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WO2005073404A3 - Functional element of siah-1b responsive p53 - Google Patents

Functional element of siah-1b responsive p53 Download PDF

Info

Publication number
WO2005073404A3
WO2005073404A3 PCT/IB2005/000392 IB2005000392W WO2005073404A3 WO 2005073404 A3 WO2005073404 A3 WO 2005073404A3 IB 2005000392 W IB2005000392 W IB 2005000392W WO 2005073404 A3 WO2005073404 A3 WO 2005073404A3
Authority
WO
WIPO (PCT)
Prior art keywords
functional element
siah
responsive
methods
neurodegenerative disorder
Prior art date
Application number
PCT/IB2005/000392
Other languages
French (fr)
Other versions
WO2005073404A2 (en
Inventor
Robert Amson
Adam Telerman
Original Assignee
Molecular Engines Lab
Robert Amson
Adam Telerman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Engines Lab, Robert Amson, Adam Telerman filed Critical Molecular Engines Lab
Publication of WO2005073404A2 publication Critical patent/WO2005073404A2/en
Publication of WO2005073404A3 publication Critical patent/WO2005073404A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A functional element of siah-lb that directly interacts with p53 is discloses. Also disclosed are methods of screening compounds useful in the treatment, prevention or management of cancer or a neurodegenerative disorder based on the interaction between p53 and the functional element, and methods of treating, preventing or managing cancer or a neurodegenerative disorder using the compounds so screened.
PCT/IB2005/000392 2004-01-29 2005-01-28 Functional element of siah-1b responsive p53 WO2005073404A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53974604P 2004-01-29 2004-01-29
US60/539,746 2004-01-29

Publications (2)

Publication Number Publication Date
WO2005073404A2 WO2005073404A2 (en) 2005-08-11
WO2005073404A3 true WO2005073404A3 (en) 2005-10-20

Family

ID=34826123

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/000392 WO2005073404A2 (en) 2004-01-29 2005-01-28 Functional element of siah-1b responsive p53

Country Status (1)

Country Link
WO (1) WO2005073404A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002002819A1 (en) * 2000-06-30 2002-01-10 University Of Utah Research Foundation Method of screening for chemotherapeutic treatments for cancer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002002819A1 (en) * 2000-06-30 2002-01-10 University Of Utah Research Foundation Method of screening for chemotherapeutic treatments for cancer

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
AMSON R B ET AL: "ISOLATION OF 10 DIFFERENTIALLY EXPRESSED CNDAS IN P53-INDUCED APOPTOSIS: ACTIVATION OF THE VERTEBRATE HOMOLOGUE OF THE DROSOPHILA SEVEN IN ABSENTIA GENE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 93, no. 9, 30 April 1996 (1996-04-30), pages 3953 - 3957, XP002032914, ISSN: 0027-8424 *
DATABASE ENSEMBLE [online] XP002335757, retrieved from ENSEMBLE.ORG Database accession no. ENSMUSG00000040749 *
DELLA N G ET AL: "ISOLATION AND CHARACTERISATION OF MURINE HOMOLOGUES OF THE DROSOPHILA SEVEN IN ABSENTIA GENE (SINA)", DEVELOPMENT, COMPANY OF BIOLOGISTS, CAMBRIDGE,, GB, vol. 117, 1993, pages 1333 - 1343, XP000601972, ISSN: 0950-1991 *
FIUCCI GIUSY ET AL: "Siah-1b is a direct transcriptional target of p53: Identification of the functional p53 responsive element in the siah-1b promoter.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 101, no. 10, 9 March 2004 (2004-03-09), pages 3510 - 3515, XP002335752, ISSN: 0027-8424 *
MAEDA A ET AL: "The characterization of the human Siah-1 promoter<1>", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 512, no. 1-3, 13 February 2002 (2002-02-13), pages 223 - 226, XP004341382, ISSN: 0014-5793 *

Also Published As

Publication number Publication date
WO2005073404A2 (en) 2005-08-11

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