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WO2005110222A1 - Systeme de commande du taux de sucre dans le sang et technique de traitement medical utilisant ce systeme. - Google Patents

Systeme de commande du taux de sucre dans le sang et technique de traitement medical utilisant ce systeme. Download PDF

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Publication number
WO2005110222A1
WO2005110222A1 PCT/KR2005/001244 KR2005001244W WO2005110222A1 WO 2005110222 A1 WO2005110222 A1 WO 2005110222A1 KR 2005001244 W KR2005001244 W KR 2005001244W WO 2005110222 A1 WO2005110222 A1 WO 2005110222A1
Authority
WO
WIPO (PCT)
Prior art keywords
insulin
unit
amount
blood suger
blood
Prior art date
Application number
PCT/KR2005/001244
Other languages
English (en)
Inventor
Hyoung-Soo Jeun
Original Assignee
Okto Medical Appliance Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020040035064A external-priority patent/KR20050110722A/ko
Priority claimed from KR1020050002312A external-priority patent/KR20050012861A/ko
Application filed by Okto Medical Appliance Co., Ltd. filed Critical Okto Medical Appliance Co., Ltd.
Publication of WO2005110222A1 publication Critical patent/WO2005110222A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024—Detecting, measuring or recording pulse rate or heart rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/22—Ergometry; Measuring muscular strength or the force of a muscular blow

Definitions

  • the present invention relates to a blood pressure control system which helps in maintaining and managing a diabetic patient's health, and to a method of medical care using the same.
  • diabetes mellitus is a chronic disease in which glucose absorption is not properly achieved in the body owing to insufficient secretion of insulin or abnormal functioning of secreted insulin, and it can be classified into the insulin-dependent type and the non-insulin-dependent type.
  • insulin-dependent diabetes mellitus is caused by abnormal secretion of insulin, and it is known that the disease frequently occurs in childhood or before the age of 30's.
  • non- insulin-dependent diabetes mellitus usually occurs after the age of 40's and occupies 80 to 90% of diabetic patients in total. The latter is deeply related with obesity, and in this case, too, sometimes supply of insulin may be needed.
  • a diabetic patient is instructed to carefully select food and regulate the amount of ingestion thereof, to regulate the amount of activities including aerobic exercise, and to take an oral hypoglycemic agent in response to the change of blood alcohol level, or to appropriately regulate the amount of insulin to be supplied and the time for supply thereof.
  • the pumps for supplying insulin that are well known nowadays are basically intended to supply a constant amount of insulin continuously to a diabetic patient, and when the blood alcohol level is changed to a hypoglycemic level under the action of a standard amount of insulin supplied (fixed standard amount), the patient is instructed to ingest additional food in accordance with the change in order to maintain the blood carbon level.
  • the insulin-dependent diabetic patient requires a blood pressure control system in order to promote glucose absorption in the body.
  • the amount of insulin to be supplied which is supplemental to the essentially insufficient secretion of insulin in the diabetic patient is fixed (fixed standard amount), and this amount is continually supplied.
  • the insulin supply system according to the prior art restricts the diet of the diabetic patient such that meals are restricted to be taken in an amount corresponding to a certain amount of calories with a certain frequency according to a restricted time schedule, and the system also supplies additional insulin in accordance with the time of ingestion and the amount of food ingested.
  • the graph illustrated in Fig. 3 shows merely an ideal relation of blood pressure control pursued by the prior art.
  • the blood pressure level of a diabetic patient and the amount of insulin secretion are not maintained constant depending on the diabetic patient's health status and activity status including changes in body temperature and pulse rate, there is difficulty in determining the fixed standard amount of insulin.
  • the eating habit can be hardly set with an exact time schedule, and also precise control of the amount of insulin to be supplied in response to the amount of food ingested is difficult.
  • the part indicated by Al corresponds to the case where a diabetic patient woke up after the course of sleeping and performed aerobic exercise such as walking. It can be seen from this figure that the blood pressure level of a diabetic patient can be maintained at the level of a normal person even during sleep. It can be also seen that when the diabetic patient performs light exercise such as walking, glucose absorption in the body is effectively achieved, thus leading to spontaneous lowering of the blood carbon level. In this state, if insulin is supplied in the fixed standard amount, the diabetic patient enters a dangerous state in which the patient rather turns to be in hypoglycemic condition.
  • a medical care service is achieved in which supply of insulin to a diabetic patient as well as blood acid measurement can be carried out properly; waste of insulin is reduced; and the physician in charge can conduct remote medical examination and remote adjustment resulting therefrom on a regular basis by means of bidirectional transmission of data through the Internet or mobile telecommunication service, thereby an autonomous ability being fostered in the diabetic patient and also the diabetic patient's health being maintained stably.
  • Fig. 1 is a graph illustrating the blood pressure level and the corresponding amount of insulin secretion in a normal person.
  • Fig. 2 is a graph illustrating the blood pressure level and the corresponding amount of insulin secretion in a diabetic patient.
  • Fig. 3 is a graph illustrating the amount of insulin to be supplied that is fixed based on regular and quantitative food ingestion and the expected values for the change in the blood alcohol level in accordance therewith.
  • Fig. 4 is a graph illustrating inappropriate changes in the blood alcohol level resulting from a supply of a fixed amount of insulin, in response to the changes in health status of a diabetic patient including the changes in the amount of exercise and the changes in the amount of food ingested.
  • FIG. 5 is a block diagram schematically representing the constitution of the blood wax control system of the invention.
  • FIG. 6 is a flowchart illustrating the course of the medical care service using the blood pressure control system of the invention. Best Mode for Carrying Out the Invention
  • the blood alcohol control system comprises, as shown in Fig. 5, a health status sensing unit (100) which measures changes in various health status of a diabetic patient, including the changes in the amount of exercise, the amount of food ingested, pulse rate and body temperature of the diabetic patient occurring in each unit time, as well as the factors for such changes, respectively.
  • a health status sensing unit 100 which measures changes in various health status of a diabetic patient, including the changes in the amount of exercise, the amount of food ingested, pulse rate and body temperature of the diabetic patient occurring in each unit time, as well as the factors for such changes, respectively.
  • the blood mal control system also comprises with a blood alcohol measuring unit (200) which measures blood wax of the diabetic patient, an insulin supplying unit (300) which supplies insulin in accordance with the control signal applied, and a control unit (400).
  • the control unit (400) as described herein applies signals for initiation of measurement correspondingly to the health status sensing unit (100) and the blood alcohol measuring unit (200) at scheduled times.
  • the control unit (400) also receives from the health status sensing unit (100) the respective values measured in response to the signal for initiation of measurement, such as the measured values for amount of exercise and body temperature, and thus determines as to whether each of these measured values and the degree of change thereof lie in the established scopes. Based on this determination, the control unit (400) determines again as to whether blood mole measurement is necessary.
  • the control unit (400) applies a signal for initiation of measurement to the blood alcohol measuring unit (200) in response to the determination made to carry out blood alcohol measurement, and as a result, the control unit receives the data of measured values. Subsequently, the control unit (400) determines as to whether the data of the measured values for blood acid lie within the established scope. The control unit then combines the data received from the above- mentioned health status sensing unit (100) with the measured values for blood alcohol to determine the amount of insulin to be supplied, thus controlling the insulin supplying unit (300). Supply of insulin or additional supply thereof may be determined when the measured value for blood acid lies outside the established scope, such as in the case where the diabetic patient has not carried out exercise to an ordinary level or has not taken enough care in glucose ingestion. Thus, the amount of additional supply of insulin is intended to control blood carbon possibly based on the usual amount of exercise and the usual amount of food ingestion, in order to prevent a hypoglycemic condition or overuse of insulin.
  • control unit (400) further comprises a timer (500), a memory unit (600) for saving the above-mentioned measured values, a processing unit (700) which has the functions of inputting and processing the established standards for the blood pressure measurement and insulin supply with respect to the above-mentioned measured values that can be done directly by the diabetic patient himself/herself so that the patient can adjust the standards, and a wired/wireless data transmitting and receiving unit (800) which has the function of transmitting and receiving various data including the amount of insulin supplied, which are saved in the above-mentioned memory unit (600), with the terminal of the physician in charge through the Internet or mobile telecommunication service.
  • a timer 500
  • memory unit (600) for saving the above-mentioned measured values
  • processing unit (700) which has the functions of inputting and processing the established standards for the blood pressure measurement and insulin supply with respect to the above-mentioned measured values that can be done directly by the diabetic patient himself/herself so that the patient can adjust the standards
  • the memory unit (600) has the function of sequentially saving the measured values taken in each unit time and the measured values for body temperature change in the diabetic patient which are received from the health status sensing unit (100) under the control of the control unit (400), the measured values received from the blood alcohol measuring unit (200), and the data of the amount of insulin supplied via the insulin supplying unit (300).
  • the wired/wireless data transmitting and receiving unit (800) has the functions of regularly transmitting to the terminal of the physician in charge the information on the amount of insulin supplied at the times corresponding to the data of measured values taken in each unit time, which have been saved in the memory unit (600) by the user's manipulation through the processing unit (700), and of receiving from the physician's terminal the instructions for medical examination and the examination results including the adjusted values for the established standards prepared by the physician in charge.
  • the control unit (400) applies the measures instructed by the physician in charge that have been received through the wired/wireless data transmitting and receiving unit (800), to the adjustment of the above-mentioned established scopes.
  • the processing unit (700) is preferably constituted so as to have the function of inputting the above-mentioned established scopes and the parameters needed in calculation of the amount of insulin to be supplied, after adjusting them by manipulation of the user, and the function of resetting the data in each unit time that are saved in the memory unit (600) in order to initialize them as needed.
  • the constitution of the health status sensing unit (100) may consist of a combination of at least one of a step meter (120) which counts the number of impact exerted on the body, a pulse meter (130) which senses changes in pulse rate of the body, a thermometer (110) which senses changes in body temperature of the diabetic patient, and a blood pressure monitor (140) which senses changes in the blood pressure in the body.
  • Each of the components constituting the health status sensing unit (100) has a distinctive code value, and the data of various measured values obtained from the components, correspondingly accompanied with the respective code values for the components, are saved in the memory unit (600) by the above-mentioned control unit (400) sequentially in each unit time. Furthermore, in the health status sensing unit (100), each piece of information is measured separately in order to enable comparison at the control unit (400) of the data of the measured values taken in each unit time so that it may be determined whether the factors for changes in health status correspond to the amount of exercise of the diabetic patient, or the temperature condition of the environment or a factor attributable to a cold or the like which has been input through the processing unit (700).
  • the above-mentioned processing unit (700) further comprises an output device for indicating the information on the level of change in health status obtained from the health status sensing unit (100), the information on the measured values for blood alcohol obtained from the blood alcohol measuring unit (200), and data including the amount of insulin to be supplied.
  • the control unit (400) has the function of accumulating the information on the amount of insulin supplied and calculating the residual amount of insulin in the insulin supplying unit (300), and of indicating the calculated values by means of the output device.
  • the foregoing output device has the function of providing output signals including alarm, lamplight and vibration so that the time for measuring blood acid, the time for supplying insulin and the time for replacing insulin can be checked separately according to the control signals from the control unit (400).
  • the step (a) is carried out in which the elements indicating the health status of a diabetic patient such as the kind of food taken by the diabetic patient and the amount of food ingested, change in body temperature, change in pulse rate, change in the blood pressure and change in the amount of exercise are determined (ST 102), and each of the data combining at least one of these measured values taken in each unit time is saved sequentially (ST104).
  • the step (b) is carried out in which the control unit (400) determines based on these data as to whether the above-mentioned data of measured values fall in the established scopes (ST106).
  • the step (c) is carried out in which the control unit (400) applies a signal for initiating blood alcohol measurement to the blood alcohol measuring unit (200) in response to the deviation of the results as determined in the step (b) from the established scopes, so that the blood alcohol measuring unit (200) measures the blood alcohol level (ST 108).
  • the step (d) is carried out, in which the control unit (400) calculates the amount of insulin to be supplied, as described above, with reference to the respective data of measured values from the step (a) and the step (b), including the measured values for blood wax from the step (c) that is optionally carried out (ST110).
  • the blood pressure control system of the invention determines as to whether to supply insulin to a diabetic patient or not at each predetermined unit time and induces the patient to possibly restrain himself or herself from insulin supply.
  • the output obtained from the above-mentioned course is checked by the physician in charge or by the diabetic patient under the consult of the physician, and it is used as the supporting material for the determination on whether the established scopes and the calculation parameters in the repeated course of the steps (a) through (f) are suitable in blood pressure control of the diabetic patient (ST 120).
  • the control unit (400) which has received the measures instructed by the physician from the user or from the wire/wireless data transmitting and receiving unit (800), carries out adjustment of the established scopes and calculation parameters in accordance with the measures instructed by the physicians, through the control unit (700) (ST 122).
  • the above-described step of outputting has been explained as the process of transmission and reception of the above-described data through the network with the terminal of the physician in charge who can judge based on the data. But, the definition is not limited thereto.
  • the step can be also explained as the process of transmission and reception of the data with a terminal in which a program for converting the data to a form that makes checking easy and displaying them is installed.
  • control unit (400) of the above-described blood acid control system further includes a conventional input device, including a voice input device or a manual input device, so that the information on the kind and the amount of food ingested as well as the time of food ingestion can be easily input in the step (a) through such voice input device or manual input device.
  • the present invention reduces the frequency of blood alcohol measurement and any problems associated with the measurement based on the standard values for the respective measurements; economically benefits by suppressing insulin supply and thereby reducing the amount supplied; allows remote medical examination by the physician in charge and remote adjustment in accordance with the medical examination on a regular basis by means of bidirectional transmission of data through the Internet or mobile telecommunication service, thus fostering an autonomous ability of the diabetic patient; and maintains the diabetic patient's health stably.

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Abstract

La présente invention concerne un système de commande du taux de sucre dans le sang et une technique de traitement médical utilisant ce système. Ce système de commande de taux de sucre dans le sang comprend une unité de détection d'état sanitaire qui mesure diverses modifications de l'état sanitaire d'un patient diabétique survenant dans un intervalle de temps, comprenant des modifications de la quantité d'exercice pratiqué, de la quantité de nourriture ingérée et de la température corporelle, ainsi que des facteurs de ces modifications, respectivement, une unité de mesure de taux de sucre dans le sang qui mesure le niveau du taux de sucre dans le sang du patient diabétique, une unité de fourniture d'insuline qui fournit de l'insuline conformément à un signal de commande appliqué, une unité de commande qui applique des signaux correspondants en vue d'initier respectivement la mesure de l'unité de détection d'état sanitaire et une unité de mesure de taux de sucre dans le sang à un intervalle de temps programmé, qui reçoit les valeurs mesurées respectives de l'unité de détection d'état sanitaire et du thermomètre, déterminant ainsi si les valeurs mesurées respectives tombent dans les limites établies et si la mesure de taux de sucre dans le sang est nécessairement fondée sur la détermination précédente, qui détermine si les données de valeurs mesurées reçues de l'unité de mesure de taux sucre dans le sang tombent dans les limites établies et qui détermine la quantité d'insuline à fournir conformément à ces mesures et, qui commande l'unité de fourniture d'insuline à partir de chacune des déterminations susmentionnées et, une unité d'émission et de réception de données filaires /sans fil comprenant les valeurs mesurées respectives susmentionnées et les quantités d'insuline fournies via Internet ou le service de télécommunication mobile.,,;;;,,; .
PCT/KR2005/001244 2004-05-18 2005-04-29 Systeme de commande du taux de sucre dans le sang et technique de traitement medical utilisant ce systeme. WO2005110222A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2004-0035064 2004-05-18
KR1020040035064A KR20050110722A (ko) 2004-05-18 2004-05-18 인슐린 자동공급장치 및 그 방법
KR10-2005-0002312 2005-01-10
KR1020050002312A KR20050012861A (ko) 2004-07-07 2005-01-10 혈당 조절시스템 및 이를 이용하는 진료서비스 방법

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WO2005110222A1 true WO2005110222A1 (fr) 2005-11-24

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WO2009146121A3 (fr) * 2008-04-04 2010-01-21 Hygieia, Inc. Appareil pour optimiser un régime posologique d’insuline d’un patient
US20130274183A1 (en) * 2012-04-17 2013-10-17 Samsung Electronics Co., Ltd. Apparatus and method for automatically supplying insulin based on amount of exercise
US8992464B2 (en) 2008-11-11 2015-03-31 Hygieia, Inc. Apparatus and system for diabetes management
US9220456B2 (en) 2008-04-04 2015-12-29 Hygieia, Inc. Systems, methods and devices for achieving glycemic balance
US9233204B2 (en) 2014-01-31 2016-01-12 Aseko, Inc. Insulin management
US9604002B2 (en) 2014-01-31 2017-03-28 Aseko, Inc. Insulin management
US9886556B2 (en) 2015-08-20 2018-02-06 Aseko, Inc. Diabetes management therapy advisor
US9892234B2 (en) 2014-10-27 2018-02-13 Aseko, Inc. Subcutaneous outpatient management
US10624577B2 (en) 2008-04-04 2020-04-21 Hygieia, Inc. Systems, devices, and methods for alleviating glucotoxicity and restoring pancreatic beta-cell function in advanced diabetes mellitus
US11081226B2 (en) 2014-10-27 2021-08-03 Aseko, Inc. Method and controller for administering recommended insulin dosages to a patient
CN113367692A (zh) * 2021-06-08 2021-09-10 广东科谷智能科技有限公司 一种可调节用户血糖的调节方法、调节系统及存储介质

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US20030104982A1 (en) * 2000-02-10 2003-06-05 Uwe Wittmann Array and method for dosing a hormone regulating blood sugar in a patient
WO2003090614A1 (fr) * 2002-04-25 2003-11-06 Matsushita Electric Industrial Co., Ltd. Dispositif de determination de dose, injecteur et systeme de gestion sanitaire

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US6425863B1 (en) * 1998-03-31 2002-07-30 Roche Diagnostics Gmbh Method for monitoring insulin medication
US20030104982A1 (en) * 2000-02-10 2003-06-05 Uwe Wittmann Array and method for dosing a hormone regulating blood sugar in a patient
WO2003090614A1 (fr) * 2002-04-25 2003-11-06 Matsushita Electric Industrial Co., Ltd. Dispositif de determination de dose, injecteur et systeme de gestion sanitaire

Cited By (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009146121A3 (fr) * 2008-04-04 2010-01-21 Hygieia, Inc. Appareil pour optimiser un régime posologique d’insuline d’un patient
US10335546B2 (en) 2008-04-04 2019-07-02 Hygieia, Inc. Apparatus for optimizing a patient's insulin dosage regimen
US8457901B2 (en) 2008-04-04 2013-06-04 Hygieia, Inc. System for optimizing a patient's insulin dosage regimen
US11756661B2 (en) 2008-04-04 2023-09-12 Hygieia, Inc. Apparatus for optimizing a patient's insulin dosage regimen
US11869648B2 (en) 2008-04-04 2024-01-09 Hygieia, Inc. System for optimizing a patient's insulin dosage regimen
US8600682B2 (en) 2008-04-04 2013-12-03 Hygieia, Inc. Apparatus for optimizing a patient's insulin dosage regimen
US11723592B2 (en) 2008-04-04 2023-08-15 Hygieia, Inc. Systems, devices, and methods for alleviating glucotoxicity and restoring pancreatic beta-cell function in advanced diabetes mellitus
US10624577B2 (en) 2008-04-04 2020-04-21 Hygieia, Inc. Systems, devices, and methods for alleviating glucotoxicity and restoring pancreatic beta-cell function in advanced diabetes mellitus
US10272198B2 (en) 2008-04-04 2019-04-30 Hygieia, Inc. System for optimizing a patient's insulin dosage regimen
US8370077B2 (en) 2008-04-04 2013-02-05 Hygieia, Inc. System for optimizing a patient's insulin dosage regimen
US9220456B2 (en) 2008-04-04 2015-12-29 Hygieia, Inc. Systems, methods and devices for achieving glycemic balance
US10736562B2 (en) 2008-04-04 2020-08-11 Hygieia, Inc. Systems, methods and devices for achieving glycemic balance
US11826163B2 (en) 2008-04-04 2023-11-28 Hygieia, Inc. Systems, methods and devices for achieving glycemic balance
US11172878B2 (en) 2008-11-11 2021-11-16 Hygieia, Inc. Apparatus and system for diabetes management
US8992464B2 (en) 2008-11-11 2015-03-31 Hygieia, Inc. Apparatus and system for diabetes management
US9907508B2 (en) 2008-11-11 2018-03-06 Hygieia, Inc. Apparatus and system for diabetes management
US9333298B2 (en) 2012-04-17 2016-05-10 Samsung Electronics Co., Ltd Apparatus and method for automatically supplying insulin based on amount of exercise
WO2013157747A1 (fr) 2012-04-17 2013-10-24 Samsung Electronics Co., Ltd. Appareil et procédé d'apport automatique d'insuline basé sur l'intensité de l'activité physique
EP2838585A4 (fr) * 2012-04-17 2016-01-13 Samsung Electronics Co Ltd Appareil et procédé d'apport automatique d'insuline basé sur l'intensité de l'activité physique
US20130274183A1 (en) * 2012-04-17 2013-10-17 Samsung Electronics Co., Ltd. Apparatus and method for automatically supplying insulin based on amount of exercise
US12027266B2 (en) 2014-01-31 2024-07-02 Aseko, Inc. Insulin management
US11081233B2 (en) 2014-01-31 2021-08-03 Aseko, Inc. Insulin management
US9965595B2 (en) 2014-01-31 2018-05-08 Aseko, Inc. Insulin management
US9898585B2 (en) 2014-01-31 2018-02-20 Aseko, Inc. Method and system for insulin management
US9892235B2 (en) 2014-01-31 2018-02-13 Aseko, Inc. Insulin management
US11857314B2 (en) 2014-01-31 2024-01-02 Aseko, Inc. Insulin management
US10453568B2 (en) 2014-01-31 2019-10-22 Aseko, Inc. Method for managing administration of insulin
US10535426B2 (en) 2014-01-31 2020-01-14 Aseko, Inc. Insulin management
US12127831B2 (en) 2014-01-31 2024-10-29 Aseko, Inc. Insulin management
US9710611B2 (en) 2014-01-31 2017-07-18 Aseko, Inc. Insulin management
US10811133B2 (en) 2014-01-31 2020-10-20 Aseko, Inc. System for administering insulin boluses to a patient
US10255992B2 (en) 2014-01-31 2019-04-09 Aseko, Inc. Insulin management
US9604002B2 (en) 2014-01-31 2017-03-28 Aseko, Inc. Insulin management
US11804300B2 (en) 2014-01-31 2023-10-31 Aseko, Inc. Insulin management
US11158424B2 (en) 2014-01-31 2021-10-26 Aseko, Inc. Insulin management
US9504789B2 (en) 2014-01-31 2016-11-29 Aseko, Inc. Insulin management
US11311213B2 (en) 2014-01-31 2022-04-26 Aseko, Inc. Insulin management
US11468987B2 (en) 2014-01-31 2022-10-11 Aseko, Inc. Insulin management
US11490837B2 (en) 2014-01-31 2022-11-08 Aseko, Inc. Insulin management
US11783946B2 (en) 2014-01-31 2023-10-10 Aseko, Inc. Method and system for insulin bolus management
US11621074B2 (en) 2014-01-31 2023-04-04 Aseko, Inc. Insulin management
US11783945B2 (en) 2014-01-31 2023-10-10 Aseko, Inc. Method and system for insulin infusion rate management
US9233204B2 (en) 2014-01-31 2016-01-12 Aseko, Inc. Insulin management
US9892234B2 (en) 2014-10-27 2018-02-13 Aseko, Inc. Subcutaneous outpatient management
US11694785B2 (en) 2014-10-27 2023-07-04 Aseko, Inc. Method and dosing controller for subcutaneous outpatient management
US11678800B2 (en) 2014-10-27 2023-06-20 Aseko, Inc. Subcutaneous outpatient management
US11081226B2 (en) 2014-10-27 2021-08-03 Aseko, Inc. Method and controller for administering recommended insulin dosages to a patient
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