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WO2001097885A1 - Seringue - Google Patents

Seringue Download PDF

Info

Publication number
WO2001097885A1
WO2001097885A1 PCT/JP2001/005216 JP0105216W WO0197885A1 WO 2001097885 A1 WO2001097885 A1 WO 2001097885A1 JP 0105216 W JP0105216 W JP 0105216W WO 0197885 A1 WO0197885 A1 WO 0197885A1
Authority
WO
WIPO (PCT)
Prior art keywords
gasket
plunger
syringe
fitting
outer cylinder
Prior art date
Application number
PCT/JP2001/005216
Other languages
English (en)
Japanese (ja)
Inventor
Masaru Saiki
Original Assignee
Terumo Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Terumo Kabushiki Kaisha filed Critical Terumo Kabushiki Kaisha
Priority to JP2002503367A priority Critical patent/JP4623927B2/ja
Priority to AU2001274548A priority patent/AU2001274548A1/en
Publication of WO2001097885A1 publication Critical patent/WO2001097885A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31515—Connection of piston with piston rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
    • A61M2005/3118—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula

Definitions

  • the present invention relates to a liquid containing a liquid such as a chemical liquid.
  • a syringe containing a chemical solution or the like in advance is provided with an outer cylinder, a gasket inserted into the outer cylinder, and a plunger (pusher) connected to the gasket, and is surrounded by the outer cylinder and the gasket. Liquid is stored in the empty space.
  • the connection between the gasket and the plunger employs a threaded structure using a female screw and a male screw.
  • the screwing when the plunger rotates in a predetermined direction with respect to the outer cylinder, the screwing may be loosened and come off. Also, if the screw of the screw structure is loose, the plunger may come off from the gasket when the pulling operation is performed!
  • An object of the present invention is to provide a syringe in which a plunger and a gasket have a sufficient bonding force and are easy to assemble. Such an object is achieved by the present invention described in the following (1) to (10).
  • a syringe comprising an outer cylinder, a gasket slidable in the outer cylinder, and a plunger for moving and operating the gasket
  • the gasket and the plunger are connected by a screwing portion that is connected by screwing screws provided inside the gasket and the plunger, respectively, and a fitting portion that is connected by fitting provided between the inside of the gasket and the plunger.
  • the fitting portion has at least one elastic piece provided on the plunger, and a projection formed on the elastic piece and capable of engaging with the gasket (1) to (4).
  • a liquid is stored in a space surrounded by the outer cylinder and the gasket.
  • the syringe according to any one of (1) to (7).
  • FIG. 1 is a partial longitudinal sectional view showing an embodiment (disassembled state) of a syringe of the present invention.
  • FIG. 2 is a partial longitudinal sectional view showing an embodiment (assembled state) of the syringe of the present invention.
  • FIG. 3 is a half-sectional view showing the structure of the screwing portion and the fitting portion (the structure before connection) in the syringe of the present invention.
  • FIG. 4 is a half sectional view showing the structure of the screwing portion and the fitting portion (structure in the middle of connection) in the syringe of the present invention.
  • FIG. 5 is a half cross-sectional view showing the structure (structure after connection) of the screwing part and the fitting part in the syringe of the present invention.
  • FIG. 6 is a front view of the tip of the plunger in the syringe of the present invention.
  • FIGS. 1 and 2 are partial longitudinal sectional views showing an embodiment of the syringe of the present invention, respectively.
  • FIGS. 3 to 5 are, respectively, a screwing portion and a fitting portion of the syringe of the present invention.
  • FIG. 6 is a front view of the tip of the plunger.
  • the upper side in FIGS. 1 to 5 is referred to as a “base end”, and the lower side in FIG.
  • the syringe 1 of the present invention is a so-called pre-filled syringe, and includes an outer cylinder (syringe outer cylinder) 2, a gasket 3 slidable in the outer cylinder 2, and a plunger (pusher) 4 for moving the gasket 3. And The gasket 3 and the plunger 4 are connected (coupled) by a connecting mechanism described later.
  • the outer cylinder 2 is formed of a bottomed cylindrical member, and a reduced diameter portion 22 having a diameter reduced with respect to the body of the outer cylinder 2 is formed at the center of the bottom 21.
  • a needle tube hub (not shown), connectors, and the like are fitted and attached to the reduced diameter portion 22.
  • a film 24 is adhered as a sealing member to the distal end of the reduced diameter portion 22 to hermetically seal the lumen 23 of the reduced diameter portion 22.
  • the method of sealing the reduced diameter portion 22 is not limited to the method using the film 24, and may be, for example, a flexible plug or a cap (not shown).
  • a plate-like flange 25 is provided on the outer periphery of the base end of the outer cylinder 2.
  • the operation can be performed by putting a finger on the flange 25.
  • the flange 25 may be formed integrally with the outer periphery of the base end of the outer cylinder, or the flange 25 and the outer cylinder 2 may be separately manufactured and joined.
  • the constituent materials of the outer cylinder 2 and the later-described plunger 4 include, for example, polyvinyl chloride, polyethylene, polypropylene, polystyrene, poly (4-methylpentene-1 1), polyacrylonitrile, acrylic resin, and acrylic nitrile.
  • Polystyrene such as butadiene-styrene copolymer and polyethylene terephthalate
  • resins such as ter, butadiene-styrene copolymer, and polyamide (for example, nylon 6, nylon 6,6, nylon 6,10, nylon 12). Among them, molding is easy. In this respect, resins such as polypropylene and poly (4-methylpentene-11) are preferred.
  • the constituent material of the outer cylinder 2 is substantially transparent in order to secure the visibility of the inside.
  • a liquid 7 is stored in the syringe 1 in a liquid-tight manner in a space surrounded by the outer cylinder 2 and the gasket 3.
  • Liquid 7 includes, for example, carbohydrate injections such as glucose, electrolyte correction injections such as sodium chloride and lactate, vitamins, vaccines, antibiotic injections, contrast agents, steroids, and protease inhibitors. , Fat emulsions, anticancer agents, anesthetics, stimulants, various drug solutions such as narcotics, or distilled water, disinfectants, liquid foods, alcohols and the like.
  • the dimensions of the syringe 1, more specifically, the inner diameter and length of the outer cylinder 2 and the outer diameter of the gasket 3 can be appropriately selected according to the amount of the liquid 7 stored therein.
  • a scale 27 may be formed on the outer peripheral surface of the outer cylinder 2 and is also preferable. Thereby, the amount of the liquid 7 in the syringe 1 can be grasped.
  • a gasket 3 made of a flexible material is accommodated in the outer cylinder 2.
  • the gasket 3 has a hollow portion 3 3.
  • the gasket 3 slides in the longitudinal direction of the outer cylinder 2, either on the proximal end side or the distal end side, by operating the plunger 4 described later. Can be.
  • a plurality of ring-shaped protrusions 31 may be formed on the outer circumference of the gasket 3 over the entire circumference.
  • the protrusion 31 slides while being in close contact with the inner peripheral surface 26 of the outer cylinder 2, whereby the liquid tightness is more reliably maintained and the slidability is improved.
  • three projections 31 are formed along the longitudinal direction of the gasket 3, but the formation position and the number of the projections 31 are not limited to this.
  • the constituent material of the gasket 3 is not particularly limited.
  • various rubber materials such as natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, silicone rubber, polyurethane, polyester, and poly Elastic materials such as various thermoplastic elastomers such as amides, olefins, and styrenes, and mixtures thereof are exemplified.
  • the gasket 3 only needs to have at least the outer peripheral portion made of the above-described elastic material.
  • the gasket 3 has a core portion (not shown) made of a resin material. May be configured such that the non-volatile material is disposed so as to cover the surface.
  • female threads 52 and Z or engagement protrusions 63 described later are formed in the core configured to have the lumen.
  • the gasket 3 has an outer periphery formed of, for example, polytetrafluoroethylene or a copolymer thereof, an ethylene-tetrafluoroethylene copolymer, tetrafluoroethylene, PVdE (polyvinylidene flow). Ride), PCTFE (polychlorotrifluoroethylene), TFE (tetrafluoroethylene), FEP (futsudani ethylene propylene) and other films composed of a fluororesin.
  • a plunger 4 for moving the gasket 3 in the longitudinal direction in the outer cylinder 2 is connected to the gasket 3.
  • the plunger 4 is formed of a cross-shaped plate piece having a cross-section, and two plate members 41 are integrally formed on the tip side thereof.
  • the shape of the plunger 4 is not limited to this, and may be a cylindrical body having an outer diameter smaller than the outer diameter of the gasket 3.
  • a plate-like flange 42 is provided at the base end of the plunger 4. The plunger 4 is operated by pressing the flange 42 with a finger or the like.
  • the flange 42 may be formed integrally with the base end of the plunger 4, or the flange 42 and the plunger 4 may be separately manufactured and joined.
  • a head portion (connecting portion) 43 which is inserted into the hollow portion 33 of the gasket 3 and is connected to the gasket 3 is formed.
  • a male screw 51 is formed on the outer peripheral surface of the head portion 43.
  • a female screw 52 that can be screwed with the male screw 51 is formed on the inner peripheral surface of the hollow portion 33 of the gasket 3.
  • a threaded portion 5 is formed by the male screw 51 and the female screw 52.
  • the male screw 51 is formed substantially at the center in the longitudinal direction of the head portion 43, but the position where the male screw 51 is formed is not limited to this.
  • a concave portion that is not continuous with the female screw 52 may be provided on the distal end side of the female screw 52.
  • the head portion 43 includes a flexible piece 61 disposed on the distal end side of the male screw 51, and a protruding portion 62 protruding in the outer peripheral direction near the end of each elastic piece 61.
  • a flexible piece 61 disposed on the distal end side of the male screw 51, and a protruding portion 62 protruding in the outer peripheral direction near the end of each elastic piece 61.
  • four conductive pieces 61 may be arranged at 90 ° intervals along the outer peripheral surface of the head part 43.
  • the number and arrangement of the conductive pieces 61 are not limited thereto, and two larger conductive pieces 61 are arranged at 180 ° intervals on the outer peripheral surface of the head portion 43 so as to face each other.
  • a larger number of the natural pieces 61 may be arranged at smaller intervals.
  • Each of the resilient pieces 61 can be elastically deformed toward the center of the head portion 43, whereby the protrusion 62 is displaced in the same direction.
  • the elastic pieces 61 and the projections 62 may be arranged in an annular shape when the gasket itself has sufficient elasticity and elastic deformation when connected to the gasket.
  • the surface (sliding surface) on the distal end side of the protrusion 62 is formed of a curved surface 621, so that the operation leading to engagement with the engagement protrusion 63 can be performed easily and reliably. You may.
  • the curved surface 621 is a curved convex surface, but may be a curved concave surface.
  • a tapered surface (inclined surface) may be used instead of the curved surface 6 21.
  • a ring-shaped engagement protrusion 63 is formed on the inner peripheral surface on the distal end side by the female screw 52 of the hollow portion 33 of the gasket 3.
  • the base end surface (sliding surface) of the engaging projection 63 is tapered (inclined) so that the operation leading to engagement with the projection 62 can be performed easily and reliably. It may be composed of 6 3 1. Note that, instead of the tapered surface 631, a curved surface may be used.
  • each of the elastic pieces 61, the protrusions 62, and the engagement protrusions 63 as described above forms the fitting portion 6.
  • the protrusions 62 formed on each of the elastic pieces 61 engage with the engagement protrusions 63, so that the head portion 43 fits into the gasket 3.
  • the screwing portions 5 provided in the gasket interior and the plunger are screwed together, and the fitting portions 6 provided in the gasket interior and the plunger are fitted.
  • the plunger 4 and the gasket 3 are connected.
  • a stronger connected state (bonded state) can be obtained.
  • the screwing portion 5 and the fitting portion 6 are both located in the hollow portion 33 of the gasket 3.
  • the fitting portion 6 is located on the tip side of the screwing portion, that is, at the back of the hollow portion 33.
  • the state in which the screw portion 5 is completely screwed means that the tip of the male screw 51 has reached the tip of the female screw 52. Further, when a concave portion that is not continuous with the female screw 52 is provided at the distal end portion of the female screw 52, it indicates a state in which the distal end of the male screw 51 reaches this concave portion and is not fitted.
  • the height H of the engaging projection 63 (the height of the wall portion on the distal end side) is not particularly limited, but is usually preferably about 0.5 to 5.0 mm, and about 0.7 to 1.2 mm. Is more preferred. If the height H is too low, the fitting of the fitting portion 6 (the engagement between the projection 62 and the engagement projection 63) is likely to be released, and if the height H is too high, the fitting portion 6 At the time of fitting, the amount of deformation of the gasket 3 when the protrusion 62 crosses over the engagement protrusion 63 increases, and the liquid 7 may leak.
  • the height H of the engaging projection 63 can be appropriately selected from the above-described preferred range.
  • the inner diameter of the outer cylinder 2 is as small as 10 mm or less (about 5 to 10 mm).
  • the height H is preferably about 0.7 mm.
  • the inner diameter of the outer cylinder 2 is about 3 Omm.
  • the height H of the contact portion 62 is preferably about 1.2 mm.
  • fittings 6 may be formed at a plurality of places by the corresponding fitting protrusions 62 and the engaging protrusions 63.
  • the fitting projection 62 located on the more distal end side of the plunger 4 also passes over the engagement projection 63 that does not form the fitting 6, so that the fitting projection located on the more proximal side is located.
  • the height is lower than 62. It is preferable that the height of the engaging projection 63 on the gasket side to be fitted therewith be higher on the distal end side.
  • the gasket 3 is inserted into a predetermined position in the outer cylinder 2, and a liquid (chemical solution, etc.) is introduced into the outer cylinder 2 from the distal end opening of the reduced diameter portion 22 of the outer cylinder 2.
  • a film 24 is adhered to the end of the reduced diameter portion 22 by a method such as fusion and adhesion, and the opening of the end of the reduced diameter portion 22 is sealed.
  • a liquid (chemical solution, etc.) is put into the outer cylinder 2, and the gasket 3 is inserted.
  • the plunger 4 is inserted from the base end opening of the outer cylinder 2, and the head portion 43 is inserted into the hollow portion 33 of the gasket 3 and connected (see FIG. 3).
  • the outer cylinder 2 is held in one hand, and the plunger 4 is rotated in a predetermined direction while being held in the other hand.
  • the male screw 51 is screwed into the female screw 52, and the plunger 4 moves so as to gradually enter the gasket 3 toward the distal end while rotating.
  • each protrusion 62 and the engagement protrusion 63 come into contact with each other (see FIG. 4). At this time, the curved surface 6 21 of each projection 62 contacts the tapered surface 6 31 of the engagement projection 63.
  • the male screw 51 moves to the distal end side of the female screw 52 in the screwed portion 5, and the screwing is completed, and the screw is removed.
  • the syringe 1 has a resistance to an operation of separating the two, and as a result, the connection between the two is reliably maintained. . Therefore, even when the operation of pulling the plunger 4 in the proximal direction is performed, the plunger 4 does not easily come off the gasket 3.
  • the film 24 is peeled and removed from the tip of the reduced diameter portion 22 to release the sealing, and a hub of a needle tube, for example, is fitted and attached to the reduced diameter portion 2.
  • the plunger 4 is pressed toward the tip.
  • the gasket 3 connected to the plunger 4 slides in the distal direction in the outer cylinder 2, and the liquid 7 in the outer cylinder 2 flows through the lumen 23 of the reduced diameter portion 22 and the installed needle tube. Exhausted through.
  • the plunger 4 may be reciprocated a plurality of times in the longitudinal direction so as to discharge the internal liquid 7 without leaving it.
  • an operation may be performed in which the plunger 4 is pulled in the proximal direction, the liquid is sucked from the distal end opening of the reduced diameter portion 22, and introduced into the syringe 1.
  • the present invention is not limited to this.
  • the shapes, structures, dimensions, and the like of the screwing portion, the fitting portion, and the rotation suppressing mechanism can be any ones that can exhibit the same function.
  • Industrial applicability ADVANTAGE OF THE INVENTION According to the syringe of this invention, a plunger and a gasket have sufficient coupling force, assembly is easy, and once a plunger and a gasket are once connected, they cannot be easily removed.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne une seringue dans laquelle un piston et un joint d'étanchéité ont une force de couplage suffisante, et qui est facile à assembler par ailleurs. Il s'agit d'une seringue (1) préalablement remplie comprenant un manchon externe à fond cylindrique (2), un joint d'étanchéité (3) et un piston (4). Le piston (4) et le joint d'étanchéité (3) sont assemblés par l'association d'un filetage mâle (51) formé dans la tête (43) de l'extrémité avant du piston et d'un filetage femelle (52) formé dans la surface interne de la partie creuse (33) du joint d'étanchéité (3), et par l'enclenchement entre chaque partie saillante (62) et une autre partie saillante correspondante (63).
PCT/JP2001/005216 2000-06-19 2001-06-19 Seringue WO2001097885A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2002503367A JP4623927B2 (ja) 2000-06-19 2001-06-19 シリンジ
AU2001274548A AU2001274548A1 (en) 2000-06-19 2001-06-19 Syringe

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000183005 2000-06-19
JP2000-183005 2000-06-19

Publications (1)

Publication Number Publication Date
WO2001097885A1 true WO2001097885A1 (fr) 2001-12-27

Family

ID=18683654

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2001/005216 WO2001097885A1 (fr) 2000-06-19 2001-06-19 Seringue

Country Status (3)

Country Link
JP (1) JP4623927B2 (fr)
AU (1) AU2001274548A1 (fr)
WO (1) WO2001097885A1 (fr)

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004075958A2 (fr) * 2003-02-27 2004-09-10 Baxter International Inc. Ensemble piston pour seringue
WO2005070484A1 (fr) * 2004-01-09 2005-08-04 Becton Dickinson And Company Seringue de nettoyage a deplacement positif
JP2007125130A (ja) * 2005-11-02 2007-05-24 Ajinomoto Co Inc シリンジ用プランジャー
JP2007289677A (ja) * 2006-03-28 2007-11-08 Jms Co Ltd プランジャーロッドとガスケットとの結合構造及びシリンジ
JP2009142508A (ja) * 2007-12-14 2009-07-02 Terumo Corp 注射器およびプレフィルドシリンジ
EP2081621A2 (fr) * 2006-11-06 2009-07-29 Safeshot Technologies, LLC Membrane perforable pour seringue de sécurité
WO2011040522A1 (fr) * 2009-09-30 2011-04-07 テルモ株式会社 Seringue pré-remplie
EP2407195A1 (fr) * 2009-03-09 2012-01-18 Terumo Kabushiki Kaisha Joint et seringue
JP2012029918A (ja) * 2010-07-30 2012-02-16 Terumo Corp ガスケット、プレフィルドシリンジ、及び打栓方法
JP2012135664A (ja) * 2006-03-28 2012-07-19 Jms Co Ltd プランジャーロッドとガスケットとの結合構造及びシリンジ
JP2012205931A (ja) * 2012-07-26 2012-10-25 Terumo Corp シリンジ
JP2013070788A (ja) * 2011-09-27 2013-04-22 Terumo Corp プレフィルドシリンジ
WO2014196057A1 (fr) * 2013-06-06 2014-12-11 テルモ株式会社 Instrument pour injection, et ampoule-seringue
WO2014196056A1 (fr) * 2013-06-06 2014-12-11 テルモ株式会社 Seringue et seringue pré-remplie
US9333301B2 (en) 2002-10-11 2016-05-10 Becton, Dickinson And Company Flush syringe having compressible plunger
EP2482872B1 (fr) 2009-09-30 2016-05-18 Sanofi-Aventis Deutschland GmbH Procédé pour l'assemblage d'un dispositif d'administration de médicaments, assemblage pour un dispositif d'administration de médicaments et tige de piston pour un dispositif d'administration de médicaments
WO2016139215A1 (fr) * 2015-03-02 2016-09-09 Fresenius Kabi Austria Gmbh Tige de piston comprenant au moins trois éléments cylindriques pour une seringue préremplie
EP1703931B1 (fr) * 2004-01-09 2018-03-07 Becton, Dickinson and Company Seringue de rin age a deplacement positif
JP2018158179A (ja) * 2018-07-12 2018-10-11 テルモ株式会社 注射器およびプレフィルドシリンジ
JP2019528833A (ja) * 2016-09-27 2019-10-17 オーウェン マンフォード リミテッドＯｗｅｎ Ｍｕｍｆｏｒｄ Ｌｉｍｉｔｅｄ ガスケットかみ合い部を備えた注射器およびプランジャーロッド
CN110785198A (zh) * 2017-05-05 2020-02-11 赛诺菲 将电子器件集成到药筒的塞子中
JP2020108858A (ja) * 2018-07-12 2020-07-16 テルモ株式会社 注射器およびプレフィルドシリンジ
WO2020203239A1 (fr) * 2019-03-29 2020-10-08 テルモ株式会社 Kit de piston, kit de seringue, et seringue pré-remplie
CN112423816A (zh) * 2018-07-10 2021-02-26 豪夫迈·罗氏有限公司 柱塞和制造柱塞的方法
US11517678B2 (en) 2017-05-05 2022-12-06 Sanofi Cartridge with distributed electronic components

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08729A (ja) * 1994-06-21 1996-01-09 Suiyoudou:Kk 注射器
JPH08182760A (ja) * 1994-12-28 1996-07-16 Nissho Corp プレフィルドシリンジ
US5688252A (en) * 1994-09-30 1997-11-18 Takeda Chemical Industries, Ltd. Syringe
JPH09308689A (ja) * 1996-05-21 1997-12-02 Nihon Medi Physics Co Ltd 突起を有するプランジャーおよび注射器

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08729A (ja) * 1994-06-21 1996-01-09 Suiyoudou:Kk 注射器
US5688252A (en) * 1994-09-30 1997-11-18 Takeda Chemical Industries, Ltd. Syringe
JPH08182760A (ja) * 1994-12-28 1996-07-16 Nissho Corp プレフィルドシリンジ
JPH09308689A (ja) * 1996-05-21 1997-12-02 Nihon Medi Physics Co Ltd 突起を有するプランジャーおよび注射器

Cited By (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9333301B2 (en) 2002-10-11 2016-05-10 Becton, Dickinson And Company Flush syringe having compressible plunger
WO2004075958A3 (fr) * 2003-02-27 2004-12-02 Baxter Int Ensemble piston pour seringue
WO2004075958A2 (fr) * 2003-02-27 2004-09-10 Baxter International Inc. Ensemble piston pour seringue
WO2005070484A1 (fr) * 2004-01-09 2005-08-04 Becton Dickinson And Company Seringue de nettoyage a deplacement positif
EP1703931B1 (fr) * 2004-01-09 2018-03-07 Becton, Dickinson and Company Seringue de rin age a deplacement positif
EP3345640A3 (fr) * 2004-01-09 2018-07-25 Becton, Dickinson and Company Seringue évacuatrice à déplacement positif
US8574202B2 (en) * 2004-01-09 2013-11-05 Becton, Dickinson And Company Positive displacement flush syringe
JP2007125130A (ja) * 2005-11-02 2007-05-24 Ajinomoto Co Inc シリンジ用プランジャー
JP2012135664A (ja) * 2006-03-28 2012-07-19 Jms Co Ltd プランジャーロッドとガスケットとの結合構造及びシリンジ
JP2007289677A (ja) * 2006-03-28 2007-11-08 Jms Co Ltd プランジャーロッドとガスケットとの結合構造及びシリンジ
EP2081621A2 (fr) * 2006-11-06 2009-07-29 Safeshot Technologies, LLC Membrane perforable pour seringue de sécurité
EP2081621A4 (fr) * 2006-11-06 2011-12-28 Safeshot Technologies Llc Membrane perforable pour seringue de sécurité
JP2009142508A (ja) * 2007-12-14 2009-07-02 Terumo Corp 注射器およびプレフィルドシリンジ
EP2407195A1 (fr) * 2009-03-09 2012-01-18 Terumo Kabushiki Kaisha Joint et seringue
US9415169B2 (en) 2009-03-09 2016-08-16 Terumo Kabushiki Kaisha Gasket and syringe
EP2407195A4 (fr) * 2009-03-09 2014-08-27 Terumo Corp Joint et seringue
JP5567026B2 (ja) * 2009-09-30 2014-08-06 テルモ株式会社 プレフィルドシリンジ
EP2484393A4 (fr) * 2009-09-30 2013-07-24 Terumo Corp Seringue pré-remplie
JPWO2011040522A1 (ja) * 2009-09-30 2013-02-28 テルモ株式会社 プレフィルドシリンジ
WO2011040522A1 (fr) * 2009-09-30 2011-04-07 テルモ株式会社 Seringue pré-remplie
US9101720B2 (en) 2009-09-30 2015-08-11 Terumo Kabushiki Kaisha Prefilled syringe
CN102639174A (zh) * 2009-09-30 2012-08-15 泰尔茂株式会社 预充式注射器
EP2482872B1 (fr) 2009-09-30 2016-05-18 Sanofi-Aventis Deutschland GmbH Procédé pour l'assemblage d'un dispositif d'administration de médicaments, assemblage pour un dispositif d'administration de médicaments et tige de piston pour un dispositif d'administration de médicaments
EP2484393A1 (fr) * 2009-09-30 2012-08-08 Terumo Kabushiki Kaisha Seringue pré-remplie
JP2012029918A (ja) * 2010-07-30 2012-02-16 Terumo Corp ガスケット、プレフィルドシリンジ、及び打栓方法
JP2013070788A (ja) * 2011-09-27 2013-04-22 Terumo Corp プレフィルドシリンジ
JP2012205931A (ja) * 2012-07-26 2012-10-25 Terumo Corp シリンジ
JPWO2014196057A1 (ja) * 2013-06-06 2017-02-23 テルモ株式会社 注射器およびプレフィルドシリンジ
US10279115B2 (en) 2013-06-06 2019-05-07 Terumo Kabushiki Kaisha Syringe and prefilled syringe
EP3006066A4 (fr) * 2013-06-06 2016-12-14 Terumo Corp Instrument pour injection, et ampoule-seringue
JPWO2014196056A1 (ja) * 2013-06-06 2017-02-23 テルモ株式会社 注射器およびプレフィルドシリンジ
US11045606B2 (en) 2013-06-06 2021-06-29 Terumo Kabushikikaisha Syringe and prefilled syringe
WO2014196056A1 (fr) * 2013-06-06 2014-12-11 テルモ株式会社 Seringue et seringue pré-remplie
WO2014196057A1 (fr) * 2013-06-06 2014-12-11 テルモ株式会社 Instrument pour injection, et ampoule-seringue
US10137250B2 (en) 2013-06-06 2018-11-27 Terumo Kabushiki Kaisha Syringe and prefilled syringe
CN107427642A (zh) * 2015-03-02 2017-12-01 费森尤斯卡比奥地利有限公司 用于预充填的注射器的带有至少三个环形元件的活塞杆
US10543319B2 (en) 2015-03-02 2020-01-28 Fresenius Kabi Austria Gmbh Plunger rod comprising at least three annular elements for a prefilled syringe
US11571520B2 (en) 2015-03-02 2023-02-07 Fresenius Kabi Austria Gmbh Plunger rod comprising at least three annular elements for a prefilled syringe
AU2016227737B2 (en) * 2015-03-02 2020-07-23 Fresenius Kabi Austria Gmbh Plunger rod comprising at least three annular elements for a prefilled syringe
WO2016139215A1 (fr) * 2015-03-02 2016-09-09 Fresenius Kabi Austria Gmbh Tige de piston comprenant au moins trois éléments cylindriques pour une seringue préremplie
EP3760260A1 (fr) * 2015-03-02 2021-01-06 Fresenius Kabi Austria GmbH Tige de piston pourvu d'au moins trois éléments de bagues pour une seringue préremplie
CN107427642B (zh) * 2015-03-02 2021-04-02 费森尤斯卡比奥地利有限公司 用于预充填的注射器的带有至少三个环形元件的活塞杆
JP2019528833A (ja) * 2016-09-27 2019-10-17 オーウェン マンフォード リミテッドＯｗｅｎ Ｍｕｍｆｏｒｄ Ｌｉｍｉｔｅｄ ガスケットかみ合い部を備えた注射器およびプランジャーロッド
US11103645B2 (en) 2016-09-27 2021-08-31 Owen Mumford Limited Syringe and piston rod with gasket engaging portion
CN110785198B (zh) * 2017-05-05 2024-05-14 赛诺菲 将电子器件集成到药筒的塞子中
CN110785198A (zh) * 2017-05-05 2020-02-11 赛诺菲 将电子器件集成到药筒的塞子中
US11517678B2 (en) 2017-05-05 2022-12-06 Sanofi Cartridge with distributed electronic components
JP2021524339A (ja) * 2018-07-10 2021-09-13 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト プランジャおよびプランジャの製造方法
CN112423816A (zh) * 2018-07-10 2021-02-26 豪夫迈·罗氏有限公司 柱塞和制造柱塞的方法
US11577027B2 (en) 2018-07-10 2023-02-14 Hoffmann-La Roche Inc. Plunger and method of manufacturing a plunger
JP7554733B2 (ja) 2018-07-10 2024-09-20 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト プランジャおよびプランジャの製造方法
JP2020108858A (ja) * 2018-07-12 2020-07-16 テルモ株式会社 注射器およびプレフィルドシリンジ
JP2018158179A (ja) * 2018-07-12 2018-10-11 テルモ株式会社 注射器およびプレフィルドシリンジ
JPWO2020203239A1 (fr) * 2019-03-29 2020-10-08
WO2020203239A1 (fr) * 2019-03-29 2020-10-08 テルモ株式会社 Kit de piston, kit de seringue, et seringue pré-remplie
JP7397065B2 (ja) 2019-03-29 2023-12-12 テルモ株式会社 プランジャーキット、シリンジキット及びプレフィルドシリンジ

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