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WO2002085847A3 - Glycine, n-[n-l-gamma-glutamyl-3-(nitrosothio)-l-valyl] and use thereof - Google Patents

Glycine, n-[n-l-gamma-glutamyl-3-(nitrosothio)-l-valyl] and use thereof Download PDF

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Publication number
WO2002085847A3
WO2002085847A3 PCT/EP2002/002598 EP0202598W WO02085847A3 WO 2002085847 A3 WO2002085847 A3 WO 2002085847A3 EP 0202598 W EP0202598 W EP 0202598W WO 02085847 A3 WO02085847 A3 WO 02085847A3
Authority
WO
WIPO (PCT)
Prior art keywords
nitrosothio
valyl
glutamyl
glycine
gamma
Prior art date
Application number
PCT/EP2002/002598
Other languages
French (fr)
Other versions
WO2002085847A2 (en
Inventor
Moliner Jose Repolles
Perez-Rasilla Eduardo Salas
Coy Francisco Pubill
Original Assignee
Lacer Sa
Moliner Jose Repolles
Perez-Rasilla Eduardo Salas
Coy Francisco Pubill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lacer Sa, Moliner Jose Repolles, Perez-Rasilla Eduardo Salas, Coy Francisco Pubill filed Critical Lacer Sa
Priority to AU2002310939A priority Critical patent/AU2002310939A1/en
Publication of WO2002085847A2 publication Critical patent/WO2002085847A2/en
Publication of WO2002085847A3 publication Critical patent/WO2002085847A3/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to glycine, N-[N-L-gamma-glutamyl-3-(nitrosothio)-L-valyl] having the following formula (I) (see formula I in paper form) and pharmaceutically acceptable salts thereof as well as pharmaceutical compositions comprising one or more of these compounds, methods for the treatment and prevention of diseases comprising administration of an effective amount of one or more of these compounds and the use of one or more or these compounds for the manufacture of a pharmaceutical composition for the treatment and prevention of diseases.
PCT/EP2002/002598 2001-03-13 2002-03-08 Glycine, n-[n-l-gamma-glutamyl-3-(nitrosothio)-l-valyl] and use thereof WO2002085847A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002310939A AU2002310939A1 (en) 2001-03-13 2002-03-08 Glycine, n-(n-l-gamma-glutamyl-3-(nitrosothio)-l-valyl) and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200100577A ES2173044B1 (en) 2001-03-13 2001-03-13 DERIVATIVES OF GLYCINE, N- (N-L-GAMMA-GLUTAMIL-3- (NITROSOTIO) -L-VALIL) AND ITS APPLICATIONS.
ES200100577 2001-03-13

Publications (2)

Publication Number Publication Date
WO2002085847A2 WO2002085847A2 (en) 2002-10-31
WO2002085847A3 true WO2002085847A3 (en) 2003-10-30

Family

ID=8497059

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/002598 WO2002085847A2 (en) 2001-03-13 2002-03-08 Glycine, n-[n-l-gamma-glutamyl-3-(nitrosothio)-l-valyl] and use thereof

Country Status (5)

Country Link
AU (1) AU2002310939A1 (en)
ES (1) ES2173044B1 (en)
PA (1) PA8541201A1 (en)
PE (1) PE20021040A1 (en)
WO (1) WO2002085847A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0412699A2 (en) * 1989-08-07 1991-02-13 Takeda Chemical Industries, Ltd. Nitrosothiol derivatives, their production and use
WO2000044714A1 (en) * 1999-01-27 2000-08-03 Lacer, S.A. S-nitrosothiols as agents for the treatment of circulatory dysfunctions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0412699A2 (en) * 1989-08-07 1991-02-13 Takeda Chemical Industries, Ltd. Nitrosothiol derivatives, their production and use
WO2000044714A1 (en) * 1999-01-27 2000-08-03 Lacer, S.A. S-nitrosothiols as agents for the treatment of circulatory dysfunctions
EP1157987A1 (en) * 1999-01-27 2001-11-28 Lacer, S.A. S-nitrosothiols as agents for the treatment of circulatory dysfunctions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ASKEW S C ET AL: "Chemical mechanisms underlying the vasodilator and platelet anti-aggregating properties of S-nitroso-N-acetyl-DL-penicillamine and S-nitrosoglutathione.", BIOORGANIC & MEDICINAL CHEMISTRY. ENGLAND JAN 1995, vol. 3, no. 1, January 1995 (1995-01-01), pages 1 - 9, XP002225525, ISSN: 0968-0896 *

Also Published As

Publication number Publication date
PE20021040A1 (en) 2002-11-19
WO2002085847A2 (en) 2002-10-31
AU2002310939A1 (en) 2002-11-05
ES2173044A1 (en) 2002-10-01
ES2173044B1 (en) 2004-01-16
PA8541201A1 (en) 2003-02-28

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