WO2006094210A3 (en) Tetrahydroquinoxalinone sirtuin modulators
WO2006094209A3 (en) N-benzimidazolylalkyl-substituted amide sirtuin modulators
WO2008156869A3 (en) Sirtuin modulating thiazolopyridine compounds
WO2007019344A8 (en) Imidazo [2,1-b] thiazole derivatives as sirtuin modulating compounds
WO2006094246A3 (en) N-arylmethyl benzamide sirtuin modulators
MY149316A (en) Sirtuin modulating imidazohiazole compounds
WO2010037127A8 (en) Chromenone analogs as sirtuin modulators
WO2009134973A8 (en) Quinolines and related analogs as sirtuin modulators
WO2006078941A3 (en) Novel sirtuin activating compounds and methods of use thereof
MY160006A (en) Thiazolopyridine sirtuin modulating compounds
WO2006105440A3 (en) Nicotinamide riboside and analogues thereof
MX2010004965A (en) Amide derivatives as sirtuin modulators.
MX2011006084A (en) Isoindolinone and related analogs as sirtuin modulators.
MX2010012961A (en) Imidazopyridine and related analogs as sirtuin modulators.
MX2011006475A (en) Phthalazinone and related analogs as sirtuin modulators.
WO2009061453A8 (en) Solubilized thiazolopyridines
IN2012DN03799A (en)
WO2008100376A3 (en) Truncation variants of sirt1 and methods of use thereof
WO2007102861A3 (en) Modulators of cdc2-like kinases (clks) and methods of use thereof
MX2011009213A (en) 8-substituted quinolines and related analogs as sirtuin modulators.
EA201170137A1 (en) BENZIMIDAZLES AND RELATED ANALOGUES AS SIRTUIN MODULATORS
WO2014186313A8 (en) Substituted bridged urea analogs as sirtuin modulators
WO2007022225A3 (en) Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof
WO2007127474A3 (en) Compositions and treatments using pyridazine compounds and cholinesterase inhibitors
WO2009085226A3 (en) Inhibitors of cdc2-like kinases (clks) and methods of use thereof

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

NENP Non-entry into the national phase

Ref country code: RU

122 Ep: pct application non-entry in european phase

Ref document number: 06736902

Country of ref document: EP

Kind code of ref document: A2