WO2000052019A3 - Crystallization products of neotame and methods for producing same - Google Patents
Crystallization products of neotame and methods for producing same Download PDFInfo
- Publication number
- WO2000052019A3 WO2000052019A3 PCT/US2000/005775 US0005775W WO0052019A3 WO 2000052019 A3 WO2000052019 A3 WO 2000052019A3 US 0005775 W US0005775 W US 0005775W WO 0052019 A3 WO0052019 A3 WO 0052019A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- neotame
- producing same
- crystallization products
- products
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
- A23L27/31—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives
- A23L27/32—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives containing dipeptides or derivatives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Peptides Or Proteins (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU44491/00A AU4449100A (en) | 1999-03-03 | 2000-03-03 | Novel crystallization products of neotame and methods for producing same |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12296999P | 1999-03-03 | 1999-03-03 | |
US60/122,969 | 1999-03-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000052019A2 WO2000052019A2 (en) | 2000-09-08 |
WO2000052019A3 true WO2000052019A3 (en) | 2001-01-11 |
Family
ID=22405963
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2000/005775 WO2000052019A2 (en) | 1999-03-03 | 2000-03-03 | Crystallization products of neotame and methods for producing same |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU4449100A (en) |
WO (1) | WO2000052019A2 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8791253B2 (en) | 2006-06-19 | 2014-07-29 | The Coca-Cola Company | Rebaudioside A composition and method for purifying rebaudioside A |
US9012626B2 (en) | 2006-06-19 | 2015-04-21 | The Coca-Cola Company | Rebaudioside a composition and method for purifying rebaudioside a |
US8030481B2 (en) | 2007-05-21 | 2011-10-04 | The Coca-Cola Company | Stevioside polymorphic and amorphous forms, methods for their formulation, and uses |
CN103342732B (en) * | 2013-07-11 | 2014-12-03 | 济南诚汇双达化工有限公司 | Crystallization method capable of improving flowability of Neotame |
CN110563797A (en) * | 2019-10-12 | 2019-12-13 | 山东奔月生物科技股份有限公司 | Method for removing viscous components in neotame |
CN114292310A (en) * | 2021-12-30 | 2022-04-08 | 山东诚汇双达药业有限公司 | Preparation method of neotame crystal form A |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0514940A1 (en) * | 1991-05-23 | 1992-11-25 | Ajinomoto Co., Inc. | Method of crystallizing alpha-L-aspartyl-L-phenylalanine methyl ester |
WO1994011391A1 (en) * | 1992-11-12 | 1994-05-26 | Claude Nofre | Compounds useful as sweetening agents and process for their preparation |
EP0600521A1 (en) * | 1992-12-07 | 1994-06-08 | Ajinomoto Co., Inc. | Method for preparing alpha-L-aspartyl-L-phenylalanine |
US5728862A (en) * | 1997-01-29 | 1998-03-17 | The Nutrasweet Company | Method for preparing and purifying an N-alkylated aspartame derivative |
WO1999020648A1 (en) * | 1997-10-23 | 1999-04-29 | Ajinomoto Co., Inc. | Process for the purification of aspartame derivative |
WO2000015656A1 (en) * | 1998-09-10 | 2000-03-23 | Holland Sweetener Company V.O.F. | Process for the preparation of neotame |
-
2000
- 2000-03-03 WO PCT/US2000/005775 patent/WO2000052019A2/en active Application Filing
- 2000-03-03 AU AU44491/00A patent/AU4449100A/en not_active Abandoned
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0514940A1 (en) * | 1991-05-23 | 1992-11-25 | Ajinomoto Co., Inc. | Method of crystallizing alpha-L-aspartyl-L-phenylalanine methyl ester |
WO1994011391A1 (en) * | 1992-11-12 | 1994-05-26 | Claude Nofre | Compounds useful as sweetening agents and process for their preparation |
EP0600521A1 (en) * | 1992-12-07 | 1994-06-08 | Ajinomoto Co., Inc. | Method for preparing alpha-L-aspartyl-L-phenylalanine |
US5728862A (en) * | 1997-01-29 | 1998-03-17 | The Nutrasweet Company | Method for preparing and purifying an N-alkylated aspartame derivative |
WO1999020648A1 (en) * | 1997-10-23 | 1999-04-29 | Ajinomoto Co., Inc. | Process for the purification of aspartame derivative |
WO2000015656A1 (en) * | 1998-09-10 | 2000-03-23 | Holland Sweetener Company V.O.F. | Process for the preparation of neotame |
Non-Patent Citations (7)
Title |
---|
ANAL. CHEM. (1999), 71(16), 3325-3331 * |
CHEMICAL ABSTRACTS, vol. 131, no. 16, 18 October 1999, Columbus, Ohio, US; abstract no. 219055, PADDEN, BRIAN E. ET AL: "Comparison of Solid-State 13C NMR Spectroscopy and Powder X-ray Diffraction for Analyzing Mixtures of Polymorphs of Neotame" XP002140649 * |
DONG, ZEDONG ET AL: "Crystal structure and physical characterization of neotame methanol solvate", J. CHEM. CRYSTALLOGR. (1999), 29(8), 967-975, XP000915724 * |
GOODMAN, MURRAY ET AL: "X-ray structures of new dipeptide taste ligands", J. PEPT. SCI. (1998), 4(4), 229-238, XP000915709 * |
MATTERN, RALPH-HEIKO ET AL: "Conformational analysis of potent sweet taste ligands by nuclear magnetic resonance, computer simulations and x-ray diffraction studies", J. PEPT. RES. (1997), 50(4), 286-299, XP000910240 * |
PADDEN, BRIAN E. ET AL: "Comparison of Solid-State 13C NMR Spectroscopy and Powder X-ray Diffraction for Analyzing Mixtures of Polymorphs of Neotame", ANAL. CHEM. (1999), 71(16), 3325-3331, XP002140644 * |
WINK, DONALD J. ET AL: "Neotame, an alkylated dipeptide and high intensity sweetener", ACTA CRYSTALLOGR., SECT. C: CRYST. STRUCT. COMMUN. (1999), C55(8), 1365-1368, XP000915725 * |
Also Published As
Publication number | Publication date |
---|---|
AU4449100A (en) | 2000-09-21 |
WO2000052019A2 (en) | 2000-09-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2001090138A3 (en) | SYNTHESIS OF N-[N-(3,3-DIMETHYLBUTYL)-L-α-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER USING OXAZOLIDINONE DERIVATIVES | |
AU2001238482A1 (en) | Process for making granulated n-(n-(3,3-dimethylbutyl)-l-alpha-aspartyl)-l-phenylalanine 1-methyl ester | |
WO2001010241A3 (en) | PROCESS FOR COATING N-[N-(3,3-DIMETHYLBUTYL)-L-α-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER ONTO A CARRIER | |
AU4028300A (en) | Particles of n-(n-(3,3-dimethylbutyl)-l-alpha-aspartyl)-l-phenylalanine 1-methylester | |
EP1908773A3 (en) | Process for producing dipeptides | |
AU2417100A (en) | N-(n-(3,3-dimethylbutyl)-l-alpha-aspartyl)-l-phenylalanine 1-methyl ester synergistic sweetener blends | |
IT1293767B1 (en) | PROCEDURE FOR ISOLATING ANTIFREEZE PROTEINS FROM FOOD PRODUCTS AND FROZEN FOOD PRODUCT CONTAINING PROTEIN FOR | |
IT1293768B1 (en) | PROCEDURE FOR ISOLATING ANTIFREEZE PROTEINS FROM FOOD PRODUCTS AND FROZEN FOOD PRODUCT CONTAINING PROTEIN FOR | |
HUP0003847A3 (en) | Basic salts of n-[n-(3,3-dimethylbutyl)-l-alpha-aspartyl]-l-phenylalanine 1-methyl ester | |
HUP0003734A2 (en) | Salts of n-[n-(3,3-dimethylbutyl)-l-alpha-aspartyl]-l-phenylalanine 1-methyl ester, sweetener compositions containing them | |
EP1852020B8 (en) | Sweetener composition improved in taste, its use and process for preparing it | |
AU5585198A (en) | N-(aryl/heteroaryl) amino acid esters, pharmaceutical compositions, and ethods for inhibiting beta-amyloid peptide release and/or its synthesis | |
AU6150499A (en) | The use of cyclodextrin to stabilize n-(n- (3,3-dimethylbutyl) -1-alpha- aspartyl) -l-phenylalanine 1-methyl ester | |
HUP0003573A3 (en) | Acid salts of n-[n-(3,3-dimethylbutyl)-l-alpha-aspartyl]-l-phenylalanine 1-methyl ester | |
AU7847400A (en) | Method for determining and modifying protein/peptide solubility | |
EE200000115A (en) | Metal complexes of N- [N- (3,3-dimethylbutyl) -L-α-aspartyl] -L-phenylalanine 1-methyl ester and low calorie liquid sweetener | |
WO2000052019A3 (en) | Crystallization products of neotame and methods for producing same | |
TR200003750T2 (en) | New aspartyl dipeptide ester derivatives and sweeteners | |
AU3637393A (en) | Method for enzymatically synthesizing peptide alkyl esters, resulting products and use thereof | |
EP1553171A4 (en) | Novel enzyme forming peptide, microorganism producing the same and process for producing dipeptide using them | |
AU1936499A (en) | Use of n-{n-(3,3-dimethylbutyl)-l-alpha-aspartyl}-l-phenylalanine 1-methyl esterin dairy and dairy analogue products | |
AU1832500A (en) | Purification of N-(N-(3,3-dimethylbutyl)-l-alpha-aspartyl)-l-phenylalanine 1-methyl ester via crystallization | |
WO2001028590A3 (en) | PHARMACEUTICAL COMPOSITIONS CONTAINING N-[N-(3,3-DIMETHYLBUTYL)-1-α-ASPARTYL]-L-PHENYLALANINE METHYL ESTER | |
DE59611398D1 (en) | Cyclopentane-beta-amino acids containing dipeptides | |
AU1094301A (en) | Personal care products using n-(n-(3,3-dimethylbutyl)-1-alpha-aspartyl)-l-phenylalanine methyl ester |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
122 | Ep: pct application non-entry in european phase |