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WO2005002514A3 - Compounds having inhibitibe activity of phosphatidylinositol 3-kinase and methods of use thereof - Google Patents

Compounds having inhibitibe activity of phosphatidylinositol 3-kinase and methods of use thereof Download PDF

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Publication number
WO2005002514A3
WO2005002514A3 PCT/US2004/019131 US2004019131W WO2005002514A3 WO 2005002514 A3 WO2005002514 A3 WO 2005002514A3 US 2004019131 W US2004019131 W US 2004019131W WO 2005002514 A3 WO2005002514 A3 WO 2005002514A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
compounds
kinase
activity
phosphatidylinositol
Prior art date
Application number
PCT/US2004/019131
Other languages
French (fr)
Other versions
WO2005002514A2 (en
Inventor
Beth E Drees
Leena Chakravarty
Glenn D Prestwich
Gyorgy Dorman
Mariann Kavecz
Andras Lukacs
Laszlo Urge
Ferenc Darvas
Original Assignee
Echelon Biosciences Inc
Comgenex Rt
Beth E Drees
Leena Chakravarty
Glenn D Prestwich
Gyorgy Dorman
Mariann Kavecz
Andras Lukacs
Laszlo Urge
Ferenc Darvas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Echelon Biosciences Inc, Comgenex Rt, Beth E Drees, Leena Chakravarty, Glenn D Prestwich, Gyorgy Dorman, Mariann Kavecz, Andras Lukacs, Laszlo Urge, Ferenc Darvas filed Critical Echelon Biosciences Inc
Publication of WO2005002514A2 publication Critical patent/WO2005002514A2/en
Publication of WO2005002514A3 publication Critical patent/WO2005002514A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds inhibiting phosphatidylinositol 3-kinase (PI 3-K) activities and methods of preparing and using thereof in treating diseases are disclosed. Compounds inhibiting PI 3-K activity and methods of using PI 3-K inhibitory compounds to inhibit cancer cell growth or to treat disorders of immunity and inflammation, in which PI 3-K plays a role in leukocyte function are also provided.
PCT/US2004/019131 2003-06-13 2004-06-14 Compounds having inhibitibe activity of phosphatidylinositol 3-kinase and methods of use thereof WO2005002514A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47816503P 2003-06-13 2003-06-13
US60/478,165 2003-06-13

Publications (2)

Publication Number Publication Date
WO2005002514A2 WO2005002514A2 (en) 2005-01-13
WO2005002514A3 true WO2005002514A3 (en) 2005-04-14

Family

ID=33563771

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/019131 WO2005002514A2 (en) 2003-06-13 2004-06-14 Compounds having inhibitibe activity of phosphatidylinositol 3-kinase and methods of use thereof

Country Status (1)

Country Link
WO (1) WO2005002514A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0426701D0 (en) * 2004-12-04 2005-01-12 Procure Therapeutics Ltd Tumour suppressor genes
US20090286779A1 (en) * 2006-09-29 2009-11-19 Novartis Ag Pyrazolopyrimidines as lipid kinase inhibitors
UY34632A (en) 2012-02-24 2013-05-31 Novartis Ag OXAZOLIDIN- 2- ONA COMPOUNDS AND USES OF THE SAME
GB201410817D0 (en) * 2014-06-17 2014-07-30 Ucb Biopharma Sprl And Katholieke Universiteit Leuven K U Leuven R & D Therapeutic agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Perkin transactions 1: Organic and bio-organic chemistry", JOURNAL OF THE CHEMICAL SOCIETY, no. 9, 1989, pages 1577 - 1584 *
DATABASE CAPLUS [online] accession no. STN Database accession no. 1990:177581 *

Also Published As

Publication number Publication date
WO2005002514A2 (en) 2005-01-13

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