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WO2004035783A3 - Protein complexes of the tumor-necrosis-factor-alpha (tnf-alpha) signalling pathway - Google Patents

Protein complexes of the tumor-necrosis-factor-alpha (tnf-alpha) signalling pathway Download PDF

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Publication number
WO2004035783A3
WO2004035783A3 PCT/EP2003/050655 EP0350655W WO2004035783A3 WO 2004035783 A3 WO2004035783 A3 WO 2004035783A3 EP 0350655 W EP0350655 W EP 0350655W WO 2004035783 A3 WO2004035783 A3 WO 2004035783A3
Authority
WO
WIPO (PCT)
Prior art keywords
alpha
complexes
tnf
signalling pathway
tumor
Prior art date
Application number
PCT/EP2003/050655
Other languages
French (fr)
Other versions
WO2004035783A2 (en
WO2004035783A9 (en
Inventor
Tewis Bouwmeester
Bettina Huhse
Angela Bauch
Heinz Ruffner
Andreas Bauer
Bernhard Kuester
Giulio Superti-Furga
Ulrich Kruse
Original Assignee
Cellzome Ag
Tewis Bouwmeester
Bettina Huhse
Angela Bauch
Heinz Ruffner
Andreas Bauer
Bernhard Kuester
Giulio Superti-Furga
Ulrich Kruse
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP20020021809 external-priority patent/EP1403282A1/en
Application filed by Cellzome Ag, Tewis Bouwmeester, Bettina Huhse, Angela Bauch, Heinz Ruffner, Andreas Bauer, Bernhard Kuester, Giulio Superti-Furga, Ulrich Kruse filed Critical Cellzome Ag
Priority to AU2003298261A priority Critical patent/AU2003298261A1/en
Publication of WO2004035783A2 publication Critical patent/WO2004035783A2/en
Publication of WO2004035783A9 publication Critical patent/WO2004035783A9/en
Publication of WO2004035783A3 publication Critical patent/WO2004035783A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4718—Cytokine-induced proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/525—Tumor necrosis factor [TNF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention relates to the protein complexes of the Tumor necrosis factor -α- (TNF-α)-signalling pathway. component proteins of the said complexes, fragments and derivatives of the component proteins, and antibodies specific to the complexes. The present invention also relates to methods for use of the complexes of the TNF-α-signalling pathway and their interaction in, inter alia, screening, diagnosis, and therapy, as well as to methods of preparing the complexes. Furthermore the invention relates to siRNA-oligonucleotides having a significant effect on the expression of the proteins of the complexes of the invention.
PCT/EP2003/050655 2002-09-26 2003-09-24 Protein complexes of the tumor-necrosis-factor-alpha (tnf-alpha) signalling pathway WO2004035783A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003298261A AU2003298261A1 (en) 2002-09-26 2003-09-24 Protein complexes of the tumor-necrosis-factor-alpha (tnf-alpha) signalling pathway

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP20020021809 EP1403282A1 (en) 2002-09-26 2002-09-26 Protein complexes of the Tumor necrosis factor-alpha (TNF-alpha) signalling pathway
EP02021809.5 2002-09-26
EP03100274 2003-02-10
EP03100274.4 2003-05-07

Publications (3)

Publication Number Publication Date
WO2004035783A2 WO2004035783A2 (en) 2004-04-29
WO2004035783A9 WO2004035783A9 (en) 2004-09-30
WO2004035783A3 true WO2004035783A3 (en) 2004-11-11

Family

ID=32109134

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/050655 WO2004035783A2 (en) 2002-09-26 2003-09-24 Protein complexes of the tumor-necrosis-factor-alpha (tnf-alpha) signalling pathway

Country Status (2)

Country Link
AU (1) AU2003298261A1 (en)
WO (1) WO2004035783A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005054284A2 (en) * 2003-11-28 2005-06-16 Medical Research Council Regulation involving abin-2
CN101925612A (en) * 2007-11-27 2010-12-22 维文蒂阿生物技术公司 At antibody of the epi-position of the relevant NFKBIB variant of cancer and uses thereof
EP3304084B1 (en) 2015-06-08 2022-03-23 Arquer Diagnostics Limited Methods and kits
US11519916B2 (en) 2015-06-08 2022-12-06 Arquer Diagnostics Limited Methods for analysing a urine sample
CN114878833A (en) * 2021-07-01 2022-08-09 浙江大学 Kit for detecting anti-peroxiredoxin-1-IgG antibody

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999044626A1 (en) * 1998-03-05 1999-09-10 Tularik Inc. Suppressors of death domains

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999044626A1 (en) * 1998-03-05 1999-09-10 Tularik Inc. Suppressors of death domains

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DENG L ET AL: "Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 103, no. 2, 13 October 2000 (2000-10-13), pages 351 - 361, XP002232447, ISSN: 0092-8674 *
JIANG Y ET AL: "Prevention of constitutive TNF receptor 1 signaling by silencer of death domains", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 283, no. 5401, 22 January 1999 (1999-01-22), pages 543 - 546, XP002232446, ISSN: 0036-8075 *
LEE JUSTINE C ET AL: "DEDD regulates degradation of intermediate filaments during apoptosis", JOURNAL OF CELL BIOLOGY, vol. 158, no. 6, 16 September 2002 (2002-09-16), &, pages 1051 - 1066, XP002274488, ISSN: 0021-9525 *
LOCKSLEY R M ET AL: "THE TNF AND TNF RECEPTOR SUPERFAMILIES: INTEGRATING MAMMALIAN BIOLOGY", CELL, CELL PRESS, CAMBRIDGE, NA, US, vol. 104, 23 February 2001 (2001-02-23), pages 487 - 501, XP002951130, ISSN: 0092-8674 *
SAKURAI HIROAKI ET AL: "Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 278, no. 38, 19 September 2003 (2003-09-19), &, pages 36916 - 36923, XP002274489, ISSN: 0021-9258 *
VAN HUFFEL S ET AL: "Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 276, no. 32, 10 August 2001 (2001-08-10), pages 30216 - 30223, XP002955138, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
WO2004035783A2 (en) 2004-04-29
AU2003298261A1 (en) 2004-05-04
AU2003298261A8 (en) 2004-05-04
WO2004035783A9 (en) 2004-09-30

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