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WO2001080921A3 - Native protein mimetic fibers, fiber networks and fabrics for medical use - Google Patents

Native protein mimetic fibers, fiber networks and fabrics for medical use Download PDF

Info

Publication number
WO2001080921A3
WO2001080921A3 PCT/US2001/012918 US0112918W WO0180921A3 WO 2001080921 A3 WO2001080921 A3 WO 2001080921A3 US 0112918 W US0112918 W US 0112918W WO 0180921 A3 WO0180921 A3 WO 0180921A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
materials
fibers
medical use
fiber networks
Prior art date
Application number
PCT/US2001/012918
Other languages
French (fr)
Other versions
WO2001080921A2 (en
Inventor
Elliot L Chaikof
Vincent Conticello
Lei Huang
Karthik Nagapudi
Original Assignee
Univ Emory
Elliot L Chaikof
Vincent Conticello
Lei Huang
Karthik Nagapudi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Emory, Elliot L Chaikof, Vincent Conticello, Lei Huang, Karthik Nagapudi filed Critical Univ Emory
Priority to US10/258,207 priority Critical patent/US20040110439A1/en
Priority to CA002406862A priority patent/CA2406862A1/en
Priority to JP2001578015A priority patent/JP2004525268A/en
Priority to EP01928716A priority patent/EP1274469A2/en
Priority to AU2001255544A priority patent/AU2001255544A1/en
Publication of WO2001080921A2 publication Critical patent/WO2001080921A2/en
Publication of WO2001080921A3 publication Critical patent/WO2001080921A3/en

Links

Classifications

    • D—TEXTILES; PAPER
    • D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
    • D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
    • D01F4/00—Monocomponent artificial filaments or the like of proteins; Manufacture thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/222—Gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0076—Chemical modification of the substrate
    • A61L33/0082—Chemical modification of the substrate by reacting with an organic compound other than heparin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Textile Engineering (AREA)
  • Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Nonwoven Fabrics (AREA)
  • Prostheses (AREA)
  • Artificial Filaments (AREA)

Abstract

The present disclosure provides spun fibers of proteins useful for the fibers, fiber networks and nonwoven fabrics for medical use, with these materials characterized by good biocompatibility properties (e.g., low tendency toward thromboses and inflammation when implanted into a human or animal). These materials can be fabricated from gelatin, collagen or elastin-mimetic proteins, functionalized proteins of the foregoing types, crosslinked functionalized proteins of the foregoing types, and there may be incorporated nonproteinaceous polymers and/or therapeutic proteins or other medicinal compounds. Additionally, there may be living cells colonized on the material of the present invention or living cells may be incorporated during the fabrication process. These materials can be used in medical applications including, without limitation, vascular grafts, reinforcement of injured tissue, wound healing, artificial organs and tissues, prosthetic heart valves and prosthetic ureters.
PCT/US2001/012918 2000-04-20 2001-04-20 Native protein mimetic fibers, fiber networks and fabrics for medical use WO2001080921A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US10/258,207 US20040110439A1 (en) 2001-04-20 2001-04-20 Native protein mimetic fibers, fiber networks and fabrics for medical use
CA002406862A CA2406862A1 (en) 2000-04-20 2001-04-20 Native protein mimetic fibers, fiber networks and fabrics for medical use
JP2001578015A JP2004525268A (en) 2000-04-20 2001-04-20 Native protein mimic fibers, fiber networks and fabrics for medical applications
EP01928716A EP1274469A2 (en) 2000-04-20 2001-04-20 Native protein mimetic fibers, fiber networks and fabrics for medical use
AU2001255544A AU2001255544A1 (en) 2000-04-20 2001-04-20 Native protein mimetic fibers, fiber networks and fabrics for medical use

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US19879200P 2000-04-20 2000-04-20
US60/198,792 2000-04-20
US22182800P 2000-07-28 2000-07-28
US60/221,828 2000-07-28

Publications (2)

Publication Number Publication Date
WO2001080921A2 WO2001080921A2 (en) 2001-11-01
WO2001080921A3 true WO2001080921A3 (en) 2002-02-28

Family

ID=26894159

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/012918 WO2001080921A2 (en) 2000-04-20 2001-04-20 Native protein mimetic fibers, fiber networks and fabrics for medical use

Country Status (5)

Country Link
EP (1) EP1274469A2 (en)
JP (1) JP2004525268A (en)
AU (1) AU2001255544A1 (en)
CA (1) CA2406862A1 (en)
WO (1) WO2001080921A2 (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020081732A1 (en) 2000-10-18 2002-06-27 Bowlin Gary L. Electroprocessing in drug delivery and cell encapsulation
CA2406343A1 (en) 2000-04-13 2001-10-25 Emory University Antithrombogenic membrane mimetic compositions and methods
WO2002009647A2 (en) 2000-07-28 2002-02-07 Emory University Biological component comprising artificial membrane
AU2002224387B2 (en) 2000-10-18 2008-02-14 Virginia Commonwealth University Intellectual Property Foundation Electroprocessing in drug delivery and cell encapsulation
ATE402002T1 (en) 2000-11-17 2008-08-15 Univ Virginia Commonwealth ELECTROPROCESSED COLLAGEN
AU2002235375A1 (en) 2001-01-12 2002-07-24 Emory University Glycopolymers and free radical polymerization methods
GB2393724B (en) * 2002-10-01 2006-04-12 Johnson & Johnson Medical Ltd Controlled release therapeutic wound dressings
EP1545638A1 (en) * 2002-10-01 2005-06-29 Johnson & Johnson Medical Ltd. Controlled release therapeutic wound dressings
EP1422242A1 (en) * 2002-11-22 2004-05-26 Emory University Plastic and elastic protein copolymers
AU2003236491B2 (en) * 2002-11-22 2010-05-13 Emory University Plastic and elastic protein copolymers
JP2004231633A (en) * 2002-11-22 2004-08-19 Emory Univ Plastic and elastic protein copolymer
US20040126405A1 (en) * 2002-12-30 2004-07-01 Scimed Life Systems, Inc. Engineered scaffolds for promoting growth of cells
WO2004062697A2 (en) 2003-01-07 2004-07-29 Tufts University Silk fibroin materials and use thereof
US20070244568A1 (en) * 2003-12-26 2007-10-18 Cardio Incorporated Decellularized Tissue and Method of Preparing the Same
US7833978B2 (en) 2004-02-20 2010-11-16 Emory University Thrombomodulin derivatives and conjugates
US7824672B2 (en) 2004-03-26 2010-11-02 Emory University Method for coating living cells
WO2006041130A1 (en) * 2004-10-14 2006-04-20 National University Corporation Hokkaido University Gel for zymography
US7993738B2 (en) * 2004-11-30 2011-08-09 The Regents Of The University Of Michigan Modified porous materials and method of forming the same
US8728463B2 (en) 2005-03-11 2014-05-20 Wake Forest University Health Science Production of tissue engineered digits and limbs
CA2602050C (en) 2005-03-11 2013-12-03 Wake Forest University Health Sciences Production of tissue engineered heart valves
US8491457B2 (en) 2005-03-11 2013-07-23 Wake Forest University Health Services Tissue engineered blood vessels
US20060204539A1 (en) * 2005-03-11 2006-09-14 Anthony Atala Electrospun cell matrices
US8846624B2 (en) 2006-09-11 2014-09-30 Emory University Modified protein polymers
EP2097115B1 (en) 2006-11-13 2017-01-25 Elastagen Pty Ltd Use of tropoelastin for repair or restoration of tissue
CA2676932C (en) 2007-02-01 2015-11-24 Technion Research & Development Foundation Ltd. Albumin fibers and fabrics and methods of generating and using same
DE102007044648B4 (en) * 2007-09-18 2020-11-26 Carl Freudenberg Kg Bioresorbable gelatin non-woven fabric
EP2295630A1 (en) * 2009-09-11 2011-03-16 Basf Se Method for producing coated protein fibres
US10092679B2 (en) 2013-10-18 2018-10-09 Wake Forest University Health Sciences Laminous vascular constructs combining cell sheet engineering and electrospinning technologies
CN105326581B (en) * 2015-09-29 2017-12-26 中国科学院金属研究所 A kind of method for preparing polyethylene glycol protein fiber composite heart valve prosthesis
JP6612664B2 (en) * 2016-03-16 2019-11-27 株式会社東芝 Fiber orientation sheet
US10801140B2 (en) 2016-03-16 2020-10-13 Kabushiki Kaisha Toshiba Fiber sheet and method for manufacturing same
CN111529759B (en) * 2020-04-23 2021-12-07 东华大学 Macroporous bone tissue engineering scaffold capable of sustainably releasing inorganic active ingredients and preparation method thereof
CN111961164B (en) * 2020-09-18 2022-04-05 宜宾惠美纤维新材料股份有限公司 Cashmere protein and preparation method of cashmere protein fiber
CN117120109A (en) 2021-02-09 2023-11-24 信越化学工业株式会社 Gelatin-containing device
CN113230461B (en) * 2021-05-06 2022-02-15 东华大学 Micro-nanofiber-hydrogel tissue engineering ureter and preparation method thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474851A (en) * 1981-10-02 1984-10-02 The University Of Alabama In Birmingham Elastomeric composite material comprising a polypeptide
WO1987006238A1 (en) * 1986-04-17 1987-10-22 University Of Alabama At Birmingham Segmented polypeptide bioeleastomers to modulate elastic modulus
WO1991008242A1 (en) * 1989-11-27 1991-06-13 Institut National De La Sante Et De La Recherche Medicale Method for obtaining copolymers by grafting vinyl chain units, and graft copolymers thereby obtained
WO1998034563A1 (en) * 1997-02-07 1998-08-13 Sisters Of Providence In Oregon Method for using tropoelastin and for producing tropoelastin biomaterials
WO1998055161A1 (en) * 1997-06-03 1998-12-10 Innogenetics N.V. New medicaments based on polymers composed of methacrylamide-modified gelatin
EP1022031A1 (en) * 1999-01-21 2000-07-26 Nissho Corporation Suturable adhesion-preventing membrane

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4474851A (en) * 1981-10-02 1984-10-02 The University Of Alabama In Birmingham Elastomeric composite material comprising a polypeptide
WO1987006238A1 (en) * 1986-04-17 1987-10-22 University Of Alabama At Birmingham Segmented polypeptide bioeleastomers to modulate elastic modulus
WO1991008242A1 (en) * 1989-11-27 1991-06-13 Institut National De La Sante Et De La Recherche Medicale Method for obtaining copolymers by grafting vinyl chain units, and graft copolymers thereby obtained
WO1998034563A1 (en) * 1997-02-07 1998-08-13 Sisters Of Providence In Oregon Method for using tropoelastin and for producing tropoelastin biomaterials
WO1998055161A1 (en) * 1997-06-03 1998-12-10 Innogenetics N.V. New medicaments based on polymers composed of methacrylamide-modified gelatin
EP1022031A1 (en) * 1999-01-21 2000-07-26 Nissho Corporation Suturable adhesion-preventing membrane

Also Published As

Publication number Publication date
JP2004525268A (en) 2004-08-19
WO2001080921A2 (en) 2001-11-01
EP1274469A2 (en) 2003-01-15
CA2406862A1 (en) 2001-11-01
AU2001255544A1 (en) 2001-11-07

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