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WO2004053140A3 - Modulators (inhibitors/activators) of histone acetyltransferases - Google Patents

Modulators (inhibitors/activators) of histone acetyltransferases Download PDF

Info

Publication number
WO2004053140A3
WO2004053140A3 PCT/IN2003/000389 IN0300389W WO2004053140A3 WO 2004053140 A3 WO2004053140 A3 WO 2004053140A3 IN 0300389 W IN0300389 W IN 0300389W WO 2004053140 A3 WO2004053140 A3 WO 2004053140A3
Authority
WO
WIPO (PCT)
Prior art keywords
modulators
activators
inhibitors
histone acetyltransferases
cancer
Prior art date
Application number
PCT/IN2003/000389
Other languages
French (fr)
Other versions
WO2004053140A2 (en
Inventor
Tapas Kumar Kundu
Karanam Balasubramanyam
Venkatesh Swaminathan
Original Assignee
Jawaharlal Nehru Ct For Advanc
Tapas Kumar Kundu
Karanam Balasubramanyam
Venkatesh Swaminathan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jawaharlal Nehru Ct For Advanc, Tapas Kumar Kundu, Karanam Balasubramanyam, Venkatesh Swaminathan filed Critical Jawaharlal Nehru Ct For Advanc
Priority to US10/538,328 priority Critical patent/US7332629B2/en
Priority to AU2003288705A priority patent/AU2003288705A1/en
Priority to EP03780608A priority patent/EP1590318A2/en
Publication of WO2004053140A2 publication Critical patent/WO2004053140A2/en
Publication of WO2004053140A3 publication Critical patent/WO2004053140A3/en
Priority to US11/959,938 priority patent/US7750047B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/64—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention provides the use of certain benzoic acid and benzamide compounds as modulators of enzymes histone acetyltransferases, which are involved in gene expression and cancer and also use of such compounds in the treatment of diseases due to defects in gene regulation predominantly cancer.
PCT/IN2003/000389 2002-12-12 2003-12-12 Modulators (inhibitors/activators) of histone acetyltransferases WO2004053140A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US10/538,328 US7332629B2 (en) 2002-12-12 2003-12-12 Modulators (inhibitors/activators) of histone acetyltransferases
AU2003288705A AU2003288705A1 (en) 2002-12-12 2003-12-12 Modulators (inhibitors/activators) of histone acetyltransferases
EP03780608A EP1590318A2 (en) 2002-12-12 2003-12-12 Modulators (inhibitors/activators) of histone acetyltransferases
US11/959,938 US7750047B2 (en) 2002-12-12 2007-12-19 Modulators (inhibitors/activators) of histone acetyltransferases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN925/MAS/2002 2002-12-12
IN925CH2002 2002-12-12

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10538328 A-371-Of-International 2003-12-12
US11/959,938 Division US7750047B2 (en) 2002-12-12 2007-12-19 Modulators (inhibitors/activators) of histone acetyltransferases

Publications (2)

Publication Number Publication Date
WO2004053140A2 WO2004053140A2 (en) 2004-06-24
WO2004053140A3 true WO2004053140A3 (en) 2004-09-16

Family

ID=32500462

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2003/000389 WO2004053140A2 (en) 2002-12-12 2003-12-12 Modulators (inhibitors/activators) of histone acetyltransferases

Country Status (2)

Country Link
EP (1) EP1590318A2 (en)
WO (1) WO2004053140A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0613429A2 (en) 2005-07-14 2009-02-10 Takeda San Diego Inc histone deacetylase inhibitors
JP6093180B2 (en) * 2009-12-10 2017-03-08 トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク Histone acetyltransferase activator and use thereof
US10640457B2 (en) 2009-12-10 2020-05-05 The Trustees Of Columbia University In The City Of New York Histone acetyltransferase activators and uses thereof
EP3323813B1 (en) 2010-12-22 2020-08-26 The Trustees of Columbia University in the City of New York Histone acetyltransferase modulators and uses thereof
CA2838844A1 (en) 2011-06-10 2012-12-13 The Trustees Of Columbia University In The City Of New York Uses of histone acetyltransferase activators
EP2841111B1 (en) 2012-04-28 2016-06-01 Jawaharlal Nehru Centre For Advanced Scientific Research A nanosphere - histone acetyltransferase (hat) activator composition, process and methods thereof
CN103752209B (en) * 2014-01-23 2015-05-27 北京工商大学 Cashew nut based amide surfactant and preparation method thereof
CA2944613A1 (en) * 2014-03-31 2015-10-08 The Trustees Of Columbia University In The City Of New York Histone acetyltransferase activators and uses thereof
MX2019000864A (en) 2016-07-20 2019-06-03 Univ Columbia Histone acetyltransferase activators and compositions and uses thereof.
CN108911965A (en) * 2018-08-03 2018-11-30 上海华堇生物技术有限责任公司 The preparation method of 2- methoxy benzoyl chloride
CN109045001A (en) * 2018-09-13 2018-12-21 潘治忠 P300 activator CTPB and its derivative are in the purposes for improving collagen Col17A1 expression
WO2020163731A1 (en) * 2019-02-08 2020-08-13 The Trustees Of Columbia University In The City Of New York Histone acetyltransferase modulators and compositions and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02306916A (en) * 1989-05-22 1990-12-20 Otsuka Pharmaceut Co Ltd Blood platelet adhesion inhibitor
JP2001139550A (en) * 1999-11-17 2001-05-22 Shionogi & Co Ltd New use of amide compound
US6369030B1 (en) * 1999-11-29 2002-04-09 The Rockfeller University Inhibitors of histone acetyltransferases (HATs) and uses thereof
WO2003103655A1 (en) * 2002-06-10 2003-12-18 株式会社医薬分子設計研究所 Therapeutic agent for cancer

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02306916A (en) * 1989-05-22 1990-12-20 Otsuka Pharmaceut Co Ltd Blood platelet adhesion inhibitor
JP2001139550A (en) * 1999-11-17 2001-05-22 Shionogi & Co Ltd New use of amide compound
US6369030B1 (en) * 1999-11-29 2002-04-09 The Rockfeller University Inhibitors of histone acetyltransferases (HATs) and uses thereof
WO2003103655A1 (en) * 2002-06-10 2003-12-18 株式会社医薬分子設計研究所 Therapeutic agent for cancer

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ARCHIV DER PHARMAZIE, vol. 321, no. 7, 1988, WEINHEIM, GERMANY, pages 419 - 422 *
CHEMICAL PAPERS, vol. 55, no. 2, 2001, pages 121 - 129 *
DATABASE CAPLUS [online] HUMM ALFRED W., SCHNEIDER MARTIN R.: "Development of potential nonsteroidal antiandrogens: N-[4-nitro-3-(trifluoromethyl)phenyl]cyclohexanecarboxamides and benzamides and N-(3,4-dichlorophenyl)- and N-(3,4,5-trichlorophenyl)benzamides", XP002903683, accession no. STN Database accession no. 1988:610640 *
DATABASE CAPLUS [online] WAISSER K. ET AL.: "Synthesis and antimycobacterial activity of salicylanilides substituted in position 5", XP002903684, accession no. STN Database accession no. 2001:436058 *

Also Published As

Publication number Publication date
EP1590318A2 (en) 2005-11-02
WO2004053140A2 (en) 2004-06-24

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