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WO2002057740A3 - Use of targeted glycemic profiles in the calibration of a noninvasive blood glucose monitor - Google Patents

Use of targeted glycemic profiles in the calibration of a noninvasive blood glucose monitor Download PDF

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Publication number
WO2002057740A3
WO2002057740A3 PCT/US2001/047751 US0147751W WO02057740A3 WO 2002057740 A3 WO2002057740 A3 WO 2002057740A3 US 0147751 W US0147751 W US 0147751W WO 02057740 A3 WO02057740 A3 WO 02057740A3
Authority
WO
WIPO (PCT)
Prior art keywords
blood glucose
targeted
profiles
calibration
profile
Prior art date
Application number
PCT/US2001/047751
Other languages
French (fr)
Other versions
WO2002057740A2 (en
Inventor
Linda Hockersmith
Thomas B Blank
Stephen L Monfre
Timothy L Ruchti
Original Assignee
Instrumentation Metrics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instrumentation Metrics Inc filed Critical Instrumentation Metrics Inc
Priority to AU2002227353A priority Critical patent/AU2002227353A1/en
Priority to EP01996210A priority patent/EP1359839A4/en
Publication of WO2002057740A2 publication Critical patent/WO2002057740A2/en
Publication of WO2002057740A3 publication Critical patent/WO2002057740A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

A method of calibrating a non-invasive blood glucose measurement instrument to a diabetic test subject employs targeted glycemic profiles in anti-correlated pairs. During calibration, reference blood glucose determinations are made using conventional invasive sampling methods. Concurrently, noninvasive spectral measurements are made using the noninvasive glucose monitor. Through controlled oral ingestion by the subject of calculated amounts of carbohydrate, the subject's blood glucose level is manipulated to mimic the patterns of the targeted profiles. During a first visit, a first profile of a pair is induced; during a second visit the inverse of the first profile is induced. The targeted profiles produce reference blood glucose values in which correlation to sampling factors is reduced or eliminated, thus the resulting calibration is correlated to glucose, and not to other analytes, sampling factors or environmental factors. A formula is provided for calculating the required amount of carbohydrate to ingest to induce a targeted glycemic profile in a test subject.
PCT/US2001/047751 2001-01-18 2001-12-11 Use of targeted glycemic profiles in the calibration of a noninvasive blood glucose monitor WO2002057740A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002227353A AU2002227353A1 (en) 2001-01-18 2001-12-11 Use of targeted glycemic profiles in the calibration of a noninvasive blood glucose monitor
EP01996210A EP1359839A4 (en) 2001-01-18 2001-12-11 Use of targeted glycemic profiles in the calibration of a noninvasive blood glucose monitor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/766,872 2001-01-18
US09/766,872 US6487429B2 (en) 2000-05-30 2001-01-18 Use of targeted glycemic profiles in the calibration of a noninvasive blood glucose monitor

Publications (2)

Publication Number Publication Date
WO2002057740A2 WO2002057740A2 (en) 2002-07-25
WO2002057740A3 true WO2002057740A3 (en) 2002-10-17

Family

ID=25077777

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/047751 WO2002057740A2 (en) 2001-01-18 2001-12-11 Use of targeted glycemic profiles in the calibration of a noninvasive blood glucose monitor

Country Status (5)

Country Link
US (1) US6487429B2 (en)
EP (1) EP1359839A4 (en)
AU (1) AU2002227353A1 (en)
TW (1) TW592666B (en)
WO (1) WO2002057740A2 (en)

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* Cited by examiner, † Cited by third party
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