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WO2002009702A8 - Use of indole derivatives for the manufacture of a medicament for reducing intracular pressure - Google Patents

Use of indole derivatives for the manufacture of a medicament for reducing intracular pressure

Info

Publication number
WO2002009702A8
WO2002009702A8 PCT/US2001/024220 US0124220W WO0209702A8 WO 2002009702 A8 WO2002009702 A8 WO 2002009702A8 US 0124220 W US0124220 W US 0124220W WO 0209702 A8 WO0209702 A8 WO 0209702A8
Authority
WO
WIPO (PCT)
Prior art keywords
indole derivatives
intraocular pressure
reducing
medicament
manufacture
Prior art date
Application number
PCT/US2001/024220
Other languages
French (fr)
Other versions
WO2002009702A2 (en
WO2002009702A3 (en
Inventor
Jesus J Pintor
Maria A Peral
Ward M Peterson
Robert Plourde Jr
Edward G Brown
Benjamin R Yerxa
Original Assignee
Inspire Pharmaceuticals Inc
Jesus J Pintor
Maria A Peral
Ward M Peterson
Robert Plourde Jr
Edward G Brown
Benjamin R Yerxa
Univ Madrid Complutense
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ES200001916A external-priority patent/ES2172415B2/en
Application filed by Inspire Pharmaceuticals Inc, Jesus J Pintor, Maria A Peral, Ward M Peterson, Robert Plourde Jr, Edward G Brown, Benjamin R Yerxa, Univ Madrid Complutense filed Critical Inspire Pharmaceuticals Inc
Priority to JP2002515255A priority Critical patent/JP2004518612A/en
Priority to MXPA03000729A priority patent/MXPA03000729A/en
Priority to AU2001280984A priority patent/AU2001280984A1/en
Priority to CA002417489A priority patent/CA2417489A1/en
Priority to KR10-2003-7001250A priority patent/KR20030046395A/en
Priority to EP01959427A priority patent/EP1307191A2/en
Publication of WO2002009702A2 publication Critical patent/WO2002009702A2/en
Publication of WO2002009702A3 publication Critical patent/WO2002009702A3/en
Publication of WO2002009702A8 publication Critical patent/WO2002009702A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides a method of reducing intraocular pressure by administering pharmaceutical compositions comprising indole derivatives. The pharmaceutical compositions useful in this invention comprise indole derivatives and melatonin analogs of Formulae (I) (II) (III) (IV). A preferred embodiment is a method of lowering intraocular pressure using 5-(methoxycarbonylamino)-N-acetyltryptamine (5-MCA-NAT), also known as GR 135531, which has a prolonged duration of action and greater efficacy in lowering intraocular pressure compared to melatonin. The present invention further provides a method of treating disorders associated with ocular hypertension, and a method of treating various forms of glaucoma; the method comprises administering an effective dose of a pharmaceutical composition comprising an indole derivative with or without agents commonly used to treat such disorders.
PCT/US2001/024220 2000-07-28 2001-07-27 Use of indole derivatives for the manufacture of a medicament for reducing intracular pressure WO2002009702A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2002515255A JP2004518612A (en) 2000-07-28 2001-07-27 Method for lowering intraocular pressure using indole derivatives
MXPA03000729A MXPA03000729A (en) 2000-07-28 2001-07-27 Method for reducing intraocular pressure using indole derivatives.
AU2001280984A AU2001280984A1 (en) 2000-07-28 2001-07-27 Use of indole derivatives for the manufacture of a medicament for reducing intracular pressure
CA002417489A CA2417489A1 (en) 2000-07-28 2001-07-27 Use of indole derivatives for the manufacture of a medicament for reducing intracular pressure
KR10-2003-7001250A KR20030046395A (en) 2000-07-28 2001-07-27 Method for reducing intraocular pressure using indole derivatives
EP01959427A EP1307191A2 (en) 2000-07-28 2001-07-27 Use of indole derivatives for the manufacture of a medicament for reducing intracular pressure

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ES200001916 2000-07-28
ES200001916A ES2172415B2 (en) 2000-07-28 2000-07-28 TREATMENT OF GLAUCOMA AND OCULAR HYPERTENSION THROUGH A MELATONINE ANALOG.
US27688501P 2001-03-16 2001-03-16
US60/276,885 2001-03-16

Publications (3)

Publication Number Publication Date
WO2002009702A2 WO2002009702A2 (en) 2002-02-07
WO2002009702A3 WO2002009702A3 (en) 2002-12-27
WO2002009702A8 true WO2002009702A8 (en) 2003-05-08

Family

ID=26156193

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/024220 WO2002009702A2 (en) 2000-07-28 2001-07-27 Use of indole derivatives for the manufacture of a medicament for reducing intracular pressure

Country Status (9)

Country Link
EP (1) EP1307191A2 (en)
JP (1) JP2004518612A (en)
KR (1) KR20030046395A (en)
CN (1) CN1450896A (en)
AR (1) AR035651A1 (en)
AU (1) AU2001280984A1 (en)
CA (1) CA2417489A1 (en)
MX (1) MXPA03000729A (en)
WO (1) WO2002009702A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12133842B2 (en) 2012-10-24 2024-11-05 Rayner Intraocular Lenses Limited Stable preservative-free mydriatic and anti-inflammatory solutions for injection

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7084128B2 (en) 2002-01-18 2006-08-01 Inspire Pharmaceuticals, Inc. Method for reducing intraocular pressure
NZ535889A (en) 2002-03-26 2006-03-31 Boehringer Ingelheim Pharma Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
CA2866848C (en) * 2002-07-30 2017-01-03 Omeros Corporation Ophthalmologic irrigation solutions and method
EP1539141B1 (en) * 2002-08-29 2010-07-14 Boehringer Ingelheim Pharmaceuticals Inc. 3-(sulfonamidoethyl)-indole derivatives for use as glucocorticoid mimetics in the treatment of inflammatory, allergic and proliferative diseases
UY28526A1 (en) 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma GLUCOCORTICOID MIMETICS, METHODS OF PREPARATION PHARMACEUTICAL COMPOSITIONS AND USES OF THE SAME
US7795272B2 (en) 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
CA2565545A1 (en) 2004-05-06 2005-12-08 Molichem Medicines, Inc. Treatment of ocular diseases and disorders using lantibiotic compositions
US7326683B2 (en) 2004-05-06 2008-02-05 Molichem Medicines, Inc. Treatment of membrane-associated diseases and disorders using lantibiotic containing compositions
ES2326907T3 (en) 2004-12-27 2009-10-21 Boehringer Ingelheim Pharmaceuticals Inc. GLUCOCORTICOID MIMETICS, METHODS FOR PREPARATION, PHARMACEUTICAL COMPOSITIONS AND USE.
JP2010512331A (en) 2006-12-06 2010-04-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Glucocorticoid mimetics, methods for their production, pharmaceutical compositions, and uses thereof
WO2009029695A1 (en) 2007-08-28 2009-03-05 Baxter International Inc. Method for producing viral vaccines
KR20110020902A (en) 2008-06-06 2011-03-03 베링거 인겔하임 인터내셔날 게엠베하 Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
AU2010321831B2 (en) * 2009-11-23 2016-07-07 Allergan, Inc. 7-[3,5-dihydroxy-2- (3-hydroxy-5-phenyl-pent-1-enyl)- cyclopentyl]-N-ethyl-hept-5-enamide (bimatoprost) in crystalline form II, methods for preparation, and methods for use thereof
CN102711771B (en) 2010-01-11 2016-05-18 伊诺泰克制药公司 Reduce combination, kit and the method for intraocular pressure
WO2011119969A1 (en) 2010-03-26 2011-09-29 Inotek Pharmaceuticals Corporation Method of reducing intraocular pressure in humans using n6 -cyclopentyladenosine (cpa), cpa derivatives or prodrugs thereof
PT2807178T (en) 2012-01-26 2017-08-08 Inotek Pharmaceuticals Corp Anhydrous polymorphs of (2r,3s,4r,5r)-5-(6-(cyclopentylamino)-9h-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl) } methyl nitrate and processes of preparation thereof
WO2014152723A1 (en) 2013-03-15 2014-09-25 Inotek Pharmaceuticals Corporation Ophthalmic formulations
TWI809304B (en) 2014-12-01 2023-07-21 奥默羅斯公司 Anti-inflammatory and mydriatic intracameral solutions for inhibition of postoperative ocular inflammatory conditions
JP2022508648A (en) 2018-10-05 2022-01-19 アンナプルナ バイオ インコーポレイテッド Compounds and compositions for treating conditions associated with APJ receptor activity
KR20230061473A (en) * 2020-09-02 2023-05-08 인베릭 바이오사이언시스 캐나다 인크. Nitrated psilocybin derivatives and their use for modulating the 5-HT2A receptor and treating psychiatric disorders
WO2023044556A1 (en) 2021-09-24 2023-03-30 Enveric Biosciences Canada Inc. Aminated psilocybin derivatives and methods of using
TW202334089A (en) 2021-11-02 2023-09-01 美商夫雷爾醫療公司 Pparg inverse agonists and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4654361A (en) * 1986-01-27 1987-03-31 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University Method of lowering intraocular pressure using melatonin
WO1989001472A1 (en) * 1987-08-17 1989-02-23 Nelson Research & Development Co. Melatonin analogues
GB9420529D0 (en) * 1994-10-12 1994-11-30 Pfizer Ltd Indoles
FR2737725B1 (en) * 1995-08-08 1997-10-31 Valentonine NOVEL ACYLATED DERIVATIVES OF MELATONIN AND MELATONINERGIC ANALOGS, THEIR PREPARATION PROCESS AND THEIR USE AS MEDICAMENTS

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12133842B2 (en) 2012-10-24 2024-11-05 Rayner Intraocular Lenses Limited Stable preservative-free mydriatic and anti-inflammatory solutions for injection

Also Published As

Publication number Publication date
EP1307191A2 (en) 2003-05-07
CA2417489A1 (en) 2002-02-07
WO2002009702A2 (en) 2002-02-07
AR035651A1 (en) 2004-06-23
WO2002009702A3 (en) 2002-12-27
AU2001280984A1 (en) 2002-02-13
JP2004518612A (en) 2004-06-24
MXPA03000729A (en) 2004-11-01
CN1450896A (en) 2003-10-22
KR20030046395A (en) 2003-06-12

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