[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

WO2002095099A1 - Fonctionnalisation non covalente de la paroi laterale de nanotubes en carbone - Google Patents

Fonctionnalisation non covalente de la paroi laterale de nanotubes en carbone Download PDF

Info

Publication number
WO2002095099A1
WO2002095099A1 PCT/US2002/021626 US0221626W WO02095099A1 WO 2002095099 A1 WO2002095099 A1 WO 2002095099A1 US 0221626 W US0221626 W US 0221626W WO 02095099 A1 WO02095099 A1 WO 02095099A1
Authority
WO
WIPO (PCT)
Prior art keywords
swnt
noncovalently
molecules
carbon nanotube
sidewall
Prior art date
Application number
PCT/US2002/021626
Other languages
English (en)
Inventor
Hongjie Dai
Robert J. Chen
Original Assignee
Stanford University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stanford University filed Critical Stanford University
Priority to US10/473,101 priority Critical patent/US8029734B2/en
Publication of WO2002095099A1 publication Critical patent/WO2002095099A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F11/00—Chemical after-treatment of artificial filaments or the like during manufacture
    • D01F11/10—Chemical after-treatment of artificial filaments or the like during manufacture of carbon
    • D01F11/14—Chemical after-treatment of artificial filaments or the like during manufacture of carbon with organic compounds, e.g. macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F9/00—Artificial filaments or the like of other substances; Manufacture thereof; Apparatus specially adapted for the manufacture of carbon filaments
    • D01F9/08—Artificial filaments or the like of other substances; Manufacture thereof; Apparatus specially adapted for the manufacture of carbon filaments of inorganic material
    • D01F9/12—Carbon filaments; Apparatus specially adapted for the manufacture thereof

Definitions

  • the present invention relates generally to carbon nanotubes and more particularly to functionalization of carbon nanotubes and related applications. Background
  • Carbon nanotubes exhibit interesting and useful electrical properties, and may be utilized for a variety of devices.
  • Single- walled carbon nanotubes having single- molecule-thick walls, have been found to be particularly useful in a variety of implementations, including integrated molecular electronic devices and chemical sensors. These devices may be implemented, for example, in chemical and biological species detection and identification, microelectronics circuitry, medical devices, environmental monitoring, medical/clinical diagnosis and biotechnology for gene mapping and drug discovery.
  • SWNTs Single- walled carbon nanotubes
  • nanotube devices exhibiting both high functionality and high flexibility are desirable. For instance, in electrical applications, the ability to manipulate electrical characteristics of a device to target the device's electrical behavior to a particular implementation increases the device's functionality and flexibility. Similarly, in chemical sensors, the ability to tailor a sensor for sensing a particular molecular species is also advantageous. In previous carbon nanotube implementations, however, achieving such high functionality and flexibility has been challenging. Summary
  • the present invention is directed to the above-mentioned challenges and applications and others that relate to carbon nanotube devices and their implementation.
  • the present invention is exemplified in a number of implementations and applications, some of which are summarized below.
  • the present invention is directed to a carbon nanotube device having a functionalized carbon nanotube sidewall, with molecules noncovalently bonded to the sidewall.
  • the present invention involves functionalizing a single-walled carbon nanotube (SWNT) by noncovalently bonding a first type of molecule to the SWNT sidewall, the noncovalently-bonded molecules being irreversibly adsorbed onto the sidewall of the SWNT.
  • SWNT single-walled carbon nanotube
  • the functionalized SWNT can be used to immobilize another molecule, such as a protein, various biological substances, polymerizable molecules and inorganic nanoparticles.
  • electrical responses of the SWNT can be used to characterize the immobilized molecule.
  • FIG. 1 is a carbon nanotube having molecules noncovalently bonded thereto, according to an example embodiment of the present invention
  • FIG. 2 is a flow diagram for noncovalent sidewall functionalization and subsequent protein immobilization of a SWNT, according to another example embodiment of the present invention
  • FIG. 3 is a system for functionalizing SWNTs and immobilizing molecules therewith, according to another example embodiment of the present invention.
  • FIG. 4 is circuit arrangement having a functionalized carbon nanotube, according to another example embodiment of the present invention. While the invention is amenable to various modifications and alternative forms, specifics thereof have been shown by way of example in the drawings and will be described in detail. It should be understood, however, that the intention is not to limit the invention to the particular embodiments described. On the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention.
  • a carbon nanotube is functionalized by noncovalently bonding molecules to a sidewall of the carbon nanotube, such as a SWNT.
  • a sidewall of the carbon nanotube such as a SWNT.
  • Such noncovalent SWNT sidewall functionalization preserves the sp 2 (electron spin) nanotube structure and thus preserves electronic characteristics of the SWNT.
  • the present invention is particularly useful for a variety of nanotube implementations, including soluble nanotubes, nanotubes self-assembled on surfaces, nanotubes for immobilization of molecules, nanotubes for chemical sensors and nanotubes for molecular electronics.
  • the noncovalent sidewall functionalization is used for self-assembly of nanotubes with unperturbed sp 2 (electron spin) structures and electronic properties.
  • FIG. 1 shows a SWNT 105 having a plurality of noncovalently-bonded molecules 110, 112, 114 and 116, according to another example embodiment of the present invention.
  • the noncovalently-bonded molecules are configured and arranged for bonding to additional molecules, such as biomolecules such as antibodies, antigens and DNA, polymerizable molecules, inorganic particles and proteins (e.g., metallothionein, streptavidin, ferritin, biotinyl-3, 6-dioxaoctanediamine (biotin-PEO-amine)), and various inorganic molecules that are electrically semi-conductive and therefore have interesting and useful electrical properties.
  • biomolecules such as antibodies, antigens and DNA
  • polymerizable molecules e.g., polymerizable molecules
  • inorganic particles and proteins e.g., metallothionein, streptavidin, ferritin, biotinyl-3, 6-dioxaoctanediamine (biotin-PEO
  • molecule 116 is functionalized with a bifunctional molecule from a succinimidyl ester group that is highly reactive to nucleophilic substitution by primary and secondary amines that exist in abundance on the surface of most proteins. More specifically, the molecule 116 can be 1-pyrenebutanoic acid, succinimidyl ester (hereinafter referred to as "the first example combination"), available from Molecular Probes, Inc., USA, and is irreversibly adsorbed onto a hydrophobic surface 108 of the SWNT 105.
  • the bifunctional molecule 116, from the pyrenyl group is highly aromatic in nature and strongly interacts with the sidewalls of the SWNT, which makes the molecule highly stable against desorption in aqueous solutions. Generally, molecules are irreversibly adsorbed onto the sidewall of the SWNT by one or more of various non-covalent forces such as van der Waals
  • FIG. 2 is a flow diagram for immobilizing a protein with a SWNT, according to another example embodiment of the present invention.
  • a SWNT is incubated in a solution to noncovalently bond a bifunctional molecule thereto, thus functionalizing the SWNT (e.g., similar to SWNT 105 of FIG. 1).
  • the functionalization is achieved using one or more of a variety of incubation solutions, such as an organic solvent dimethylformamide (DMF) or methanol, with a functionalizing reagent therein.
  • DMF organic solvent dimethylformamide
  • methanol a functionalizing reagent
  • SWNT 105 with molecule 116 in FIG. 1 can be achieved via incubation in a 1-pyrenebutanoic acid, succinimidyl ester solution (about 6 mM of the first example combination in DMF or about 1 mM in methanol) for 1 hour at room temperature.
  • the functionalized SWNT is then rinsed at block 220 using, for example, pure DMF or methanol to wash away excess reagent.
  • the functionalized SWNT is incubated in an aqueous solution of protein at block 230, subsequently rinsed at block 240 and dried at block 250.
  • the protein 120 immobilization can be achieved via incubation at block 230 for about 18 hours at room temperature. After the protein immobilization, the SWNT 105 is rinsed thoroughly in pure water for about 6 hours, and then dried.
  • biotin-PEO-amine (available from Pierce Chemical, USA) is immobilized onto a SWNT at block 230.
  • the incubation is carried out using an aqueous solution of biotin-PEO-amine (about 20 mg/mL) for about 18 hours to covalently link the biotin group to via an amide-forming reaction mechanism, similar to that discussed above.
  • the SWNT is then exposed to a solution of streptavidin- Au conjugate to achieve streptavidin-biotin coupling, and subsequently rinsed and dried at blocks 240 and 250, respectively.
  • SWNTs formed using laser ablation are deposited onto a SiO 2 substrate from suspension in 1 ,2-dichloroethane (e.g., about 1 mg of SWNT/10 mL of solvent).
  • the substrate is then incubated in the first example combination (6 mM, in DMF) for 1 hour, rinsed thoroughly in pure DMF, exposed to a dilute
  • ferritin solution e.g., about 10 ⁇ g/mL in a 15 ⁇ M NaCl solution
  • This approach is effective in providing bonding to the SWNT and not to the substrate.
  • a bundle of SWNTs is functionalized at block 210.
  • the SWNT bundle is similarly used to immobilize a protein at block 230. Because of concave regions formed between neighboring individual SWNTs, proteins can be readily anchored (or immobilized) via noncovalent bonds with one or more SWNTs in the SWNT bundle.
  • FIG. 3 shows one such protein immobilization system 300, according to another example embodiment of the present invention.
  • the system 300 includes four chambers 310, 320, 330 and 340, with each chamber being arranged to hold a plurality of SWNTs, such as an array of SWNTs formed on a grid of catalyst over a substrate.
  • Incubation station 310 is arranged to hold an aqueous solvent with a reagent suspended therein, which noncovalently bonds to and functionalizes the SWNTs.
  • station 320 is arranged to rinse SWNTs using, for example, a solvent as discussed above.
  • Station 330 also is arranged to hold an aqueous solution with molecules for immobilization using the functionalized SWNTs rinsed at station 320.
  • station 340 is arranged for rinsing the functionalized SWNTs with immobilized molecules from station 330.
  • FIG. 4 is a circuit arrangement 400 with a functionalized SWNT 410, according to another example embodiment of the present invention.
  • the circuit arrangement includes circuitry 440 coupled via interconnects 430 and 432 to the SWNT 410 via electrodes 420 and 422.
  • the electrodes are coupled to opposite ends of the SWNT 410, which is functionalized by molecules 412 that are noncovalently bonded thereto.
  • the noncovalently bonded molecules 412 may, for example, be bonded to the SWNT using one or more of the implementations discussed herein.
  • the functionalized SWNT 410 exhibits electrical characteristics that are a function of the noncovalently-bonded molecules 412. In this regard, the selection of the molecules 412 is tailored to a desired electrical characteristic for the circuit arrangement.
  • the circuit arrangement 400 further includes immobilized molecules coupled to the noncovalently-bonded molecules 412 of the functionalized SWNT 410.
  • the immobilized molecules alter an electrical characteristic of the SWNT, thus altering an electrical characteristic of the circuit arrangement 400.
  • the type of immobilized molecule is selected for achieving the desired characteristics for the SWNT.
  • the circuit arrangement 400 is part of a sensor for detecting and identifying molecules via immobilization with the functionalized SWNT.
  • the noncovalently-bonded molecules 412 have a composition that selectively immobilizes one or more types of molecules.
  • the circuitry 440 coupled across the SWNT 410 at electrodes 420 and 422, detects an electrical characteristic, or a change thereof, for the SWNT 410 in response to the immobilized molecule.
  • the detected electrical characteristic is used to identify the composition of the immobilized molecule (e.g., by comparing the detected characteristic to a known response of the SWNT to particular molecules).
  • U.S. Provisional Patent Application Serial No. 60/335,306 STFD.023P1/S01-208

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Nanotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Textile Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mathematical Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Carbon And Carbon Compounds (AREA)

Abstract

Les nanotubes en carbone sont fonctionnalisés de manière à pouvoir être utilisés dans une gamme d'applications. Selon un mode de réalisation, de la présente invention,des nanotubes à simple paroi de carbone (SWNTs) sont fonctionnalisés de manière non covalente. Les SWNTs fonctionnalisés sont extrêmement polyvalents ; ils peuvent être utilisés pour diverses applications, telles que l'immobilisation de molécules, les agencements de circuit, l'électronique moléculaire et les détecteurs moléculaires. De plus, des suspensions stables de ces SWNTs fonctionnalisés dans des solutions peuvent être obtenues, tout comme l'auto-assemblage de nanotubes avec des structures sp2 non perturbées et, par conséquent, leurs caractéristiques électroniques.
PCT/US2002/021626 2001-03-29 2002-03-29 Fonctionnalisation non covalente de la paroi laterale de nanotubes en carbone WO2002095099A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US10/473,101 US8029734B2 (en) 2001-03-29 2002-03-29 Noncovalent sidewall functionalization of carbon nanotubes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28060501P 2001-03-29 2001-03-29
US60/280,605 2001-03-29

Publications (1)

Publication Number Publication Date
WO2002095099A1 true WO2002095099A1 (fr) 2002-11-28

Family

ID=23073803

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/021626 WO2002095099A1 (fr) 2001-03-29 2002-03-29 Fonctionnalisation non covalente de la paroi laterale de nanotubes en carbone

Country Status (2)

Country Link
US (1) US8029734B2 (fr)
WO (1) WO2002095099A1 (fr)

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004020450A1 (fr) * 2002-08-30 2004-03-11 Commonwealth Scientific And Industrial Research Organisation Procedes de modification chimique et physique de nanotubes, procedes de liaison de nanotubes, procedes de positionnement dirige de nanotubes, et utilisations associees
WO2004044586A1 (fr) * 2002-11-08 2004-05-27 Nanomix, Inc. Detection electronique de molecules biologiques fondee sur des nanotubes
EP1426470A1 (fr) * 2002-12-03 2004-06-09 Motorola, Inc. Liaison de carbon nanomorphique avec acides nucléiques
US6905667B1 (en) 2002-05-02 2005-06-14 Zyvex Corporation Polymer and method for using the polymer for noncovalently functionalizing nanotubes
WO2006128828A1 (fr) 2005-05-31 2006-12-07 Thales Reseau de transistors fet a nanotube ou nanofil semi-conducteur et dispositif electronique correspondant, pour la detection d'analytes
US7178378B2 (en) 2002-08-29 2007-02-20 Bioscale, Inc. Resonant sensor and sensing system
US7226818B2 (en) 2004-10-15 2007-06-05 General Electric Company High performance field effect transistors comprising carbon nanotubes fabricated using solution based processing
US7244407B2 (en) 2002-05-02 2007-07-17 Zyvex Performance Materials, Llc Polymer and method for using the polymer for solubilizing nanotubes
US7296576B2 (en) 2004-08-18 2007-11-20 Zyvex Performance Materials, Llc Polymers for enhanced solubility of nanomaterials, compositions and methods therefor
US7344691B2 (en) 2001-05-17 2008-03-18 Zyvek Performance Materials, Llc System and method for manipulating nanotubes
US7374649B2 (en) * 2002-11-21 2008-05-20 E. I. Du Pont De Nemours And Company Dispersion of carbon nanotubes by nucleic acids
US7385266B2 (en) 2003-05-14 2008-06-10 Nantero, Inc. Sensor platform using a non-horizontally oriented nanotube element
US7479516B2 (en) 2003-05-22 2009-01-20 Zyvex Performance Materials, Llc Nanocomposites and methods thereto
US7522040B2 (en) 2004-04-20 2009-04-21 Nanomix, Inc. Remotely communicating, battery-powered nanostructure sensor devices
US7547931B2 (en) 2003-09-05 2009-06-16 Nanomix, Inc. Nanoelectronic capnometer adaptor including a nanoelectric sensor selectively sensitive to at least one gaseous constituent of exhaled breath
WO2011072228A1 (fr) 2009-12-11 2011-06-16 Massachusetts Institute Of Technology Imagerie spectrale de matériaux photoluminescents
US8246995B2 (en) 2005-05-10 2012-08-21 The Board Of Trustees Of The Leland Stanford Junior University Hydrophobic nanotubes and nanoparticles as transporters for the delivery of drugs into cells
WO2013019722A1 (fr) 2011-08-01 2013-02-07 Massachusetts Institute Of Technology Capteurs à base de nanostructures photoluminescentes
US8535726B2 (en) 2007-07-27 2013-09-17 The Board Of Trustees Of The Leland Stanford Junior University Supramolecular functionalization of graphitic nanoparticles for drug delivery
US8765488B2 (en) 2004-07-22 2014-07-01 The Board Of Trustees Of The University Of Illinois Sensors employing single-walled carbon nanotubes
US8778226B2 (en) 2010-09-30 2014-07-15 Ut-Battelle, Llc Luminescent systems based on the isolation of conjugated PI systems and edge charge compensation with polar molecules on a charged nanostructured surface
WO2015021063A1 (fr) 2013-08-05 2015-02-12 Northeastern University Biocapteur à nanotube de carbone simple paroi (swcnt) destiné à détecter du glucose, du lactate et de l'urée
US8993346B2 (en) 2009-08-07 2015-03-31 Nanomix, Inc. Magnetic carbon nanotube based biodetection
US9103775B2 (en) 2002-01-16 2015-08-11 Nanomix, Inc. Nano-electronic sensors for chemical and biological analytes, including capacitance and bio-membrane devices
WO2015191389A2 (fr) 2014-06-13 2015-12-17 Massachusetts Institute Of Tecnology Nanocapteurs optiques sensibles au saccharide
US9291613B2 (en) 2002-06-21 2016-03-22 Nanomix, Inc. Sensor having a thin-film inhibition layer
WO2016100581A1 (fr) * 2014-12-16 2016-06-23 Northeastern University Biocapteur à base de nanotubes pour la détection de pathogènes

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7301199B2 (en) * 2000-08-22 2007-11-27 President And Fellows Of Harvard College Nanoscale wires and related devices
US20060175601A1 (en) * 2000-08-22 2006-08-10 President And Fellows Of Harvard College Nanoscale wires and related devices
KR100995457B1 (ko) * 2000-08-22 2010-11-18 프레지던트 앤드 펠로우즈 오브 하버드 칼리지 나노센서 제조 방법
KR100991573B1 (ko) * 2000-12-11 2010-11-04 프레지던트 앤드 펠로우즈 오브 하버드 칼리지 나노센서
US6896864B2 (en) * 2001-07-10 2005-05-24 Battelle Memorial Institute Spatial localization of dispersed single walled carbon nanotubes into useful structures
US7776444B2 (en) * 2002-07-19 2010-08-17 University Of Florida Research Foundation, Inc. Transparent and electrically conductive single wall carbon nanotube films
WO2004010552A1 (fr) 2002-07-19 2004-01-29 President And Fellows Of Harvard College Composants optiques coherents nanometriques
DE10247679A1 (de) * 2002-10-12 2004-04-22 Fujitsu Ltd., Kawasaki Halbleitergrundstruktur für Molekularelektronik und Molekularelektronik-basierte Biosensorik
US20090227107A9 (en) * 2004-02-13 2009-09-10 President And Fellows Of Havard College Nanostructures Containing Metal Semiconductor Compounds
WO2006107312A1 (fr) * 2004-06-15 2006-10-12 President And Fellows Of Harvard College Nanocapteurs
WO2007044034A2 (fr) * 2004-12-06 2007-04-19 President And Fellows Of Harvard College Unite de stockage de donnees a base de fils a l'echelle nanometrique
US20100227382A1 (en) * 2005-05-25 2010-09-09 President And Fellows Of Harvard College Nanoscale sensors
WO2006132659A2 (fr) * 2005-06-06 2006-12-14 President And Fellows Of Harvard College Heterostructures nanofils
KR100682381B1 (ko) 2005-11-16 2007-02-15 광주과학기술원 단일벽 탄소 나노튜브-난백 단백질 복합체 및 그 제조 방법
KR100779008B1 (ko) * 2005-11-16 2007-11-28 광주과학기술원 ｐＨ-감응 발광성 단일벽 탄소 나노튜브 유도체 및 그 제조방법
AU2007309660A1 (en) * 2006-06-12 2008-05-02 President And Fellows Of Harvard College Nanosensors and related technologies
US8058640B2 (en) 2006-09-11 2011-11-15 President And Fellows Of Harvard College Branched nanoscale wires
US20080213189A1 (en) * 2006-10-17 2008-09-04 The Board Of Trustees Of The Leland Stanford Junior University Multifunctional metal-graphite nanocrystals
US20090166560A1 (en) * 2006-10-26 2009-07-02 The Board Of Trustees Of The Leland Stanford Junior University Sensing of biological molecules using carbon nanotubes as optical labels
TWI463713B (zh) 2006-11-09 2014-12-01 Nanosys Inc 用於奈米導線對準及沈積的方法
US8575663B2 (en) * 2006-11-22 2013-11-05 President And Fellows Of Harvard College High-sensitivity nanoscale wire sensors
US7959969B2 (en) 2007-07-10 2011-06-14 California Institute Of Technology Fabrication of anchored carbon nanotube array devices for integrated light collection and energy conversion
CN101643702B (zh) * 2008-08-09 2014-09-10 清华大学 细胞定向培养系统、细胞定向培养基板及培养定向细胞的方法
WO2010087971A2 (fr) 2009-01-27 2010-08-05 California Institute Of Technology Administration de médicament et transfert de substance facilités par un dispositif nano-amélioré comprenant des nanotubes de carbone alignés saillant à la surface du dispositif
EP2425486A4 (fr) 2009-04-30 2017-05-03 University of Florida Research Foundation, Inc. Cathodes à air à base de nanotubes de carbon monofeuillets
JP2012528020A (ja) 2009-05-26 2012-11-12 ナノシス・インク． ナノワイヤおよび他のデバイスの電場沈着のための方法およびシステム
US9297796B2 (en) 2009-09-24 2016-03-29 President And Fellows Of Harvard College Bent nanowires and related probing of species
US8916606B2 (en) * 2009-10-27 2014-12-23 William Marsh Rice University Therapeutic compositions and methods for targeted delivery of active agents
US9115424B2 (en) 2010-04-07 2015-08-25 California Institute Of Technology Simple method for producing superhydrophobic carbon nanotube array
WO2012031164A2 (fr) * 2010-09-02 2012-03-08 California Institute Of Technology Administration de médicaments par réseaux de nanotubes de carbone
WO2012079066A2 (fr) 2010-12-10 2012-06-14 California Institute Of Technology Procédé de production d'oxyde de graphène avec écartement accordable
CN103403935B (zh) 2010-12-17 2016-08-24 佛罗里达大学研究基金会有限公司 基于碳膜的氢的氧化和产生
US8976507B2 (en) 2011-03-29 2015-03-10 California Institute Of Technology Method to increase the capacitance of electrochemical carbon nanotube capacitors by conformal deposition of nanoparticles
BR112013025503A2 (pt) 2011-04-04 2016-12-27 Univ Florida dispersantes de nanotubos e películas de nanotubos sem dispersantes a partir das mesmas
US9164053B2 (en) 2011-09-26 2015-10-20 The Regents Of The University Of California Electronic device for monitoring single molecule dynamics
WO2014022314A1 (fr) 2012-07-30 2014-02-06 California Institute Of Technology Systèmes composites de nano tri-carbone et fabrication
KR20160033118A (ko) * 2013-07-25 2016-03-25 도레이 카부시키가이샤 카본 나노 튜브 복합체, 반도체 소자 및 그것을 사용한 센서
JP6106339B2 (ja) * 2013-08-01 2017-03-29 エルジー・ケム・リミテッド 分散剤、その製造方法およびこれを含む炭素系素材の分散組成物
CN105764838B (zh) 2013-11-20 2019-03-01 佛罗里达大学研究基金会有限公司 含碳材料上的二氧化碳还原
KR101624389B1 (ko) * 2013-12-24 2016-05-25 주식회사 포스코 비공유결합 개질된 탄소구조체 및 이를 포함하는 탄소구조체/고분자 복합체
US20180088079A1 (en) * 2015-04-03 2018-03-29 President And Fellows Of Harvard College Nanoscale wires with external layers for sensors and other applications
WO2019075050A1 (fr) 2017-10-10 2019-04-18 Thermo Electron Scientific Instruments Llc Dispositif à base de nanotubes de carbone servant à détecter une interaction moléculaire
WO2022035907A1 (fr) 2020-08-13 2022-02-17 R.D. Abbott Company, Inc. Procédé de fabrication d'une matrice composite par incorporation de nanotubes de carbone

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6159742A (en) * 1998-06-05 2000-12-12 President And Fellows Of Harvard College Nanometer-scale microscopy probes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866434A (en) * 1994-12-08 1999-02-02 Meso Scale Technology Graphitic nanotubes in luminescence assays
US6683783B1 (en) * 1997-03-07 2004-01-27 William Marsh Rice University Carbon fibers formed from single-wall carbon nanotubes
AU3529299A (en) * 1998-05-07 1999-11-23 Centre National De La Recherche Scientifique-Cnrs Method for immobilising and/or crystallising biological macromolecules on carbonnanotubes and uses
US20020102617A1 (en) * 2000-08-03 2002-08-01 Macbeath Gavin Protein microarrays
KR100991573B1 (ko) * 2000-12-11 2010-11-04 프레지던트 앤드 펠로우즈 오브 하버드 칼리지 나노센서
US20020172767A1 (en) * 2001-04-05 2002-11-21 Leonid Grigorian Chemical vapor deposition growth of single-wall carbon nanotubes
US20030113940A1 (en) * 2001-07-16 2003-06-19 Erlanger Bernard F. Antibodies specific for nanotubes and related methods and compositions

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6159742A (en) * 1998-06-05 2000-12-12 President And Fellows Of Harvard College Nanometer-scale microscopy probes

Cited By (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7344691B2 (en) 2001-05-17 2008-03-18 Zyvek Performance Materials, Llc System and method for manipulating nanotubes
US9103775B2 (en) 2002-01-16 2015-08-11 Nanomix, Inc. Nano-electronic sensors for chemical and biological analytes, including capacitance and bio-membrane devices
US7241496B2 (en) 2002-05-02 2007-07-10 Zyvex Performance Materials, LLC. Polymer and method for using the polymer for noncovalently functionalizing nanotubes
US7244407B2 (en) 2002-05-02 2007-07-17 Zyvex Performance Materials, Llc Polymer and method for using the polymer for solubilizing nanotubes
US6905667B1 (en) 2002-05-02 2005-06-14 Zyvex Corporation Polymer and method for using the polymer for noncovalently functionalizing nanotubes
US7547472B2 (en) 2002-05-02 2009-06-16 Zyvex Performance Materials, Inc. Polymer and method for using the polymer for noncovalently functionalizing nanotubes
US7544415B2 (en) 2002-05-02 2009-06-09 Zyvex Performance Materials, Inc. Polymer and method for using the polymer for solubilizing nanotubes
US9291613B2 (en) 2002-06-21 2016-03-22 Nanomix, Inc. Sensor having a thin-film inhibition layer
US7178378B2 (en) 2002-08-29 2007-02-20 Bioscale, Inc. Resonant sensor and sensing system
WO2004020450A1 (fr) * 2002-08-30 2004-03-11 Commonwealth Scientific And Industrial Research Organisation Procedes de modification chimique et physique de nanotubes, procedes de liaison de nanotubes, procedes de positionnement dirige de nanotubes, et utilisations associees
WO2004044586A1 (fr) * 2002-11-08 2004-05-27 Nanomix, Inc. Detection electronique de molecules biologiques fondee sur des nanotubes
US7374649B2 (en) * 2002-11-21 2008-05-20 E. I. Du Pont De Nemours And Company Dispersion of carbon nanotubes by nucleic acids
EP1426470A1 (fr) * 2002-12-03 2004-06-09 Motorola, Inc. Liaison de carbon nanomorphique avec acides nucléiques
WO2004050967A1 (fr) * 2002-12-03 2004-06-17 Motorola Inc Liaison de carbone nanomorphe a un acide nucleique
US8310015B2 (en) 2003-05-14 2012-11-13 Nantero Inc. Sensor platform using a horizontally oriented nanotube element
US7385266B2 (en) 2003-05-14 2008-06-10 Nantero, Inc. Sensor platform using a non-horizontally oriented nanotube element
US7780918B2 (en) 2003-05-14 2010-08-24 Nantero, Inc. Sensor platform using a horizontally oriented nanotube element
US7479516B2 (en) 2003-05-22 2009-01-20 Zyvex Performance Materials, Llc Nanocomposites and methods thereto
US7547931B2 (en) 2003-09-05 2009-06-16 Nanomix, Inc. Nanoelectronic capnometer adaptor including a nanoelectric sensor selectively sensitive to at least one gaseous constituent of exhaled breath
US7522040B2 (en) 2004-04-20 2009-04-21 Nanomix, Inc. Remotely communicating, battery-powered nanostructure sensor devices
US10712347B2 (en) 2004-07-22 2020-07-14 The Board Of Trustees Of The University Of Illinois Sensors employing single-walled carbon nanotubes
US8765488B2 (en) 2004-07-22 2014-07-01 The Board Of Trustees Of The University Of Illinois Sensors employing single-walled carbon nanotubes
US7296576B2 (en) 2004-08-18 2007-11-20 Zyvex Performance Materials, Llc Polymers for enhanced solubility of nanomaterials, compositions and methods therefor
US7226818B2 (en) 2004-10-15 2007-06-05 General Electric Company High performance field effect transistors comprising carbon nanotubes fabricated using solution based processing
US8795734B2 (en) 2005-05-10 2014-08-05 The Board Of Trustees Of The Leland Stanford Junior University Hydrophobic nanotubes and nanoparticles as transporters for the delivery of drugs into cells
US8246995B2 (en) 2005-05-10 2012-08-21 The Board Of Trustees Of The Leland Stanford Junior University Hydrophobic nanotubes and nanoparticles as transporters for the delivery of drugs into cells
US8115198B2 (en) 2005-05-31 2012-02-14 Thales and Ecole Polytechnique Array of differentiated FETS having a nanotube or nanowire channel and corresponding electronic device, for the detection of analytes
WO2006128828A1 (fr) 2005-05-31 2006-12-07 Thales Reseau de transistors fet a nanotube ou nanofil semi-conducteur et dispositif electronique correspondant, pour la detection d'analytes
US8535726B2 (en) 2007-07-27 2013-09-17 The Board Of Trustees Of The Leland Stanford Junior University Supramolecular functionalization of graphitic nanoparticles for drug delivery
US9233166B2 (en) 2007-07-27 2016-01-12 The Board Of Trustees Of The Leland Stanford Junior University Supramolecular functionalization of graphitic nanoparticles for drug delivery
US8993346B2 (en) 2009-08-07 2015-03-31 Nanomix, Inc. Magnetic carbon nanotube based biodetection
WO2011072228A1 (fr) 2009-12-11 2011-06-16 Massachusetts Institute Of Technology Imagerie spectrale de matériaux photoluminescents
US8778226B2 (en) 2010-09-30 2014-07-15 Ut-Battelle, Llc Luminescent systems based on the isolation of conjugated PI systems and edge charge compensation with polar molecules on a charged nanostructured surface
WO2013019722A1 (fr) 2011-08-01 2013-02-07 Massachusetts Institute Of Technology Capteurs à base de nanostructures photoluminescentes
EP3030891A4 (fr) * 2013-08-05 2017-05-10 Northeastern University Biocapteur à nanotube de carbone simple paroi (swcnt) destiné à détecter du glucose, du lactate et de l'urée
US10031102B2 (en) 2013-08-05 2018-07-24 Northeastern University Single-walled carbon nanotube biosensor for detection of glucose, lactate, and urea
WO2015021063A1 (fr) 2013-08-05 2015-02-12 Northeastern University Biocapteur à nanotube de carbone simple paroi (swcnt) destiné à détecter du glucose, du lactate et de l'urée
WO2015191389A2 (fr) 2014-06-13 2015-12-17 Massachusetts Institute Of Tecnology Nanocapteurs optiques sensibles au saccharide
WO2016100581A1 (fr) * 2014-12-16 2016-06-23 Northeastern University Biocapteur à base de nanotubes pour la détection de pathogènes

Also Published As

Publication number Publication date
US8029734B2 (en) 2011-10-04
US20050100960A1 (en) 2005-05-12

Similar Documents

Publication Publication Date Title
US8029734B2 (en) Noncovalent sidewall functionalization of carbon nanotubes
JP5743974B2 (ja) Ｄｎａ検出用ナノチューブセンサー装置
Veetil et al. Development of immunosensors using carbon nanotubes
US7786540B2 (en) Sensor platform using a non-horizontally oriented nanotube element
Radi Electrochemical Aptamer‐Based Biosensors: Recent Advances and Perspectives
JP4618886B2 (ja) サンプル中の標的の検出
US20040132070A1 (en) Nonotube-based electronic detection of biological molecules
KR20050105205A (ko) 나노실린더-변형된 표면
US20100047901A1 (en) System and method for electronic sensing of biomolecules
US20070178477A1 (en) Nanotube sensor devices for DNA detection
US20020179434A1 (en) Carbon nanotube devices
EP1558933A1 (fr) Detection electronique de molecules biologiques fondee sur des nanotubes
KR20070099462A (ko) 나노선을 이용한 바이오센서 및 이의 제조 방법
JP2008525822A (ja) ポリヌクレオチド配列のｄｎａ検出／認識用ナノ電子装置
KR100680132B1 (ko) 자기성 물질을 이용한 탄소나노튜브 어레이의 제조방법
US20060194263A1 (en) Small molecule mediated, heterogeneous, carbon nanotube biosensing
KR100244202B1 (ko) 생물전자소자의 인터페이스 감지막 및 그 제조방법
Lenihan et al. Protein immobilization on carbon nanotubes through a molecular adapter
Filik et al. Electrochemical immunosensors based on nanostructured materials for sensing of prostate-specific antigen: a Review
Byon et al. Label-free biomolecular detection using carbon nanotube field effect transistors
JP2007520887A (ja) 基板上に導体構造部を配置するための方法及び該導体構造部を備えた基板
KR20160086668A (ko) 나노센서 트랜스듀서의 제조방법
Li Applications Biosensors
Lee WALLED-CARBON NANOTUBE (MWCNT) NANOELECTRODE
Do Hyun Kim¹ et al. WALLED-CARBON NANOTUBE (MWCNT) NANOELECTRODE

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 10473101

Country of ref document: US

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP