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WO2005046561A3 - Mehrschichtige arzneiform mit einer die abgabe einer modulatorischen substanz beeinflussenden matrix - Google Patents

Mehrschichtige arzneiform mit einer die abgabe einer modulatorischen substanz beeinflussenden matrix Download PDF

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Publication number
WO2005046561A3
WO2005046561A3 PCT/EP2004/010300 EP2004010300W WO2005046561A3 WO 2005046561 A3 WO2005046561 A3 WO 2005046561A3 EP 2004010300 W EP2004010300 W EP 2004010300W WO 2005046561 A3 WO2005046561 A3 WO 2005046561A3
Authority
WO
WIPO (PCT)
Prior art keywords
substance
optionally
matrix
dosage form
modulatory
Prior art date
Application number
PCT/EP2004/010300
Other languages
English (en)
French (fr)
Other versions
WO2005046561A2 (de
Inventor
Rosario Lizio
Hans-Ulrich Petereit
Manfred Assmus
Hema Ravishankar
Original Assignee
Roehm Gmbh
Rosario Lizio
Hans-Ulrich Petereit
Manfred Assmus
Hema Ravishankar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roehm Gmbh, Rosario Lizio, Hans-Ulrich Petereit, Manfred Assmus, Hema Ravishankar filed Critical Roehm Gmbh
Priority to US10/573,019 priority Critical patent/US20070042045A1/en
Priority to EP04765214A priority patent/EP1682094A2/de
Priority to JP2006538672A priority patent/JP2007510677A/ja
Priority to BRPI0416492-0A priority patent/BRPI0416492A/pt
Priority to CA002544487A priority patent/CA2544487A1/en
Publication of WO2005046561A2 publication Critical patent/WO2005046561A2/de
Publication of WO2005046561A3 publication Critical patent/WO2005046561A3/de
Priority to IL175562A priority patent/IL175562A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Die Erfindung betrifft eine mehrschichtige Arzneiform für die kontrollierte Wirkstofffreisetzung, enthaltend im wesentlichen a) optional einen neutralen Kern (Nonpareilles), b) eine innere Kontrollschicht, enthaltend eine modulatorisch wirkende Substanz, die in eine die Abgabe der modulatorischen Substanz beeinflussende Matrix eingebettet ist, die pharmazeutisch verwendbare - Polymere, Wachse, Harze und/oder Proteine sowie gegebenenfalls einen Wirkstoff enthält, c) eine Wirkstoffschicht, enthaltend einen pharmazeutischen Wirkstoff und gegebenenfalls eine modulatorisch wirkende Substanz, d) eine äussere Kontrollschicht, enthaltend zu mindestens 60 Gew.-% ein oder eine Mischung aus mehreren (Meth)acrylatcopolymeren, aus 98 bis 85 C1,- bis C4-Alkylestern der (Meth)acrylsäure und 2 bis 15 Gew.-% Methacrylatmonomeren mit einer quaternären Ammoniumgruppe im Alkylrest, und gegebenenfalls bis zu 40 Gew.-% weitere pharmazeutisch verwendbare Polymere, wobei die Schichten zusätzlich und in an sich bekannter Weise pharmazeutisch übliche Hilfsstoffe enthalten können.
PCT/EP2004/010300 2003-11-13 2004-09-15 Mehrschichtige arzneiform mit einer die abgabe einer modulatorischen substanz beeinflussenden matrix WO2005046561A2 (de)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US10/573,019 US20070042045A1 (en) 2003-11-13 2004-09-15 Multilayer dosage form comprising a matrix that influences release of a modulatory substance
EP04765214A EP1682094A2 (de) 2003-11-13 2004-09-15 Mehrschichtige arzneiform mit einer die abgabe einer modulatorischen substanz beeinflussenden matrix
JP2006538672A JP2007510677A (ja) 2003-11-13 2004-09-15 調節性の物質の放出に影響を及ぼすマトリックスを有する多層の剤形
BRPI0416492-0A BRPI0416492A (pt) 2003-11-13 2004-09-15 forma farmacêutica multicamadas com uma matriz a qual influencia a distribuição de uma substáncia modulatória
CA002544487A CA2544487A1 (en) 2003-11-13 2004-09-15 Multilayer pharmaceutical form with a matrix which influences the delivery of a modulatory substance
IL175562A IL175562A0 (en) 2003-11-13 2006-05-11 Multilayer dosage form comprising a matrix that influences release of a modulatory substance

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10353196A DE10353196A1 (de) 2003-11-13 2003-11-13 Mehrschichtige Arzneiform mit einer die Abgabe einer modulatorischen Substanz beeinflussenden Matrix
DE10353196.3 2003-11-13

Publications (2)

Publication Number Publication Date
WO2005046561A2 WO2005046561A2 (de) 2005-05-26
WO2005046561A3 true WO2005046561A3 (de) 2006-03-16

Family

ID=34585091

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/010300 WO2005046561A2 (de) 2003-11-13 2004-09-15 Mehrschichtige arzneiform mit einer die abgabe einer modulatorischen substanz beeinflussenden matrix

Country Status (10)

Country Link
US (1) US20070042045A1 (de)
EP (1) EP1682094A2 (de)
JP (1) JP2007510677A (de)
KR (1) KR20060113728A (de)
CN (1) CN1863516A (de)
BR (1) BRPI0416492A (de)
CA (1) CA2544487A1 (de)
DE (1) DE10353196A1 (de)
IL (1) IL175562A0 (de)
WO (1) WO2005046561A2 (de)

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DE102004036437A1 (de) 2004-07-27 2006-03-23 Röhm GmbH & Co. KG Multipartikuläre Arzneiform für wenig lösliche Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform
DE102004059792A1 (de) * 2004-12-10 2006-06-14 Röhm GmbH & Co. KG Multipartikuläre Arzneiform, enthaltend mucoadhaesiv formulierte Nukleinsäure-Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform
DE102005007059A1 (de) 2005-02-15 2006-08-24 Röhm GmbH & Co. KG Teilneutralisiertes anionisches (Meth)acrylat-Copolymer
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Also Published As

Publication number Publication date
JP2007510677A (ja) 2007-04-26
CA2544487A1 (en) 2005-05-26
CN1863516A (zh) 2006-11-15
BRPI0416492A (pt) 2007-03-13
EP1682094A2 (de) 2006-07-26
IL175562A0 (en) 2008-04-13
KR20060113728A (ko) 2006-11-02
DE10353196A1 (de) 2005-06-16
WO2005046561A2 (de) 2005-05-26
US20070042045A1 (en) 2007-02-22

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