[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

WO2001007026A3 - Improved method of treating type ii diabetes and obesity - Google Patents

Improved method of treating type ii diabetes and obesity Download PDF

Info

Publication number
WO2001007026A3
WO2001007026A3 PCT/US2000/016325 US0016325W WO0107026A3 WO 2001007026 A3 WO2001007026 A3 WO 2001007026A3 US 0016325 W US0016325 W US 0016325W WO 0107026 A3 WO0107026 A3 WO 0107026A3
Authority
WO
WIPO (PCT)
Prior art keywords
diabetes
obesity
improved method
treating type
type
Prior art date
Application number
PCT/US2000/016325
Other languages
French (fr)
Other versions
WO2001007026A2 (en
Inventor
William Elmer Bloomquist
Marlene Lois Cohen
Original Assignee
Lilly Co Eli
William Elmer Bloomquist
Marlene Lois Cohen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, William Elmer Bloomquist, Marlene Lois Cohen filed Critical Lilly Co Eli
Priority to AU60500/00A priority Critical patent/AU6050000A/en
Publication of WO2001007026A2 publication Critical patent/WO2001007026A2/en
Publication of WO2001007026A3 publication Critical patent/WO2001007026A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Disclosed is the use of aryloxyprolanolamine to agonize the beta 3 receptor, to treat obesity, type II diabetes and cardiac abnormalities.
PCT/US2000/016325 1999-07-22 2000-07-12 Improved method of treating type ii diabetes and obesity WO2001007026A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU60500/00A AU6050000A (en) 1999-07-22 2000-07-12 Improved method of treating type ii diabetes and obesity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14514999P 1999-07-22 1999-07-22
US60/145,149 1999-07-22

Publications (2)

Publication Number Publication Date
WO2001007026A2 WO2001007026A2 (en) 2001-02-01
WO2001007026A3 true WO2001007026A3 (en) 2002-02-28

Family

ID=22511805

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/016325 WO2001007026A2 (en) 1999-07-22 2000-07-12 Improved method of treating type ii diabetes and obesity

Country Status (2)

Country Link
AU (1) AU6050000A (en)
WO (1) WO2001007026A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6049500A (en) * 1999-07-22 2001-02-13 Eli Lilly And Company Treatment of cardiac abnormalities with aryloxy propanolamines
AU2002234134A1 (en) 2000-11-10 2002-05-21 Eli Lilly And Company 3-substituted oxindole beta 3 agonists
ES2272749T3 (en) 2001-08-14 2007-05-01 Eli Lilly And Company DERIVATIVES OF INDOL AS BETA-3 ADRENERGIC AGONISTS FOR THE TREATMENT OF TYPE 2 DIABETES.
ES2262817T3 (en) 2001-08-14 2006-12-01 Eli Lilly And Company BETA-3 OXINDOL 3-SUBSTITUTED AGONISTS.
TWI249515B (en) 2001-11-13 2006-02-21 Theravance Inc Aryl aniline beta2 adrenergic receptor agonists
WO2003042160A1 (en) 2001-11-13 2003-05-22 Theravance, Inc. Aryl aniline beta-2 adrenergic receptor agonists
ES2242890T3 (en) 2001-11-20 2005-11-16 Eli Lilly And Company BETA 3 AGONISTS OF OXINDOL 3-REPLACED.
ATE386740T1 (en) 2001-11-20 2008-03-15 Lilly Co Eli BETA-3 ADRENERGIC AGONISTS
US7009060B2 (en) 2002-01-11 2006-03-07 Eli Lilly And Company 2-oxo-benzimidazolyl substituted ethanolamine derivatives and their use as β3 agonists
FR2840304B1 (en) * 2002-05-29 2007-05-18 Sanofi Synthelabo OXOPHENYL-CYCLOHEXYL-PROPANOLAMINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
UY28089A1 (en) 2002-11-26 2004-06-30 Smithkline Beecham Corp CALCILITICAL COMPOUNDS
TW200531692A (en) 2004-01-12 2005-10-01 Theravance Inc Aryl aniline derivatives as β2 adrenergic receptor agonists
JP2008507532A (en) 2004-07-21 2008-03-13 セラヴァンス， インコーポレーテッド Diaryl ether β2 adrenergic receptor agonist
WO2006031556A2 (en) 2004-09-10 2006-03-23 Theravance. Inc. Amidine substituted aryl aniline compounds
CA3023763A1 (en) * 2016-05-13 2017-11-16 The Board Of Trustees Of The Leland Stanford Junior University Adrenergic receptor modulating compounds and methods of using the same
CN107266341B (en) * 2017-06-23 2020-01-07 华东师范大学 Aryloxy substituted propan-2-ol amine derivative as beta3 adrenergic receptor antagonist, preparation method and application

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0611003A1 (en) * 1993-02-09 1994-08-17 Merck & Co. Inc. Substituted phenyl sulfonamides as selective B3 agonists for the treatment of diabetes and obesity
EP0764640A1 (en) * 1995-09-21 1997-03-26 Eli Lilly And Company Selective beta3 adrenergic agonists
EP0827746A1 (en) * 1996-09-05 1998-03-11 Eli Lilly And Company Carbazole analogues as selective B3 adrenergic agonists
WO1999029672A1 (en) * 1997-12-05 1999-06-17 Eli Lilly And Company SELECTIVE β3 ADRENERGIC AGONISTS
WO2001007025A2 (en) * 1999-07-22 2001-02-01 Eli Lilly And Company Treatment of cardiac abnormalities with aryloxy propanolamines

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0611003A1 (en) * 1993-02-09 1994-08-17 Merck & Co. Inc. Substituted phenyl sulfonamides as selective B3 agonists for the treatment of diabetes and obesity
EP0764640A1 (en) * 1995-09-21 1997-03-26 Eli Lilly And Company Selective beta3 adrenergic agonists
US5786356A (en) * 1995-09-21 1998-07-28 Eli Lilly And Company Selective β3 adrenergic agonists
EP0827746A1 (en) * 1996-09-05 1998-03-11 Eli Lilly And Company Carbazole analogues as selective B3 adrenergic agonists
WO1999029672A1 (en) * 1997-12-05 1999-06-17 Eli Lilly And Company SELECTIVE β3 ADRENERGIC AGONISTS
WO2001007025A2 (en) * 1999-07-22 2001-02-01 Eli Lilly And Company Treatment of cardiac abnormalities with aryloxy propanolamines

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CANDELORE, MARI RIOS ET AL: "Potent and selective human.beta.3-adrenergic receptor antagonists", J. PHARMACOL. EXP. THER. (1999), 290(2), 649-655, 1999, XP001031847 *
COHEN M L ET AL: "ARYL PROPANOLAMINES: COMPARISON OF ACTIVITY AT HUMAN BETA3 RECEPTORS, RAT BETA3 RECEPTORS AND RAT ATRIAL RECEPTORS MEDIATING TACHYCARDIA", BRITISH JOURNAL OF PHARMACOLOGY, BASINGSTOKE, HANTS, GB, vol. 126, no. 4, 1999, pages 1018 - 1024, XP001015387, ISSN: 0007-1188 *
WEBER A E ET AL: "3-pyridyloxypropanolamine agonists of the beta3 adrenergic receptor with improved pharmacokinetic properties", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 8, no. 16, 18 August 1998 (1998-08-18), pages 2111 - 2116, XP004137229, ISSN: 0960-894X *
WEBER A E ET AL: "Potent, selective benzenesulfonamide agonists of the human beta3 adrenergic receptor", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 8, no. 9, 1 May 1998 (1998-05-01), pages 1101 - 1106, XP004137028, ISSN: 0960-894X *

Also Published As

Publication number Publication date
WO2001007026A2 (en) 2001-02-01
AU6050000A (en) 2001-02-13

Similar Documents

Publication Publication Date Title
WO2001007026A3 (en) Improved method of treating type ii diabetes and obesity
AU6530600A (en) Use of neurotoxin for treating cardiac muscle disorders
AU6406996A (en) Compositions for the treatment and diagnosis of body weight disorders, including obesity
AU3497295A (en) Compositions and methods for the treatment of body weight disorders, including obesity
AU3920900A (en) Compounds and methods to treat cardiac failure and other disorders
AU1450900A (en) Methods of treatment of type 2 diabetes
WO2000056401A8 (en) Apparatus and methods for reducing pain and/or retraining muscles
BG107537A (en) Method for the inhibition of human tnf alpha activity and its application
WO2001010370A3 (en) Therapeutic bandage
ZA961927B (en) Method of treating cardiac inflammatory disease.
AU9262598A (en) Interferon-gamma-binding molecules for treating septic shock, cachexia, immune diseases and skin disorders
WO2003057837A3 (en) Methods for using anti-muc18 antibodies
AU4297685A (en) Compositions for the allevation, treatment and diagnosis of arthritic disease and related conditions
ITTO950104A0 (en) CATHETER, PARTICULARLY FOR THE TREATMENT OF CARDIAC ARHYTHMIAS.
AU4130497A (en) Materials and methods relating to the diagnosis and treatment of diabetes and obesity
ZA991220B (en) Method of treating heart failure.
EP1235785A4 (en) Novel compounds to treat diabetes and associated conditions
ZA200004854B (en) Treatment of cardiac hypertrophy.
AU3308099A (en) Method for the treatment of pain, including chronic and female specific pain
ZA974918B (en) Method of treatment of sugar plant to improve the sugar content.
WO2000000159A3 (en) Method of treatment for dermatological disorders
AU7078298A (en) Method for the diagnosis, treatment and prophylaxis of premature ejaculation andcatheter for the diagnosis, treatment and prophylaxis of premature ejaculation
AU1931895A (en) Treatment of graft-versus-host disease
WO2001007025A3 (en) Treatment of cardiac abnormalities with aryloxy propanolamines
EP1071754A4 (en) Recombinant secoisolariciresinol dehydrogenase, and methods of use

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
NENP Non-entry into the national phase

Ref country code: JP