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WO2001030752A3 - Indole compounds for treating bacterial infections - Google Patents

Indole compounds for treating bacterial infections Download PDF

Info

Publication number
WO2001030752A3
WO2001030752A3 PCT/US2000/029082 US0029082W WO0130752A3 WO 2001030752 A3 WO2001030752 A3 WO 2001030752A3 US 0029082 W US0029082 W US 0029082W WO 0130752 A3 WO0130752 A3 WO 0130752A3
Authority
WO
WIPO (PCT)
Prior art keywords
bacterial infections
treating bacterial
indole compounds
compounds
indole
Prior art date
Application number
PCT/US2000/029082
Other languages
French (fr)
Other versions
WO2001030752A2 (en
Inventor
Robert A Daines
George Wai-Kin Chan
Kelvin Kin Cheong Sham
Original Assignee
Smithkline Beecham Corp
Robert A Daines
Chan George Wai Kin
Kelvin Kin Cheong Sham
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp, Robert A Daines, Chan George Wai Kin, Kelvin Kin Cheong Sham filed Critical Smithkline Beecham Corp
Priority to EP00991850A priority Critical patent/EP1242075A4/en
Priority to AU36340/01A priority patent/AU3634001A/en
Priority to JP2001533107A priority patent/JP2003512452A/en
Publication of WO2001030752A2 publication Critical patent/WO2001030752A2/en
Publication of WO2001030752A3 publication Critical patent/WO2001030752A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

This invention relates to the use of compounds as inhibitors of the fatty acid synthase FabH.
PCT/US2000/029082 1999-10-22 2000-10-20 Indole compounds for treating bacterial infections WO2001030752A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP00991850A EP1242075A4 (en) 1999-10-22 2000-10-20 Indole compounds
AU36340/01A AU3634001A (en) 1999-10-22 2000-10-20 Indole compounds
JP2001533107A JP2003512452A (en) 1999-10-22 2000-10-20 New indole compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16112299P 1999-10-22 1999-10-22
US60/161,122 1999-10-22

Publications (2)

Publication Number Publication Date
WO2001030752A2 WO2001030752A2 (en) 2001-05-03
WO2001030752A3 true WO2001030752A3 (en) 2001-11-22

Family

ID=22579913

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/029082 WO2001030752A2 (en) 1999-10-22 2000-10-20 Indole compounds for treating bacterial infections

Country Status (4)

Country Link
EP (1) EP1242075A4 (en)
JP (1) JP2003512452A (en)
AU (1) AU3634001A (en)
WO (1) WO2001030752A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015023279B1 (en) 2013-03-13 2021-01-19 Forma Therapeutics, Inc. compounds for fasn inhibition
EP3873214A4 (en) 2018-10-29 2022-07-13 Forma Therapeutics, Inc. Solid forms of (4-(2-fluoro-4-(1-methyl-1 h-benzo[d]imidazol-5-yl)benzoyl) piperazin-1-yl)(1-hydroxycyclopropyl)methanone

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955492A (en) * 1996-03-28 1999-09-21 Smithkline Beecham Corporation Carboxylic acid indole inhibitors of chemokines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996018393A1 (en) * 1994-12-13 1996-06-20 Smithkline Beecham Corporation Novel compounds
US6486211B1 (en) * 1999-10-22 2002-11-26 Smithkline Beecham Corporation Indole compounds
US6670388B1 (en) * 2000-06-27 2003-12-30 Smithkline Beecham Corporation Fatty acid synthase inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5955492A (en) * 1996-03-28 1999-09-21 Smithkline Beecham Corporation Carboxylic acid indole inhibitors of chemokines

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1242075A4 *

Also Published As

Publication number Publication date
WO2001030752A2 (en) 2001-05-03
JP2003512452A (en) 2003-04-02
EP1242075A4 (en) 2002-12-04
AU3634001A (en) 2001-05-08
EP1242075A2 (en) 2002-09-25

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