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WO2005085867A3 - Screening method for emulators of neural activity and digestive system using gpr35 - Google Patents

Screening method for emulators of neural activity and digestive system using gpr35 Download PDF

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Publication number
WO2005085867A3
WO2005085867A3 PCT/IB2005/000382 IB2005000382W WO2005085867A3 WO 2005085867 A3 WO2005085867 A3 WO 2005085867A3 IB 2005000382 W IB2005000382 W IB 2005000382W WO 2005085867 A3 WO2005085867 A3 WO 2005085867A3
Authority
WO
WIPO (PCT)
Prior art keywords
gpr35
screening method
receptor
emulators
digestive system
Prior art date
Application number
PCT/IB2005/000382
Other languages
French (fr)
Other versions
WO2005085867A2 (en
WO2005085867A8 (en
Inventor
Yasuhito Taniguchi
Hiroko Kachi
Kimihiko Tomotoshi
Katsuhiro Shinjo
Tohru Komada
Original Assignee
Pfizer Japan Inc
Pfizer
Yasuhito Taniguchi
Hiroko Kachi
Kimihiko Tomotoshi
Katsuhiro Shinjo
Tohru Komada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Japan Inc, Pfizer, Yasuhito Taniguchi, Hiroko Kachi, Kimihiko Tomotoshi, Katsuhiro Shinjo, Tohru Komada filed Critical Pfizer Japan Inc
Priority to EP05702505A priority Critical patent/EP1720530A2/en
Priority to CA002558721A priority patent/CA2558721A1/en
Publication of WO2005085867A2 publication Critical patent/WO2005085867A2/en
Publication of WO2005085867A3 publication Critical patent/WO2005085867A3/en
Publication of WO2005085867A8 publication Critical patent/WO2005085867A8/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention primarily relates to function analysis of GPR35, an orphan GPCR (G protein coupled receptor), a screening method to identify modulators (agonists/antagonists) of the receptor, cells stably expressing the receptor, and the discovery of modulators of the receptor. The present invention also relates to novel rat GPR35.
PCT/IB2005/000382 2004-02-27 2005-02-14 Screening method for emulators of neural activity and digestive system using gpr35 WO2005085867A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP05702505A EP1720530A2 (en) 2004-02-27 2005-02-14 Screening method for emulators of neural activity and digestive system using gpr35
CA002558721A CA2558721A1 (en) 2004-02-27 2005-02-14 Screening method for emulators of neural activity and digestive system using gpr35

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54871904P 2004-02-27 2004-02-27
US60/548,719 2004-02-27

Publications (3)

Publication Number Publication Date
WO2005085867A2 WO2005085867A2 (en) 2005-09-15
WO2005085867A3 true WO2005085867A3 (en) 2006-04-20
WO2005085867A8 WO2005085867A8 (en) 2006-06-22

Family

ID=34919394

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/000382 WO2005085867A2 (en) 2004-02-27 2005-02-14 Screening method for emulators of neural activity and digestive system using gpr35

Country Status (3)

Country Link
EP (1) EP1720530A2 (en)
CA (1) CA2558721A1 (en)
WO (1) WO2005085867A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7491699B2 (en) 2002-12-09 2009-02-17 Ramot At Tel Aviv University Ltd. Peptide nanostructures and methods of generating and using the same
WO2006013552A2 (en) 2004-08-02 2006-02-09 Ramot At Tel Aviv University Ltd. Articles of peptide nanostructures and method of forming the same
WO2006018850A2 (en) * 2004-08-19 2006-02-23 Tel Aviv University Future Technology Development L.P. Compositions for treating amyloid associated diseases
US10004828B2 (en) 2005-10-11 2018-06-26 Romat at Tel-Aviv University Ltd. Self-assembled Fmoc-ff hydrogels
US9040583B2 (en) 2009-07-22 2015-05-26 Temple University-Of The Commonwealth System Of Higher Education Treatment of disorders associated with G protein-coupled receptor 35 (GPR35)
US20120022116A1 (en) * 2010-07-20 2012-01-26 Huayun Deng Compositions and methods for the treatment of pathological condition(s) related to gpr35 and/or gpr35-herg complex
WO2020128948A1 (en) * 2018-12-21 2020-06-25 Glycom A/S Composition and method for promoting intestinal barrier healing

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999064452A1 (en) * 1998-06-11 1999-12-16 Smithkline Beecham Corporation Gpr35a receptor
WO2000008155A2 (en) * 1998-08-07 2000-02-17 Incyte Pharmaceuticals, Inc. Human receptor-associated proteins
US6403305B1 (en) * 1997-02-06 2002-06-11 Cornell Research Foundation, Inc. Methods of identifying peptide agonists or negative antagonists of a G protein coupled receptor
WO2002059344A2 (en) * 2000-12-18 2002-08-01 Merck & Co., Inc. Gpr54 g protein-coupled receptor
WO2002061087A2 (en) * 2000-12-19 2002-08-08 Lifespan Biosciences, Inc. Antigenic peptides, such as for g protein-coupled receptors (gpcrs), antibodies thereto, and systems for identifying such antigenic peptides
WO2004040000A2 (en) * 2002-09-09 2004-05-13 Nura, Inc G protein coupled receptors and uses thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6403305B1 (en) * 1997-02-06 2002-06-11 Cornell Research Foundation, Inc. Methods of identifying peptide agonists or negative antagonists of a G protein coupled receptor
WO1999064452A1 (en) * 1998-06-11 1999-12-16 Smithkline Beecham Corporation Gpr35a receptor
WO2000008155A2 (en) * 1998-08-07 2000-02-17 Incyte Pharmaceuticals, Inc. Human receptor-associated proteins
WO2002059344A2 (en) * 2000-12-18 2002-08-01 Merck & Co., Inc. Gpr54 g protein-coupled receptor
WO2002061087A2 (en) * 2000-12-19 2002-08-08 Lifespan Biosciences, Inc. Antigenic peptides, such as for g protein-coupled receptors (gpcrs), antibodies thereto, and systems for identifying such antigenic peptides
WO2004040000A2 (en) * 2002-09-09 2004-05-13 Nura, Inc G protein coupled receptors and uses thereof

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 21 November 2002 (2002-11-21), "Rattus norvegicus clone CH230-unknown, *** SEQUENCING IN PROGRESS ***, 9 unordered pieces.", XP002330589, retrieved from EBI accession no. EM_HTG:AC137209 Database accession no. AC137209 *
DATABASE Geneseq [online] 11 April 2000 (2000-04-11), "Human G-protein coupled receptor GPR35A.", XP002330409, retrieved from EBI accession no. GSP:AAY58645 Database accession no. AAY58645 *
DATABASE Geneseq [online] 29 July 2004 (2004-07-29), "Mouse GPCR GPR35, SEQ ID NO:497.", XP002330410, retrieved from EBI accession no. GSP:ADO29395 Database accession no. ADO29395 *
DATABASE Geneseq [online] 31 May 2000 (2000-05-31), "Human receptor-associated protein from Incyte clone 3083742.", XP002330411, retrieved from EBI accession no. GSP:AAY69989 Database accession no. AAY69989 *
DATABASE Geneseq [online] 4 March 2003 (2003-03-04), "Human G protein-coupled receptor GPR35 protein SEQ ID NO:492.", XP002330412, retrieved from EBI accession no. GSP:ABP82002 Database accession no. ABP82002 *
DATABASE UniProt [online] 1 March 2003 (2003-03-01), "Mus musculus adult male bone cDNA, RIKEN full-length enriched library, clone:9830121M19 product:G protein-coupled receptor 35, full insert sequence.", XP002330588, retrieved from EBI accession no. UNIPROT:Q8CB97 Database accession no. Q8CB97 *
DATABASE UniProt [online] 16 October 2001 (2001-10-16), "Probable G-protein coupled receptor 35.", XP002330587, retrieved from EBI accession no. UNIPROT:GPR35_MOUSE Database accession no. GPR35_MOUSE *

Also Published As

Publication number Publication date
WO2005085867A2 (en) 2005-09-15
CA2558721A1 (en) 2005-09-15
EP1720530A2 (en) 2006-11-15
WO2005085867A8 (en) 2006-06-22

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