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WO2000001817A3 - Mammalian genes; dendritic cell prostaglandin-like transponder (dc-pgt), hdtea84, hsljd37r and rankl, hcc5 chemokine, deubiquitinating 11 and 12 (dub11, dub12), md-1, md2 and cyclin e2, related reagents and methods - Google Patents

Mammalian genes; dendritic cell prostaglandin-like transponder (dc-pgt), hdtea84, hsljd37r and rankl, hcc5 chemokine, deubiquitinating 11 and 12 (dub11, dub12), md-1, md2 and cyclin e2, related reagents and methods Download PDF

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Publication number
WO2000001817A3
WO2000001817A3 PCT/US1999/012366 US9912366W WO0001817A3 WO 2000001817 A3 WO2000001817 A3 WO 2000001817A3 US 9912366 W US9912366 W US 9912366W WO 0001817 A3 WO0001817 A3 WO 0001817A3
Authority
WO
WIPO (PCT)
Prior art keywords
hsljd37r
hdtea84
hcc5
deubiquitinating
pgt
Prior art date
Application number
PCT/US1999/012366
Other languages
French (fr)
Other versions
WO2000001817A2 (en
Inventor
Elizabeth Esther Mary Bates
Serge J E Lebecque
Erin E Murphy
Jeanine D Mattson
Daniel M Gorman
Joseph A Hedrick
Luquan Wang
Albert Zlotnik
Nicholas J Murgolo
Jonathan R Greene
James A Johnston
Jose Fernando Bazan
Daniel Mahony
Emma M Lees
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Priority to AU48185/99A priority Critical patent/AU4818599A/en
Priority to EP99931753A priority patent/EP1093516A2/en
Priority to JP2000558207A priority patent/JP2002519062A/en
Priority to CA002332573A priority patent/CA2332573A1/en
Publication of WO2000001817A2 publication Critical patent/WO2000001817A2/en
Publication of WO2000001817A3 publication Critical patent/WO2000001817A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Purified genes from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding the polypeptides are provided. Methods of using said reagents and diagnostic kits are also provided. Characterization of genes and products relating to DC-PGT (Dendritic cell prostaglandin-like transporter), HDTEA84, HSLJD37R and RANKL (related to TNF receptor family), HCC5 chemokine, Dub 11 and Dub 12 (Deubiquitinating 11 and 12), MD-1 and MD-2 (proteins which exhibit properties of ligands for proteins exhibiting a leucine-rich protein motif (LRR)) and cyclin E2.
PCT/US1999/012366 1998-07-06 1999-07-06 Mammalian genes; dendritic cell prostaglandin-like transponder (dc-pgt), hdtea84, hsljd37r and rankl, hcc5 chemokine, deubiquitinating 11 and 12 (dub11, dub12), md-1, md2 and cyclin e2, related reagents and methods WO2000001817A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU48185/99A AU4818599A (en) 1998-07-06 1999-07-06 Mammalian genes; dendritic cell prostaglandin-like transponder (dc-pgt), hdtea84, hsljd37r and rankl, hcc5 chemokine, deubiquitinating 11 and 12 (dub11, dub12),md-1, md2 and cyclin e2, related reagents and methods
EP99931753A EP1093516A2 (en) 1998-07-06 1999-07-06 Mammalian genes; dendritic cell prostaglandin-like transporter (dc-pgt), hdtea84, hsljd37r and rankl, hcc5 chemokine, deubiquitinating 11 and 12 (dub11, dub12), md-1, md2 and cyclin e2, related reagents and methods
JP2000558207A JP2002519062A (en) 1998-07-06 1999-07-06 Mammalian genes; dendritic cell prostaglandin-like transporter (DC-PGT), HDTEA, HSLJD37R and RANKL, HCC5 chemokine, deubiquitination 11 and 12 (DUB11, DUB12), MD-1, MD-2 and cyclin E2 , Related reagents and methods
CA002332573A CA2332573A1 (en) 1998-07-06 1999-07-06 Mammalian genes; dendritic cell prostaglandin-like transponder (dc-pgt), hdtea84, hsljd37r and rankl, hcc5 chemokine, deubiquitinating 11 and 12 (dub11, dub12), md-1, md2 and cyclin e2, related reagents and methods

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US11093898A 1998-07-06 1998-07-06
US09/110,938 1998-07-06
US11446698A 1998-07-13 1998-07-13
US09/114,466 1998-07-13
US9389798P 1998-07-23 1998-07-23
US60/093,897 1998-07-23
US13296898A 1998-08-12 1998-08-12
US09/132,968 1998-08-12
US13621498A 1998-08-18 1998-08-18
US09/136,214 1998-08-18
US9999998P 1998-09-11 1998-09-11
US60/099,999 1998-09-11

Publications (2)

Publication Number Publication Date
WO2000001817A2 WO2000001817A2 (en) 2000-01-13
WO2000001817A3 true WO2000001817A3 (en) 2000-06-29

Family

ID=27557472

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/012366 WO2000001817A2 (en) 1998-07-06 1999-07-06 Mammalian genes; dendritic cell prostaglandin-like transponder (dc-pgt), hdtea84, hsljd37r and rankl, hcc5 chemokine, deubiquitinating 11 and 12 (dub11, dub12), md-1, md2 and cyclin e2, related reagents and methods

Country Status (5)

Country Link
EP (1) EP1093516A2 (en)
JP (1) JP2002519062A (en)
AU (1) AU4818599A (en)
CA (1) CA2332573A1 (en)
WO (1) WO2000001817A2 (en)

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CA2277925A1 (en) 1997-01-14 1998-07-16 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6.alpha. and 6.beta.
US7285267B2 (en) 1997-01-14 2007-10-23 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6α & 6β
US6358508B1 (en) 1997-06-11 2002-03-19 Human Genome Sciences, Inc. Antibodies to human tumor necrosis factor receptor TR9
ES2286856T3 (en) 1997-09-12 2007-12-01 Biogen Idec Ma Inc. TRAIN RICH RECEIVERS IN CISTEINA.
KR20010030984A (en) * 1997-10-07 2001-04-16 오노 야꾸힝 고교 가부시키가이샤 POLYPEPTIDE, cDNA ENCODING THE SAME, AND USE OF THEM
CA2349818A1 (en) * 1998-11-04 2000-05-11 Incyte Pharmaceuticals, Inc. Membrane transport proteins
WO2000039284A1 (en) * 1998-12-30 2000-07-06 Millennium Pharmaceuticals, Inc. Secreted proteins and nucleic acids encoding them
US6534061B1 (en) * 1999-04-12 2003-03-18 Genentech, Inc. Tumor necrosis factor receptor homologs and nucleic acids encoding the same
EP1190047A1 (en) * 1999-06-23 2002-03-27 Angiogene, Inc. Antisense oligonucleotide modulating cyclin e gene expression and therapeutic uses thereof
US6951738B2 (en) 1999-07-16 2005-10-04 Human Genome Sciences, Inc. Human tumor necrosis factor receptors TR13 and TR14
US6329171B1 (en) 1999-09-30 2001-12-11 Millennium Pharmaceuticals, Inc. 23484, A novel human ubiquitin protease
US7329529B2 (en) 1999-09-03 2008-02-12 Millennium Pharmaceuticals, Inc. Ubiqutin proteases
JP4838961B2 (en) * 1999-09-21 2011-12-14 中外製薬株式会社 Transporter genes OATP-B, C, D, and E
US7029895B2 (en) 1999-09-27 2006-04-18 Millennium Pharmaceuticals, Inc. 27411, a novel human PGP synthase
US6451994B1 (en) 1999-09-27 2002-09-17 Millennium Pharmaceuticals, Inc. 23413, a novel human ubiquitin protease
EP1237921A1 (en) * 1999-10-22 2002-09-11 ZymoGenetics, Inc. Umlr polypeptides
WO2002038761A2 (en) * 2000-11-09 2002-05-16 Bayer Aktiengesellschaft Regulation of human oat-like protein
US6900044B2 (en) 2001-03-27 2005-05-31 Millennium Pharmaceutical, Inc. 68999, a human ubiquitin carboxyl-terminal hydrolase family member and uses therefor
WO2003013583A1 (en) * 2001-08-10 2003-02-20 Genset S.A. Faxigen agonists and antagonists in the treatment of metabolic disorders
WO2003072724A2 (en) * 2002-02-22 2003-09-04 Aventis Pharmaceuticals Inc. Human analogs of murine deubiquitinating protease genes
GB0218518D0 (en) 2002-03-22 2002-09-18 Aventis Pharma Inc Human deubiquitinating protease gene on chromosome 7 and its murine ortholog
JP2007514410A (en) * 2003-11-14 2007-06-07 ザ クイーンズ ユニヴァーシティ オブ ベルファスト gene
US7312320B2 (en) 2003-12-10 2007-12-25 Novimmune Sa Neutralizing antibodies and methods of use thereof
US7674884B2 (en) * 2003-12-10 2010-03-09 Novimmune S.A. Neutralizing antibodies and methods of use thereof
GB0412186D0 (en) * 2004-05-28 2004-06-30 Univ Cambridge Tech Production of recombinant protein
CA2576193A1 (en) 2004-08-03 2006-02-16 Biogen Idec Ma Inc. Taj in neuronal function
EP2776066B1 (en) 2011-11-07 2018-09-19 Universite Laval Rank/rankl antagonists for use in treating neuromuscular disorders, genetic myopathies and/or non genetic myopathies

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Publication number Publication date
CA2332573A1 (en) 2000-01-13
EP1093516A2 (en) 2001-04-25
JP2002519062A (en) 2002-07-02
AU4818599A (en) 2000-01-24
WO2000001817A2 (en) 2000-01-13

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