WO2004017979A2 - Medicament, food supplement, and fodder additive - Google Patents
Medicament, food supplement, and fodder additive Download PDFInfo
- Publication number
- WO2004017979A2 WO2004017979A2 PCT/EP2003/009068 EP0309068W WO2004017979A2 WO 2004017979 A2 WO2004017979 A2 WO 2004017979A2 EP 0309068 W EP0309068 W EP 0309068W WO 2004017979 A2 WO2004017979 A2 WO 2004017979A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- medicament
- feed additive
- additive according
- food supplement
- prebiotics
- Prior art date
Links
- 235000015872 dietary supplement Nutrition 0.000 title claims abstract description 23
- 239000003814 drug Substances 0.000 title claims abstract description 17
- 239000000654 additive Substances 0.000 title abstract 2
- 230000000996 additive effect Effects 0.000 title abstract 2
- 235000013406 prebiotics Nutrition 0.000 claims abstract description 23
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 15
- 229920001202 Inulin Polymers 0.000 claims description 18
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims description 18
- 229940029339 inulin Drugs 0.000 claims description 18
- 239000003674 animal food additive Substances 0.000 claims description 17
- 235000006708 antioxidants Nutrition 0.000 claims description 14
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- FVVCFHXLWDDRHG-UPLOTWCNSA-N (2s,3r,4s,5r,6r)-2-[(2r,3s,4r,5r,6r)-6-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](CO)O1 FVVCFHXLWDDRHG-UPLOTWCNSA-N 0.000 claims description 2
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- the present invention relates to a pharmaceutical, a food supplement and a feed additive.
- Prebiotics are non-digestible food components that have a beneficial effect on the growth and activity of individual or a limited number of (positive) intestinal bacteria and thus improve human or animal health.
- Prebiotics change the intestinal microflora by influencing the intestinal milieu, not by oral bacteria.
- Prebiotics are neither hydrolyzed nor absorbed in the upper area of the margin-intestinal tract. They are available in the large intestine as a fermentable substrate or as a growth substance for individual bacterial strains. These bacterial strains include Lactobacillii, Bifidobacteria and Eubacteria, which have health-promoting properties.
- prebiotics In contrast to fiber such as starch, hemicelluloses, pectin and plant gums, prebiotics have a specificity for health-promoting bacteria, while common dietary fibers can also promote growth and metabolic activity of potentially harmful germs.
- Typical prebiotics are fructooligosaccharides such as inulin and oligofructose, some synthetic galactose-containing oiigosaccharides and soybean oiigosaccharides.
- Inulin consists of a mixture of different fructose chains, the shorter chain fraction is called oligofructose. Inulin occurs in over 36,000 plant species, some of which are also used for human consumption. For example, chicory contains 15 to 20% inulin and oligofructose, garlic 9 to 16%, wheat 1 to 4%, Jerusalem artichoke 16 to 20%, leek 3 to 10%, rye 0.5 to 1 %, in asparagus 1 to 30%, in onions 2 to 6% and in bananas 0.3 to 0.7%.
- inulin is obtained commercially from chicory roots.
- Other commercially available fructooligosaccharides are enzymatically synthesized from sucrose.
- Inulin is glucose-free and indigestible in the human small intestine.
- fructooligosaccharides are fermented microbially to short-chain fatty acids, especially to acetate, propionate, butyrate and L-lactic acid.
- inulin is used for solid and liquid preparations in order to influence viscosity, freezing point, liquid content, color and emulsifiability of foods as well as gel formation and yellowing.
- Inulin is very hygroscopic.
- the hygroscopicity has the disadvantage that the preparation, for example a beverage powder, clumps after a short time.
- the object of the present invention was to provide a more manageable inulin without losing its health-promoting properties.
- the invention therefore relates, on the one hand, to a dietary supplement or pharmaceutical containing antioxidants of plant origin and prebiotics.
- the prebiotics used according to the invention can be poly- or oligosaccharides which are of vegetable, synthetic and / or fermentative origin. Particularly preferred prebiotics are selected from the group consisting of fructooligosaccharides, inulin, oligofructose, galactooligosaccharides, transgalactosyloligosaccharides (TOS), lactulose, lactosucrose, glucooligosaccharides (GOS), xylooligosaccharide / Ixomaccharide (XOSaccharide), gentosolcharide (XOSaccharide), gentosolcharide (XOSaccharide), and XOS oligosaccharide (XOSaccharide) maltooligosaccharides.
- the antioxidants used according to the invention are of vegetable origin, and preferably components of plant extracts from grape seeds and extracts from lamiaceae, in particular rosemary.
- the antioxidants used according to the invention preferably originate from the substance classes of proanthocyanidins, anthocyanins, polyphenols, phenolic acids, flavonoids, protease inhibitors, sulfides, carotenoids, ascorbates, lignans, quinones and / or selenium compounds. Mixtures can also be used.
- the agent according to the invention preferably contains about 5 to 20% by weight of antioxidants and 75 to 90% by weight of prebiotics.
- the ratio of the weights of antioxidants to prebiotics is preferably between 1:20 and 1: 3, preferably between 1:15 and 1: 5, even more preferably between 1:12 and 1: 8.
- the product according to the invention is preferably free from probiotics, in particular probiotic bacterial strains, since these can negatively influence the shelf life of the product.
- the agent according to the invention can contain further substances, in particular from the group of pharmaceutical formulation auxiliaries and / or biologically active substances.
- Typical formulation auxiliaries are, for example, silicon dioxide, dicalci umphosphate, maltodextrin, cellulose derivatives such as microcrystalline cellulose (MCC), etc.
- Typical other active substances are plant substances without an antioxidative and / or prebiotic effect, for example substances with an anti-inflammatory effect such as ginger and cardamon extract or oil, as well as medicinal and silica.
- the preparation is obtained by a special manufacturing process (cf. WO 03/09515, with priority among others EP 02 000 740.7).
- the prebiotic is spray-dried, while the antioxidants and optionally formulation aids are added in dry form.
- the prebiotic is coated with a layer of the antioxidants.
- the agent according to the invention is suitable both for the therapy of gastrointestinal complaints, in particular inflammatory processes, such as e.g. Colitis, Crohn's disease, ulcerative colitis, etc., as well as a prophylactic agent, and can e.g. as a food supplement or in the veterinary field as a feed additive, and here, for example, in horses for the treatment and prevention of colic, in the rearing of calves and piglets for the prevention of diarrhea.
- gastrointestinal complaints in particular inflammatory processes, such as e.g. Colitis, Crohn's disease, ulcerative colitis, etc.
- a prophylactic agent can e.g. as a food supplement or in the veterinary field as a feed additive, and here, for example, in horses for the treatment and prevention of colic, in the rearing of calves and piglets for the prevention of diarrhea.
- Another object of the invention is a composition containing inulin and components of plant extracts from grape seeds and / or rosemary, optionally together with the above-mentioned probiotic components or the other substances, in particular in connection with ginger extract or healing earth.
- the dry product can be filled into hard gelatin capsules as a food supplement.
- Example 1 80 kg of dry product from Example 1 are mixed with 20 kg of rosemary extract and mixed with 10% silicified microcrystalline ceilulose (MCC) ProSolv ® , compacted. The granulate is filled into hard gelatin capsules and marketed as a dietary supplement.
- MCC microcrystalline ceilulose
- inulin spray solution with 42% dry matter 300 kg are spray dried at 210 ° C air inlet temperature and 40 bar nozzle pressure.
- 12.6 kg of grape seed extract, 6.3 kg of rosemary extract and 126 kg of silica are powdered into the dryer.
- 259 kg of dry product are obtained.
- 247 kg of dry product are mixed with 2.5 kg of ginger extract and 0.5 kg of caramon oil.
- the end product is used as a feed additive in horses for the prevention and treatment of colic.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Birds (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003266285A AU2003266285A1 (en) | 2002-08-16 | 2003-08-15 | Medicament, food supplement, and fodder additive |
EP03792330A EP1530479A2 (en) | 2002-08-16 | 2003-08-15 | Medicament, food supplement, and fodder additive |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02018416.4 | 2002-08-16 | ||
EP02018416 | 2002-08-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004017979A2 true WO2004017979A2 (en) | 2004-03-04 |
WO2004017979A3 WO2004017979A3 (en) | 2004-04-22 |
Family
ID=31896834
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2003/009068 WO2004017979A2 (en) | 2002-08-16 | 2003-08-15 | Medicament, food supplement, and fodder additive |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1530479A2 (en) |
AU (1) | AU2003266285A1 (en) |
PL (1) | PL373549A1 (en) |
WO (1) | WO2004017979A2 (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006055711A1 (en) * | 2004-11-18 | 2006-05-26 | Kent Hann | Compositions containing aloe vera isolate and a prebiotic and their therapeutic application |
EP1887017A1 (en) * | 2006-08-09 | 2008-02-13 | Friesland Brands B.V. | Prebiotic carbohydrate |
RU2473680C2 (en) * | 2011-03-17 | 2013-01-27 | Общество с ограниченной ответственностью "Альбит" | Selenium-containing complex of trace elements |
US20160051626A1 (en) * | 2013-03-28 | 2016-02-25 | Novintethical Pharma Sa | Compositions comprising complexes of proanthocyanidins with vegetable proteins |
US9539344B2 (en) | 2014-09-30 | 2017-01-10 | Kimberly-Clark Worldwide, Inc. | Creped prebiotic tissue |
IT201600115007A1 (en) * | 2016-11-15 | 2018-05-15 | Frabes S P A | FOOD COMPOSITIONS, THEIR USES AND PROCEDURES FOR THEIR PREPARATION |
US10441603B2 (en) | 2014-09-30 | 2019-10-15 | Kimberly-Clark Worldwide, Inc. | Synergistic prebiotic composition |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996003150A1 (en) * | 1994-07-21 | 1996-02-08 | The University Of Montana | Compositions containing hemicelluloses and polyphenols for treating gastrointestinal disorders |
WO1999007239A1 (en) * | 1997-07-25 | 1999-02-18 | Oy Borago Ab | Functional food preparate |
US20010041187A1 (en) * | 1998-10-20 | 2001-11-15 | Carl W Hastings | Performance-enhancing dietary supplement |
US20010046523A1 (en) * | 2000-02-25 | 2001-11-29 | Thomas Newmark | Ginger-based herbal composition for promoting health and methods of using same |
WO2002039834A1 (en) * | 2000-11-14 | 2002-05-23 | Societe Des Produits Nestle S.A. | Nutritional composition for an immune condition |
DE20202562U1 (en) * | 2002-02-19 | 2002-05-23 | Orthomol pharmazeutische Vertriebs GmbH, 40764 Langenfeld | Micronutrient combination product with probiotics and prebiotics |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2161894C1 (en) * | 1999-08-10 | 2001-01-20 | НИФ "Ультрасан" | Treatment-and-prophylactic composition |
-
2003
- 2003-08-15 PL PL03373549A patent/PL373549A1/en unknown
- 2003-08-15 EP EP03792330A patent/EP1530479A2/en not_active Withdrawn
- 2003-08-15 AU AU2003266285A patent/AU2003266285A1/en not_active Abandoned
- 2003-08-15 WO PCT/EP2003/009068 patent/WO2004017979A2/en not_active Application Discontinuation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996003150A1 (en) * | 1994-07-21 | 1996-02-08 | The University Of Montana | Compositions containing hemicelluloses and polyphenols for treating gastrointestinal disorders |
WO1999007239A1 (en) * | 1997-07-25 | 1999-02-18 | Oy Borago Ab | Functional food preparate |
US20010041187A1 (en) * | 1998-10-20 | 2001-11-15 | Carl W Hastings | Performance-enhancing dietary supplement |
US20010046523A1 (en) * | 2000-02-25 | 2001-11-29 | Thomas Newmark | Ginger-based herbal composition for promoting health and methods of using same |
WO2002039834A1 (en) * | 2000-11-14 | 2002-05-23 | Societe Des Produits Nestle S.A. | Nutritional composition for an immune condition |
DE20202562U1 (en) * | 2002-02-19 | 2002-05-23 | Orthomol pharmazeutische Vertriebs GmbH, 40764 Langenfeld | Micronutrient combination product with probiotics and prebiotics |
Non-Patent Citations (1)
Title |
---|
DATABASE WPI Section Ch, Week 200127 Derwent Publications Ltd., London, GB; Class B04, AN 2001-264614 XP002268125 DUBININ A V: "Treatment and prophylactic composition" & RU 2 161 894 C (ULTRASAN RES FIRM), 20. Januar 2001 (2001-01-20) * |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006055711A1 (en) * | 2004-11-18 | 2006-05-26 | Kent Hann | Compositions containing aloe vera isolate and a prebiotic and their therapeutic application |
EP1887017A1 (en) * | 2006-08-09 | 2008-02-13 | Friesland Brands B.V. | Prebiotic carbohydrate |
RU2473680C2 (en) * | 2011-03-17 | 2013-01-27 | Общество с ограниченной ответственностью "Альбит" | Selenium-containing complex of trace elements |
US20160051626A1 (en) * | 2013-03-28 | 2016-02-25 | Novintethical Pharma Sa | Compositions comprising complexes of proanthocyanidins with vegetable proteins |
US9901613B2 (en) | 2013-03-28 | 2018-02-27 | Novintethical Pharma Sa | Compositions comprising complexes of proanthocyanidins with pea proteins |
US9539344B2 (en) | 2014-09-30 | 2017-01-10 | Kimberly-Clark Worldwide, Inc. | Creped prebiotic tissue |
US9744248B2 (en) | 2014-09-30 | 2017-08-29 | Kimberly-Clark Worldwide, Inc. | Creped prebiotic tissue |
US10441603B2 (en) | 2014-09-30 | 2019-10-15 | Kimberly-Clark Worldwide, Inc. | Synergistic prebiotic composition |
IT201600115007A1 (en) * | 2016-11-15 | 2018-05-15 | Frabes S P A | FOOD COMPOSITIONS, THEIR USES AND PROCEDURES FOR THEIR PREPARATION |
EP3320786A1 (en) * | 2016-11-15 | 2018-05-16 | Frabes S.p.A. | Food compositions, their uses and process for their preparation |
Also Published As
Publication number | Publication date |
---|---|
AU2003266285A1 (en) | 2004-03-11 |
PL373549A1 (en) | 2005-09-05 |
AU2003266285A8 (en) | 2004-03-11 |
WO2004017979A3 (en) | 2004-04-22 |
EP1530479A2 (en) | 2005-05-18 |
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