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WO2000074583A1 - Structure pour thermo-ablation de tissus absorbant l'energie et s'eliminant spontanement - Google Patents

Structure pour thermo-ablation de tissus absorbant l'energie et s'eliminant spontanement Download PDF

Info

Publication number
WO2000074583A1
WO2000074583A1 PCT/US2000/015665 US0015665W WO0074583A1 WO 2000074583 A1 WO2000074583 A1 WO 2000074583A1 US 0015665 W US0015665 W US 0015665W WO 0074583 A1 WO0074583 A1 WO 0074583A1
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
aperture
energy
film layer
absorbent film
Prior art date
Application number
PCT/US2000/015665
Other languages
English (en)
Inventor
Jonathan A. Eppstein
Stuart Mcrae
Original Assignee
Spectrx, Inc.
Altea Technologies, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spectrx, Inc., Altea Technologies, Inc. filed Critical Spectrx, Inc.
Priority to US10/018,015 priority Critical patent/US6685699B1/en
Priority to AU54699/00A priority patent/AU5469900A/en
Priority to EP00939642A priority patent/EP1182982A1/fr
Publication of WO2000074583A1 publication Critical patent/WO2000074583A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/203—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
    • A61B18/28—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor for heating a thermal probe or absorber
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/008—Interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00765—Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452—Skin

Definitions

  • This invention relates to the field of tissue ablation for the formation of openings in the tissue.
  • this invention relates to self-removing energy absorbing structures for achieving thermal tissue ablation.
  • the flux of a drug or analyte across a biological tissue can be increased by changing the diffusion coefficient or the gradient for diffusion. Commonly, the flux is enhanced by increasing the permeability of the skin, such as by chemical penetration enhancers, iontophoresis, and poration techniques.
  • Thermal tissue ablation for forming openings in tissue is disclosed in commonly assigned U.S. Patent No. 5,885,211 to Eppstein, et al. There is room for improving the thermal tissue ablation process.
  • the present invention is directed to a device to facilitate ablation of tissue, such as for forming one or more openings in the tissue for transdermal monitoring and/or delivery applications.
  • the device comprises: (a) a support layer having at least one aperture therein, and (b) at least one energy absorbent film layer disposed over at least one aperture in the support layer for making substantial contact with tissue through the aperture.
  • the at least one energy absorbent film layer is under a tension force over or across the aperture and absorbs energy focused thereon to thermally ablate the tissue. After ablation, and because it is under tension, the film layer breaks apart allowing access to the ablated tissue beneath it.
  • the present invention is further directed at a method for forming openings in a tissue comprising the steps of: (a) positioning a support layer having an aperture therein on a tissue; (b) positioning an energy absorbent film layer over the aperture to make substantial contact with the tissue through the aperture; and (c) focusing energy onto the energy absorbent film layer to conduct heat to the tissue thereby ablating the tissue.
  • Figure 1 is a perspective view of one embodiment of a portion of the device of the present invention.
  • Figure 2 is cross-sectional view taken through line A-A of Figure 1 and illustrating the relationship of the energy absorbent film to the tissue when suction is applied to the device.
  • Figure 3 is a top view of one embodiment of a portion of the device showing the energy absorbent film before it has been affected by energy.
  • Figure 4 is a top view of one embodiment of a portion of the device showing the energy absorbing layer after it has been affected by energy.
  • Figure 5 is a top view of one embodiment of a portion of the device used as part of a transdermal delivery system.
  • Figure 6 is a top view of one embodiment of a portion of the device used as part of a monitoring system.
  • opening means any size hole, aperture or pore of any depth, that is capable of substance transport therethrough.
  • Inclusive in this term is at least one opening in the tissue sized no larger than about 1000 ⁇ m in diameter called a micropore.
  • the device 100 includes at least a support layer 7 and an energy absorbent film layer 25. Depending on the application of the device 100, it also includes an optional assay reagent pad 20.
  • the energy absorbent film layer 25 is stretched or otherwise placed under tension across a hole or aperture 40 in the support layer 7.
  • At least one hole or aperture 35 is provided in the assay reagent pad 20 above the hole 40 and the energy absorbent film 25.
  • the hole(s) 35 may be any shape or size to provide a suitable site for tissue ablation.
  • the energy absorbent film layer 25 of Figure 1 is held in place and under tension across the aperture 40 by at least one tension member 30.
  • This tension member(s) 30 may be constructed of any suitable material in any shape to create a tension force across the film 25.
  • at least one tension member 30 is provided at one end of the energy absorbent film layer 25 and the other end is fixed to the support layer 7 by other suitable means, such as by glue or spot weld attachment.
  • at least one tension member 30 is provided at both ends of the energy absorbent film layer 25 to hold it under tension across the aperture 40.
  • materials suitable for the tension member(s) 30 include elastic, rubber, metal springs, or plastic springs or the like.
  • tension members 30 are not needed and the film 25 is anchored directly to the support layer 7.
  • Such anchoring may be performed by any suitable means including adhesive bonding, electromagnetic bonding, hot plate welding, induction bonding, insert bonding, radio-frequency sealing, spot welding, thermostacking, chemical bonding, thermo bonding, vibration welding or ultrasonic welding.
  • film 25 suitable for such use without tension members include pre-stretched mylar, rubber, silicone, polycarbonate, polyurethane, polyvinyl chloride, or polypropylene film.
  • the support layer 7 serves to support the film 25 across the aperture 40.
  • suitable materials for the support layer 7 include polyester, ceramic, polycarbonate (PC), polyvinylchloride (PVC), and mixtures thereof.
  • This support layer can be of any suitable thickness to maintain structural support for the film 25.
  • the optional assay reagent pad 20 serves to detect the presence of a substance in the fluid.
  • the assay reagent pad 20 may be useful in detecting the presence of an analyte (such as glucose) in blood or interstitial fluid.
  • the assay reagent pad 20 may be constructed of any suitable material, with as many layers or materials as necessary for detecting the presence of a substance in a fluid. Elements of the assay reagent pad include electrodes, one or more enzymes, and one or more indicators as is well known in the electrochemical biosensor art.
  • the assay reagent pad 20 alternatively may be a type that is optically interrogated to determine a measurement of an analyte.
  • the assay reagent pad 20 may be attached to the film 25 or may be placed proximate to the film 25 such that the pad 20 is capable of fluid communication with the film 25.
  • the energy absorbent film layer 25 includes a layer of material that absorbs energy and heats up. As the energy absorbent film layer 25 is heated by a beam or field 10 of energy, the film 25 transfers heat to the tissue by conduction, thereby ablating the tissue. One use of ablating the tissue is to form one or more openings in the tissue for transdermal monitoring or delivery applications. Thermal tissue ablation for forming openings is described more fully in U.S. Patent No. 5,885,211. Any suitable energy may be used for the beam of energy 10 to heat the energy absorbent film 25. In one embodiment, the beam of energy 10 is a beam of optical energy, which may for example be provided by a laser diode.
  • the energy 10 is comprised of electromagnetic energy, laser, gamma radiation, and/or beta radiation, etc.
  • the types of energy absorbing substances that are suitable for the film 25 include those disclosed in commonly assigned U.S. Patent No. 5,885,211, and in commonly assigned PCT/0599/04929, filed March 5, 1999, both of which are incorporated herein by reference in their entireties.
  • Copper pythalocyanine doped film is an example of a suitable film 25 material.
  • a clear film 25 with an absorbent adhesive layer can be used whereby the adhesive provides a positive attachment to the targeted tissue, and a thermal conduction path to the tissue.
  • a vacuum or suction 15 is applied (by a vacuum source not shown) to a region 27 of the device 100 so as to pull the tissue 5 up to contact the film 25 through the aperture 40 of the support layer 7 ( Figure 2).
  • the film 25 flexes to provide good physical contact with the underlying tissue 5 which is desirable to achieve efficient transfer of heat to the tissue when the energy absorbent film layer 25 is heated.
  • the beam or field 10 of energy is then directed onto the energy absorbent film 25.
  • the film 25 heats up and the heat in the film is transferred by conduction to the tissue 5, thereby ablating the tissue.
  • the film 25 absorbs the energy and transfers it to the tissue, eventually, because of the tension force, it breaks and separates across the aperture 40 as illustrated in Figure 4.
  • the film 25 burns up as the thermal ablation process occurs and in so doing is weakened to be overcome by the tension force.
  • This self-removal or self-separating feature of the film 25 allows access to the ablated area of the tissue to facilitate fluid communication with the opening(s) 45 without any additional steps.
  • Figure 5 depicts the device 100 used in connection with a transdermal delivery system wherein at least one drug or agent is delivered to the tissue 5 via the opening(s) in the tissue 45.
  • a reservoir 70 containing the at least one drug or agent may be in fluid communication with the opening(s) in the tissue 45 via a conduit 60, such as tubing.
  • the reservoir 70 may be integrally formed with the support layer 7 so that the at least one drug or agent can be delivered into the tissue 5 in a single step procedure with gravity or pressure forcing the drugs or agents into the tissue 5.
  • Figure 6 shows the device 100 used in connection with a monitoring system.
  • the assay reagent pad 20 may be located on the device 100 and connected (wired or wirelessly) to a monitoring apparatus 200.
  • the assay reagent pad 20 may be located remotely in the monitoring apparatus 200 and coupled via fluid conduit 60 that carries the fluid.
  • the assay reagent pad 20 is located remote or proximate to the opening(s) in the tissue 45 depends on the specific application. Both embodiments are useful in discrete monitoring applications for analyzing fluid on a single use basis, as well as in continuous monitoring applications for continuously extracting and analyzing fluid over a longer term basis, such as several hours, days, etc. See, for example, International Application No. PCT US99/16378, filed July 20, 1999, entitled “System and Method for Continuous Analyte Monitoring".

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Optics & Photonics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Otolaryngology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Electromagnetism (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)

Abstract

La présente invention concerne un dispositif destiné à simplifier l'ablation de tissus, notamment la formation d'une ou de plusieurs ouverture dans le tissu pour des applications de surveillance et/ou d'administration transcutanée. Le dispositif est constitué (a) d'une couche support dans laquelle est ménagée au moins une ouverture, et (b) d'au moins une couche mince absorbant l'énergie disposée au-dessus de l'ouverture dans la couche support de façon établir un contact substantiel avec le tissu au travers de l'ouverture. Cette couche mince absorbant l'énergie, qui est soumise à une force de tension, absorbe l'énergie qui s'y concentre de façon à faire l'ablation du tissu. Après ablation, le film mince se casse en petits morceaux, libérant ainsi l'accès aux tissus d'ablation sous-jacents.
PCT/US2000/015665 1999-06-09 2000-06-07 Structure pour thermo-ablation de tissus absorbant l'energie et s'eliminant spontanement WO2000074583A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US10/018,015 US6685699B1 (en) 1999-06-09 2000-06-07 Self-removing energy absorbing structure for thermal tissue ablation
AU54699/00A AU5469900A (en) 1999-06-09 2000-06-07 Self-removing energy absorbing structure for thermal tissue ablation
EP00939642A EP1182982A1 (fr) 1999-06-09 2000-06-07 Structure pour thermo-ablation de tissus absorbant l'energie et s'eliminant spontanement

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13819399P 1999-06-09 1999-06-09
US60/138,193 1999-06-09

Publications (1)

Publication Number Publication Date
WO2000074583A1 true WO2000074583A1 (fr) 2000-12-14

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Country Status (3)

Country Link
EP (1) EP1182982A1 (fr)
AU (1) AU5469900A (fr)
WO (1) WO2000074583A1 (fr)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005046793A2 (fr) * 2001-11-29 2005-05-26 Palomar Medical Technologies, Inc. Procedes et appareil pour l'application de traitements optiques de faible puissance
US7223281B2 (en) 2001-11-29 2007-05-29 Altshuler Gregory B Multi-directional oral phototherapy applicator
US8002768B1 (en) 1997-05-15 2011-08-23 Palomar Medical Technologies, Inc. Light energy delivery head
US8281675B2 (en) 2007-10-17 2012-10-09 Syneron Medical Ltd Dissolution rate verification
US8328794B2 (en) 1996-12-02 2012-12-11 Palomar Medical Technologies, Inc. System for electromagnetic radiation dermatology and head for use therewith
US8337493B2 (en) 2002-04-19 2012-12-25 Syneron Medical Ltd Handheld transdermal drug delivery and analyte extraction
US8915948B2 (en) 2002-06-19 2014-12-23 Palomar Medical Technologies, Llc Method and apparatus for photothermal treatment of tissue at depth
US9011419B2 (en) 2007-12-05 2015-04-21 Syneron Medical Ltd Disposable electromagnetic energy applicator
US9028536B2 (en) 2006-08-02 2015-05-12 Cynosure, Inc. Picosecond laser apparatus and methods for its operation and use
US9037229B2 (en) 2007-10-09 2015-05-19 Syneron Medical Ltd Magnetic patch coupling
US9504826B2 (en) 2009-02-18 2016-11-29 Syneron Medical Ltd Skin treatment apparatus for personal use and method for using same
US9780518B2 (en) 2012-04-18 2017-10-03 Cynosure, Inc. Picosecond laser apparatus and methods for treating target tissues with same
US9919168B2 (en) 2009-07-23 2018-03-20 Palomar Medical Technologies, Inc. Method for improvement of cellulite appearance
US10245107B2 (en) 2013-03-15 2019-04-02 Cynosure, Inc. Picosecond optical radiation systems and methods of use
US10434324B2 (en) 2005-04-22 2019-10-08 Cynosure, Llc Methods and systems for laser treatment using non-uniform output beam
US11418000B2 (en) 2018-02-26 2022-08-16 Cynosure, Llc Q-switched cavity dumped sub-nanosecond laser

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775361A (en) * 1986-04-10 1988-10-04 The General Hospital Corporation Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport
US5643252A (en) * 1992-10-28 1997-07-01 Venisect, Inc. Laser perforator
WO1998042267A1 (fr) * 1997-03-25 1998-10-01 Abbott Laboratories Ablation de la couche cornee au moyen d'une source de lumiere
US5885211A (en) * 1993-11-15 1999-03-23 Spectrix, Inc. Microporation of human skin for monitoring the concentration of an analyte
WO1999040848A1 (fr) * 1998-02-17 1999-08-19 Abbott Laboratories Dispositif de collecte et de controle de liquide interstitiel

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775361A (en) * 1986-04-10 1988-10-04 The General Hospital Corporation Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport
US5643252A (en) * 1992-10-28 1997-07-01 Venisect, Inc. Laser perforator
US5885211A (en) * 1993-11-15 1999-03-23 Spectrix, Inc. Microporation of human skin for monitoring the concentration of an analyte
WO1998042267A1 (fr) * 1997-03-25 1998-10-01 Abbott Laboratories Ablation de la couche cornee au moyen d'une source de lumiere
WO1999040848A1 (fr) * 1998-02-17 1999-08-19 Abbott Laboratories Dispositif de collecte et de controle de liquide interstitiel

Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8328794B2 (en) 1996-12-02 2012-12-11 Palomar Medical Technologies, Inc. System for electromagnetic radiation dermatology and head for use therewith
US8002768B1 (en) 1997-05-15 2011-08-23 Palomar Medical Technologies, Inc. Light energy delivery head
US8328796B2 (en) 1997-05-15 2012-12-11 Palomar Medical Technologies, Inc. Light energy delivery head
WO2005046793A3 (fr) * 2001-11-29 2005-09-29 Palomar Medical Tech Inc Procedes et appareil pour l'application de traitements optiques de faible puissance
US7223281B2 (en) 2001-11-29 2007-05-29 Altshuler Gregory B Multi-directional oral phototherapy applicator
US7223270B2 (en) 2001-11-29 2007-05-29 Altshuler Gregory B Light emitting toothbrush for oral phototherapy
WO2005046793A2 (fr) * 2001-11-29 2005-05-26 Palomar Medical Technologies, Inc. Procedes et appareil pour l'application de traitements optiques de faible puissance
US8337493B2 (en) 2002-04-19 2012-12-25 Syneron Medical Ltd Handheld transdermal drug delivery and analyte extraction
US8915948B2 (en) 2002-06-19 2014-12-23 Palomar Medical Technologies, Llc Method and apparatus for photothermal treatment of tissue at depth
US10434324B2 (en) 2005-04-22 2019-10-08 Cynosure, Llc Methods and systems for laser treatment using non-uniform output beam
US9028536B2 (en) 2006-08-02 2015-05-12 Cynosure, Inc. Picosecond laser apparatus and methods for its operation and use
US11712299B2 (en) 2006-08-02 2023-08-01 Cynosure, LLC. Picosecond laser apparatus and methods for its operation and use
US10966785B2 (en) 2006-08-02 2021-04-06 Cynosure, Llc Picosecond laser apparatus and methods for its operation and use
US10849687B2 (en) 2006-08-02 2020-12-01 Cynosure, Llc Picosecond laser apparatus and methods for its operation and use
US9037229B2 (en) 2007-10-09 2015-05-19 Syneron Medical Ltd Magnetic patch coupling
US8281675B2 (en) 2007-10-17 2012-10-09 Syneron Medical Ltd Dissolution rate verification
US9011419B2 (en) 2007-12-05 2015-04-21 Syneron Medical Ltd Disposable electromagnetic energy applicator
US9504826B2 (en) 2009-02-18 2016-11-29 Syneron Medical Ltd Skin treatment apparatus for personal use and method for using same
US9919168B2 (en) 2009-07-23 2018-03-20 Palomar Medical Technologies, Inc. Method for improvement of cellulite appearance
US9780518B2 (en) 2012-04-18 2017-10-03 Cynosure, Inc. Picosecond laser apparatus and methods for treating target tissues with same
US10581217B2 (en) 2012-04-18 2020-03-03 Cynosure, Llc Picosecond laser apparatus and methods for treating target tissues with same
US10305244B2 (en) 2012-04-18 2019-05-28 Cynosure, Llc Picosecond laser apparatus and methods for treating target tissues with same
US11095087B2 (en) 2012-04-18 2021-08-17 Cynosure, Llc Picosecond laser apparatus and methods for treating target tissues with same
US11664637B2 (en) 2012-04-18 2023-05-30 Cynosure, Llc Picosecond laser apparatus and methods for treating target tissues with same
US12068571B2 (en) 2012-04-18 2024-08-20 Cynosure, Llc Picosecond laser apparatus and methods for treating target tissues with same
US10765478B2 (en) 2013-03-15 2020-09-08 Cynosurce, Llc Picosecond optical radiation systems and methods of use
US10285757B2 (en) 2013-03-15 2019-05-14 Cynosure, Llc Picosecond optical radiation systems and methods of use
US11446086B2 (en) 2013-03-15 2022-09-20 Cynosure, Llc Picosecond optical radiation systems and methods of use
US10245107B2 (en) 2013-03-15 2019-04-02 Cynosure, Inc. Picosecond optical radiation systems and methods of use
US11418000B2 (en) 2018-02-26 2022-08-16 Cynosure, Llc Q-switched cavity dumped sub-nanosecond laser
US11791603B2 (en) 2018-02-26 2023-10-17 Cynosure, LLC. Q-switched cavity dumped sub-nanosecond laser

Also Published As

Publication number Publication date
EP1182982A1 (fr) 2002-03-06
AU5469900A (en) 2000-12-28

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