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WO2002060486A3 - Controlled release microsphere system for administration of drug to the eye - Google Patents

Controlled release microsphere system for administration of drug to the eye Download PDF

Info

Publication number
WO2002060486A3
WO2002060486A3 PCT/CA2002/000086 CA0200086W WO02060486A3 WO 2002060486 A3 WO2002060486 A3 WO 2002060486A3 CA 0200086 W CA0200086 W CA 0200086W WO 02060486 A3 WO02060486 A3 WO 02060486A3
Authority
WO
WIPO (PCT)
Prior art keywords
eye
administration
drug
controlled release
collagenase
Prior art date
Application number
PCT/CA2002/000086
Other languages
French (fr)
Other versions
WO2002060486A2 (en
Inventor
Bernard B Fresco
Original Assignee
Bernard B Fresco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bernard B Fresco filed Critical Bernard B Fresco
Priority to AU2002229434A priority Critical patent/AU2002229434A1/en
Publication of WO2002060486A2 publication Critical patent/WO2002060486A2/en
Publication of WO2002060486A3 publication Critical patent/WO2002060486A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5052—Proteins, e.g. albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/00781—Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

A device and method for using microspheres containing a neutralizing agent to automatically stop a chemical reaction after a selected period of time, or after a selected result has occurred. A particular application is for the treatment of glaucoma, wherein the treatment involves the administering of collagenase to the limbus of the eye, and the microspheres contain EDTA which is automatically released into the collagenase after a selected period of time, neutralizing the collagenase.
PCT/CA2002/000086 2001-01-29 2002-01-29 Controlled release microsphere system for administration of drug to the eye WO2002060486A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002229434A AU2002229434A1 (en) 2001-01-29 2002-01-29 Controlled release microsphere system for administration of drug to the eye

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26429001P 2001-01-29 2001-01-29
US60/264,290 2001-01-29

Publications (2)

Publication Number Publication Date
WO2002060486A2 WO2002060486A2 (en) 2002-08-08
WO2002060486A3 true WO2002060486A3 (en) 2003-01-09

Family

ID=23005380

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2002/000086 WO2002060486A2 (en) 2001-01-29 2002-01-29 Controlled release microsphere system for administration of drug to the eye

Country Status (2)

Country Link
AU (1) AU2002229434A1 (en)
WO (1) WO2002060486A2 (en)

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276284A (en) * 1971-07-26 1981-06-30 Brown Stuart I Prevention of collagenase induced disease by treatment with collagenase inhibitors
GB2237510A (en) * 1989-11-04 1991-05-08 Danbiosyst Uk Small particle drug compositions for nasal administration
DE4038887A1 (en) * 1990-12-06 1992-07-02 Lohmann Therapie Syst Lts METHOD FOR THE PRODUCTION OF COLLAGEN PARTICLES AND THEIR USE AS AN ACTIVE SUBSTANCE
US5185152A (en) * 1990-01-10 1993-02-09 Peyman Gholam A Method and apparatus for controlled release drug delivery to the cornea and anterior chamber of the eye
WO1994010980A1 (en) * 1992-11-16 1994-05-26 Corporation Of Mercer University Compositions using microencapsulated neutralizing antibodies
US5462739A (en) * 1991-11-21 1995-10-31 Yeda Research And Development Co., Ltd. Microdelivery device and method for enhanced drug administration to the eye
WO1998028357A1 (en) * 1996-12-20 1998-07-02 Connaught Laboratories Limited Biodegradable targetable microparticle delivery system
US5965152A (en) * 1995-04-18 1999-10-12 Galin; Miles A. Controlled release of miotic and mydriatic drugs in the anterior chamber
US6001386A (en) * 1995-09-27 1999-12-14 University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276284A (en) * 1971-07-26 1981-06-30 Brown Stuart I Prevention of collagenase induced disease by treatment with collagenase inhibitors
GB2237510A (en) * 1989-11-04 1991-05-08 Danbiosyst Uk Small particle drug compositions for nasal administration
US5185152A (en) * 1990-01-10 1993-02-09 Peyman Gholam A Method and apparatus for controlled release drug delivery to the cornea and anterior chamber of the eye
DE4038887A1 (en) * 1990-12-06 1992-07-02 Lohmann Therapie Syst Lts METHOD FOR THE PRODUCTION OF COLLAGEN PARTICLES AND THEIR USE AS AN ACTIVE SUBSTANCE
US5462739A (en) * 1991-11-21 1995-10-31 Yeda Research And Development Co., Ltd. Microdelivery device and method for enhanced drug administration to the eye
WO1994010980A1 (en) * 1992-11-16 1994-05-26 Corporation Of Mercer University Compositions using microencapsulated neutralizing antibodies
US5965152A (en) * 1995-04-18 1999-10-12 Galin; Miles A. Controlled release of miotic and mydriatic drugs in the anterior chamber
US6001386A (en) * 1995-09-27 1999-12-14 University Of Kentucky Research Foundation Implantable controlled release device to deliver drugs directly to an internal portion of the body
WO1998028357A1 (en) * 1996-12-20 1998-07-02 Connaught Laboratories Limited Biodegradable targetable microparticle delivery system

Also Published As

Publication number Publication date
AU2002229434A1 (en) 2002-08-12
WO2002060486A2 (en) 2002-08-08

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