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WO2001098354A3 - Human receptors - Google Patents

Human receptors Download PDF

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Publication number
WO2001098354A3
WO2001098354A3 PCT/US2001/019942 US0119942W WO0198354A3 WO 2001098354 A3 WO2001098354 A3 WO 2001098354A3 US 0119942 W US0119942 W US 0119942W WO 0198354 A3 WO0198354 A3 WO 0198354A3
Authority
WO
WIPO (PCT)
Prior art keywords
reptr
human receptors
provides
polynucleotides
agonists
Prior art date
Application number
PCT/US2001/019942
Other languages
French (fr)
Other versions
WO2001098354A2 (en
Inventor
Jennifer A Griffin
Original Assignee
Incyte Genomics Inc
Jennifer A Griffin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc, Jennifer A Griffin filed Critical Incyte Genomics Inc
Priority to CA002414015A priority Critical patent/CA2414015A1/en
Priority to EP01952189A priority patent/EP1294764A2/en
Priority to AU2001272974A priority patent/AU2001272974A1/en
Priority to US10/311,623 priority patent/US20040023244A1/en
Priority to JP2002504309A priority patent/JP2004516812A/en
Publication of WO2001098354A2 publication Critical patent/WO2001098354A2/en
Publication of WO2001098354A3 publication Critical patent/WO2001098354A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Reproductive Health (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention provides human receptors (REPTR) and polynucleotides which identify and encode REPTR. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of REPTR.
PCT/US2001/019942 2000-06-21 2001-06-21 Human receptors WO2001098354A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002414015A CA2414015A1 (en) 2000-06-21 2001-06-21 Human receptors
EP01952189A EP1294764A2 (en) 2000-06-21 2001-06-21 Human receptors
AU2001272974A AU2001272974A1 (en) 2000-06-21 2001-06-21 Human receptors
US10/311,623 US20040023244A1 (en) 2001-06-21 2001-06-21 Receptors
JP2002504309A JP2004516812A (en) 2000-06-21 2001-06-21 Receptor

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US21402700P 2000-06-21 2000-06-21
US60/214,027 2000-06-21
US22804500P 2000-08-25 2000-08-25
US60/228,045 2000-08-25
US25510400P 2000-12-12 2000-12-12
US60/255,104 2000-12-12

Publications (2)

Publication Number Publication Date
WO2001098354A2 WO2001098354A2 (en) 2001-12-27
WO2001098354A3 true WO2001098354A3 (en) 2002-10-17

Family

ID=27395939

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/019942 WO2001098354A2 (en) 2000-06-21 2001-06-21 Human receptors

Country Status (4)

Country Link
JP (1) JP2004516812A (en)
AU (1) AU2001272974A1 (en)
CA (1) CA2414015A1 (en)
WO (1) WO2001098354A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9228013B2 (en) 2005-10-31 2016-01-05 OncoMed Pharmaceuticals Methods of using the FRI domain of human frizzled receptor for inhibiting Wnt signaling in a tumor or tumor cell

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030204052A1 (en) * 2000-10-04 2003-10-30 Herrmann John L. Novel proteins and nucleic acids encoding same and antibodies directed against these proteins
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
AU2001293870A1 (en) * 2000-10-16 2002-04-29 Bayer Aktiengesellschaft Regulation of human netrin binding membrane receptor unc5h-1
AU2002235748A1 (en) * 2000-12-05 2002-06-18 Bayer Aktiengesellschaft Regulation of human patched-like protein
WO2002046403A2 (en) * 2000-12-05 2002-06-13 Bayer Aktiengesellschaft Regulation of human patched-like protein
WO2004035789A1 (en) * 2002-10-18 2004-04-29 Lg Life Sciences Ltd. Gene families associated with cancers
JP4675671B2 (en) * 2005-05-11 2011-04-27 学校法人北里研究所 Novel short-time detection method for nucleic acid amplification reaction
EP1978993B1 (en) 2005-10-31 2016-12-14 Oncomed Pharmaceuticals, Inc. Compositions and methods for treating cancer based on human fzd receptors
WO2008031009A2 (en) 2006-09-08 2008-03-13 Genentech, Inc. Wnt antagonists and their use in the diagnosis and treatment of wnt-mediated disorders
RU2579897C2 (en) 2008-09-26 2016-04-10 Онкомед Фармасьютикалс, Инк. Agents linking frizzled receptor and their use
TWI535445B (en) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Wnt antagonists and methods of treatment and screening
CN102971337B (en) 2010-04-01 2016-09-21 昂考梅德药品有限公司 FZ combines medicament and application thereof
CN104768579A (en) 2012-10-23 2015-07-08 昂科梅德制药有限公司 Methods of treating neuroendocrine tumors using Wnt pathway-binding agents
CN105073195A (en) 2013-02-04 2015-11-18 昂科梅德制药有限公司 Methods and monitoring of treatment with a Wnt pathway inhibitor
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998037085A1 (en) * 1997-02-19 1998-08-27 The Regents Of The University Of California Netrin receptors
WO2001057190A2 (en) * 2000-02-03 2001-08-09 Hyseq, Inc. Novel nucleic acids and polypeptides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998037085A1 (en) * 1997-02-19 1998-08-27 The Regents Of The University Of California Netrin receptors
WO2001057190A2 (en) * 2000-02-03 2001-08-09 Hyseq, Inc. Novel nucleic acids and polypeptides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 16 June 2001 (2001-06-16), STRAUSBERG, R.: "Homo sapiens, Similar to transmembrane receptor Unc5H1, clone IMAGE:4126760, mRNA, partial cds.", XP002197545 *
DATABASE EMBL 24 October 1999 (1999-10-24), BIRREN, B. ET AL.: "Homo sapiens clone RP11-1G22, WORKING DRAFT SEQUENCE, 8 unordered pieces.", XP002197544 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9228013B2 (en) 2005-10-31 2016-01-05 OncoMed Pharmaceuticals Methods of using the FRI domain of human frizzled receptor for inhibiting Wnt signaling in a tumor or tumor cell

Also Published As

Publication number Publication date
JP2004516812A (en) 2004-06-10
CA2414015A1 (en) 2001-12-27
AU2001272974A1 (en) 2002-01-02
WO2001098354A2 (en) 2001-12-27

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