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WO2002022826A3 - Methods and compositions for the construction and use of fusion libraries - Google Patents

Methods and compositions for the construction and use of fusion libraries Download PDF

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Publication number
WO2002022826A3
WO2002022826A3 PCT/US2001/028702 US0128702W WO0222826A3 WO 2002022826 A3 WO2002022826 A3 WO 2002022826A3 US 0128702 W US0128702 W US 0128702W WO 0222826 A3 WO0222826 A3 WO 0222826A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
compositions
construction
fusion libraries
libraries
Prior art date
Application number
PCT/US2001/028702
Other languages
French (fr)
Other versions
WO2002022826A2 (en
Inventor
Min Li
Christian Melander
Hongxiang Liu
Original Assignee
Xencor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xencor Inc filed Critical Xencor Inc
Priority to AU2001294556A priority Critical patent/AU2001294556A1/en
Publication of WO2002022826A2 publication Critical patent/WO2002022826A2/en
Publication of WO2002022826A3 publication Critical patent/WO2002022826A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1075—Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

This invention pertains to genetic libraries encoding enzyme fusion proteins and methods of use to identify a nucleic acid of interest.
PCT/US2001/028702 2000-09-14 2001-09-14 Methods and compositions for the construction and use of fusion libraries WO2002022826A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001294556A AU2001294556A1 (en) 2000-09-14 2001-09-14 Methods and compositions for the construction and use of fusion libraries

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23296000P 2000-09-14 2000-09-14
US60/232,960 2000-09-14

Publications (2)

Publication Number Publication Date
WO2002022826A2 WO2002022826A2 (en) 2002-03-21
WO2002022826A3 true WO2002022826A3 (en) 2003-03-06

Family

ID=22875265

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/028702 WO2002022826A2 (en) 2000-09-14 2001-09-14 Methods and compositions for the construction and use of fusion libraries

Country Status (2)

Country Link
AU (1) AU2001294556A1 (en)
WO (1) WO2002022826A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8852586B2 (en) 2004-11-12 2014-10-07 Xencor, Inc. Fc variants with altered binding to FcRn
US8937158B2 (en) 2003-03-03 2015-01-20 Xencor, Inc. Fc variants with increased affinity for FcγRIIc
US9200079B2 (en) 2004-11-12 2015-12-01 Xencor, Inc. Fc variants with altered binding to FcRn

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030124537A1 (en) * 2000-12-14 2003-07-03 Yuan-Chin Liu Procaryotic libraries and uses
US20020168640A1 (en) * 2001-02-22 2002-11-14 Min Li Biochips comprising nucleic acid/protein conjugates
WO2002068698A2 (en) * 2001-02-22 2002-09-06 Xencor, Inc. Use of nucleic acid libraries to create toxicological profiles
WO2002068453A2 (en) * 2001-02-22 2002-09-06 Xencor Methods and compositions for the construction and use of fusion libraries using computational protein design methods
US8883147B2 (en) 2004-10-21 2014-11-11 Xencor, Inc. Immunoglobulins insertions, deletions, and substitutions
US8399618B2 (en) 2004-10-21 2013-03-19 Xencor, Inc. Immunoglobulin insertions, deletions, and substitutions
US9714282B2 (en) 2003-09-26 2017-07-25 Xencor, Inc. Optimized Fc variants and methods for their generation
AU2004297616B2 (en) 2003-12-04 2008-12-18 Xencor, Inc. Methods of generating variant proteins with increased host string content and compositions thereof
US8716461B2 (en) * 2004-05-24 2014-05-06 Blood Systems, Inc. Human parvovirus
AU2006299429B2 (en) 2005-10-03 2012-02-23 Xencor, Inc. Fc variants with optimized Fc receptor binding properties
CA3147069A1 (en) 2007-12-26 2009-07-09 Xencor, Inc. Fc variants with altered binding to fcrn
WO2011028952A1 (en) 2009-09-02 2011-03-10 Xencor, Inc. Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998037186A1 (en) * 1997-02-18 1998-08-27 Actinova Limited In vitro peptide or protein expression library
US5856090A (en) * 1994-09-09 1999-01-05 The Scripps Research Institute DNA-methylase linking reaction
WO1999054458A1 (en) * 1998-04-17 1999-10-28 Whitehead Institute For Biomedical Research Use of a ribozyme to join nucleic acids and peptides
WO2001014539A2 (en) * 1999-08-20 2001-03-01 Johns Hopkins University School Of Medicine Methods and compositions for the construction and use of fusion libraries

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5856090A (en) * 1994-09-09 1999-01-05 The Scripps Research Institute DNA-methylase linking reaction
WO1998037186A1 (en) * 1997-02-18 1998-08-27 Actinova Limited In vitro peptide or protein expression library
WO1999054458A1 (en) * 1998-04-17 1999-10-28 Whitehead Institute For Biomedical Research Use of a ribozyme to join nucleic acids and peptides
WO2001014539A2 (en) * 1999-08-20 2001-03-01 Johns Hopkins University School Of Medicine Methods and compositions for the construction and use of fusion libraries

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8937158B2 (en) 2003-03-03 2015-01-20 Xencor, Inc. Fc variants with increased affinity for FcγRIIc
US8852586B2 (en) 2004-11-12 2014-10-07 Xencor, Inc. Fc variants with altered binding to FcRn
US8883973B2 (en) 2004-11-12 2014-11-11 Xencor, Inc. Fc variants with altered binding to FcRn
US9200079B2 (en) 2004-11-12 2015-12-01 Xencor, Inc. Fc variants with altered binding to FcRn

Also Published As

Publication number Publication date
AU2001294556A1 (en) 2002-03-26
WO2002022826A2 (en) 2002-03-21

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