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WO2000078275A3 - Antibacterial compositions - Google Patents

Antibacterial compositions Download PDF

Info

Publication number
WO2000078275A3
WO2000078275A3 PCT/US2000/015729 US0015729W WO0078275A3 WO 2000078275 A3 WO2000078275 A3 WO 2000078275A3 US 0015729 W US0015729 W US 0015729W WO 0078275 A3 WO0078275 A3 WO 0078275A3
Authority
WO
WIPO (PCT)
Prior art keywords
antibacterial
antibacterial compositions
compositions
antibacterial agent
agent
Prior art date
Application number
PCT/US2000/015729
Other languages
French (fr)
Other versions
WO2000078275A2 (en
Inventor
Timothy J Taylor
Earl P Seitz Jr
Priscilla S Fox
Original Assignee
Dial Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/338,654 external-priority patent/US6107261A/en
Application filed by Dial Corp filed Critical Dial Corp
Priority to BR0011860-5A priority Critical patent/BR0011860A/en
Priority to JP2001504341A priority patent/JP2003502353A/en
Priority to MXPA01013312A priority patent/MXPA01013312A/en
Priority to AU54720/00A priority patent/AU777059B2/en
Priority to EP00939667A priority patent/EP1191843A2/en
Priority to CA002371925A priority patent/CA2371925C/en
Publication of WO2000078275A2 publication Critical patent/WO2000078275A2/en
Publication of WO2000078275A3 publication Critical patent/WO2000078275A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
    • A01N31/16—Oxygen or sulfur directly attached to an aromatic ring system with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/02—Anionic compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/38—Cationic compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/38—Cationic compounds
    • C11D1/65—Mixtures of anionic with cationic compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66—Non-ionic compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66—Non-ionic compounds
    • C11D1/83—Mixtures of non-ionic with anionic compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/66—Non-ionic compounds
    • C11D1/835—Mixtures of non-ionic with cationic compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
    • C11D1/86—Mixtures of anionic, cationic, and non-ionic compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/43—Solvents
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Emergency Medicine (AREA)
  • Agronomy & Crop Science (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Dermatology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Antibacterial compositions having enhanced antibacterial effectiveness are disclosed. The antibacterial compositions contain a phenolic antibacterial agent, a surfactant or a disinfecting alcohol, and water, wherein a percent saturation of the antibacterial agent in a continous aqueous phase of the composition is at least 25 %.
PCT/US2000/015729 1999-06-23 2000-06-08 Antibacterial compositions WO2000078275A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
BR0011860-5A BR0011860A (en) 1999-06-23 2000-06-08 Antibacterial compositions and process for reducing a population of bacteria on a surface
JP2001504341A JP2003502353A (en) 1999-06-23 2000-06-08 Antimicrobial composition
MXPA01013312A MXPA01013312A (en) 1999-06-23 2000-06-08 Antibacterial compositions.
AU54720/00A AU777059B2 (en) 1999-06-23 2000-06-08 Antibacterial compositions
EP00939667A EP1191843A2 (en) 1999-06-23 2000-06-08 Antibacterial compositions
CA002371925A CA2371925C (en) 1999-06-23 2000-06-08 Antibacterial compositions

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/338,654 1999-06-23
US09/338,654 US6107261A (en) 1999-06-23 1999-06-23 Compositions containing a high percent saturation concentration of antibacterial agent
US09/425,521 1999-10-22
US09/425,521 US6136771A (en) 1999-06-23 1999-10-22 Compositions containing a high percent saturation concentration of antibacterial agent

Publications (2)

Publication Number Publication Date
WO2000078275A2 WO2000078275A2 (en) 2000-12-28
WO2000078275A3 true WO2000078275A3 (en) 2001-09-27

Family

ID=26991292

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/015729 WO2000078275A2 (en) 1999-06-23 2000-06-08 Antibacterial compositions

Country Status (8)

Country Link
EP (1) EP1191843A2 (en)
JP (1) JP2003502353A (en)
AU (1) AU777059B2 (en)
BR (1) BR0011860A (en)
CA (1) CA2371925C (en)
MX (1) MXPA01013312A (en)
TW (1) TWI284020B (en)
WO (1) WO2000078275A2 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6861397B2 (en) * 1999-06-23 2005-03-01 The Dial Corporation Compositions having enhanced deposition of a topically active compound on a surface
CA2515032A1 (en) * 2003-03-10 2004-09-23 Xantech Pharmaceuticals, Inc. Surface sanitizing compositions with improved antimicrobial performance
JP2005029532A (en) * 2003-07-09 2005-02-03 Asahi Kasei Chemicals Corp Skin cleanser
US7268165B2 (en) * 2004-08-20 2007-09-11 Steris Inc. Enhanced activity alcohol-based antimicrobial compositions
WO2006062846A2 (en) * 2004-12-09 2006-06-15 The Dial Corporation Compositions having a high antiviral and antibacterial efficacy
EP1827099A2 (en) * 2004-12-09 2007-09-05 The DIal Corporation Compositions having a high antiviral and antibacterial efficacy
WO2006062835A2 (en) * 2004-12-09 2006-06-15 The Dial Corporation Compositions having a high antiviral and antibacterial efficacy
GB0802189D0 (en) * 2008-02-07 2008-03-12 Reckitt Benckiser Inc Topical antimicrobial compositions
EP2273875B1 (en) 2008-04-08 2018-03-07 Laboratoire M2 Aqueous disinfectant formulation comprising a phenolic compound, a surfactant, and a solvent.
US10111425B2 (en) 2008-04-08 2018-10-30 Laboratoire M2 Disinfectant formulation
US9609864B2 (en) 2008-04-08 2017-04-04 Laboratoire M2 Disinfectant formulation
US10405544B2 (en) 2008-04-08 2019-09-10 Laboratoire M2 Disinfectant formulation
US9451763B2 (en) 2008-04-08 2016-09-27 Laboratoire M2 Disinfectant formulation
EP2436754A1 (en) * 2011-09-30 2012-04-04 Basf Se Antimicrobial cleaning compound
US8415286B1 (en) * 2012-06-13 2013-04-09 Green On Industries Inc. Solvent-free oil dispersant
RU2708207C9 (en) 2015-01-19 2020-02-04 Као Корпорейшн Absorbent article material, method for production thereof and absorbent article using same
JP6956462B2 (en) * 2015-10-07 2021-11-02 花王株式会社 Absorbent article
JP6800585B2 (en) * 2015-01-19 2020-12-16 花王株式会社 Water-absorbent resin composition and its manufacturing method
CA2973671C (en) 2015-02-16 2024-02-27 Laboratoire M2 Aqueous compositions for controlling pests, said compositions comprising thymol, a surfactant, and a solvent
JP6785600B2 (en) * 2015-08-31 2020-11-18 アース製薬株式会社 Sterilizing agent for hard surface and sterilizing method
WO2017063848A1 (en) * 2015-10-12 2017-04-20 Unilever N.V. Sanitising and disinfecting compositions
JP7515092B2 (en) * 2017-10-18 2024-07-12 北海道公立大学法人 札幌医科大学 Methods for screening antibacterial agents
WO2019086463A1 (en) 2017-10-30 2019-05-09 Baxalta GmbH Environmentally compatible detergents for inactivation of lipid-enveloped viruses
JP7340929B2 (en) 2017-12-27 2023-09-08 花王株式会社 Method for producing a composition containing a poorly water-soluble aromatic compound
CN112898696A (en) * 2021-01-21 2021-06-04 南亚塑胶工业（南通）有限公司 Preparation method of mildew-proof antibacterial adhesive tape

Citations (15)

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Publication number Priority date Publication date Assignee Title
GB743984A (en) * 1952-09-03 1956-01-25 Monsanto Chemicals Improvements relating to germicides
US3326808A (en) * 1965-08-25 1967-06-20 Pfizer & Co C Antiseptic detergent composition
EP0259249A2 (en) * 1986-07-23 1988-03-09 Ciba-Geigy Ag Microbicidal preparations
AU3001889A (en) * 1988-02-17 1989-08-17 Ciba-Geigy Ag Antimicrobial soap composition
FR2629095A1 (en) * 1988-03-22 1989-09-29 Reckitt Colman Cleaning composition for hard surfaces
EP0505935A1 (en) * 1991-03-25 1992-09-30 Becton, Dickinson and Company Ph controlled antimicrobial formulation
US5288486A (en) * 1985-10-28 1994-02-22 Calgon Corporation Alcohol-based antimicrobial compositions
EP0604848A2 (en) * 1992-12-28 1994-07-06 Toko Yakuhin Kogyo Kabushiki Kaisha Quick-drying gel-type disinfectant for hands and fingers
US5403864A (en) * 1993-04-01 1995-04-04 John A. Manfuso, Jr. Rapidly-acting topical antimicrobial composition
WO1995009605A1 (en) * 1993-10-06 1995-04-13 Henkel Corporation Improving phenolic disinfectant cleaning compositions with alkylpolyglucoside surfactants
DE19530833A1 (en) * 1994-08-25 1996-02-29 Ciba Geigy Ag Surfactant mixts. for use as disinfectants
WO1996006152A2 (en) * 1994-08-25 1996-02-29 Ciba Specialty Chemicals Holding Inc. Surface-active formulations
US5635462A (en) * 1994-07-08 1997-06-03 Gojo Industries, Inc. Antimicrobial cleansing compositions
WO1997046218A2 (en) * 1996-06-04 1997-12-11 Ciba Specialty Chemicals Holding Inc. Concentrated liquid formulations comprising a microbicidally active ingredient
EP0855440A1 (en) * 1997-01-24 1998-07-29 The Procter & Gamble Company Antibacterial liquid dishwashing detergent compositions

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JPS6345217A (en) * 1986-07-23 1988-02-26 チバ−ガイギ　アクチエンゲゼルシヤフト Fungicidal composition
JPS63222766A (en) * 1987-03-12 1988-09-16 株式会社ハッチ Preparatory sanitation treatment of beddings
MX9701416A (en) * 1994-08-25 1997-05-31 Ciba Sc Holding Ag Surface-active formulations.
WO1998055095A1 (en) * 1997-06-04 1998-12-10 The Procter & Gamble Company Liquid antimicrobial cleansing compositions which provide residual benefit versus gram negative bacteria

Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB743984A (en) * 1952-09-03 1956-01-25 Monsanto Chemicals Improvements relating to germicides
US3326808A (en) * 1965-08-25 1967-06-20 Pfizer & Co C Antiseptic detergent composition
US5288486A (en) * 1985-10-28 1994-02-22 Calgon Corporation Alcohol-based antimicrobial compositions
EP0259249A2 (en) * 1986-07-23 1988-03-09 Ciba-Geigy Ag Microbicidal preparations
AU3001889A (en) * 1988-02-17 1989-08-17 Ciba-Geigy Ag Antimicrobial soap composition
JPH01249897A (en) * 1988-02-17 1989-10-05 Ciba Geigy Ag Sterilizable soap composition
FR2629095A1 (en) * 1988-03-22 1989-09-29 Reckitt Colman Cleaning composition for hard surfaces
EP0505935A1 (en) * 1991-03-25 1992-09-30 Becton, Dickinson and Company Ph controlled antimicrobial formulation
EP0604848A2 (en) * 1992-12-28 1994-07-06 Toko Yakuhin Kogyo Kabushiki Kaisha Quick-drying gel-type disinfectant for hands and fingers
US5403864A (en) * 1993-04-01 1995-04-04 John A. Manfuso, Jr. Rapidly-acting topical antimicrobial composition
WO1995009605A1 (en) * 1993-10-06 1995-04-13 Henkel Corporation Improving phenolic disinfectant cleaning compositions with alkylpolyglucoside surfactants
US5635462A (en) * 1994-07-08 1997-06-03 Gojo Industries, Inc. Antimicrobial cleansing compositions
DE19530833A1 (en) * 1994-08-25 1996-02-29 Ciba Geigy Ag Surfactant mixts. for use as disinfectants
WO1996006152A2 (en) * 1994-08-25 1996-02-29 Ciba Specialty Chemicals Holding Inc. Surface-active formulations
WO1997046218A2 (en) * 1996-06-04 1997-12-11 Ciba Specialty Chemicals Holding Inc. Concentrated liquid formulations comprising a microbicidally active ingredient
EP0855440A1 (en) * 1997-01-24 1998-07-29 The Procter & Gamble Company Antibacterial liquid dishwashing detergent compositions

Non-Patent Citations (3)

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Title
CHEMICAL ABSTRACTS, vol. 122, no. 2, 9 January 1995, Columbus, Ohio, US; abstract no. 16825, KJAERHEIM, V. ET AL: "Biological activities of different triclosan-detergent combinations" XP002150726 *
COLLOIDS SURF., B (1994), 3(1/2), 19-24, 1994 *
DATABASE WPI Section Ch Week 198946, Derwent World Patents Index; Class D21, AN 1989-292819, XP002164623 *

Also Published As

Publication number Publication date
JP2003502353A (en) 2003-01-21
BR0011860A (en) 2002-04-30
EP1191843A2 (en) 2002-04-03
TWI284020B (en) 2007-07-21
MXPA01013312A (en) 2003-09-04
AU777059B2 (en) 2004-09-30
WO2000078275A2 (en) 2000-12-28
CA2371925A1 (en) 2000-12-28
AU5472000A (en) 2001-01-09
CA2371925C (en) 2009-02-17

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