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WO2006093832A3 - Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same - Google Patents

Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same Download PDF

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Publication number
WO2006093832A3
WO2006093832A3 PCT/US2006/006615 US2006006615W WO2006093832A3 WO 2006093832 A3 WO2006093832 A3 WO 2006093832A3 US 2006006615 W US2006006615 W US 2006006615W WO 2006093832 A3 WO2006093832 A3 WO 2006093832A3
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WO
WIPO (PCT)
Prior art keywords
pharmaceutical compositions
ion
methods
same
amide derivatives
Prior art date
Application number
PCT/US2006/006615
Other languages
French (fr)
Other versions
WO2006093832A2 (en
Inventor
Michael Kelly
John Kincaid
Matthew Duncton
Kiran Sahasrabudhe
Satynarahana Janagani
Ravindra Upasani
Guoxian Wu
Yunfeng Fang
Zhi-Liang Wei
Original Assignee
Renovis Inc
Michael Kelly
John Kincaid
Matthew Duncton
Kiran Sahasrabudhe
Satynarahana Janagani
Ravindra Upasani
Guoxian Wu
Yunfeng Fang
Zhi-Liang Wei
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU2006218824A priority Critical patent/AU2006218824A1/en
Priority to CA002600933A priority patent/CA2600933A1/en
Priority to EP06736043A priority patent/EP1853269A4/en
Priority to MX2007009381A priority patent/MX2007009381A/en
Priority to BRPI0606365A priority patent/BRPI0606365A2/en
Priority to US11/885,300 priority patent/US20080300243A1/en
Priority to EA200701835A priority patent/EA200701835A1/en
Priority to JP2007558085A priority patent/JP2008531690A/en
Application filed by Renovis Inc, Michael Kelly, John Kincaid, Matthew Duncton, Kiran Sahasrabudhe, Satynarahana Janagani, Ravindra Upasani, Guoxian Wu, Yunfeng Fang, Zhi-Liang Wei filed Critical Renovis Inc
Priority to AP2007004119A priority patent/AP2007004119A0/en
Publication of WO2006093832A2 publication Critical patent/WO2006093832A2/en
Publication of WO2006093832A3 publication Critical patent/WO2006093832A3/en
Priority to TNP2007000283A priority patent/TNSN07283A1/en
Priority to IL185205A priority patent/IL185205A0/en
Priority to NO20074739A priority patent/NO20074739L/en

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    • C07D209/04—Indoles; Hydrogenated indoles
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Abstract

Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.
PCT/US2006/006615 2005-02-28 2006-02-24 Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same WO2006093832A2 (en)

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EA200701835A EA200701835A1 (en) 2005-02-28 2006-02-24 AMIDIC DERIVATIVES AS THE LIGANDS OF IONIC CHANNELS, THEIR PHARMACEUTICAL COMPOSITIONS AND METHODS OF THEIR APPLICATION
EP06736043A EP1853269A4 (en) 2005-02-28 2006-02-24 Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
MX2007009381A MX2007009381A (en) 2005-02-28 2006-02-24 Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same.
BRPI0606365A BRPI0606365A2 (en) 2005-02-28 2006-02-24 compound or a pharmaceutically acceptable salt, solvate or prodrug thereof and stereoisomers and tautomers thereof, pharmaceutical composition, methods for preventing, treating, ameliorating or controlling a disease or condition and for preparing a compound, use of a compound or a salt , solvate or pharmaceutically acceptable composition thereof, method of treating a mammal, and, combination
US11/885,300 US20080300243A1 (en) 2005-02-28 2006-02-24 Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same
AU2006218824A AU2006218824A1 (en) 2005-02-28 2006-02-24 Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
JP2007558085A JP2008531690A (en) 2005-02-28 2006-02-24 Amide derivatives as ion channel ligands and pharmaceutical compositions and methods using the same
CA002600933A CA2600933A1 (en) 2005-02-28 2006-02-24 Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
AP2007004119A AP2007004119A0 (en) 2005-02-28 2006-02-24 Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
TNP2007000283A TNSN07283A1 (en) 2005-02-28 2007-07-20 Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
IL185205A IL185205A0 (en) 2005-02-28 2007-08-12 Amide derivatives as ion-channel ligands and pharmaceutical composition and methods of using the same
NO20074739A NO20074739L (en) 2005-02-28 2007-09-17 Amide derivatives such as ion channel ligands and pharmaceutical compositions and methods for using the same

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US65698405P 2005-02-28 2005-02-28
US60/656,984 2005-02-28
US71044505P 2005-08-23 2005-08-23
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US77605606P 2006-02-23 2006-02-23
US77603306P 2006-02-23 2006-02-23
US77605806P 2006-02-23 2006-02-23
US77594506P 2006-02-23 2006-02-23
US77610506P 2006-02-23 2006-02-23
US77610606P 2006-02-23 2006-02-23
US77593006P 2006-02-23 2006-02-23
US77605706P 2006-02-23 2006-02-23
US77594906P 2006-02-23 2006-02-23
US77606406P 2006-02-23 2006-02-23
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KR20070119655A (en) * 2005-02-28 2007-12-20 레노비스, 인크. Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same
US20080221128A1 (en) 2007-03-07 2008-09-11 Christian Gege Metalloprotease inhibitors containing a squaramide moiety
JP5622568B2 (en) * 2007-06-03 2014-11-12 バンダービルト ユニバーシティ Positive allosteric modulators of benzamide mGluR5 and methods of making and using the same
US8853392B2 (en) 2007-06-03 2014-10-07 Vanderbilt University Benzamide mGluR5 positive allosteric modulators and methods of making and using same
ES2372655T3 (en) * 2007-11-13 2012-01-25 Evotec Ag MEDICAL DERIVATIVES AS LIGANDS OF ION CHANNELS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF THE SAME.
WO2009062319A1 (en) * 2007-11-16 2009-05-22 Neuraxon, Inc. Indole compounds and methods for treating visceral pain
FR2933977B1 (en) * 2008-07-18 2013-04-26 Centre Nat Rech Scient HETEROCYCLIC DERIVATIVES USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
WO2011016234A1 (en) * 2009-08-04 2011-02-10 Raqualia Pharma Inc. Picolinamide derivatives as ttx-s blockers
BR112013028895A2 (en) 2011-05-10 2016-08-09 Bayer Ip Gmbh (thio) bicyclic carbonylamidines
HUE032086T2 (en) * 2011-09-29 2017-09-28 Mitsui Chemicals Agro Inc Production method for 4, 4-difluoro-3,4-dihydroisoquinoline derivative
TWI580677B (en) * 2011-09-29 2017-05-01 三井化學Ａｇｒｏ股份有限公司 Method of producing 3,4-dihydroisoquinoline derivative and production intermediate therefor
CN103958525A (en) 2011-11-30 2014-07-30 埃科特莱茵药品有限公司 3,7-disubstituted octahydro-2h-pyrido[4,3-e][1,3]oxazin-2-one antibiotics
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BRPI0415179A (en) * 2003-10-07 2006-11-28 Renovis Inc amide derivatives such as ion channel ligands and pharmaceutical compositions and methods of employing them
US20060035939A1 (en) * 2004-07-14 2006-02-16 Japan Tobacco Inc. 3-Aminobenzamide compounds and inhibitors of vanilloid receptor subtype 1 (VR1) activity
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