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WO2003091421A3 - Methods and systems for the prediction of the biological function of biopolymers - Google Patents

Methods and systems for the prediction of the biological function of biopolymers Download PDF

Info

Publication number
WO2003091421A3
WO2003091421A3 PCT/US2003/008931 US0308931W WO03091421A3 WO 2003091421 A3 WO2003091421 A3 WO 2003091421A3 US 0308931 W US0308931 W US 0308931W WO 03091421 A3 WO03091421 A3 WO 03091421A3
Authority
WO
WIPO (PCT)
Prior art keywords
biopolymer
biochemical properties
function
biopolymers
prediction
Prior art date
Application number
PCT/US2003/008931
Other languages
French (fr)
Other versions
WO2003091421A2 (en
Inventor
Kayvan Najarian
Dean Scott Warren
Original Assignee
Univ North Carolina
Kayvan Najarian
Dean Scott Warren
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina, Kayvan Najarian, Dean Scott Warren filed Critical Univ North Carolina
Priority to AU2003251289A priority Critical patent/AU2003251289A1/en
Publication of WO2003091421A2 publication Critical patent/WO2003091421A2/en
Publication of WO2003091421A3 publication Critical patent/WO2003091421A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/30—Detection of binding sites or motifs
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/99—Isomerases (5.)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Evolutionary Biology (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A method for predicting the function of a biopolymer is disclosed. One method according to the present invention includes determining the biochemical properties of the amino acids, creating a representation of the biopolymer by combining the biochemical properties, and predicting the function of the biopolymer based at least in part on the representation. Many biochemical properties may be relevant to the function of a biopolymer. For example, in one embodiment, hydrophobicity, solubility, and a quantum value are determined for each amino acid. Another method according to the present invention includes determining signal-processing measures for the biopolymer based at least in part on the biochemical properties and classifying the biopolymer based at least in part on the signal-processing measures. These measures may include, for example, fractal dimension, entropy, mobility, and complexity. The biochemical properties may be measured or retrieved from a database.
PCT/US2003/008931 2002-03-25 2003-03-21 Methods and systems for the prediction of the biological function of biopolymers WO2003091421A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003251289A AU2003251289A1 (en) 2002-03-25 2003-03-21 Methods and systems for the prediction of the biological function of biopolymers

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36677802P 2002-03-25 2002-03-25
US60/366,778 2002-03-25

Publications (2)

Publication Number Publication Date
WO2003091421A2 WO2003091421A2 (en) 2003-11-06
WO2003091421A3 true WO2003091421A3 (en) 2004-09-02

Family

ID=29270480

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/008931 WO2003091421A2 (en) 2002-03-25 2003-03-21 Methods and systems for the prediction of the biological function of biopolymers

Country Status (2)

Country Link
AU (1) AU2003251289A1 (en)
WO (1) WO2003091421A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11395594B2 (en) 2008-10-29 2022-07-26 Flashback Technologies, Inc. Noninvasive monitoring for fluid resuscitation
US8512260B2 (en) 2008-10-29 2013-08-20 The Regents Of The University Of Colorado, A Body Corporate Statistical, noninvasive measurement of intracranial pressure
US11857293B2 (en) 2008-10-29 2024-01-02 Flashback Technologies, Inc. Rapid detection of bleeding before, during, and after fluid resuscitation
US11478190B2 (en) 2008-10-29 2022-10-25 Flashback Technologies, Inc. Noninvasive hydration monitoring
US11395634B2 (en) 2008-10-29 2022-07-26 Flashback Technologies, Inc. Estimating physiological states based on changes in CRI
US12201405B2 (en) 2008-10-29 2025-01-21 Flashback Technologies, Inc. Assessing effectiveness of CPR
US11406269B2 (en) 2008-10-29 2022-08-09 Flashback Technologies, Inc. Rapid detection of bleeding following injury
US11382571B2 (en) 2008-10-29 2022-07-12 Flashback Technologies, Inc. Noninvasive predictive and/or estimative blood pressure monitoring
US20110295902A1 (en) * 2010-05-26 2011-12-01 Tata Consultancy Service Limited Taxonomic classification of metagenomic sequences
WO2013016212A1 (en) 2011-07-22 2013-01-31 Flashback Technologies, Inc. Hemodynamic reserve monitor and hemodialysis control
US11918386B2 (en) 2018-12-26 2024-03-05 Flashback Technologies, Inc. Device-based maneuver and activity state-based physiologic status monitoring

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010016314A1 (en) * 1998-10-29 2001-08-23 Stephen Anderson Linking gene sequence to gene function by three dimesional (3d) protein structure determination
US6490532B1 (en) * 1999-01-25 2002-12-03 Mount Sinai Hospital Method to construct protein structures
US6493637B1 (en) * 1997-03-24 2002-12-10 Queen's University At Kingston Coincidence detection method, products and apparatus
US6651008B1 (en) * 1999-05-14 2003-11-18 Cytokinetics, Inc. Database system including computer code for predictive cellular bioinformatics

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6493637B1 (en) * 1997-03-24 2002-12-10 Queen's University At Kingston Coincidence detection method, products and apparatus
US20010016314A1 (en) * 1998-10-29 2001-08-23 Stephen Anderson Linking gene sequence to gene function by three dimesional (3d) protein structure determination
US6490532B1 (en) * 1999-01-25 2002-12-03 Mount Sinai Hospital Method to construct protein structures
US6651008B1 (en) * 1999-05-14 2003-11-18 Cytokinetics, Inc. Database system including computer code for predictive cellular bioinformatics

Also Published As

Publication number Publication date
AU2003251289A1 (en) 2003-11-10
AU2003251289A8 (en) 2003-11-10
WO2003091421A2 (en) 2003-11-06

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